BOOKS the field of micro, or capillary LC, but more importantly, they explain and summarize many aspects of the current theory and practice of LC. This text may be most useful as a general reference book for the scientist who is searching for explanations and examples of various aspects of theory for the design of experiments using HPLC. If it were necessary to describe this volume in only a couple of words, those words would be "quality scholarship." The authors have broadly defined
capillary LC as any HPLC technique employing column diameters of about 1 mm or less. They divide this category into microbore and microcapillary LC. The former is further divided into applications of semi-microbore (about 1-mm i.d.) and ultra-microbore (0.20.3-mm i.d.) columns. Microcapillary LC is divided into applications of open tubular and irregularly packed capillary columns. Not everyone will be comfortable with this nomenclature scheme, but it has the advantage of be-
Analytical Chemists/ Quality Assurance We have 2 positions open in our San Antonio, Texas site office for highly qualified individuals to help us develop and monitor quality assurance activities in a major environmental sampling and analysis program. Individuals will be responsible for developing QA/QC requirements and evaluating commercial testing laboratories' performance in meeting those requirements. Evaluations will be based on a review of data and documentation and on-site inspections of laboratory operations. Both positions require expertise in analytical chemistry, a working knowledge of Q A / Q C principles and practices, and hands-on experience with the instrumentation and methods used in environmental testing (e.g., A A , ICP, GC, GC/MS). Experience with EPAtest methods is highly desirable. The first position requires an advanced degree in Analytical Chemistry, 10 years of analytical laboratory or quality assurance experience, and at least one year of experience in environmental laboratory supervision. The second position requires a BS in Chemistry with emphasis on analytical procedures plus at least 5 years of experience in the quantitative analysis of environmental samples under a comprehensive Q A / Q C program. Individuals must be willing to travel 10 to 12 weeks a year. For consideration, please submit your resume to J.A. Goudarzi, The MITRE Corporation, 7525 Colshire Drive, McLean, VA 2 2 1 0 2 . U.S. Citizenship required. An Equal Opportunity/ Affirmative Action Employer.
MITRE 248 A · ANALYTICAL CHEMISTRY, VOL. 60, NO. 3, FEBRUARY 1, 1988
ing technically correct, and it could help bring about some much-needed order in the naming of the diverse techniques associated with capillary HPLC. The authors point out that HPLC on columns of small diameter was attempted as early as 1961 by several groups working with amino acid analyses. In addition, the first successful applications of HPLC employed instruments with column diameters of 1-2 mm. The authors also point out that while research into capillary HPLC languished for more than a decade in Japan, the United States, and Europe, researchers in the Soviet Union developed many aspects of the technique that, because of the lack of communication, were later duplicated in Western research. Not until 1979 did interest in HPLC miniaturization reemerge, primarily through the research of Ishii in Japan and Scott and Kucera, Novotny, and others in the United States and Europe. Rather than being a homily on the virtues of "small is better," Capillary Liquid Chromatography is a well-balanced, scholarly review of all aspects of chromatographic theory that impinge on questions of the redesign of HPLC instrumentation on a small scale. The beauty of this book is its universal appeal. Except for open tubular HPLC, or irregularly packed capillary columns, there is little or no theoretical difference among packed columns of various diameters. Therefore discussions in chapter 3 regarding the theoretical basis of capillary LC summarize LC theory relevant to all column diameters and types. Likewise, chapters 4 and 5 discuss equipment and column preparation and present comprehensive reviews of the roles of time constants, flow dispersion, optical design, and current column packing theory. Although they are discussed in the context of narrow-bore columns, these topics are equally relevant to the 4.6-mm columns widely used today. An outstanding feature of the book is the list of 369 references, which represent a cross section of the most pertinent aspects of HLPC theory and practice. On the other hand, it is unfortunate that the book contains no index. In its present state, HPLC is a conservative practice, partly because of its widespread use in several regulated industries. Many scientists have discounted the value of column miniaturization, which offers few clear theoretical advantages. However, the many good scientific papers that have appeared in the literature in the past six or seven years and the introduction of several commercial systems attest to
