Looking for the best articles at the chemistry-biology interface? Let Chemical Science help. It might be a new journal – but it’s making an impressive impact.* Supported by an international team of Associate Editors, all active researchers and renowned experts, the journal represents the best new thinking in the chemical sciences. And you’ll see why when you read these articles as recommended by the Associate Editors for the chemistry-biology interface: ”This edge article illustrates how a powerful chemical biology tool can furnish new biological insights whilst providing a starting point for the development of potential therapeutic agents.“
A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
Tom Muir Associate Editor: Chemical Biology Princeton University, USA
Charles N. Birts, Sharandip K. Nijjar, Charlotte A. Mardle, Franciane Hoakwie, Patrick J. Duriez, Jeremy P. Blaydes and Ali Tavassoli Chem. Sci., 2013, 4, 3046-3057 http://rsc.li/tavassoli
”This paper is a gem - it observes fundamental emergent properties underlying substrate selectivity in a ribozyme. To find chemical selectivity during different steps controlled by what is essentially a de novo biocatalyst implies that there is something inherent driving the evolution of, at least, polymerase systems (and likely others). For me that makes it a really very profound study.“
Chemical fidelity of an RNA polymerase ribozyme James Attwater, Shunsuke Tagami, Michiko Kimoto, Kyle Butler, Eric T. Kool, Jesper Wengel, Piet Herdewijn, Ichiro Hiraob and Philipp Holliger Chem. Sci., 2013, 4, 2804-2814 http://rsc.li/holliger
Ben Davis Associate Editor: Chemical Biology & Bioorganic Chemistry University of Oxford, UK
“Multimetallic active sites are common in biology and perform fascinating chemical transformations. This article describes a creative approach for accessing such multimetallic moieties in small synthetic molecules and expands the toolbox of conceptual strategies to complicated clusters.”
Metal-templated ligand architectures for trinuclear chemistry: tricopper complexes and their O2 reactivity Davide Lionetti, Michael W. Day and Theodor Agapie Chem. Sci., 2013, 4, 785-790 http://rsc.li/agapie
Wonwoo Nam Associate Editor: Bioinorganic Chemistry Ewha Womans University, Korea Impact Factor 8.314 (2012 Journal Citation Reports ® (Thomson Reuters 2013))
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