Overcondensstion, which is evident throughout the text, is a limitation of this hook. I t is too brief to he recommended for medical or graduate students. Thus the chemistry of blood is dealt with in less than one page, urine in 2 pages, and acidbase balance in 2 pages. However, it meets adequately the needs of undergraduate students of the physical and biological sciences as well as students of dentistrv. ", pharmacy, agriculture, food ~cience,and nutrition. On the whole, this textbook is very clearly written, well illustrated, and smoothly translated.
ods are brief. Witkop's exhaustive review of chemical methods in "Advances in Protein Chemistry" is a necessary supplement to this chapter. The review of enzymatic llydn,lyi.ie rnethocls is adequare. N-trmminul und C-teruunal sequcnre determinnriorta un diwuseed in Cha~tem 6 and 7. These procedures are reviewed in many books. The present treatment ia thorough and balanced. Procedures artre described in sufficient detail so that the original literature may be readily ewluated. This section is a valuable summary of analytical methods. The chapter on dialysis and gel filtration is s. good practical introduction conEBBAT S. YOUNATHAN taining information such as the porosity Univetsity of Arkansas Medical Cater of Viaking cellophane tubing a t different I d l e Rock thicknesses. It is unfortunate that Porath's review in "Advances in Protein Chemistry" is too recent for inclusion in this section. The next two chapters on column chromatography and zone eleotrophoresis are goad introductions to the subject. Techniques in Protein Chemistry The final chapter outlines miscellaneous methods such as the Folin-Cioealteau, J . Leggett Bailey, Twyford Laboratories, biuret, and Kjeldahl procedures for estiLondon. American Elsevier Publishmating protein and nitrogen. ing Co., New York, 1962. xii 310 In this review, it has been suggested pp. Figs. and tables. 14.5 X 22 that more authoritative discussions of cm. $11. specific topics are available. This in no This hook is a thorough laboratory manway detracts from Bailey's hook. The ual on protein isolation, protein cleavage, real merit of this book is found in ita baland amino acid analysis. The subject is a ance and selectivity. The hook is much fortunate choice. Msny excellent dismore than a. survey. I t is a good working cussions of protein chemistry have been manual and should fill this important funepublished; however, 3. Leggett Bailey tion in the personal libraries of many has written the heat concise and yet critical chemists and hiochemists. summary of analytical methods that is D ~ v mG. CORNWELL now available. Ohio State University Paper chromatography is discussed in Columbus Chapter 1. The discussion includes general conaiderations and detailed inatructions. The partition coefficient theory of Martin and Synge is reviewed and a h g e series of experimental Rr values are recorded. Thin-layer chromatography is Methods in Carbohydrole Chemistry. too recent a development for inclusion Volume 2, Reactions of Carbohydrates in this section. Chapter 2 discusses high-voltage elecEdited by Roy L . Whistler, Purdue trophoresis. Line drawings and circuit University, Lafayette, Indiana, and diagram are used to describe apparatus. M. L. Wolfrom, Ohio State University, The actual separations achieved with a Columbus, assisted by James N . Benumber of system are represented scheMiller, Southern Illinois University, matically and with several photographa. Carbondale. Academic Press, Inc., The combination of electrophoresis and New York, 1963. xv 572 pp. Figchromatography for the separation of ures. 16 X 23.5 om. $19.50. amino acids and peptides is described. Ion-exchange chromatography is oub This volume, the second in a series of lined in Chapter 3. This chapter includes five volumes to be published, is concerned a brief discussion of ion-exchange resins with reactions of simple carbohydrates. which will serve aa an introduction to the I t is designed primarily sa a working detailed information available in specific reference for the laboratory. In general boob on ion-excbange chromatography. each reaction is briefly discussed and variThe elution analysis scheme developed ous modifications evaluated. This is folbv Moore and Stein is covered adeaustelv. lowed by a detailed procedure for one or . , ljrtte on tho frartimkrion of prptidw are more specificreactions. inrluded in this vlmprrr. Section 1, General Considerations, conThe sperific clr~vageof disulCde b w h tains only one article: Claasitioation of and disulfide interchirnge me disruased in Blocking Groups. Thia is a brief outline a n interesting chnptcr. Inrra- and iuterof the stability and use of various derivarnolerul?r didtide lronds have presented tives. Many of the descriptions are too a formidable analncial ~roblem. Bnilrv brief to be of much value, particularly for has made original &ntridutions and writ& the non-expert. with authority on this subject. Section 2, Oxidation Products, is suhChapter 5, Selective Cletwrtge of Pepdivided into sections entitled: Aldonic tide Chains, is perhaps the least adequate Acids, Uronic Acids, Aldaric Acids, Hexochapter in this book. The sections on losonic Acids, and Esterification. partial acid hydrolysis and chemical methSection 3, Reduction Pmduets, contains
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Journal o f Chemical Education
descriptions of different metal hydride reductions, catalytic hydrogenation, reductive amination, and also methods for the preparation of inositol, mannitol, and pemeitol. Section 4 discusses Derive tives of Nitrogen Bases; Section 5, Etheritication; Section 6, Esterification. The remaining sections are: 7, Acetalation; 8, Unsaturated Sugars; 9, Aldosuloses; 10, Acyclic Monosaccharides; 11, Thiosugars; 12, Configurational Inversion; 13, The 0x0 Reaction; 14, Grignard and Friedel-Crafta Reaction; 15, Saccharinic Acids; 16, Determination of Isotopic Carbon Distribution in Aldoaes; 17, Selected Methods in Carbohydrate Chemistry Found in Other Collections. Each section is written hy an investigator who haa had direct experience with the method described. There are 86 contributors to the volume. As would be expected, the degree of detailing and the extent of evalustion of different methods varies considerably from section to section. The footnotes in several sections appear to contain much helpful information, particularly if modification of the described method is required. This volume is a definite contribution to the research worker dealing directly with carbohydrates. Every research laboratory having occasion to deaJ with csrbohydrates will find this book moat helpful. R. H. MCCLUER Ohw Stote University Columbus
Methods in Carbohydrate Chemistry. Volume 3, Cellulose
Edited hy Roy L. Whistler, Purdue University, Lafsyette, Indiana, and M . L. Wolfrorn, Ohio State University, Columbus. Academic Press, Inc., New York, 1963. xvi 407 pp. Figs. and tables. 16 X 23.5 cm. $15.50.
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This volume presents methods in cellulose chemistry only, and is thus of more specialieed interest than the preceding volumes of the aeries. It is closely restricted to the subject of cellulose; plant and wood chemistry are only briefly considered, and applications to textile and paper technology have been omitted. Since little background material is given with the procedures, uae of s. standard text in cellulose cbemiatry in conjunction with the volume is recommended far the nan-specialists. The volume is divided into the following sections: 1, Preparation of Cellulose; 2, Chemical Analyses; 3, Physical Analyses; 4, Degradation of Cellulose; 5, Cellulose Esters: Preparation, Properties, Reactions, and Analyses; 6, Cellulose Ethers: Preparation, Properties, Reactions, and Analyses; 7, Microscopy; 8, Laboratory Equipment; 9, Preparation and Analysis of C'4-Labeled Cellulose. The form, as in the preceding volumes, for each procedure consists of sn intraduction in which some general information is
(Continued a page A&8)
BOOK REVIEWS
Reactions of Coordinated Ligands and Homogeneous Catalysis
oresented. and corn~srison of various
Symposium Chairman, Dale H. Busch, Ohio State University. Advances in Chemistry Series No. 37. ACS, 255 pp. Washington, D. C. vii Figs. and tables. 15.5 X 23 cm. Paperbound. $7.
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and discussions in this volume me quite adequate. Certain sections such as Section2, Chemical Analyses, are good supplements to Volume 1 (Analysis and Preparation of Sugutrs) as many of the procedures and techniques are thoroughly detailed and of mare general interest. The volume appears to he an essential tool in any laboratory handling cellulose. R. H. MCCLUER Ohio Slate University Columbus
This volume is another excellent contribution to the Advances in Chemistry Series. It represents a collection of eighteen papers from a symposium held during the 141st meeting of the American Chemical Society. It is unfortunate that all papers were not included. After a short preface by Prof. John C. Bailar, Jr., Dr. Busch's introductory lecture paints out the various research
arena which are going to be discussed. This is followed by two excellent papers by Myron L. Bender on Metal Ion Catalysis of Nucleophilic Organic Reactions in Solution, and Gunther L. Eichhorn on Metal Ion Catalysis in Biological Systems. In the next paper, Marvin D. Rausch reviews the field of Metd-Cyclopentadienyls and Meta-Arenes, a field of interest to many inorganic and organic chemists. These three papers are truly outstanding in scope and clarity of presentation. They should be assigned reading for all graduate students. The other papers cover a variety of topics such as Quasiaromatic Metal Chelates, Catalytic Hydrogenation by Pentacymocobaltatate(I1) and Reaction of Some Niohium(V) and Tantalum(V) Halides with Pyridine. More or less specific results are discussed in these papers, some of them however contain excellent bibliographies One area of prime industrial importance which this reviewer feels was slighted is that of the reaction of Metal s complexes. This volume is a very excellent addition on Tnorgurrie to r1.e mne) p~perbuck~ (:l~etnisrry whirh hare uppe;,red recently; it is t w bad 111.11 i t i~not in tile uwal rrricr range
HANSB. JONASSEN Tulane Univrrsity New Orleans, Louisiana
Chemistry in Nonaqueous Ionizing Solvents. Volume 1, Part 2, Organic Reactions in Liquid Ammonia
Herschel Smith Interscience Publishers (a division of John Wiley and Sonns, 363 pp. Inc.), New York, 1963. xv Figs. and tables. 17 X 24.5 cm. $14.
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The problem faced by the student and research worker in sohieving an adequate familiarity with a particular area of investigation becomes more time-consuming from yesr to year. Scientists increasingly owe a special debt of gratitude therefore to those who make available comprehensive review8 and monographs that provide orientation in depth. The present volume is an outstanding example. The first three sections (38 pages) of this book include brief but adequate discussions of ammoniates, the solvent properties of ammonia, solubilities (mostly qualitative), and physical properties of solutions in ammonia. A brief section on industrial uses of ammonia serves only to underscore the paucity of such applications. This is followed by a review of ionic reactions (74 pages) appropriately subdivided to include, for example, addition processes, elimination reactions, and molecular rearrangements. Three short treae ments (38 pages) are concerned with ammonolytic reactions, electrolyses, and oxidation processes. The longest and probably the most useful section (141 pages) is devoted to a very thorough discussion of reduction reactions in
(Continued on page A470)
A468 / Chemical Education
