Chemical Education Today
CLIP, Chemical Laboratory Information Profile “Only when you know the hazards, can you take the necessary precautionary measures.”
CH3OCOCCH3⫽CH2
Methyl Methacrylate
CAS No.: 80-62-6
Synonyms: Methyl 2-methylpropenoate
Physical Properties
Exposure Limits
Colorless liquid with a characteristic odor Vapor pressure at 20 °C: 38 torr Melting point: ⫺48 °C Boiling point: 101 °C
OSHA PEL: ACGIH TLV: ACGIH STEL:
100 ppm 50 ppm 100 ppm
Hazardous Characteristics Overall toxicity 3
Flammability 4
Destructive to skin/eye 2
Absorbed through skin? No
Sensitizer? Yes
Selfreactive? Yes
Incompatible with: Oxidizing agents, oxygen, peroxides*
0: None (or very low); 1: Slight; 2: Moderate; 3: High; 4: Severe. *Reactivity Hazards
The reaction of methyl methacrylate with moderate to strong oxidizing agents is usually vigorous. Either oxygen or peroxides actively promote an always-exothermic polymerization that, after an induction period of variable length, results in a violent selfaccelerating runaway reaction. See Bretherick’s Handbook of Reactive Chemical Hazards for other incompatibilities and for details regarding the inhibition of polymerization. Cited as known to be or reasonably anticipated to be carcinogenic in NTP-11?
Identified as a reproductive toxin in Frazier and Hage, Reproductive Hazards of the Workplace? Insufficient data
No
Typical symptoms of acute exposures:
If inhaled, coughing, sore throat, labored breathing, dizziness, dullness, loss of control, lung edema. On the skin, irritation, dermatitis, eczema. In the eyes, irritation, pain. If ingested, sore throat, abdominal pain, vomiting. Principal target organ(s) or system(s):
Skin, respiratory tract, central nervous system, eyes.
Storage Requirements The uninhibited monomer is not suitable for untended storage. Store the inhibited monomer, but no longer than 6 months, with other flammables and combustibles in a cool, dry, well-ventilated location away from ignition sources and separated from oxidizing agents.
Additional Remarks At ordinary temperatures, the vapor pressure of methyl methacrylate is approximately 50,000 ppm and therefore greatly exceeds the limits established by OSHA and ACGIH. Accordingly, users will be likely to be over-exposed to the vapors of this compound unless appropriate precautions are rigidly maintained; see the MSDS for details. The vapor is more dense than air; it is explosive when mixed with air; the vapor will travel long distances and collect in low-lying and/or poorly ventilated locations. Symptoms of lung edema are not manifest immediately in victims who have inhaled methyl methacrylate vapors; some hours may elapse first; physical effort can exaggerate these symptoms. Rest is essential for persons exposed to excess vapor.
Notes ReadMe
This Chemical Laboratory Information Profile is not a Material Safety Data Sheet. It is a brief summary for teachers and their students that describes some of the hazards of this chemical as it is typically used in laboratories. On the basis of your knowledge of these hazards and before using or handling this chemical, you need to select the precautions and first-aid procedures to be followed. For that information as well as for other useful information, refer to Material Safety Data Sheets, container labels, and references in the scientific literature that pertain to this chemical. Reproductive Toxins
Some substances that in fact are reproductive toxins are not yet recognized as such. For the best readily available and up-to-date information, refer to “DART/ETIC”. See the TOXNET home page at http://toxnet.nlm.nih.gov/. Note that some of the data in DART/ETIC have not been peer-reviewed. See also Frazier, Linda M.; Hage, Marvin L. Reproductive Hazards of the Workplace; Wiley: New York, 1998; and Shepard, T. H. Catalog of Teratogenic Agents, 9th ed.; Johns Hopkins University Press: Baltimore, MD, 1998. Abbreviations
ACGIH TLV—American Conference of Governmental Industrial Hygienists–Threshold Limit Value. C—Ceiling. CAS—Chemical Abstracts Service. mg/m3—milligrams per cubic meter. NA—Not applicable. NE—Not established. NI—No information. NTP-11—National Toxicology Program, Eleventh Annual Report on Carcinogens. OSHA PEL—Occupational Safety and Health Administration–Permissible Exposure Limit. ppm—parts per million. STEL/C—Short-term exposure limit and ceiling. Prepared by: Jay A. Young
www.JCE.DivCHED.org
Date of preparation: July 24, 2005
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Vol. 83 No. 5 May 2006
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Journal of Chemical Education
695
