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Magnetic resonance imaging quantification of gastrointestinal liquid volumes and distribution in the gastro-intestinal tract of children Eleni Papadatou-Soulou, Julie Mason, Caron Parsons, Adam Oates, Manigandan Thyagarajan, and Hannah Katharine Batchelor Mol. Pharmaceutics, Just Accepted Manuscript • DOI: 10.1021/acs.molpharmaceut.9b00510 • Publication Date (Web): 02 Aug 2019 Downloaded from pubs.acs.org on August 2, 2019
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Molecular Pharmaceutics
Magnetic resonance imaging quantification of gastrointestinal liquid volumes and distribution in the gastro-intestinal tract of children Authors Eleni Papadatou-Soulou1, Julie Mason1, Caron Parsons2, Adam Oates3, Manigandan Thyagarajan3, 5
Hannah Katharine Batchelor1* 1
School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston, B15 2TT, UK
2
University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Rd, Coventry CV2 2DX, UK
3 Birmingham
Children’s Hospita NHS Trustl, Steelhouse Lane, Birmingham B4 6NH, UK
Corresponding author: Hannah Batchelor
[email protected] 10
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Dr Hannah Batchelor Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery School of Pharmacy Institute of Clinical Sciences Robert Aitken Building University of Birmingham Edgbaston, B15 2TT Tel: +44 (0)121 414 3717
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MRI to image fluid pockets in children
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Molecular Pharmaceutics
Abstract The volume and localisation of fluid in the paediatric gastro-intestinal tract is crucial to inform the design of in vitro and in silico models that predict the absorption of oral drugs administered to children. Previous studies have used magnetic resonance imaging (MRI) to quantify fluid volumes and localisation in the intestines of adults; this study is the first to undertake similar analysis of paediatric participants.
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This study quantified the amount and distribution of fluid in fasted and fluid-fed children using MRI data captured during routine clinical assessment. Data from 32 fasted children (aged 0-16 years) and 23 fluid-fed (aged 8-16 years) was evaluated. The gastric volume ranged from 0-9mL in the fasted and 19-423mL in the fluid-fed state. The small intestinal volume was recorded to be 0-51mL in the fasted and 6-91mL in the fluid-fed state with an average
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number of 7.7 and 22.4 fluid pockets respectively. The data showed significant differences in gastric volumes and the number of fluid pockets in the small intestine for age-matched fasted and fluid-fed children (p
