Article pubs.acs.org/journal/abseba
Multiscale Porosity Directs Bone Regeneration in Biphasic Calcium Phosphate Scaffolds Laurence E. Rustom,†,‡ Thomas Boudou,‡,§ Brett W. Nemke,∥ Yan Lu,∥ David J. Hoelzle,⊥ Mark D. Markel,∥ Catherine Picart,‡,§ and Amy J. Wagoner Johnson*,†,‡,# †
Department of Bioengineering, University of Illinois at Urbana−Champaign, 1270 Digital Computer Laboratory, MC-278, 1304 West Springfield Avenue, Urbana, Illinois 61801, United States ‡ Le Laboratoire des Matériaux et du Génie Physique (LMGP), University Grenoble Alpes, 38000 Grenoble, France § CNRS UMR 5628 (LMGP), Grenoble Institute of Technology, 3 parvis Louis Néel, 38016 Grenoble, France ∥ School of Veterinary Medicine, University of WisconsinMadison, 2015 Linden Drive, Madison, Wisconsin 53706, United States ⊥ Department of Mechanical and Aerospace Engineering, Ohio State University, 201 W 19th Avenue, Columbus, Ohio 43210, United States # Department of Mechanical Science and Engineering, University of Illinois at Urbana−Champaign, 1206 West Green Street, Urbana, Illinois 61801, United States ABSTRACT: Large and load-bearing bone defects are challenging to treat and cause pain and disfigurement. The design of efficacious bone scaffolds for the repair of such defects involves a range of length scales from the centimeter down to the micrometer-scale. Here, we assess the influence on bone regeneration of scaffold rod spacing (>300 μm) and microporosity (
