INSTRUMENTATION tion while being swept slowly toward the mass spectrometer by the bulk electroosmotic flow within the capil
lary. As the separated bands of analyte elute from the CE column, they are car ried through the liquid junction to the
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Marine Toxins: Origin, Structure, and Molecular Pharmacology
B
ringing together research from many disciplines, this comprehensive volume reports the latest results in the study of marine toxins. This unique book covers the en tire range of source organisms and toxins while focusing on the structure and metabolic origin of toxins and the molecular basis of tox icity. In addition, this volume discusses con temporary molecular pharmacology and con formational chemistry as well as the traditional structural studies. Divided into four sections, the 27 chapters cover the following areas:
Figure 6. L C / M S / M S analysis of a tryptic digest of hemoglobin normal β chain, (a) Full-scan micro LC/MS/MS TIC chromatogram for the same sample shown in Figure 5a. The doubly charged ion (signal at m/z 658) was focused into the collision cell, which was charged with argon gas; CID was carried out with a collision energy of 50 eV. (b) Full-scan CID product ion mass spectrum for the ion (signal at m/z 658) of the tryptic fragment eluting at 12 min in Figure 5a. The retention times in Fig ures 5a and 6a differ somewhat because of minor variations in HPLC reproducibility; micro LC conditions were the same as described in Figure 5.
• General considerations • Polyether toxins • Palytoxin • Peptide toxins
The scope of the book goes slightly beyond the title and includes cyanophytes that occur in fresh or brackish waters. Also, an examina tion of the interactions between toxins and their primary sites of action is provided. Sherwood Hall, Editor, U.S. Food and Drug Administration Gary Strichartz, Editor, Harvard Medical School Developed from a symposium held under the auspices of the Commission on Food Chemistry. Applied Chem istry Division, International Union of Pure and Applied Chemistry." ACS Symposium Series No. 418 390 pages (1989) Clothbound ISBN 0-8412-1733-5 LC 89-18505 $74.95 0
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Figure 7 . C E / S I M M S total selected ion current electropherogram for 4 0 0 - 5 0 0 pg of synthetic sulfonylurea herbicides using the ion spray L C / M S interface. Conditions: 50:50 CH.,CN/10 mM NH4OAc (pH = 5.5), 17 kV (13 mA); samples injected for 30 s at 5 cm hydrostatic head (injection volume of 6-7 nL); 100 ^m X 100 cm fused-silica column; and the ion spray interface held at 3 kV. The elution order is 1, bensulfuron methyl; 2, sulfometuron methyl; 3, tribenuron methyl; 4, chlorimuron ethyl; and 5, thifensulfuron methyl. (Separation and samples kindly provided by G. Sherwood, E. I. du Pont de Nemours & Co., Wilmington, DE.)
720 A • ANALYTICAL CHEMISTRY, VOL. 62, NO. 13, JULY 1, 1990
