Subscriber access provided by UB + Fachbibliothek Chemie | (FU-Bibliothekssystem)
Article
A metabolomics approach to investigate estrogen receptor-dependent and independent effects of o,p’-DDT in the uterus and brain of immature mice DeZhen Wang, Wentao Zhu, Yao Wang, Jin Yan, Miaomiao Teng, Jiyan Miao, and Zhiqiang Zhou J. Agric. Food Chem., Just Accepted Manuscript • Publication Date (Web): 28 Apr 2017 Downloaded from http://pubs.acs.org on April 30, 2017
Just Accepted “Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides “Just Accepted” as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these “Just Accepted” manuscripts.
Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
Page 1 of 27
Journal of Agricultural and Food Chemistry
! ( " + ) " ( "
# ,
(('
'4
)"
!
"
% "
&
' " ' *
")
-..-/0 1232 ! # (('
! "" )( 5
!
" # " $
!
)" !
"
' " '*
"4 6
2
2
ACS Paragon Plus Environment
")
& '
Journal of Agricultural and Food Chemistry
1"
) )
)
+ ##
)
)" -
)
) #
"
&% 39 )
(78
:0..
9 '
" '2 9
)"
"
' 538
(
9
8 A( )
'
'
##
(
" ) + '
"
)
((" 4
2 )
9 '
"
' '
)
( )
(78 ## '
+ "
9 '
)
A "
)
" ) 9
') +
+ )
9 '
9
9 )
' )"
)E % 3E (78
) 538
D8
'
(
)
(
"
%8
538
(
9 '
ACS Paragon Plus Environment
##
'
) )
')2 E ! -B, CB.E ) "
"# 9 ' )
#
'
) "9
)
) # " '
! -B, CB.2 $ "
" + (
# "
9 '
) + " 9"
2 )"
=
9"
"
9"
(
8 )"
) )
' ) ) :1?@8
)
(78
' :55 -.. > ;< = + ) )
( "8:53=8 (
#
)
)( "
("
)
+ '
' "
)
# )
" ) ' )"
) ( " )
)" (
) (("
;< =
)"
Page 2 of 27
)2
Page 3 of 27
Journal of Agricultural and Food Chemistry
5) "
') "
" ' ) )) )"
#
#
( ) # #
) ( )
( ''
' (
)" )
=
2 5(
)
'
# " '
A
)"
)
)
9"
" ) "
"
"
"
"
+
2$ "
"
) ') ( )
"
)
9
) ) )"
)2
)" + "
5,
9 '
) 9 '
)
9
)
'
9
( " # ' +
'
))
9 )
"
)
) ((" )2
) #
ACS Paragon Plus Environment
"
"
) (" : H = #(
, ,89 ):(8
' " +
)
" " (
" '
)
F '
" ) "(
#
: 1 =
)) )
#"
A( "
)
# '
) ) # " " " A (
" (" '
)
)2
9
)"
2 " ) " ( " )( '
"
"
)"
'
"
:&1 5= + " ) )
9
)
#
)
) #A
)
)"
)"
) 2& +
"
")
) " ' :50= 9 )(
' "
)"
' ))+ ) )
')
A
)
#A
)
" ""
)
'
"
8" ("
" " (
' '
"( "
("
#
' (
' +
") ) )
#
)"
"
) " ") 9 "
)
)'
A
"
9 '
9
' (
" )(
)) 2
)
' (
#
"
"
"
'
#
9" )
+
)" ( ")2
'
" G# "
"
)
')
) )
)
#'
)"
+
# "
)
'
# )"
)" (
"
'
)"
") ( "
)) ) : 2 2
( )) 9'
')
" '
)
')
"
) A( ) "
) (' )
' ) ' "
("
) 2 5) "
')
# " (" "
" ' )"
) 2 5) "
)" '
)
"# " +
9
'
#
)" ( ")
" )( "
)
"
"
' ) +
'=8- - -8 "
) 2 '')
"
Journal of Agricultural and Food Chemistry
9 '
')
(' )2 !
( "
" ) )
" #
9 ' (
#
9 '
' )" '
#'
9 ' "
9 '
) #
# "
'
)
'
-I8,.J
#
(" )
)
+ )
') 9
)
(78
2
) "9
) #
' '
) ) )
)
' (
" )
)
"
9"
9
(78
9
# "
' "
")2
2
"
9 ' 2
"
+
'
) )
) + " ) '
)
'
)2
)
#
" )9 +
55
'
# ")
2
"
'
'8
"#
-,... W
2
)+ " ' ( '
)(
,H
,-
-..
) ( "
II. >' (
+
' #' " )
(' + ) ' ( '
*
+
'' #
("
9 ## " :.2,
@18 L :-
-I...W # " -.
'
'
+
)
" + "
&'! $ %(
# "
9 # "% 3
" ' A
# .2.- )2
A '
#P
))2
''
" + )" (
(" 9 : " < "
+
)) ) + "
9 ' )
+
% 3
) -& % 3 )(
) A"
2
("
+ )
"#
" < "
"
)) ))
)
% &,1HL (& C2L=
I
+
)
A"
) ( "
# "
" + )
% "
''
"
)
! ''
" "
)
$
) ( "
.2,
#
A"
" ) '
% ,&1HL
" ' A
'
)
A"
2
' 8# A
" ) (
"
+ )
"
9
)) ) + "
# " -.
'
# "
(
" ) )) ) + "
A"
' 2
) '
2
)
+
# "
#
'' #
"
:0TL > =
'#
"
9"
#
# '' +
) "
!
'' )
+ A )
:&U5=
(
)
Page 6 of 27
#
I..>' ) ( "
+ )
' ))
)( "
'' -& % 3 )(
)
& % 3 )( X "
+ )) ' ' )( ' " "
ACS Paragon Plus Environment
" + " "
((
=2 $ " 9"
# "
# L)
"
)
('
)
" - %H5@
)
# ,2VV ) ' (" 8)
" ''
'
" )2 $ "
Page 7 of 27
Journal of Agricultural and Food Chemistry
)(
"
' # -,B )
+
# ,. ((
$ %
:# "
"
)3
9"
#
''
2 5
'' )( #
"
+ )
# '' +
'#
'#8
)
)(
"
"
+
( " 1
"
)
' ) ")
'
+ ) "
( "
( "
3,
' ) ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
> 3 ;! 3 ! 9/ % 95 &0% % & % F!0 E 0 E ? 7 , % & ( % & ( ! & 2 )% . 4 0% 4 1 & %. 95% && ( 5 ( ! & & " 7 ) %. & # 0 % % 5!/ ( . 95% && "
3 7!0 . 7!
$ ;! " "0 . 1 & 55%
, 3 F! . $ : E 95 & ( 1 2 &% ( ! !0 $
# 7! 0 %
. < 7
Page 18 of 27
7 < ! % & && && 2 1 & & %0 ( . & !#
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
' "
' " )(
!Q
)"
)
) =2
)
## "
0
)"
"
)
:
+
Z, :
) " " ()
#
9 '
): =
"
# "
" # "
0
)
+
-
&% 3
# ("
) " ('
#( " '' ) )
#"
)
9"
(' ) #
(
( ' )
538
)
' ) ) :1?@8
=
:-& % 3=
" ))
#"
'
#
(
'
) ##
' ) 9 A8+ )< " ('
:$
)
55 9
:1[.2.I )2 !Q ) a=2 $ "
"
'
" @I=2
(
(' ) #
R!
( )"
' ) ) :1! = !Q 55
" )8 ) "
!Q
< b)
!Q 55 55R !
# "
9"
' ) )+ "
9
' ) "
) `E 1[.2.I )
@ (( "
#"
'
9 )"
"
) " ('
32
'
" () :3,^].2BLC 3, ].2/V/
" "
" (" )
) E 1[.2.I ) 55
)
') ( ))
#"
:!= + " ' )
! -B, CB.
9' @-=2
9
) 9
9 '
=2
" () :3,^].2B0V 3, ].2CVI Z,
) 1?@8 :
" ): =2
'' )
3 )
55R !
"#
9 '
8 )"
" )8 ) "
R!
(
:
!Q :1[.2.I )2
: %HP = # '' +
!Q
22 &
)
' "
( " 9
% ' "
))+
0
")
# ( " ' ' ) )
= ].2B0L= : =2
( "
"
!Q 55
= ].2IIC= : =
'"
"
) :1[.2.I=2
1"
(' ) #
(
) a=2
:&@ = ( )
) " ('
12 ')
' 9 "
#
# "
#
) `E 1[.2.I ) ' ))
'
' "
" 55 + ) )
)
) #
' :55=
(78
:1[.2.I ) 55
)
" #
Page 20 of 27
55R !
' ) ) :1?@8 R!
')
=
"
)" () : =
') )
" () :3,^].2V-, 3, ].2CLB
ACS Paragon Plus Environment
Page 21 of 27
Journal of Agricultural and Food Chemistry
Z, : )
= ].2LLI=2 : = "
( "
") # " " ))
'
9' @-2
ACS Paragon Plus Environment
( "
))+ "
Journal of Agricultural and Food Chemistry
9' -2 "
9 ' ) ' "
()2
"
+ 8"
' "
" )
"
