ARTICLE pubs.acs.org/Biomac
Osteogenic Differentiation of Pre-Osteoblasts on Biomimetic Tyrosine-Derived Polycarbonate Scaffolds Jinku Kim,† Maria Hanshella R. Magno,‡ Pedro Alvarez,† Aniq Darr,‡ Joachim Kohn,‡ and Jeffrey O. Hollinger*,† †
Bone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States ‡ Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States ABSTRACT: The osteogenic potential of biomimetic tyrosinederived polycarbonate (TyrPC) scaffolds containing either an ethyl ester or a methyl ester group combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) was assessed using the preosteoblast cell line MC3T3-E1. Each composition of TyrPC was fabricated into 3D porous scaffolds with a bimodal pore distribution of micropores
