328
lournu! of Medicznal ~ ' h ~ v z r ~197.9, t q , Vu( 22 .Vo 3
Note5
Paradoxical Effects of N-Cyanoalkyl Substituents upon the Activities of Several Classes of Opioids Arthur E. Jacobson,* Kenner C. Rice, Jargen Reden, Lillian Lupinacci, Arno!d Brossi,
5ef:tiun on Medicinal Chemistry, National Institute of Arthritis, M e t a b o h m , and Digestive Diseases, National Institutes of H e d L h , Rethosda. Mar:
