Monograph pubs.acs.org/doi/book/10.1021/acsreagents
Mannitol Part 4, Monographs for Reagent Chemicals: General Descriptions, Specifications, and Tests eISBN: 9780841230460 Tom Tyner Chair, ACS Committee on Analytical Reagents James Francis Secretary, ACS Committee on Analytical Reagents
ABSTRACT This monograph for Mannitol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state (approximate), and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Specific Rotation, Reducing Sugars, Insoluble Matter, Loss on Drying, Residue after Ignition, Titrable Acid, and Heavy Metals.
HOCH2(CHOH)4CH2OH
Formula Wt 182.17
CAS No. 69-65-8
GENERAL DESCRIPTION Typical appearance . . . . . . . . Applications . . . . . . . . . . . . . Change in state (approximate) . Aqueous solubility . . . . . . . . .
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© 2017 American Chemical Society
white solid titrimetric determination of boric acid melting point, 167 °C 18 g in 100 mL at 20 °C
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DOI:10.1021/acsreagents.4210 ACS Reagent Chemicals, Part 4
ACS Reagent Chemicals
Monograph
pubs.acs.org/doi/book/10.1021/acsreagents
SPECIFICATIONS Specific rotation [α]25°D . . . . . . . . . . . . . . . . +23.3° to +24.3° Reducing sugars . . . . . . . . . . . . . . . . . . . . . Passes test
Insoluble matter . . . . Loss on drying . . . . . Residue after ignition. Titrable acid . . . . . . Heavy metals (as Pb) .
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Maximum Allowable 0.01% 0.05% 0.01% 0.0008 meq/g 5 ppm
TESTS Specific Rotation [Part 2: Measurement of Physical Properties; Specific Rotation]. Weigh accurately about 10 g, transfer to a 100 mL volumetric flask, and add 12.8 g of sodium borate. Dissolve the mixture in sufficient water to make about 90 mL of solution, allow to stand with occasional shaking for 1 h, dilute with water to volume at 25 °C, and mix. Observe the optical rotation in a polarimeter at 25 °C using sodium D-line, and calculate the specific rotation.
Reducing Sugars Add 1 mL of a saturated solution of the mannitol (about 0.2 g per mL) to 5 mL of Benedict’s solution on a hot plate (~100 °C), and heat for 5 min. No more than a slight precipitate should form.
Insoluble Matter [Part 2: Gravimetric Methods; Insoluble Matter]. Use 20 g dissolved in 100 mL of water.
Loss on Drying Weigh accurately 5.0 g in a tared, preconditioned dish or crucible, and dry at 105 °C for 2 h.
Residue after Ignition [Part 2: Gravimetric Methods; Residue after Ignition]. Ignite 10 g. Moisten the char with 1 mL of sulfuric acid.
Titrable Acid To 100 mL of carbon dioxide-free water, add 0.15 mL of phenolphthalein indicator solution and 0.01 N sodium hydroxide until a pink color is produced. Dissolve 10 g of the sample in this solution, and titrate with 0.01 N sodium hydroxide to the same end point. Not more than 0.8 mL should be required.
Heavy Metals ([Part 2: Trace and Ultratrace Elemental Analysis; Inductively Coupled Plasma−Optical Emission Spectroscopy (ICP–OES); Calculation of Heavy Metals (by ICP–OES) Results], by ICP–OES). Use 2.0 g sample.
© 2017 American Chemical Society
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DOI:10.1021/acsreagents.4210 ACS Reagent Chemicals, Part 4
