PREFACE
Pesticide Analytical Methodology Downloaded from pubs.acs.org by 46.148.115.111 on 11/19/18. For personal use only.
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nalytical methodology for pesticide determinations has greatly advanced ^ during the past 30 years. The emphasis during thefirst20 years was placed on increased sensitivity of detection. That these efforts were successful is attested by achieving sensitivity both quantitatively and qualitatively in the femtogram range (10" g). In a recent review of pesticide analytical methodology (Zweig, G. "The Vanishing Zero—Ten Years Later," JAOAC, 1978, 67(2), 229-248) the author pleaded with analytical chemists to improve the selectivity, resolving power, and identification capability for sub-microgram quantities of pesticide residues. The rationale was that the toxicologists lag far behind the analytical chemists and often are not able to assess the toxicological significance of minute levels of pesticide residues. We believe that this symposium on Recent Advances in Pesticide Analytical Methodology fulfills this plea. High-performance liquid chromatography (HPLC) has made the greatest advances. Chapters on HPLC cover subjects on metabolism studies; automation of HPLC; evaluation of LC columns; the effect of the mobile phase on reversed-phase chromatography; the electrochemical or amperometric detector; and fluorogenic detection. Quantitative thin-layer chromatography (TLC) has progressed considerably and has been adapted to forensic chemistry of pesticide poisoning incidents. High-performance TLC (HPTLC) with precoated plates is discussed separately. Fourier transform infrared spectroscopy; negative ion spectroscopy; and immunochemical technology are the subjects of several chapters. A chapter on cleanup presents a general challenge for all types of analytical techniques. Chemical derivatization of pesticides and metabolites enhances the detectability and ability to analyze small quantities of pesticide residues. Applications of modern analytical techniques also are discussed relative to the analysis of tetrachlorodibenzo-p-dioxin; organotin compounds; airborne pesticides; computerized data processing for metabolism studies; and human exposure studies. The organizers of this symposium wish to thank the contributors for their excellent talks, written chapters, and cooperation in meeting all 15
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deadlines. The Division of Pesticide Chemistry also wishes to acknowledge the joint sponsorship of this symposium with the Division of Analytical Chemistry. Biochemicals Department
JOHN HARVEY, JR.
Experimental Station E. I. Du Pont de Nemours and Company Wilmington, Delaware 19898 Hazard Evaluation Division Environmental Protection Agency Washington, D.C. 20460 April 17, 1980
GUNTER ZWEIG
