Article pubs.acs.org/JAFC
Multi-mycotoxin Analysis of Finished Grain and Nut Products Using Ultrahigh-Performance Liquid Chromatography and Positive Electrospray Ionization−Quadrupole Orbital Ion Trap High-Resolution Mass Spectrometry Chia-Ding Liao,*,†,‡,# Jon W. Wong,*,†,# Kai Zhang,† Paul Yang,§ James B. Wittenberg,† Mary W. Trucksess,† Douglas G. Hayward,† Nathaniel S. Lee,∥ and James S. Chang⊥ †
Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, United States ‡ Food and Drug Administration, Ministry of Health and Welfare, Taiwan, No. 161-2, Kunyang Street, Nangang District, Taipei City 115, Taiwan § Laboratory Services Branch, Ontario Ministry of the Environment, 125 Resources Road, Etobicoke, Ontario M9P 3V6, Canada ∥ Joint Institute for Food Safety and Applied Nutrition, University of Maryland, 2134 Patapsco Building, College Park, Maryland 20742-6730, United States ⊥ ThermoFisher Scientific, 355 River Oaks Parkway, San Jose, California 95134-1908, United States S Supporting Information *
ABSTRACT: Ultrahigh-performance liquid chromatography using positive electrospray ionization and quadrupole orbital ion trap high-resolution mass spectrometry was evaluated for analyzing mycotoxins in finished cereal and nut products. Optimizing the orbital ion trap mass analyzer in full-scan mode using mycotoxin-fortified matrix extracts gave mass accuracies, δM, of +2 or +2 or +2 or
