In the Laboratory edited by
JCE Featured Molecules
William F. Coleman Wellesley College Wellesley, MA 02481
Molecular Model of Creatine Synthesis November Featured Molecules The featured molecules for this month come from the paper on page 1654 by Andri Smith and Paula Tan on the synthesis of creatine in introductory organic chemistry. This synthesis is sufficiently straightforward to be used in nonmajors and general chemistry courses. The structures illustrate some of the limitations associated with the computation of molecular structure. The two adenosine phosphates ADP and ATP exhibit a large number of conformations due to rotation of the adenine system around the bond to the ribose ring, multiple rotational conformations in the phosphate groups, the ionic state of the compound, and the interaction with the solvent or another species such as creatine. The structures that are given for ADP and ATP are derived from PM3MM calculations and are very similar to those derived using the UFF force field. Sarcosine, creatine, and creatine phosphate were treated using the model chemistry B3LYP/ 6-31+G(d). Perhaps the most interesting structural feature is found in the small molecule cyanamide. Observant students might notice in the Web-based structure that the NCN grouping in cyanamide is non-linear, with an angle of about 177o. This is found for essentially all levels of theory we examined up through the G2 combined model. For students who do notice this deviation from linearity it is useful to ask them whether they are surprised, ask them to defend their answer, send them to the literature to see whether such behavior is seen for cyanamide in other phases (it is), and finally to speculate on possible explanations for the observed non-linearity.
www.JCE.DivCHED.org
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creatine
adenosine triphosphate
Fully manipulable (Chime and Jmol) versions of creatine, phosphocreatine, ADP, ATP, cyanamide, and sarcosine, as well the other molecules in the collection are available at the JCE Digital Library Web site: http://www.JCE.DivCHED.org/JCEWWW/Features/ MonthlyMolecules/2006/Nov
Vol. 83 No. 11 November 2006
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Journal of Chemical Education
1657
