Pharmaceuticals and related drugs - Analytical Chemistry (ACS

Pharmaceuticals and Related Drugs I . G. Jheivagt, V . E. Pcipendick, and D. C. Wimer, Analytical Research Department, Abbott laboratories, North Chicago, 111.

T

(831, 1298, 2l34), barbiturates (2013), dyes (84), sulfonamides (747), sulfonamide-type diuretics (691), and vitamins (950, 1064, 1065, 1066). An English translation of Stahl’s book (2107), a n d a book by Bobbitt (fog), are useful volumes on the subject of TLC a n d contain many references t o drugs. The uses of chromatography in pharmacy have been discussed (1380, 2Ol4), a n d reviews on gas chromatography (276, 1620), ion exchange resins (698), a n d paper electrophoresis (983, 984), all as applied to analysis of medicinal substances, were noted. General articles discussing the prese n t status and progress of pharmaceutical analysis are included in the following papers (270, 834, 980, 1135, 1424, 1597, 1892, 1916, 2405), a s well as instrumental methods (1586) and physicochemical methods applicable to drugs (1671). llO~,1367,1383,1~76,1547,1687,1938, Analytical automation in drug manufacture and quality assurance were dis2011, 2503). Applications of TLC to alkaloids have been described ( 8 ~ ~ , 2 0 0 5 , cussed (60, 123, 2457). 2256, SSOS), as well a s TLC of steroids Zone melting was reviewed as a means

REVIEW includes analytical methods a n d subjects related to pharmaceutical analysis which have appeared since the last published survey (2442), or were not included in previous reviews. The literature through June 1966 is covered. The same tabular format is retained from the last review. An addition suggested b y Florey (621) is the use of a superscriptB denoting references t o the analysis of a drug in biological media. Such references are restricted t o the determination of administered pharmaceutical agents. This will provide information t o the pharmaceutical analytical chemist working with biological media, as well as offer alternate methods of analysis a n d separation to other workers. Numerous reviews of interest have appeared. Thin layer chromatography (TLC) of pharmaceuticitls h a s received much attention (421, 648, 665, 825,

HIS

Table 1. Compound or class Method or subject Alkaloidal Amines Ephedrine Chromatographic, gas Chromatographic, ion exchinge Chromatographic, paper Chromatographic, partition column Chromstographic, thin layer

Llescaline Methglephedrine Pseudoephedrines

(1238, 2357) (203) (11, 468, 649) (1464) (190, 1638,

Distribution coefficients Extrac.;ive, from mixtures Identity Optical rotatory dispersion Phosphorimetric Po1aroh;raphic Iteacticln, with chloroform Spectrcspolarimetric Yolumc’tric, acid-base Yolumr tric, mercurometric Volumetric, ox.-red. Chrom:ttographic, paper Chromatographic, thin layer Fluorometric Optical rotatory dispersion Polarographic

2284) (294, 378, 649, 1143, 1901) (511) (264) (1474, 2486) (1052) (2444) (1349) (2439) (1761) (488) (2237) (326 (649) (1638) (1Y 8 S B) (1062) (1349)

Fluorometric

(1983B)

Identit:! Optical rotatory dispersion Chromr.tographic, paper Identity Polarographic Optical rotatory dispersion Spectro polarimetric

(2423) (1052)

Coloririetric

Ephedrine derivatives

Reference

(649)

q 9 >1474) (1349) 11052) (1761)

of achieving ultrapurity of pharmaceuticals (650,651,966). In the field of spectrophotometric analysis, the following area reviews have appeared: ultraviolet (1182, 1527, 1930), infrared (72, 1527), a n d fluorometric approaches (525, 558, 1244). T h e characterization of drugs b y their self emitted infrared radiation was reviewed (1302). Winefordner a n d Tin (2444) reported on the use of phosphorimetry in drug analysis, and spectropolarimetric determinations have been described (1761). Konaqueous titrimetry was reviewed (98, 389, 834). Kucharsky’s a n d Safarik’s book “Titrations in Nonaqueous Solvents,” appeared (1 a n d is devoted primarily to applications of the technique. A reversible internal indicator for sodium nitrite titrations was described b y Schilt a n d Sutherland (1951). Ashworth’s “Titrimetric Organic Analysis,” P a r t I1 (61), is an extensive bibliographic compilation of indirect

m4),

(Tezt continued on page 212)

Alkaloids Compound or class Alkaloids, general methods

Method or subject

Reference

Chromatographic, adsorption (46) Chromatographic, gas (277, 278, 1103, 1381) Chromatographic, paper (399, 428, 836, 1032, 1209, 2091, 2472) Chromatographic, partition (1257) Chromatographic, thin layer (561B, 790B, 836, 844, 1032, 1383, 1 ~ $ 8 71547, ~, 1621, 1978, 2005, 2010, 2012, 2091, 8160, 2164, 2256, 2296, 2318, 2419, 2503) Colorimetric (243, 873, 1143, 1969, 2392) Countercurrent, distributive (406) ElectSophoretic, paper; (9841 review Extractive (331,1143, 1187) Fluorometric (326, 1215, 1244) Identity (873, 1389, 1393, 1839, 1939, 2192,

2264B) (Continued)

VOL. 39, NO. 5, APRIL 1967

191 R

Table 1. Compound or class

Method or subject Incompatibility, pH Mixtures, complex; review of analysis Physicochemical methods, review Polarographic, review Review Spectrophotometric Volumetric. acid-base

Alkaloids (Continued) Compound or

Reference (1900) (2111) (1373) (1915)

t??ii, 1573, 1700. 1913)

Indole Blkaloids Ajmaline Brucine

Ergotamine

(2566, 1760, ’ 1884, 1885, 1972, 1975, 2087, 2110,

S’olumetric, amperometric Volumetric, complexometric Volumetric, with tungsto(1337) silicic acid J’olnmetric, two-phase (1657) Water methods, comparative (1766) study X-ray (1373) Alkaloids, miscellaneous Aconitum Chromatographic, thin layer ilconitine Chromatographic, adsorption Chromatographic, thin layer Anabssine Identity Aristolochic Polarographic acid Catharanthus Chromatographic; coloriroseus metric Chromatographic, thin layer Chenopodium Chromatographic, adsorption - botrys Cissampelos Spectrophotometric, ultraviolet Coptis Amperometric Dionine Chromatographic, thin layer Extractive; spectrophotometric Identity Galanthamine Chromatographic, paper Colorimetric Identity Harmine ; Chromatographic, adsorption derivatives Identity Heroin Spectrophotometric, ultraviolet Leguminosae Chromatographic, thin layer N-Nethylhaya- Spectrophotometric, ultratinium iodide violet Pachycarpine Chromatographic, adsorption Identity Pethidine Activation analysis Volumetric Promedol Extractive; spectrophotometric Identity Sarracine Extractive; pH effect Securinine Colorimetric; extractive Polarimetric Spherophysine Identitv Tilia Chromatographic, thin layer Glyoxaline Alkaloids Pilocarpine Chromatographic, thin layer Colorimetric

class

(387) (15, 1868) (15, 587, 489) (1536)

Colorimetric

(2018) (2376) (2385)

(1433) (1636) (2481 ) (1699)

Fluorometric Spectrophotometric, infrared Spectrophotometric, ultraviolet

Chromatographic, paper Chromatographic, thin layer Spectrophotometric, ultraviolet Indoles,. general Phosphorimetric Physostigmine Chromatographic, paper; stabilitv Colorimeiiic Phosphorimetric Volumetric Rauwolfia Chromatographic, adsorption alkaloids Chromatographic, paper

Reserpine

Chromatographic, thin layer Electrophoretic Fluorometric Spectrophotometric, ultraviolet Chromatographic, adsorption Chromatographic, paper

Colorimetric Extractive

(1376)

Identity Spectrophotometric Volumetric, mercurometric

1857, 2057, 2506) (24811 (3261 (2237)

Colorimetric Volumetric, acid-base Chromatographic, adsorption Chromatographic, paper Chromatographic, thin layer

(2006) (6991 (1858) (1921) ( 1723, 1866B,

(94, 690) (861, 1263, 1264, is2r, 1887, 2619) (9411778, 25121 (1887) (1472)

Colorimetric

Chromatographic, thin layer

(280, 579,

(1567) (1611) (1712) (168.4, 1792) (1778)

if$:;

(1709) (118”) (534) (2481) (120) (1583)

Reference (127) (1921) (1674)

Fluorometric Identity, flame test Spectrophotometric, infrared Stability Ergot alkaloids Chromatographic, adsorption (1684, 1792) Chromatographic, ion ex(585, 1792) change Chromatographic, paper Chromatographic, thin layer

Hy drogenat,ed ergot alkaloids

188L ’r

Method or subject Colorimetric Electrophoretic, paper Extractive; spectrophotometric Extractive; volumetric Identity Kuclear magnetic resonance Chromatographic, adsorption Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer

Strychnine

Identity Polarographic Spectrophotometric, ultraviolet Chromatographic, paper

(865 1 (1525)

(1858)

(2444)

(2088) (2289, 2322)

22T2, 93i2) (932, 1876) (1374) (2272) (2007) (2532) (1374, 2271, 2273) (125, 1789, 1876) (284, 1567, 1876, 2271, 2273) (236, 613, 1789) (1675, 2522) (52828) (35, 284)

(11, 1921, 2068)

Chromatographic, ion exchange Chromatographic, thin layer

(1, 240, 1028)

Colorimetric Complexometric Electrophoretic Extractive

1915)

dinued )

192 R

ANALYTICAL CHEMISTRY

Table I. Compound or class

Strychnos alkaloids

Vincamine Vinca rosea Yohimbine

Isoquinoline Alkaloids Apomorphine

Berberine

Codeine

Alk:aloids (Continued)

Method or subject Gamrr a ray irradiation, effect on Nuc1e:tr magnetic resonance Radio netric Spectrophotometric Spectrophotometric, infrared Spectrophotometric, ultravioljt Volurrletric (2088, 2206) Volurr etric, acid-base (imr,1759, 1760) Chromatographic, paper Chromatographic, thin layer Colorimetric Electrophoretic Extractive Radio netric Volurr etric, acid-base Chrorrtatographic, thin layer Chroniatographic, thin layer Chromatographic, gas Chromatographic, paper Colorimetric Polarographic Chroniatographic, paper; identity Polarographic Spectrophotometric, ultraviol :t Stability kinetics Volurr etric Volurr etric, acid-base Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Spectrophotometric Volurr etric Chrontatographic, adsorption Chromatographic, gas Chroniatographic, ion exchange Chroniatographic, misi:ellaneous Chroniatographic, paper

(2068) (1836) (5288)

(604) (1699)

Compound or class Method or subject Dihydrocodein e Colorimetric Mass spectrometric Volumetric, acid-base DihydroChromatographic, p a p r codeinone Chromatographic, partition column Chromatographic, thin layer Identity Dihydrohydroxycodeinone Identity, color reactions DihydroxyChromatographic, paper; identitv codeinone DihydroChromaGgraphic, paper morphinone Identity Polarographic Volumetric, acid-base Ethyl Chromatographic, gas. Colorimetric; extractive morphine Extractive Identity Spectrophotometric, ultraviolet Volumetric Volumetric, mercurometric Hydrastine Chromatographic, thin layer; fluorometric Hydrastinine Spectrophotometric, ultraviolet Meconic acid Colorimetric Morphine Chromatographic, adsorption

Chromatographic, ion exchange Chromatographic, paper (723, 8068)

Chromatographic, partition column Chromatographic, thin layer

(1218)

Colorimetric Extractive


Fluorometric Gravimetric Identity Mass spectrometric Oxidation, enzyme Phosphorimetric Polarographic

Colorimetric Complexometric Extractive Fluorc metric Identity

Review, comparison of methods Reaction chloridewith iodine mono-

Spectrophotometric, ultraviolet Stability

Morphine derivatives

Volumetric, acid-base Volumetric, ox.-red. Volumetric, mercurometric 1dentii)y Reaction with iodine monochloride

(2826) (1768) (1818, 1164B) (1268)

(1818)

( i i ~ isr7) , (2163) (1134B)

(1768) (8237) (1789) (1699) (696) (249, 1071, 1730, 1966, 1966, 2181, 2186) (2401486) (976, 1134, 1336, 1665) (1947) (1g6, 3Y1, 663, 8431 8441 846, 1078, 1248, 1466, 1722, 1936, 2203, 2239, 2284 ) (1896) (293, 696, 1693) (266, 1216) (249, 1966, 21 81

(604; 716, 846, 97S8, 1601) (209) (1096) . .

Spectrophotometric, infrared (230, 696,

Mass spectrometric Polarographic Reaction with iodine monochloride Sodium in,. by- flame photometric Spectrs3photometric, infrared Spectr3photometriq ultraviolet

Cotarnine Diacetylmorphine

Reference

(I893)

(2350)

(1096)

(1003, 1.9421699, 1 1947) (230,m o , 2186) ’ (649, 1768) (2365) (1693)

Volumetric, acid-base Volumetric, amperometric Volumetric, ox.-red. Volumetric, mercurometric (2237) Chromatographic, paper (1663) Mass spectrometric (66) Polarographic (604) Reaction with iodine mono- (1096) chloride Volumetric, acid-base (1768) Volumetric, amperometric (,9363) (Continued)

VOL 39, NO. 5, APRIL 1967

193 R

Table 1. Compound or class Nalorphine

Narceine Nar cot irre

Method or subject Chromatographic, ion exchange Chromatographic, paper Polarographic Volumetric, acid-base Chromatographic, thin layer Spectrophotometric, ultraviolet Chromatographic, adsorption Chromatographic, ion exchange Chromatographic, paper

Alkaloids (Continued) Compound or

Reference (1663)

class Salsolidine

(2377) (504) (604, 1768) (1248) (1242, 1699)

(466, 966, 1134) (126, 371, 663, 1719, 1720, 1722) Extractive (293, 696, 1837) Identity (8018, 2019) Spectrophotometric, infrared (695) (1699) Spectrophotometric, ultraviolet (2377) Chromatographic, paper


Normorphine Opium alkaloids, general

Papaverine

Papaverine alkaloids Porphyroxine Pseudomorphine

Chromatographic, adsorption Chromatographic, gas (27‘9,’ 466, Chromatographic, paper 1134) (301, 966) Chromatographic, partition column Chromatographic, thin layer (126, 187, %79, 371, 663, 1242, 1466, 1719, 1720, 1722, 1790 2203, 2239 Extractive (993) (1134, 1681, Identity 2018) Mass spectrometric Optical rotatory dispersion Spectrophotometric, infrared Spectrophotometric, ultraviolet Volumetric, acid-base Chromatographic, adsorption Chromatographic, gas (466, 966, Chromatographic, paper 1134, 2326) Chromatographic, thin layer (126, 371, 461, 663, l,t?.@?, 1466, 1719, 1780, 1721, 1922, 1936, 2803, 2284) Colorimetric (483, 1144, 1211) Complexometric ($498) (116, 189, 293, Extractive 696,1144, 1211) Identity, flame tests (1134, 1471) Spectrophotometric, infrared (695) (966; 1003, Spectrophotometric, ultra1248, 1699, violet 1705) (189, 296, 376, Volumetric, acid-base 377, 1496, 1670, 2341) (2237) Volumetric, mercurometric Chromatographic, thin layer (4611 Chromatographic, adsorption ; colorimetric Chromatographic, in opium Chromatographic, paper Polarographic Spectrophotometric, infrared

Tecodine Thebaine

Method or subject Chromatographic, ion exchange Chromatographic thin la er Distribution, liqdd-liquiJ Identity Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, mercurometric Chromatographic, ion exchange Identity Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, mercurometric Spectrophotometric, ultra- violef Chromatographic, absorption and Dartition Chrom^atographic, ion exchange Chromatographic, paper Chromatographic, thin layer Colorimetric Extractive Spectrophotometric, infrared Spectrophotometric, ultraviolet

Isoquinoline, bis-benzyl, alkaloids Cephaeline Curare Emetine

Chromatographic, paper Review Chromatographic, paper Chromatographic, thin layer Colorimetric Extractive Identity Spectrophotometric, infrared Spectrophotometric, ultraviolet Stability General Chromatographic, thin layer Optical rotatory dispersion Ipecacuanha Chromatographic, adsorption alkaloids Chromatographic, paper Extractive Stability Volumetric. acid-base Tubocurarine Fluorometric Spectrophotometric, ultraviolet Lu inane Alkaloids general Chromatographic, paper Polarographic Sparteine Chromatographic, paper Colorimetric Polarographic Spectrophotometric, infrared; stability Sparteine beta Volumetric camphorsulfonate Pyridine Alkaloids Lobelia Chromatographic, thin layer alkaloids Polarographic Lobeline Chromatographic; colorimetric Chromatographic, thin layer Colorimetric; extractive Extractive Polarographic; stability Thermopsis Extractive; volumetric alkaloids

(1495) (2237) (1096) (1667, 2481 ) (1699) (1495) (2237) (1003) (301) (486) (455,966) (126, 371, 665, 1466, 1719, 1722,2239) (1838,1894) (293, 696, 1838) (696) (466, 1699)

(1324, 2117) (1661) (1324, 1117)

(2,903)

(1699) (230, 1324) (187)

[(2117) ;E;) (2087)

(2117) (1782, 2087) (40gB) ($4191 (2078) (1166) (2078j (483, 2130) (1166) (230)

(1731)

(237, 1623) (1623) (473)

(237, 1623) (880B) (1146, 121gB) (1623) (474)

(Continued)

194 R


Compound or class Quinoline Alkaloids Cinchona alkaloids

Cinchonidine

Cinchonine

Cinchoninic acid Equinine

Method or subject Chromatographic, ion Chroinatographic, thin layer Colorimetric Phosphorimetric Spectrophotometric, ultraviolet Chroinatographic, paper Chroinatographic, thin layer Detei,mination, in quinine Fluoi ometric Spectrophotometric, ultraviolet Chroinatographic, thin layer Colorimetric Spectrophotometric, ultraviolet Identitv

Table I. Alkaloids (Continued) Compound or Reference

(1030) (269, 1999, 21 71, 2171, 21 73) (1660).

,;E$:

1698)

(g068) (1999, 2171) (838) (1030) (1034, 1698)

class Solanidine; solanine Solanum alkaloids

Solasodine

Identity Pyrrolizidine alkaloids Steroidal Alkaloids Holarrhena alkaloids Sanguinarine

Stability Chroinatographic, thin layer

Chroinatographic, thin layer Chroinatographic, for iml~urities

(2609)

(1238) (240)

(12661 , 136.4) (86, 86, 128, 304, 306,

Chromatographic, review Chromatographic, thin layer

1632, 1799, 2143, 23%) (306 (16, 306, 306,

sor, img,

1006, 1603, 2803, 228.4, Colorimetric

Complexometric Extractive

(116, 116, 2326)

Fluorometric Hydrolysis of Identity

(1677) 1,%?06'S

Impurities in Phosphorimetric Spectrophotometric Spectrophotometric, ultraviolet Stability

(838) '

2142; sidsj (1767, m o l

Volumetric, acid-base

8061, 2088,

Belladonna alkaloids

Monograph, proposed Phosphorimetric Polarographic Spectrophotometric, infrared Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, ox.-red. Colorimetric

Senecio Alkaloids Platyphylline Chroinatographic, thin layer Colorimetric Extractive

(784, 1619, 1960, 2399) (784, 2399)

$;;1261,#2 1364,

Fluorometric Identity

Quinine derivatives

Reference

Colorimetric Polarographic (1688) Review Chromatographic, thin layer; colorimetric Chromatographic, paper

beta-Tomatine Tropane Alkaloids Atropine Adsorption, by antacids Chromatographic Chromatographic, gas Chromatographic, ion exchange Chromatographic, ion exchange, paper Chromatographic, paper

Chroinatographic, ion exchange; fluorometric Volumetric, ox.-red. Hydroquinidine Chroinatographic, thin layer Fluorometric Identity S ectrophotometric, infrared Quinic acid; dloiimetric natural esters Quinicine Polarographic Quinidine Chromatographic, thin layer Colorimetric Fluorometric Identity Monograph, proposed Nuclmr magnetic resonance Phosphorimetric Spectrophotometric, infrared Spectrophotometric, ultraviolet Quinine Assay, in mixture (100) Chroinatographic, ion (1028, 1030) exchange Chroinatographic, thin layer C+chonidine, determination in Colorimetric

Method or subject Chromatographic, thin layer Polarographic Chromatographic, thin layer

Chromatographic, Chromatographic, exchange Chromatographic, exchange pa er Chromatographc,

2342) adsorption (748) ion (20)

ion

(1261)

paper

(306, 306, 1861, 1363, 1799) (413)

Chromatographic, partition column Chromatographic, thin layer (6284) (2268) (113, 116, 660, 1146) (1211,2486, 261 7 (2268)

(ZmQ1

Colorimetric Electrophoretic, paper; fluorometric I d entity Monograph, proposed Volumetric, acid-base Cocaine

(306, 306,307, 1363, 1603) (2473) (1363) (1363,2oir)

(irir)

(20.748. 1606. . 1667,1967) ' (~367) (1636)

Chromatographic, gas Chromatographic, ion exchanee Chromatographic, paper ChromatogTaphic, thin layer Colorimetric

(876, 1338, 1339, 8238) (666, 788) (244, 246. 481. 48'3, i049) '

(Continued)

VOL. 39, NO. 5, APRIL 1967

0

195 R

Table I.

Compound or class

Method or subject Gravimetric Phosphorimetric Review of methods Spectrophotometric, ultraviolet Stability Volumetric, acid-base Volumetric, mercurometric Chromatographic, paper

Ecgonine

Alkaloids (Continued) Compound or Reference class (2266) Scopolamine (24441

(2266)

(1004) (4821 788, 1338) (182. ~. 1767. 24469 ’ (2237) (13 8, 1339,

Method or subject Chromatographic Chromatographic, gas Chromatographic; ion exchange, paper Chromatographic, paper

Reference (2609) (2367)

(1366)


2266)

Homatropine

Homatropine methylbromide

Hyoscyamine

Chromatographic, thin layer Extractive; Kjeldahl nitrogen Adsorption, on antacids Chromatographic, paper Chromatographic, thin layer Colorimetric Identity Volumetric, acid-base Chromatographic, ion exchange paper Chromatographic, paper Spectrophotometric, ultraviolet Volumetric, acid-base Chromatographic, absorption Chromatographic, paper Chromatographic, partition column Chromatographic, thin layer Colorimetric Extractive Volumetric, acid-base Identity

Methyl homatropine Pseudotropine Chromatographic, ga? Chromatographic, thin layer

(788) (2266)

(20.L)

Aureomy cin Bacitracin Ce haloridine Ch! oramphenicol

Method or subject Chromatographic, paper Chromatographic, thin layer Stability Spectrophotometric, ultraviolet Chromatographic, thin layer Review, methods Chromatographic, paper Chromatographic, thin layer Colorimetric Microbiological Polarographic Spectrophotometric, ultraviolet Stability Volumetric, ox.-red. Volumetric, precipitation

Chlortetracycline Chromatographic, column Chromatographic, paper Chromatographic, thin layer Colorimetric Identification Microscopic Polarographic

196 R


Complexometric Identity S ectrophotometric olumetric, acid-base

(128,’876)

(1002)

(1626) (128, 1626)

(349)

Tropane, general

(1666, 1767) (748) (114, 306, 473, 876, 1043)

Tropic acid Tropine

(2360) (2373) (1628)

Reference

(1660) (1372) (1666, 1862, 2002)

(1829, 1978, 1888) (231, 810, 936, 1428, 2066)

Tropinone

Antibiotics Compound or claw

Colimy Cin Colistin Cranomycin Cycloheximide Cycloserine

(2601) (1867, 1869,

1870, 1871, 2161) (620, 1666, 2371 )

[%I,

1993) (608, 623, 1486, 2100) (881) (1342)

(1037, 2096) (921, 1086, 1126, 1344,

1709) (1709) (1046) (328, 682)

1767, 2088,

Volumetric, mercurometric Chromatographic, gas Chromatographic, ion exchange pa er Chromatograpgic, paper Chromatographic, thin layer

(133) (306, 306, 307) (133, 876) (116) (114, 748)

(217 0 ) (1002, 2360) (8491) (114, 1666,

VP

(876) (2360) (1666, 1767)

Table II. Compound or class Actinomycin

Colorimetric

Dactinomycin Desertomy cin Erythromycin

(306, 306, 307, 1002, 1603, 2203, 2610) (86,86, 876. 1868,‘ 2129, 2610)

Colorimetric Volumetric, acid-base Spectrophotometric, ultraviolet Chromatographic, paper Chromatographic, thm layer

2609) (2237) (637) (1261) (8:k4!17%61 1686) (306, 1002,

1602, 1603) (1686) (1767)

(686)

Luminescent Review Chromatographic, thin layer Reineckate evaluationmethod,

Method or subject Refractometric Review, feed additives Stability Volumetric, acid-base Volumetric, ox.-red. Chromatographic, ion exchange Stability Identification Stability Stability Colorimetric Polarographic Stability

Reference (2416) (716) (2416)

[it;;,

2169) (1223,1783)

(1223) (2437) (1137)

(681, 682) (1060, 1169) (2180)

( 1169, 1347, 231 2) Review, official methods (6941 Chromatographic, paper (2198) (2198) Colorimetric Identification (2198) Chromatographic, thin layer (46, 1863) Spectrophotometric, ultra(1147) vinlet . ._.__

Furacillin Furadonin Furazolidone

,

Stability

(367, 2034, 2302)

Volumetric, acid-base Colorimetric Identification Volumetric. ox.-red. Identification Identification

(619)

(2297) (2274) (2166)

(2274j (2274)

(Continued)

Table II. Compound or class General

Antibiotics (Confinued) Compound or Reference class (2306)

Method or subject Calorinietric, review Chromcitographic, absorption (438) column Chromittographic, ion (9411 exchrtnge (179, 206, 807, Chromrttographic, paper 283, 922,

Chromatographic, pH Chromatographic, thin layer Colorimetric Sedimentation Solubility Spectrophotometric, flame Spectrophotometric infrared Spectrophotometric, ultraviolet Stability


Gramicidin Griseofulvin

Hamycin Kanamycin Linomycin Mycerin Neomycin

Novobiocin Nystatin

Oleandomycin

Olivomy cin Oxacillin Oxtetracycline

Paromomycin Penicillins

Countercurrent distribution Electrophoretic Identification Po1aroE;raphic Review Spectrcphotometric, infrared Spectrc photometric, ultraviolet Stability Turbidimetric Chrom,ttographic, paper Chrom:ttographic, thin layer Colorimetric Fluorometric Identification Spectrc photometric, lumiiiescence Spectrcphotometric, ultraviolet Stabilily Chrom,ttographic, column Colorimetric Stabilit,y Chromntographic, ion exchitnge Stability Chromntographic, ion exchange Chromrttographic, paper Chromrttographic, thin layer Colorimetric General Microbiological Radiographic Review, official methods Stability Chromcitographic, paper Colorimetric International Standard Colorinietric Spectrophotometric, ultraviolel; Stability Chrom:ttographic, thin layer Colorimetric Microbiological Spectrophotometric, ultraviole; Stability Chromrttographic, paper Stability Biological Chromritographic, column Chromrttographic, thin layer Colorimetric Identification Polarographic Review, feed additives Review, methods Spectrophotometric Stability Volumetric, ox.-red. Chromrttographic, paper Stability Chromrttographic, gas

(2049) (1669) (1330,23W) (669, 1188) (2199) (1630)

Phalamycin Phenethicillin Polymyxin Porfiromycin Primycin Ramycin Rifamycin

Ristomycin (1223, 1329, 1914) (1005, 1914) (631) (768)' (1005) (693) (1223)

Method or subject Chromatographic, ion exchange Chromatographic, paper

Sekasin Spiramycin Streptomycin

Streptothricins Tetracycline

Volumetric, ox.-red. Stability Chromatographic, paper Stability Agar diffusion Identification Stability Stability Chromatographic, paper Identification Chromatographic, paper Colorimetric Spectrophotometric, ultraviolet Chromatographic, ion exchange Electrophoretic Colorimetric Chromatographic, paper Chromatographic, ion exchange Chromatographic, thin layer Colorimetric Fluorometric Identification Microbiological Volumetric, ox.-red. Chromatographic, ion exchange Chromatographic, paper Chromatographic, column Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Polarographic Review, feed additives Spectrophotometric, ultraviolet Spectroscopic, mass Stability

Trichothecin Tylosin Tyrothricin Viomycin Zygomycin

Reference (239) (618, 1098, 1834, 2334) (177) (982, 1668) (2178) (1686) (261) (1106) (2618)

(906, 2306) (385, 611, 982, 1614, 1616, 1688, 1618, i69r,irr6, 1974, 1976, i9r6, 2299, 2244, 2417) (229, 1410)

(886,1239, 1342, 1343, 1931) (1037, 1874, 2068, 2096) ( ~ ~ , i o 8 r ) (1692)

Thermal analysis Volumetric, ox.-red. Colorimetric Extractive Chromatographic, thin layer Colorimetric Stability Chromatographic, column

VOL. 39, NO. 5, APRIL 1967

197 R

Table 111. Compound or class Aluminum

Method or subject Colorimetric Identification Neutron activation analysis S ectrographic olumetric, complexometric Review, official methods Radiometric Volumetric, ox.-red. Colorimetric Identification Review, official methods Volumetric, complexometric Volumetric, ox.-red. Volumetric, complexometric Colorimetric Identification Neutron activation analysis Radiometric Volumetric, complexometric Volumetric, ox.-red. Spectrophotometric, flame Volumetric, ox.-red. Amperometric Identification Neutron activation analysis Gravimetric Volumetric, complexometric Amperometric Chromatographic, paper Identification Radiometric Stability Volumetric complexometric

Inorganic and Metal-Organic Compounds Compound or class Iodine

vp

Ammonia Antimony Arsenic

Barium Bismuth

Boron Bromine Cadmium Calcium

Colorimetric Identification Volumetric, ox.-red. Chromium Identification Cobalt Colorimetric Fluorometric Copper Colorimetric Gravimetric Identification Radiometric Spectrographic Fluorine Colorimetric Volumetric, complexometric General Neutron activation analysis Polarographic Radiometric Volumetric, complexometric Gold Radiometric Spectrophotometric, X-ray Halogens, general Radiometric Review, methods Volumetric, ox.-red. Heavy metals, Identification general Hydrogen Biological peroxide Stability

Iodine, organic Iron

Method or subject Chromatographic, ion exchange Identification Review Spectrophotometric, ultraviolet Volumetric, ox.-red. Chromatographic, paper Electrophoretic Volumetric, ox.-red. Chromatographic, paper Chromatographic, thin layer Colorimetric Identification Neutron activation analysis S ectrographic olumetric, complexometric Volumetric, ox .-red. Colorimetric Identification Volumetric, complexometric Volumetric, ox.-red. Volumetric, complexometric Neutron activation analysis Spectrographic Chromatographic, thin layer Colorimetric Polarographic Volumetric, acid-base Volumetric, ox .-red.

(1960) (947, 1370) (8026) (1123) (2888)

(41

(219, B O , 699) (686)

Lead

Magnesium Manganese Mercury

fT%) (6, 86844) (1649) (1448) (19.&,. 1949)

fT%)

(491

(141, 217, 323, 721, 1384, 1660, 1668, 8118, 2366)

Phosphorus

Potassium (816, 1418) (468)

Selenium

Silver Sodium Sulfur

(8343) ($02) (1689, 1949) (1830) (8268) (1388) (1664) (1460, 1961)

(686) (948) (24W (322, 666, 961 ) (200, 870) (419) (683,1267,

8086) Molybdenum Nitrogen

Tellurium Tin

Water

zinc

Neutron activation analysis Chromatoeraphic, gas Identification Colorimetric Radiometric Review, methods Spectrophotometric, X-ray Amperometric Spectrophotometric, flame Colorimetric Neutron activation analysis Spectrophotometric, ultraviolet Chromatographic, thin layer Radiometric Spectrophotometric, flame Amperometric Identification Radiometric Review, methods Stability Radiometric Colorimetric Neutron activation analysis Radiometric Refractometric Volumetric, ox.-red. Colorimetric Identification Polarographic Radiometric Volumetric, complexometric


(1862, 1838) (730, 1971)

vp

Chlorine

198 R

Reference

(1416, 8090) (8268) (1388) (8268)

(866, 1346) (867) (1346) (1919, 1984, 1949) (1083, 1113)

Table IV. Compound or class Acridines

Amides

Method or subject Colorimetric Fluorometric Therniogravimetric Volunietric, conductometric Volumetric, ox.-red. Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Crystdlographic Identification Polarographic Review, analysis of Phenacetin Intermediates Specti*ophotometric,ultraviolet Stability Volunietric, acid-base

Amine oxides Amines Alicyclic Amines

Volumetric, ox.-red. Chroriatographic, gas

Gasorietric Identification Stability Aliphatic Colorimetric Amines Volumetric, acid-base Antihistamines Chroriatographic, gas Chroriatographic, paper Fluorometric Identification Miscellaneous Chromatographic, gas Amines Color metric Colorimetric, dye transfer

Morpholines Nitrogenous Organic Bases

Nitrogen-Containing Compounds Compound or Reference class Method or subject (616, 2098) Spectrophotometric, infrared (557,1124) Stability (616) Volumetric, acid-base Volumetric, conductometric (616, 616) (1751) Procaine and Chromatographic, gas (1167, 1624) analogs Chromatographic, paper (139,1991) Colorimetric

(1131)

(289, 439)

(,wm (139, 163, (431) (171) (166) (2456) (434, 1678)

tWA, 1321) (71SB)

(972) (994) (1238) (1980) (1941, 1942, 1944, 1945) Identification (2246) Specti~ophotometric,infrared (2246) Specti~ophotometric,ultra(469) violet Volunietric, dye transfer (1836) Volunietric, precipitation (426) Identification (642) Volunietric, acid-base (642) Chrornatographic, paper (676, 707, 1480, 1963)

Volumetric, ox.-red. Pyridines Chromatographic, paper Colorimetric Identification Polarographic Spectrophotometric, ultraviolet Stability Volumetric, acid-base Sympathomi- Chromatographic, thin layer metic Amines Gravimetric Identification Volumetric, amperometric Amino Acids Chromatographic, gas Chromatographic, ion exchange

Piperazines Piperidines

1w1

2336) (786) (894, 1648) (894, 2212) (596, 2314) (8061 1142) (437)

(1648, 2212) (23411 (21) (1107) (21 ) (2083) (7141955) (lr3J 420, 1193, 1315, 1828)

Chromatographic, paper


(32, 74, 233, 968, 970, 1064, 1391, 1647) (233, 496, 1631, 1638,

Colorimetric

Chroriatographic, thin layer Colorimetric

Phenylalkylamines

(134, 1572) (635, 1270, 2039) Crystdlographic (1163, 1765) Differential thermal analysis (1985) Fluorometric (1224B,1480, 8370) Identification (369, 598) (1572) Polarographic Review, methods (2497) Specti-ophotometric, ultra(349, 2303, violet 2361) Stability (411, 1138, 1246) Volumetric, acid-base (663, 2476) Volunietric, amperometric (1303, 2069) Volumetric, conductometric (2381) Volumetric, ox.-red. (1462, 1951) Volunietric, precipitation (1923) ( 1 l O f LgNOa) Volumetric, turbidimetric (2499) Chromatographic, adsorption (876) Chroriatographic, gas (156", 15rB) Chroniatographic, thin layer (43) Colorimetric (2079, 2390, 2398) Identification (398) Polarographic (2079) Stability Volunietric, acid-base Volunietric, acid-base (2337) Identification (726, 1865) Polarographic (462)

1%)

(2062, 2448)

( 9 P , 119, 1221, 1774, 2301, 2387) Identification (2035) Spectrophotometric, infrared ( 1128) Spectrophotometric, ultra(487, 2062) violet Stability (17, 271, 612, 761, iios, 1227, 1781, 1873, 1883, 2044, 2064, 2279, 2448, 2614, 2515) Volumetric, acid-base (791, 1128,

(1829, 1842) (646, 1573, 1932, 2194) (1846) (340, 1673, 1710, 2061) (282)

1276) (1020)

Reference (1465) (2154, 2202) (946, 8339)

Fluorometric Identification Polarographic Review, chromatography Separation, gel filtration Spectrophotometric, reflectance Spectrophotometric, ultraviolet Stability Volumetric, acid-base

Amino Alcohols

Volumetric, amperometric Volumetric, complexometric Volumetric, ox.-red. Chromatographic, gas Chromatographic, ion exchange Chromatographic, thin layer Colorimetric

1797, 1956, 2231 ) (95, 109, 639, 80QB,957, 1666, 2033) (1578, 2526) (600, 1417) (2139, 2607) (998) (1477) (638) (1170, 1391)

(dr7J 1482,

1647, 2121, 2434 ) (1669, 1962, 2036) (2624) (638) (1616, 1962) (2428) (360)

(770) (770, 1416, 1984) (1365)

Identification Ionization constants (803) Polarographic (1348, 1349) Spectrophotometric, infrared (1366) Spectrophotometric, ultra(1365) violet Spectropolarimetric (1762) Volumetric, acid-base (1366) Volumetric, ox.-red. (1365) (Continued)

VOL. 39, NO. 5, APRIL 1967

199 R

~~~~

Table IV.

Compound or class Amino Esters Amino Ethers

Amino Phenols

Azepins

Azomethines Barbituric acids and Barbiturates

[y7$l

200 R

~

~~~~~

Nitrogen-Containing Compounds (Continued) Compound or Method or subject Reference class Method or subject Reference (1021, 1637) Volumetric, coulometric Volumetric, acid-base (1431) Chromatographic, paper (613) Volumetric, ox.-red. (964) Colorimetric (1987) Volumetric, photometric (1660) Spectrophotometric, ultra(2435) X-Ray diffraction (77) violet Carbamates Chromatographic, thin layer (846, 1279) Biological determination ( 10618) Colorimetric (274, 846) Chromatographic, paper (16, 1390, Identification (6641 1473, 1827) Review, methods (664) Chromatographic, thin layer (1543, 1763) Spectrophotometric, infrared (554) Colorimetric (232, 670, 779, Spectrophotometric, NMR (2080) 8 0 2 , l l SO, Stability (607) i473) Volumetric, acid-base (173) Electrophoretic ( 5 ~ 2 ~ ) Hydantoins Colorimetric (1070) Fluorometric (1409') Identification (1053, 1666) Gravimetric (1038) Microsublimation (1053) Identification (996) Polarographic (1685) Spectrophotometric, ultra(1665) Identification, review (1461) violet Ionization constants (802) Polarimetric (1038) Guanidines Chromatographic, paper (161rB) Polarographic Colorimetric (841, 161YB) Review, methods Volumetric, acid-base (1732) Spectrophotometric, ultra(401, 1171) Volumetric, ox .-red. (944) violet Hydrazides Chromatographic, adsorption ( 1 0 P ) Stability (73, 678, 878) Chromatographic, ion (1010) Chromatographic,. paper (1441) exchange Spectrophotometric, ultra(1441) Colorimetric (19, 48.4, 6661 violet 1010, 2236, Chromatographic, thin layer (18,466, 123dB, 2277, 2616) 1773, 1831) Complex with p-amino(1811) salicylic acid Colorimetric (466, 878) Dissociation constants (1902) Gravimetric (466,469) Identification (1773, 1831, Gasometric (362, 2369) 2857) Gravimetric (756, 1696) Polarographic (39ZB,1669, Identification (340) i67o1i57i, Mass spectroscopic (352) 1996) Polarographic (267) Spectrophotometric, ultra(531) Spectrophotometric, ultra(466, 469, 963) violet violet Stability (1608) Stability (1010, 1011, Volumetric, acid-base (153, &6) 2384 ) Volumetric, ox.-red. (963) Thiocyanato-metal com(756) plexes Polarographic (67) Chromatographic, gas (256, 969, Volumetric, acid-base (2236) 1371, 1624, Volumetric, complexometric (393) 1526, 18OgB) Volumetric, conductometric (64, 891) Chromatographic, paper (1114, 1164, Volumetric, ox.-red. (741, 1694, 2176B, 2248, 1696, 2277, 2384, 2493) 2400) Chromatographic, partition (1840) Hydrazines Gasometric (2360) Chromatographic, thin layer (78, Z l P , Volumetric, amperometric (1024) 1084B, Volumetric, coulometric (1586) 168SB, 1762, Volumetric, ox.-red. (914, 1024) 1886, 2410, Hydrazones Volumetric, acid-base (224) Volumetric, ox.-red. (167, 913) 2486 ) Colorimetric (79, 545, 1288, Hypnotics Chromatographic, gas (1928) 1292, 1804B, Chromatographic, thin layer (2278B) 1402, 1903) Identification (6391 Colorimetric, phase titration ( 4 4 4 9 Spectrophotometric, ultra(639) violet Crystallographic Y43) Imidazoles Chromatographic, paper (868) Differentiation Extraction (1291) Chromatographic, thin layer (762) Fluorometric (8016, ,818~7~) Colorimetric (176, 772) Identification (18, 78, 388, Stability (1880) 943, 1290, Volumetric, acid-base (1880) 1293, 1894, Volumetric, ox.-red. (1518) 1295, 1683, Imidazolines Chromatographic, paper (1646) 1771) Colorimetric (1645, 2316) Microsublimation (78) Stability (1646) Oxidative resolution (2131, 2132) Volumetric, acid-base (764) (mixtures) Imides Chromatographic, gas (1911) Polarographic (407, 667) Chromatographic, paper (470) Chromatographic, partition (2082) Refractometric (1438, 1439) Review, methods (155, 2252) Identification (2298) Solubility (14C labeling) (1982) Polarographic (840, 8-41, 842) Spectrophotometric, (257) Review, methods ( 1888) Spectrophotometric, infrared (1738) reflectance Spectrophotometric, ultra(288, 1840, Spectrophotometric, ultra(355, 2082) violet 2426 ) violet Stability (356, 683) Stability (494,572,673) Sublimation (782) Volumetric, acid-base (946 ) Volumetric, acid-base (1332, 2260) Volumetric, amperometric (168, 1491) Volumetric, complexometric (942) (Continued)

tE;{

Azauridines

~~~


Table IV. Compound or class Indoles

Method or subject Chromatographic, ion exchange Colorimetric Dissolution rate-solubility Indolines Coloiimetric Revicw, methods Voluinetric, ox.-red. Naphthyridines Colorimetric Specixophotometric, infrared Spect,rophotometric, ultraviclet Voluinetric, acid-base Chromatographic, thin layer Narcotics Nitro Chromatographic, thin layer (14C labeling) Colo1,imetric Distribution coefficients Gravimetric Polaimographic Review, methods Specixophotometric, infrared Speclrophotometric, ultraviclet Volumetric, acid-base Voluinetric, ox.-red. Nucleic Acids Chromatographic, thin layer Stability Chromatographic, paper Nucleosides Speci,rophotometric, ultravic let Revit:w, methods Oxazines Colorimetric Oxazolidones Pola1,ographic Review, methods \'olu metric, precipitation Oxazolidinediones Specwophotometric, infrared Stabj lity Volumetric, ox.-red. Oxazolinones Chromatographic, ion Peptides exvhange, review Chromatographic, thin layer Phenanthrenes Speci,rophotometric, ultraviolet Colo mimetric Phthalazines Iden ification Volu netric, conductometric Volu netric, coulometric Volu netric, precipitation Purines Chromatographic, thin layer Coloi*imetric Deariination Revii?w, methods Pyrazolidines Iden ification Volu netric, coulometric Volu netric, ox.-red. Pyrazolones Chromatographic, paper Chromatographic, partition Chromatographic, thin layer Coloi*imetric ~

Pyridoindoles

Flame photometric Idenlification Specmophotometric, infrared Specl,rophotometric, ultraviolet Stability Volu metric, acid-base Volu metric, complexometric Volu netric, ox.-red. Volu netric, precipitation Chromatographic, paper Spec trophotometric, ultraviolet

Nitrogen-Containing Compounds (Continued) Compound or class Method or subject Volumetric, acid-base Pyrimidines Identification Polarographic Review, methods Stability Volumetric, ox.-red. Pyrrolidines Colorimetric Quaternary Chromatographic, paper Ammonium Chromatographic, thin layer Colorimetric Compounds Crystallographic Identification

(1081, 1129) (643)

(673) (673)

(18M) ( I 787, 2396)

(20608) ( I 280) (112, $478) (1026) (690) (1378, 1661) ( 1260) (1661) (236, 397, 686, 776,879, 1068, 14.44, 1690, 21 12, 2276) (299) (2331, 2382) (1681) ( 1260)

Microbiological Review, indicator-complex methods Review, methods Stability Volumetric, acid-base Volumetric, thermometric Colorimetric Quinazolones Identification Volumetric, ox.-red. Quinolines Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Polarographic Review, methods Spectrophotometric, ultraviolet Volumetric, indicatorcomplex Colorimetric Tetrazoles Precipitation with tungstophosphoric acid Volumetric, acid-base Volumetric, complexometric Triazines Chromatographic, paper Stability Uracils Chromatographic, paper Chromatographic, partition Colorimetric Review, methods Spectrophotometric, ultraviolet Stability ( 1801, zotsr, 2179) Stability, gamma radiation (2366) Urea and Deriva- Colorimetric tives Identification Review, color reactions Review, methods Stability Tensiometric Volumetric, precipitation Ureides Chromatographic, thin layer Colorimetric Identification X-ray diffraction Xanthenes Chromatographic, thin layer (1663) Spectrophotometric, ultra(1184) violet Stability (1663) Xanthines Chromatographic, pa.pr (223, 819, 820) Chromatographic, thin layer (1262) Colorimetric (338, 1981) Identification (820, 1682, Stability Volumetric, amperometric Volumetric, complexometric

irw

(2126 ) ' (262, 266) ('717, 1466, 209L)

Volumetric, coulometric Volumetric, ox.-red.


201 R

Table V. Compound or class Acids and derivatives Carboxylic acids, aliphatic

Method or subject Chromatographic, paper Colorimetric Fluorometric Gravimetric Spectrophotometric, infrared Stability Volumetric, acid-base

Carboxylic acids, aromatic

Esters

Salicylic acid and derivatives

Volumetric, complexometric Chromatographic, - . ion exchange Chromatographic, thin layer Colorimetric Fluorometric General Polarographic Spectrophotometric, ultraviolet Volumetric, complexometric Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Stability Spectrophotometric, ultraviolet Volumetric, acid-base Chromatographic, gas Chromatographic, ion exchange Chromatographic, thin layer Colorimetric Coulometric Fluorometric Identification Spectrophotometric, ultraviolet Stability

Aldehydes

Chromatographic, thin layer Colorimetric

Carbohydrates

Identification Spectrophotometric, infrared Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Colorimetric Identification Physical methods Stability

Chromones

Coumarins

Volumetric, ox.-red. Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Polarographic Nuclear magnetic resonance Review Spectrophotometric, ultraviolet Volumetric, ox.-red. Chromatographic, gas Chromatographic, paper Colorimetric Fluorometric Fractional separation Identification Polarographic

202 R

0


Oxygen-Containing Compounds Compound or Reference class Method or subject Spectrophotometric, ultraviolet (218. 281) Ethers Chromatographic, gas Chromatographic, paper (195; 281; 381, 388, 1786, Chromatographic, thin layer 8109, 2323) (1453) Colorimetric (8495) Polarographic (345) Review, methods Review, spectrophotometric (50,847) Stability Volumetric, ox.-red. (724, 21741 8495 ) Chromatographic, adsorption Fats and oils (538, 1926) ~. column (2076) Chromatographic, gas (1468, 1898) Chromatographic, paper

(630)

(1028) (798) (1007) (1007, 2435)

Glycosides Cardiac glycosides

Digitoxin

Chromatographic, column Chromatographic, gas Chromatographic, paper

Chromatographic, paper review Chromatographic, thin layer

(mooj

(1180, 1988,

8487) (597 ) (381) (18%0)

(1080) (977) (383, S8dB, 654, 1599, 1933) (1779, 1933, 2114) (2488) (185) (47, 643) (1599, 1600)


Identification Extractive Polarographic Review, identification Stability

(2475) (1534) (2076)

(196, 335, 532) (81 448, 3378, 2480) (162, 1667) (153) (496) (1166, 1228, 1460, 1513, 2466 1 (169, 563) (1747, 1933) (546, 666, 853) (91, 1747, 1933, 2367) (7256) (1598) (1319) (851) (1285, 2058)


Colorimetric

(2147j (1898) (1988, 1479) (2028) (507, 1481, 1483, 1501) (1241)

(82, 647, 653, 1705) (1346)' (1538) (2088) (2333) (358, 653, 1802) (743, 744, 746, 930. 1368)

Stability

Flavones

General Lanatosides Miscellaneous

Reference (2488) (14) (712, 8147)

(%'4l, 8142, 2418) (14, 634) (678) (1794) (1812) (1844) (1890, 2299, 2404 ) (2146)

(1379) (997, 1566, 21L71 (290)' ' (198, 560, 2102, 82518) (198, 706, 1805, 2097) (2072, 2102, 6216. .... 2217. - -- . 2818: 2219; 2220, 2251B. 2508) . (1458, 2216) (1198) (2379) (346) (789, 1341, 1587, 2215, 2218, 2219 8220, 250.4) (1427) (969) (37, 39, 300, 872, 1088, 1426, 1427, 2191, 2411, 2455 ) (38)

(258, 587, 967, 1236,1804, 2095, 2519, 2520) Colorimetric (107, 108, 811, 872, 1426, 1728, 2191) Fluorometric (927) Identification (6451 Review, methods (347,1220) Stability (858, 1907, 2191) Chromatographic, column (1877, 1125) Chromatographic, paper (1284, 1680, 1748, 2125) Chromatographic, thin layer (547, 1284, 1711, 2125) Colorimetric (1680, 1748) Identification (2367) Spectrophotometric, ultra(1877) violet Chromatographic, gas (2810) Colorimetric (1668) Chromatographic, thin layer (2512, 2522) Stability (1199) Chromatographic, paper (2525) Chromatographic, thin layer (740, 1136, 1208)

Colorimetric Extractive Fluorometric Spectrophotometric, ultra-

(509, 581, 2391) (581) (%391)

(671, 1810)

vinlet, . .___.

Phenol

Chromatographic, column Identification

(2240) ($240)

(Continued)

Table V. Oxygen-Containing Compounds (Continued) Compound or class Method or subject Reference Quinones Chromatographic, paper (210, 212, i i r r , me, 1249, 1680) Chromatographic, thin layer (210, 212, 868, 1190. 1297. 2046) Colorixnetric (1247, 1680,

Table V. Oxygen-Containing Compounds (Continued) Compound or class Method or subject Reference Hydroxyl, poly- Chromatographic, column hydric Chromatographic, paper Colorimetric Identification Review, methods Spectrophotometric, infrared Volumetric, ox.-red. Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Identification Polarographic Volumetric, ox.-red. Spectrophotometric, infrared Volumetric, acid-base Volumetric, ox.-red. Chromatographic, paper

20.U

Santonin Saponins

Strophanthin

Polarographic Rev iePr Review, official methods Spectrophotometric, ultraviol& Volumetric, acid-base Chromatographic, gas Fluorometric Spectrophotometric, infrared Chromatographic, paper Chromatographic, thin layer Coloriinetric Review Chromatographic, column Chromatographic, thin layer Coloriinetric

Hydroxyl, alcoholic

Identilication Stability Chrom atographic, gas Chromatographic, paper Chromatographic, thin layer Coloriinetric

Hydroxyl, phenolic

Identihation Interactions Refractometric Review, methods Volumetric, phase measurement Volumetric, ox.-red. Chrorr atographic, gas Chromatographic, ion exchange Chromatographic, paper Chrom atographic, thin layer Colorimetric

(i7iSj ' (680) (211)

Ketones

(1177, 1297)

(iirr) (1927) (23941 (194) (446) (366, 1078, 1100, 2207) (1614) (893) (1401) (423, 424, 697, 1401) (433, 697, 1401, 2073) (424) (2146) (1281, 1808, 1864) (281, 467) (770) (242, 281, 309, 360, 634, 770) (467) (80)

(94464) (992) (709)

Lactones Quinones

Chromatographic, thin layer Colorimetric Identification Polarographic Stability Volumetric, acid-base

Table Vi. Compound or class Aerosols Drugs

(783, 1048) (2166) (1076, 1423,

i?ow

Drug Stability

(1246, 1636) (647, 1423, 2108, 2176) (110. 238. 936.

Identihation 2368) Polarographic (68,2162) Spectrophotometric, infrared Spectrophotometric, ultraviolet Stability Volumetric, acid-base Volumetric, complexometric Volumetric, ox.-red.

. ,

X-ray analysis (Continued)

Stability (General)

Method or subject Stability testing, reaction kinetics Autooxidation and antioxidants Review, use of preservatives in Stability in polyethylene Kinetics of Prediction of Review of

Solubility analysis for measurement of F a t Bases Stability testing of Glass Containers Physical and chemical control of Liquid Pharma- Effect on plastics and ceuticals rubbers Parenterals Stability of preservatives in Pharmaceuticals Radioactive irradiation of Tablet Formulations

iirisi

(1248j (1816)

Physical and chemical stability testing of

Reference (1979) (1093) (2606)

(1620) (286, 883, 1299. i r m (671, 679, 896, 1090, 1108, ism, 2492) (70. 1318,

..

2433j (416) (8449) (1469) (1833)

(1796) (302,303, $440) (1230)

VOL. 39, NO. 5, APRIL 1967

203 R

Table VII. Steroids Compound or class Method or subject Reference Adrenocorticals Aldosterone Chromatographic, thin layer Betamethasone Chromatographic, column Chromatographic, thin layer Corticosterone Chromatographic, paper Chromatographic, thin layer Cortisone Chromatographic, paper (362,' 503, 1213, 21 16B) Chromatographic, thin layer (722) Colorimetric (1174, 1213, 1618) Nuclear magnetic resonance Optical rotatory dispersion Spectrophotometric, ultraviolet Dexamethasone Chromatographic, thin layer Colorimetric Polarographic SDectro.ohotometric, ultra-violei Fluorocortisone Chromatographic, thin layer St,ahilitv General Chrom&ographic, gas Chromatographic, paper Chromatographic, thin layer

(76 ) (419 (1848) (603, 1213, 21 15) Chromatographic, thin layer (7.22) Colorimetric (182, 1548) Crystallographic (197) Spectrophotometric, infrared (197) Spectrophotometric, ultra(197, d69) violet Spectrophotometric, X-ray (197) Prednisolone Chromatographic, ion (899) exchange Chromatographic, paper (1$313) Chromatographic, thin layer (1529) Colorimetric (182. 1176. 1213, 1214, 1314) Crystallographic (197) Spectrophotometric, infrared (197) Spectrophotometric, ultra(269, 1498) violet Spectrophotometric, X-ray (197) Stability (971, 1574) Prednisone Chromatographic, paper (1213) Chromatographic, thin layer (1529) Colorimetric (1175, 1213, 1498) Spectrophotometric, ultra(269, 1498) violet Triamcinolone Colorimetric (59) Volumetric, precipitation (987) Androgens Androsterone Chromatographic, paper (595) Chromatographic, thin layer (367, 728) Adrosteneol Chromatographic, paper (739) Chromatographic, thin layer (SS7, 739) Colorimetric (1986) Fluandrenolone Chromatographic, column (960) General Chromatographic, thin layer (701) Methandrostenolone Polarographic (370) Spectrophotometric (1173) Testosterone Colorimetric (492, 1059, 1139, 1140,

204 R

Fluorometric Nuclear magnetic resonance Spectrophotometric, ultraviolet Volumetric, ox.-red.

(436) (1035)

Chromatographic, column Chromatographic, gas

(260, 1568) (1196, 8267)


Estrenol Estriol

Estrone

Method or subject Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Optical rotatory dispersion Spectrophotometric Chromatographic, thin layer Colorimetric Chromatographic, Chromatographic, Chromatographic, Colorimetric Fluorometric Chromatographic,

column ga; thin layer column

Chromatographic, ga? Chromatographic, thin layer

Ethinylestradiol

Colorimetric Electrophoretic ReviewSpectrophotometric Hydrocortisone Chromatographic, gas Chromatographic, paper

Estrogens Estradiol

and Hormones Compound or class

General Mestranol General

Fluorometric Optical rotatory dispersion Spectrophotometric, ultraviolet Volumetric, acid-base Chromatographic, gas

Keto steroids

Miscellaneous

Oxosteroids

Oxytocin Pregnane Progesterone Stanols Sterols

(1879)

Vasopressin

(1196, 2W?) (615, 958) (1311) (958) (260, 1110, 1568) (1196. 8267) (958,'1109, ' 1110, 1311, 1430, 1503) (958, 2085) (1504) (1504) (735) (1967, 2209)

Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric (1396) Chromatographic, paper (1000) Chromatographic, thin layer Colorimetric Chromatographic, absorption Chromatographic, gas Chromatographic, pa.per Chromatographic, thin layer

Insulin

Reference (1776) (615, 958) (492, 1311 ) (958, 1317) (1604) (1604) (337) (669, 1055, 1057)

(525; 708, 830, 1225, 1664, .213S, 2208, 2372) Dichroimetry (1677) Identification (605) Nuclear magnetic resonance (436 1 Radiometric (512, 1046) Review (1821) Spectrophotometric, infrared (519) Volumetric, ox.-red. (732, 733, 734, 2086) Polarographic (2371) Radiometric (124) Chromatographic, paper (2075) Chromatographic, thin layer (1906) Colorimetric (106, 1.286, 1544, 1676 1906, 1969) Volumetric, ox.-red. (1082) Amperomet,ric (606 ) Chromatographic, paper (841, 43.3) Chromatographic, thin layer (658, 797, 1196) Colorimetric (341) Review (2227) Spectrophotometric, ultra(658) violet Chromatographic, ga? Chromatographic, thin layer W A B ) Colorimetric (898, 1233, 1512, 1679, 1968, 1969, 1970) Identification (898, 1282) Review (141gB) Chromatographic, partition (2469) Spectrophotometric, X-ray (1579) Chromatographic, thin layer (726) Colorimetric (492) Chromatographic, thin layer (568, 929) Colorimetric (1511) Chromatographic, thin layer (69, 928, 929) Colorimetric (1056, 1356, 151 1 , 2623) Volumetric, ox.-red. (2213 ) Chromatographic, thin layer (6049

Table VIII. Sulfur-Containing Compounds Compound or Compound or Method or subject class class Method or subject Reference Thermal analysis Benzothiadiazines Chromatographic, thin layer Volumetric, amperometic Countercurrent distribution Volumetric, complexometric Degradation kinetics Volumetric, coulometric Ideniification Volumetric, ox.-red. Review, methods Speci rophotometric, infrared Volumetric, turbidimetric Specixophotometric, ultraSulfur (Miscelviclet laneous) Stability ‘8;:6!y2$68) Benzothiepins Spectrophotometric, ultraviolet (316, 628, 777, Phenothiazines Chromatographic, gas Volumetric, ox.-red. 778) CyclohexylChromatographic, ion (2119) Colorimetric sulf amates exchange Review, pharmaceutical Chromatographic, pajper applications 1361, Chromatographic, thin layer (ii80,’ Volumetric, coulometric 1362, 1646, capto-l1646, 1649 Propanol 1866, 1997, Disulfides Volumetric, complexometric 2182) (988, 1714, Isothiocyanates Colorimetric Co1o::imetric Volumetric, precipitation 1798) 6-hlercaptoChromatographic, paper Extr,tction (414) purine (1398) Flu0 *ometric Methionine Gravimetric (760, 2190) Volumetric, ox.-red. (221, 988, Chromatographic, gas PhosphoroIden tification 1161, 1180, thioates Saccharin 2066, 2290) Chromatographic, gas Sodium Nor(1766) Volumetric, precipitation Pola.ographic (129,’706, amidopyrine Review, methods methane2066) sulfonate Spectrophotometric, infrared (1680, 2413) Sulfamoylureas Colorimetric Spectrophotometric, N M R ($413) Chromatographic, gas (135, 1704, Spectrophotometric, ultraSulfides Sulfonic acids Chromatographic, paper 2066, 2413) violet Sulfonylureas Review, methods Spectrophotometric, visible (136) Volumetric, coulometric (379, 601, 602, Stab ,lity 616, 778, Sulfophthaleins Chromatographic, adsorption Sulfoxides 1643, 1997, Polarographic Sulfur Gravimetric 2364 ) (83, 1633, Polarographic Volumetric, acid-base 1689, 1640, Volumetric, ox.-red. 1641, 1642, Volumetric, precipitation 2066) Thiadiazines Stability (160, 161, Volumetric, complexometric Volumetric, amperometric Spectrophotometric, infrared Thiazoles 1490) Spectrophotometric, ultraVolumetric, complexometric (760) violet Volumetric, conductometric (664) Volumetric, coulometric (1404, 1406) Volumetric, acid-base Thiazolidines Volumetric, ox.-red. (170) Volumetric, ox.-red. Thioamides Sulfonamides Chrcmatographic, paper (746, 1328, Colorimetric 1826, 1998, Spectrophotometric, ultra2287, 835.4) violet Chromatographic, thin layer (626, 672, 747, Volumetric, ox.-red. 1029,1177, Thiobarbituric 1363, 1422, acids Colorimetric 1467, 1525, Chromatographic, paper 1629, 1630, Polarographic Review, mercury complexes 1721, 1807, 1826, 24Oi, Review, reaction with aldehydes analytical applica2426) .. Collrbborative study, mixtures (1212) tions Colorimetric Stability (396, 410, Volumetric. comdexometric 1060, 2286, 8388, 2397, Thioctic acid Chromatographic, gas Thioglucose Volumetric, complexometric 2401 1 Crystallographic identifica(1640) Volumetric, ox.-red. Thioimidazoles Spectrophotometric, infrared tic n Thioxazolidones Spectrophotometric, ultraIdentification (247, 990, 1243, 1467, violet 1763) Thioxolones Polarographic (2, 1014, 1861) Thiophenes Volumetric, ox.-red. Review methods (958. 1766. Thio-TEPA Chromatographic, thin layer Solubility . 1909) ’ of %-labeled Spectrophotometric, infrared Thiouracils Identification Spectrophotometric, ultraVolumetric, ox.-red. violet Stability

Reference (348) (169) (1742, 1891) (1749) (93, 676, 886, 1231,2468) (2069)

(314) (1132) (481) (2406) (916) (1033) (769) (689)

(24479 (1966) (1628)

I:%,2f;2)

(910) (617) (1362, 1400) (2167) (2168) (1362, 8106) (2309)

(2309) (2064) (2064) (1744) (736) (1784B) (1740) (88 )

(1616) (1516) (2263) (1726) (1414) (1616) (662) (924; 986) (386) (3861 (884) (774)

(2168) (1998) (1440) (8016) (918)

VOL. 39, NO. 5, APRIL 1967

205 R

Table IX. Compound or class Oil soluble Vitamin A

Method or subject Chromatographic, Chromatographic, Chromatographic, Chromatographic,

column gas pa.per thin layer

Colorimetric

Reference (626,’2471) (1063, 1770) (336, 391, 960, 979, 1068, . 1822, 2330) (62L.699. 986.

Extractive Polarographic Review, official methods Spectrophotometric, infrared Spectrophotometric, ultraviolet

Stabili ty

Vitamin D

Chromatographic, column Chromatographic, gas Chromatographic, paper Chromatographic, thin layer

Colorimetric

Vitamin E

Extractive Fluorometric Identification Microbiological Polarographic Review Stability Spectrophotometric, ultraviolet Chromatographic, gas Chromatographic, thin layer Colorimetric

Vitamin K

Water soluble B Complex

B1,Thiamine

Polarographic Stability Chromatographic, column Chromatographic, ga; Chromatographic, thm layer Stability Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Fluorometric Identification Review Chromatographic, paper Chromatographic, thin layer Colorimetric

(1336) ’ (497, 498) (1683, 2177) (986, 1420, 1609. 1676. 9436 j (338. 8.93, ’ 1&2, i i 9 , 1116, 1364, 1777, 1822, 2981 ) (111,601, 1662. 2286. 2461j (2368) (601) (216, 226, 666, 8281 14461 1621, 1662, 1626) (111. 226. 601.

Vitamins Compound or class

Method or subject Stability

Reference (67, 226, 610, 1216, 1777, 9206, 2443)

Volumetric, acid-base Volumetric, precipitation Volumetric, ox.-red. Stability

Dihydrothiamine Oxythiamine Colorimetric Stability Thiamine p ophosPGte Bn, riboflavine Chromatographic, column Chromatographic, paper Colorimetric Complex formation Electrophoretic Fluorometric Identification Stability Spectrophotometric, ultraviolet Be, pyridoxine Chromatographic, ion exchange Chromatographic, paper Colorimetric

BIZ,Cyanocobalamine

Electrophoretic Identification Spectrophotometric, luminescence Spectrophotometric, ultra-violet Stability Volumetric. acid-base Chromatographic, adsorption column Chromatographic, ion exchange Chromatographic, partition column Chromatographic, thin layer

(332, 1608, 2023) (1067, 2077, 8138, 2234) (1087, 1376’, 1610, f968, 2294 1 (1199,2249) (833,2023) (1301)

(1118, 1119) (738) (902, 1308) ( 4 P , 1178, 1179) (31) - ‘ (1008) (261, 1937) (468) (26, 26, 476B,

Radiometric Radiometric, review Spectrophotometric, ultraviolet Stability

206 R


(189. 888.

Bn, pangamic acid Hydroxocobalamine C, ascorbic acid

(130, 148, 1366. 2L90)

Volumetric, complexometric Volumetric ox.-red. Polarographic

(2324j


(327)

Chromatographic, Chromatographic, exchange Chromatographic, Chromatographic, Colorimetric

disk ion paper thin layer

Identification Spectrophotometric, ultraviolet Stability

(499; 667, 2260) (1996) (1369)

(1434) (272,664) (188, 447, 1083, 1494, 1601, 1716, 1872, 2099, 2 2 0 P , 2293) (2319)

(us)

Identification Isotopic dilution

Review Spectrophotometric, ultraviolet

(776, 901, 1366, 1739) (1791)

Colorimetric

Electrophoretic Fluorometric

Polarographic

(1116)

Volumetric, acid-base Volumetric, complexometric

(768, 896, 1396, 1604, 1606, 1606, 1607, 1818, 2462, 2463) [8::)1788)

(Continued)

Table IX. Compound or class Folic acid

General

Nicotinamide

Method or subject Volumetric, ox.-red. Co1o:imetric Spectrophotometric, ultraviolet' Stab .lity Volumetric. ox.-red. Polarographic Review Spec trophotometric Volumetric, acid-base Chromatographic, ion exi:hange Chromatographic, paper Colo :imetric Eleci,rophoretic Gravimetric

Vitamins (Continued) Compound or Reference class

(1388, 1368)

Nicotinic acid

Panthenol (88, '396, 934, 1917 ) (1368) (2513)

Pantothenol Vitamin P

Method or subject Identification

Reference

Spectrophotometric, ultraviolet Stability Chromatographic, paper Colorimetric Identification Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, complexometric Chromatographic, ion exchange Colorimetric Colorimetric Fluorometric Identification

Table X.

Formulations, Mixtures, and General Methods Compound or Method or subject Reference class Method or subject Antihistamines Chromatographic, gas Chromatographic, thin layer Chromatographic, paper Identity Thermal analysis Polarographic Volumetric, acid-base Antimalarials Chromatographic, paper Acids, aryl Spectrophotometric, ultraAntioxidants Chromatographic,, paper violet glycolic Spectrophotometric, ultraAcids, fatty Chromatographic, paper violet Acetylenes Spec,;rophotometric, ultraAntipyretics Chromatographic, gas violet Chromatographic, thin layer Alcohols Refrrictometric Antituberculars Identity Alcohols, fatty Chromatographic, paper Aromatics Chromatographic, gas Alkylating Co1o:imetric Ataractics Polarographic agents Barbiturates Chromatographic, paper Amines Chromatographic, gas (1238, 8867) Chromatographic, thin layer Chromatographic, paper (1886) Colorimetric Chromatographic, thin layer Identity Coloi*imetric Miscellaneous Com plexometric Volumetric, complexometric Extmctive BenzothiadiChromatographic, miscellaneIden.;ity azines ous Volu netric, acid-bwe Carbamic acid Review Volu metric, complexometric esters Citrates Volumetric, acid-base Amines, benzyl Iden.;ity Diuretics Chromatographic, thin layer Dyes Chromatographic, adsorption Amines, Volumetric Chromatographic, ion primary exchange Chromatographic, ion Amines, Chromatographic, paper exchange quaternary Chromatographic, thin layer Chromatographic, thin layer Identity Coloiimetric Miscellaneous Analgesics Chromatographic, ion Ester Chromatographic, thin layer exchange Ethoxy groups Volumetric, ox.-red. Chromatographic, thin layer Fats Chromatographic, paper

Compound or class A. General Methods Acids

Anesthetics Anesthetics, local

Anthelmintics Anthracene derivatives Anticholinergics Antibiotics

1den;ity Chromatographic, gas Review Chromatographic, pa.per Chromatographic, thin layer Ideniity Chromatographic, thin layer Chromatographic, in crude drugs Adsorption, on antacids Chro natographic, thin layer Review, physicochemical methods

General techniques

Chromatographic, thin layer Volumetric, ox.-red. Activation analysis Ashing Capillary luminescence Catalytic analysis, review Chromatographic, adsorption Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Chromatographic, paper, review Chromatographic, partition column

Reference (6299) (6OgB,1471) (994, 996) (390)

[%$ (1767)

(818, 1074) (2503) (2029) (9200) (911) (1408) (1886, 2013) (21Sl) (1101) (155) (1920) (9)

(12) (412) (691) (975, 2137) (749) (1407, 1750) (84, 103, 2187) (103,1407, 1656, 1659, gi5r) (64) (9270)

(2147, 2148, 215 0 ) (23811 (1169, 1990) (120)

(2092) (2026) (792) (1636) (668B,711, 849, 920) (662) (10, 11, 999, 1209, 2068) (2472)

(374) (Continued)


207 R

Table X.

Compound or class

Hydrophilics Hydroxyquinones Hypnotics Iodides Nitrogen Oils Oils, essential Oils, umbelliferous Ointments Ophthalmic preparation

208 R

Formulations, Mixtures, and General Methods (Continued) Compound or Method or subject Reference class Method or subject Reference Chromatographic, thin layer (666, 843, Phenols Chromatographic, thin layer (763) 1065, 1066, Phenothiazines ChromatoaraDhic. ion (2119) 1380. 1705. exchange ’ 1897; 2010; Chromatographic, thin layer (315,1547) Preservatives Chromatographic, gas (926, 1655) 2012, 2103, Chromatographic, thin layer (422, 1705) 21648, 2284, Proteins Chromatographic; polaro(1027) 2419, 2503) (576, 1351) graphic Color reflectance Psychotropics Chromatographic, thin layer (1152, 82.46) Colorimetric (527, 1211, Identity 1316, 1323, (125B,1159, 1835, 2070) 9,945 1 Purines Chromatographic, thin layer (2503) Complexometric (834, 104% Pyrazolones Chromatographic, thin layer (787) 1172) Pyridine Spectrophotometric, ultraDielectric constants (1702) (809) derivatives violet Drug partitioning (511, 999, Pyrogens Polarographic 1145, 1803) (5841 Quinones Chromatographic, thin layer (753) Electrophoretic, paper (493) Use as reagent (298, 1472) Flame photometric (2480) Chromatographic, thin layer (9) Saluretics Flask combustion (8105) Salves Identity Fluorometric (2152, 2163) (3255) Chromatographic, gas (1287, 1881, Sedatives Identity, spot tests (1.469’) Chromatographic, thin layer (831, 1298, 2122, 2320, Steroids 1383, 1622. 2338, 2350, m4j 2482, 2483, 1L86 Stimulants Chromatographic, paper (649) Chromatographic, thin layer (1647) Isotope dilution, review (1463)’ Sulfonamides Chromatographic, thin layer (191, 747, Kinetic (807, 808) Mass spectrometric 1029, 2503) (222.8,2223) (1539, 1861, Microcrystallographic Critical review (1411B) 1862) Surface-active Review (175) Microcrystallographic, agents Terpenes Chromatographic, paper (2188) critical review Vitamins Chromatographic, thin layer (950, 1064, Microcharacterization (H3, 264) 1065, 1066, Nuclear magnetic resonance (22) Phosphorimetric (8444) Review Polarimetric (939, 1761 ) Dielectric Water (716, 839) Polarographic Polarographic, identity (529) Karl Fischer reagent (834) Spectrophotometric, infrared (2123) Radiometric (1154, 1463, 2259) Waxes Identity (2149) B. Formulations, Radiometric, review (451) mixtures and (703, 704, 720, Refractometric miscellaneous 1309, 1310, 1796, 2196) Acedicon Chromatographic (1818) Acetaminophen Chromatographic, partition (1165) Solubility analysis (416, 2196) column Spectrophotometric, infrared (122, 1389, Acetylene Chromatographic, gas (2084) 1908) Acetylsalicylic Chromatographic, gas (1259) Spectrophotometric, ultra(265, 864, acid Chromatographic, partition ( 1165, 2288) 1207, 1323, violet column 1389, 1703, Chromatographic, thin layer (105) 1835, 2074, 2233) Mixtures, miscellaneous (254) (1761) Spectropolarimetric Spectrophotometric ( 2040 ) Spectrophotometric, ultra(402) (479, 613, 949, Thermal analysis violet 1061) Volumetric, amperometric, Volumetric, acid-base (248, 973, (167) 1275 ) review Acetylsalicylic Moisture in, spectrophoto(2123) Volumetric, conductimetric (51,521 acid, alummetric, infrared (1387, 1634, Volumetric, coulometric, inum salt 1635) review Polarographic Ad en ine Volumetric, ox.-red. (144, 569, Adenosin-5’Chromatographic, column 1519) triphosphate (2259) Volumetric, radiometric Allobarbitone Complexometric (1980) Volumetric, thermometric (479, 480) Amethocaine Volumetric, acid-base (485) (667, 1618) X-ray p-AminoColorimetric (6.95) (2152) Chromatographic, paper benzoic acid Extractive; colorimetric (9gB) Chromatographic, thin layer ( 753) Aminophylline Chromatographic, ionexchange (2262) Chromatographic, pa.per n-Aminophenol Extractive; colorimetric Chromatographic, thin layer (665, 2263) Aminopyrine Chromatographic, thin layer (22662) Electrophoretic, paper Colorimetric Amperometric Spectrophotometric, infrared Colorimetric, automatic Volumetric, acid-base Volumetric, ox.-red. Chromatographic, gas Volumetric, ox.-red. Volumetric, ox.-red. p-Aminosalicy- Volumetric, ox.-red. Volumetric, distillation late Aminofurin Spectrophotometric, ultra(1672) Chromatographic, thin layer violet Amphetamine Chromatographic, partition (1464) Chromatographic, paper column Miscellaneous (Continued)


Table X. Formulations, Mixtures, and General Methods (Continued) Compound or Compound or class Method or subject class Method or subject Reference Ceresin Fluorometric Amylocaine Colorimetric (244, 246) Chamazulene Chromatographic, thin layer Analgin Volumetric, ox.-red. (781) Chloroform Chromatographic, gas (164) Androisoxazole Spectrophotometric, ultraVolumetric, ox.-red. violet Chlorophyllin Chromatographic, adsorption Anisotropine Monograph, proposed (989) column Chroinatographic (1306) Anthracene ChlorphenirChromatographic, partition derivatives Chro natographic, adsorption (2144) amine column colJmn ChlorphenirColorimetric Coloximetric (490) amine Antipyrine Gravimetric (36) maleate Volumetric, acid-base (1194) Chlorpromazine Assay in mixture Chromatographic, thin layer (1191) Arbutin Phosphorimetric Armin Spec1 rophotometric, ultra(1736) Chymotrypsin Colorimetric violet Volumetric, acid-base Atropine Phosphorimetric (24459 Choline Chromatographic, thin layer \’oluinetric, acid-base (2342) Cicutine Colorimetric Microcrystallographic (1289) Barbital Cital T’olumetric, ox.-red. Barbiturates Voluinetric, acid-base Citric esters Chromatographic, thin layer Belladonna Chromatographic, partition Cocaine Colorimetric alkaloids column- ‘ Phosphorimetric Bengal Red Chromatographic, adsorption (974) Codeine base Volumetric, acid-base Benzactyzine Coloiimetric (2039) Codeine Chromatographic hydrochloride Chromatographic, partition phosphate Benzoic acids Chromatographic, thin layer (1706) column Benzalkonium Standard methods, review (760) Colorimetric chloride Countercurrent, extractive BenzoylChromatographic, paper (1339) Volumetric, acid-base ecgonine Colamine Chromatographic, thin layer Bergapten Colorimetric; spectrophoto(1678) cephalin metric, ultraviolet Chromatographic; spectroCortisones Betaine Chromatographic, thin layer (8160) photometric Bile acids Chromatographic, thin layer (813) Colorimetric Cysteine Bisacodyl Spec xophotometric, ultra(1497) Cyclamate Chromatographic, thin layer violet sodium Bisadolal oxides Chromatographic, thin layer (1940) Cyclohexane Complexometric Levo-alphaChromatographic, thin layer (1940) sulfamic acid Bisabolol Polarimetric DexamphetBismuth Volumetric, amperometric (6) amine Boric acid Volumetric, mid-base (485) 4,4’-Diacetoxy- Spectrophotometric, ultraBovine plasma Elecl rophoretic (1609) diphenyl-2violet Brilliant Green Polarographic (1360) pyridylBucetin Chromatographic, paper (918) methane Butylhyoscine Chromatographic, paper (473) Dibasol Countercurrent, extractive bromide Gravimetric Spectrophotometric, ultraSpecxophotometric, ultra$%5) violet violet Volumetric, acid-base Caffeine Chromatographic, ion (2028) Dicaine Spectrophotometric, ultraex :hang; Chromatographic, paper (1209, 2221 ) violet Chromatographic, partition Volumetric, acid-base (375, 1165, Volumetric, mercurometric co umn Chrc matographic, thin layer Dienestrol Chromatographic, paper Colorimetric Diethylpropion Colorimetric hydrochloride Coulometric DihydroChromatographic, paper codeinone Countercurrent, extractive Gra\,imetric DihydroChromatographic, spectroIdentity codeinone photometric Nuclear magnetic resonance bitartrate Spectrophotometric, infrared DiiodqfluorRadiometric escein Spectrophotometric, ultraviolet Dimethylamino- Colorimetric ethyl diVolumetric, acid-base Spectrophotometric, ultraphenylhyviolet droxyacetate Volumetric, ox.-red. Caffeine Spectrophotometric, ultrahydrochloride DimethylChromatographic, thin layer sodium violet benzoate Volumetric, acid-base aminoethyl Caffeine sodium Volumetric, acid-base benzilate salicylate DiphenylChromatographic, partition Calcium lactate Colorimetric hydantoin column Spectrophotometric, ultraCapsicum Spectrophotometric violet Carbon monChromatographic, gas Dionine Countercurrent, extractive oxide Volumetric, acid-base Carbon tetra- Chromatographic, gas Dipyrone Spectrophotometric, ultrachloride violet Cascara anColorimetric Volumetric, ox .-red. thracenes Doxylamine Sustained release study succinate Cascara Chromatographic, thin layer Dulcin Chromatographic, thin layer sagrada Volumetric, ox.-red. anthrones Cellulases Analysis in enzyme mixtures

?!%

(1918) (1136) (1031, 1899)

(1670) (1004)

(1097)

(1367) (1929) 1113)

(1670) (2055)

(1031, 1899) (1429)

mtinued)

VOL. 39, NO. 5, APRIL 1967

209 R

Table X. Formulations, Mixtures, and General Methods (Confinued) Compound or Compound or class Method or subject Reference class Method or subject Reference Ecgonine Chromatographic, paper (1339) IsopropylMiscellaneous (794) Ephedrine, and Chromatographic, ion (603) phenazone salts exchange Itobarbital Chromatographic, partition (8888) Chromatographic, paper (466) column Chromatographic, partition (1464) Lactic acid Colorimetric column Lanolin esters, Chromatographic, paper Colorimetric (894) sterols Extractive Lecithin Chromatographic, thin layer ($408) Epinephrine Colorimetric Lidocaine Colorimetric (483, 1881) Chromatographic, thin layer (669) Estr-4-en 17 ($043) Lipase Turbidimetric beta-ol Lisozime Chromatographic (4866) Estrogen Chromatographic, gas (1~507~) Liver hydroly- Chromatographic, paper (1018) sates Ethanol Chromatographic, gas (1648) Ebuliometric (8460) Luminal Volumetric, acid-base (896) Refractometric Lysergic acid Chromatographic, thin layer (693) EthoxybenzColorimetric diethylamide amide Marijuana Chromatographic, thin layer (1160) EthoxypolyStability, hydrolytic (666) Colorimetric (766) siloxane Review (766, 1964) Marsalid Polarographic EthylaminoMiscellaneous ($54) benzoate Meclizine Spectrophotometric, ultraviolet Ethyl chloride Chromatographic, gas (719) Ethylendiamine Complexometric (8109) Melphalan Fluorometric (378B) tetracetic Menthol Turbidimetric (8474) acid, and salts BlephenterChromatographic, partition (1464) Eucalyptus Identity (8030) minesulfate column Euphylline Volumetric Metaldehyde Colorimetric (433) Fats Peroxide value Methapyrilene Colorimetric (1980) Ferrocal Volumetric, coulometric (8089) MethylethylSustained release study (1039) Folia uvae ursi Miscellaneous (1306) aminophenylFolic acid Colorimetric (8136) propanol hydrochloride Frangula Colorimetric (490) Methylamphet- Chromatographic, partition (688) anthracenes Fuchsin Chromatographic, ion (8169) amine hydroexchange chloride ( 1843) Methylcellulose Chromatographic, paper (8148) Fumaric acid Identity, in ferrofumarate Furazolidone S ectrophotometric ( 1687) Methyl-N-tri- Chromatographic, gas (931) Glyceryl CPhromatographic, partition (860) fluoroacetyl trinitrate column derivatives Colorimetric MethylepheIdentity (9463) Volumetric acid-base drine Methylene blue Gravimetric; polarographic (1360) Glycyrrhizic Spectrophotometric, ultra(1736) acid violet N-Methyl-3Volumetric, acid-base (168) benzoyl4 GuaiacolChromatographic, ion (680) hydroxy-4sulfonate, exchange potassium phenyl-piperiHampi Constituents of (669, 660) dine hydroHawthorne Chromatographic, paper (1686) chloride base Methyl-paraChromatographic, thin layer (1706) hydroxyHemicellulases Methods discussion Heparin Standardization of benzoate Hetrazan Colorimetric (8021) Methylmethionine Colorimetric (1676) sulfonium gamma Hexa- Polarographic (149.9, derivatives chlorocyclohexane Molybdenum Polarographic (1467) Hexestrol Chromatographic, paper (8$66B) Moroxydine Spectrophotometric (8039) Muscarine Chromatographic, thin layer (8160) Hydrocortisone Colorimetric (1639) Naphazoline Identity, micro (8423) ortho-Hydroxy- Volumetric, acid-base (9344) Neon Chromatographic, gas; in (8084) anesthetics quinolinemeta-sulf onic Neostygmine Colorimetric, spectrophoto- (1186) acid bromide, metric sulfate Inositol Colorimetric (848) Niamid Polarographic Intrinsic factor Radiometric (811B) Nicotine Chromatographic, ion Iodine Volumetric, ox.-red. (1994) exchange Distillation (8866) IodochloroColorimetric (409) hydroxyquin Extractive (81) Radiometric (8489) Iron Colorimetric, automatic (193) Nitrates, Colorimetric (1741) Volumetric, ox.-red. (1964) nitrites Isoniazid Colorimetric (8048) Nitroglycerin Chromatographic, partition (860) Spectrophotometric, ultra(631) column violet Colorimetric Isonicotinic Chromatographic, ion (1696) Volumetric, acid-base hydrazide exchange Nitropentone Analysis, in mixtures (1690) Isonicotinyliso- Spectrophotometric, ultra(796) Nitrous-oxide Chromatographic, gas (1861) violet Norethynodrel Colorimetric (373) propylhydraNovalgin Gravimetric (319) zine phosphate Isopimpinellin Colorimetric; spectrophoto- (1676) Novocaine Chromatographic,. paper ($88) Spectrophotometric, ultra(1004) metric, ultraviolet violet IsopropylMiscellaneous (794) antipyrine Spectrophotometric, infrared (1688) (Continued)

$;:;{

[%)

I%[

[!:A)

f%)

W)

KJ)

[E!;)

{:%)

~~

210 R


Table X.

Formulations, Mixtures, and General Methods (Continued)

Compound or class Ointments

Method or subject Chromatographic, paper General 17-Oxosteroids Chromatographic, gas Oxytetracycline Colorj metric hydrochloride Pachycarpine Identity PaDain Volunietric, acid-base Volunietric, acid-base Papaverine Paracetamol

Spectrophotometric

Pentobarbital Perphenazine Persedon Pervitin Phenacetin

Specti~ophotometric;kinetic Chromatographic, paper Miscellaneous Colorimetric Chromatographic, ion exchange Chroniatographic, paper Chromatographic, partition column Chroniatographic, thin layer Nucleitr magnetic resonance Spectrophotometric, ultraviolet Volurr.etric, acid-base Volumetric. ox.-red. Volurcetric; ox.-red. Volumetric, acid-base

Phenazone Phendimetrazine; phenmetrazine Phenobarbital

Phenothiazine; derivatives Phenol Phenurnne Phenylbutazone Phenylephrine

Chromatographic, ion exchange Chrolr atographic, paper Chromatographic, partition column Chromatographic, thin layer Complexometric Kineti:. Phospliorimetric Spectrophotometric, ultraviolcmt Volumetric, acid-base Volumetric, argentometric Spectfophotometric, ultravlolr't Colorimetric Colorimetric Volum Btric, acid-base Chromatographic, partition coluinn Chromatographic, thin layer Methods, discussion Stabili1,y Colorimetric

PhenylproChromatographic, partition anolamine column ydrochloride Phenylquinoline Analysis, in mixtures carboxylic acid Phenytoin Chrom,itographic, partition column Extraciive; spectrophotometric Spectrcphotometric, ultraviolet Pholcodine Chrom:ttographic, paper Phosphacol Spectrcphotometric Phthalic esters Chromittographic, thin layer Piperazine Colorimetric citrate Platyphylline Countercurrent, extractive hydrotartrate Polyethylene Colorinietric glycol Polyisobutene Spectrophotometric, infrared Poly(ethy1ene Effect cn assays oxide) base

E

Reference (2153) (1176) (150~) (1639) (8511) (1878) (295, 377, 1495, 1670, 2348) (889, 1163, 1724) (351) (999j (794) (8386) (794) (918) (2888) 1106)

(1126, 1367, 2LLSlB)

(35, 3 f 7 , 413, 638, 1495) (319) (8288)

(860j '

(908, 909)

(1901; 2389, 2393) (1464)

Compound or class Method or subject PolyvinylChromatographic, paper; pyrrolidone miscellaneous Potassium Volumetric guaiacolVolumetric, ox.-red. sulfonate Pregnanediol Chromatographic, gas Procaine Colorimetric hydrochloride Phosphorimetric Volumetric, acid-base Volumetric, ox.-red. Promedol Assay in mixture Propylhydroxy- Chromatographic, thin layer benzoate Chromatographic, partition Pyramidon column Countercurrent, extractive Volumetric, acid-base Pyrazolone Chromatographic, paper derivatives Pyrethrum Method review Spot tests Pyridoxal Chromatographic, paper Pyridoxal derivatives Chromatographic, thin layer Colorimetric Pyridoxine Spectrophotometric, ultraviolet Pyrrivinium Chlorimetric pamoate Quinine Chromatographic, ion exchange Chromatographic, thin layer Rose Bengal Radiometric; miscellaneous Rhubarb Chromatographic, adsorption anthracenes column Colorimetric Rutin Saccharin Chromatographic, thin layer Colorimetric Chromatographic; spectroSalicylamide photometric Spectrophotometric, ultraSalicylic acid

Salsolidine, salsoline Senna leaves

Reference (2032)

(378) (394)

(1192) (1097) (8144)

violet

Review, standard methods Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, acid-base

Extractive; colorimetric Spectrophotometric, ultraviolet Sodium-4Chromatographic, ion aminosalicyexchange late Sodium Volumetric, acid-base benzoate Sodium iodide Radiometric Sodium+rthoRadiometric iodohippurate Sodium theoVolumetric, acid-base bromine Sorbic acid Chromatographic, thin layer Spherophysine Volumetric, ox.-red. Stilbestrol Chromatographic, paper Strychnine Chromatographic, ion exchange Colorimetric Sulfadiazine Chromatographic, paper Sulprifen Colorimetric Sulpyrine Colorimetric Equilibria, aqueous Sympathol Colorimetric Tetracaine Analysis, in mixtures TetrachlorChromatographic, gas ethylene Theobromine Amperometric Chromatographic, paper Chromatographic, thin layer Volumetric, acid-base Volumetric, coulometric

(1853) (68) (1696) (700) (2308) (2S08)

(700) (1706)

)%;I

(1088)

(2292) (999) (2393) (1591) (1954)

(Continued)

VOL. 39, NO. 5, APRIL 1967

211 R

Table X.

Compound or class Theobromine sodium salicylate Theophylline

Theophylline aminoisobutanol Thyme oil, phenol in Thiamine Trichlorethylene

Formulations, Mixtures, and General Methods (Continued) Compound or hlethod or subject Reference class hlethod or subject Volumetric, acid base TriethanolSpectrophotometric, infrared amine Triipdothyro- Radiometric Chromatographic, ion nine exchange Chromabographic, paper Trimeprazine Chromatographic, paper Colorimetric Trypsin Chromatographic, thin layer Volumetric, acid-base Dissolution rate Colorimetric Ureides Volumetric, coulometric Turbidimetric Validol Dissolution rate Fluorometric Vaselines Chromatographic, ion Veratrine Chromatographic; coloriexchange metric Chromatographic, paper Xanthine Volumetric, ox.-red. alkaloids Chromatographic, gas Polarographic Zinc oxide

(Continued from page 191R ) methods for organic compounds, and numerous drug references are cited. A book, “Newer Redox Titrants,” (17.2) describes many of the newer and less familiar oxidation-reduction titrants. The “Encyclopedia of Industrial Chemical Analysis,” contains various articles of interest, one example of which is Wimer’s review of acid-base titrations (2441) . Two books, “Dissociation Constants of Organic Acids in Aqueous Solution,” b y Kortum, Vogel, and Andrussow (1161), a n d “Dissociation Constants of Organic Bases in Aqueous Solution,” by Perrin (1673), cite data for nearly 5000 compounds, including many of a pharmaceutical nature. Polarographic analysis of medicinal substances was reviewed a n d considered in several papers (441, 628, 762, 966, 1664). An investigation of the reliability of chemical analyses of biological materials in a number of French pharmaceutical laboratories was reported (107gB). Lachman (1230) reviewed stability in tablet dosage forms. The effect of auxiliary tablet components on the accuracy of analyses of active components was examined (1860), a n d the identification of unknown tablets with the help of systematic classification has been described b y Mueller (1484). LITERATURE CITED

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212 R


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Reference

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~

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-.I

(53) Artamanov, B. P. Konenkova, T. Y. and hlaiofis, S. L., Med. Prom. SSSR 19 (9) 57 (1965); C.A. 63, 17800f (196.5).

(54,-A&monov, B. P. and Kupina, N. A., Zbid., 19 ( l o ) , 61 (1965); C.A. 64, 4b71c (1966). (55) Artamonov. B. P. and hlaiofis. S.L.. Zbid., 19 (6), 48 (1965); C.A. 63,’8125; ~

( 1 96.5\.

\ - - - - ,

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?.I.

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(84) Balatre, P. and Traisnel, M.,Bull. SOC.Pharm. Lille 1, 41 (1965); C.A. 64, 11029c (1966). (85) Balcarbwna, E., Biul. Znst. RoSlin Leczniczych. 9, 21 (1963); Anal. Ahstr. 11, 3318 (1964). (86) Zhid., p. 32; Anal. Abstr. 11, 3319 (1964). (87) Balkay, A. and Nagy, G. T., Acta Pharm. Hung. 34 (l), 14 (1964); C.A. 61,2910f (1964). (88) Balkay, A. and Nagy, G. T., Ibid., 35 (2), 84 (1965); C.A. 63, 1659e (1965). (89) Baltazar, J. and Braga F. M. ?*I., Rev. Port Farm. 14 (2), 116 (1964); C.A. 61, 159358 (1964). (90) ,Baltazar, J. and Braga F. &I. M., Zhzd., 15 (2), 85 (1965); C.A. 63, 17802h (1965). (91) Bandyukova, V. A., Materialy 1-go Vseros. S’ezda Farmatsevtov. Sh. 1962, 227 (Pub. 1964); C.A. 62, 11631c (1965). (92) Banfi, R. F. and de Wikinski, R. W., Rev. Asoc. Bioquim Arg. 29, 100 (1964); C . A . 62, 1 0 2 9 6 ~(1965). (93) Banick, W. M., and Valentine, J. R., J . Pharm. Sci. 53, 1242 (1964). (94) Ban’kovskaya, A. N., Ban’kovskii, A. I. and Ostrovskii, N. I., filed. Prom. SSSR 18 (4), 42 (1964); C.A. 61, 54539 (1964). (95) Barac, G. and Morren, H., Protides Biol. Fluids, Proc. Collop. 8, 272 (1960) (Pub. 1961); C.A. 61, 68639 (1964). (96) Barakat, & Z.I. and Shehab, S. K., Analyst 90, 50 (1965). (97) Barakat, M. Z. and Shehab, S. K., Microchem. J. 8 (l), 6 (1964); C.A. 61, 546lg (1964). (98) Barashkov, K . M., Aptechn. Delo 13, 77 (1964); C . A . 61, 8127a (1964). (99) Barcza, L., Magy. Kem. Folyoirat 69, 248 (1963); Anal. Abstr. 11, 5447 (1964). (100) Barkov, N. K., Farmakol. i Toksikol. 27 (l), 91 (1964); C . A . 60, 14336c (1964). (101) Baron, M. S., Aptechn. Delo 13 (I), 72 (1964); C.A. 61, 9361h (1964). (102) Barreto, R. C. R. and Sabino, S. O., J. Chromatog. 13, 435 (1964). (103) Barrett, J. F. and Ryan, A. J., Nature 199, 372 (1963). (104) Barrosa, M. T. de O., Rev. Port. Farm. 13 (4), 491 (1963); C.A. 61, 2909a (1964). (105) Barrosa, M. T., Zhid., 15 (3), 239 (1965); C.A. 6 4 , 9 5 0 8 ~(1966). (106) Bartos, J., Ann. Pharm. Franc. 20, 650 (1962); C.A. 61, 3701e (1964). (107) Bartos, J., Ibid., 21, 603 (1963). (108) Bartos, J., Ibid., 22 (3), 223 (1964); C.A. 6 1 , 4 1 5 1 ~(1964). (109) Bartos, J., Ibid., 22 (5), 383 (1964). (110) Barua, R. K . and Rao, M. V. K., Analvst 89 (1061), 534 (1964). (111) Barua, R. K. and Rao, M. V. Zhid., 90 (1074), 571 (1965). (112) Barysheva, A. I. Aptechn. Delo 14 (2) 73 (1965); C.A. 63, 9749d (1965). (113) Bashilova, V. M., Zhid., 13 (1) 42 (1964): C.A. 61.9356e (1964). (114)‘Basdilova, V. M . and Figurovskii, N. A., Zbid., 11 (4), 29 (1962); C.A. 60, 13093h (1964). (115j Bashilova, V.’ M., and Figurovskii, S . A., Zbid., 12 (3), 31 (1963); C . A . 61, 81286 (1964). (116) Bashilova, V. M. and Figurovskii, N. A.,Zhur. AnaLKhim. 18,396 (1963); Anal. Abstr. 11, 1079 (1964). (117) Bastin. M.. Bull. SOC. Rou. Sci. Liege 33 (5-6),’ 349 (1964); C.2. 61, 11849f (1964). (118) Basu, D. K. and Pradham. S. N.. Indian J. Esp. Biol. 2, 129 (1964); Anal. Ahstr. 12,5975 (1965). ~

(119) Bataliri, A. Kh., Zzv. Vysshikh Uchehn. Zavedenii, Khim. i Khim. Tekhnol, 5 (5), 845 (1962); Anal. Ahstr. 11, 916 (1964). (120) Bate, L. C. and Pro, M. J., Int. J. Appl. Radiation and Isotopes 15, 111 (1964); Anal. Ahstr. 12, 3497 (1965). (121) Battersby, A. R., Bick, I. R. C., Klyne, W., Jennings, J. P., Scopes, P. M. and Vernengo, M. J., J. Chem. SOC. 1965,2239. (122) Baudet, P., Otten, Cl., and Cherbuliez, E., Helv. Chim. Acta 47 ( 8 ) , 2430 (1964); C . A . 62, 9768d (1965). (123) Baulina, E. A., Keimakh, R. Ya., Kudryavtsev, V. I. and Portnov, M. A., Med. Prom. SSSR 20 (l), 41 (1966); C.A. 64, 11032c (1966). (124) Baum, W. E., Brown, W. F., and Crabtree, R. E., J. Pharm. Sci. 53 (7), 735 (1964). (125) Baumler, J., Chimia 17, 257 (1963); Anal. Ahstr. 11, 4511 (1964). (126) Bayer, I., J . Chromatog. 16, 237 (1964); Anal. Ahstr. 13,911 (1966). (127) Bayer, I., and Farkas, S., Acta Chim. Acad. Sci. Hung. 41 (1-2), 209 (1964); C . A . 62,6342e (1965). (128) Bayer, I. and Majlat, P., Acta Pharm. Hung. 34 (2), 65 (1964); C.A. 6 1 , 2 8 0 7 ~(1964). (129) Bayer, I. and hlajlat, P., Arzneimittelstandardisierung, Znformationdienst 3 (l), 1 (1962); C.A. 61, 3698c (1964). (130) Bayer, J., Pharmuzie 19 (9), 602 (1964); C . A . 61, 14471d (1964). (131) Bayer, J., Zbid., 20 (5), 328 (1965); C.A. 63, 6792d (1965). (132) Bazhulina, N. P., Morozov, Yu. V., Karpeiskii, AI. Ya., Ivanov, V. I. and Kuklin, A. I., Biofzika 11 (l), 42 (1966); C.A. 64, 1685ld (1966). (133) Beck, E. B., Penner, M. H. and J. ,Pharm. Sci. 53 (lo), Talmage, J. ll. 1257 (1964). (134) Beckett, A. H. and Choulis, N. H., Kongr. Pharm. Wiss., Vortr. Originalmitt., 23, Muenster, (Westfalen) Ger. 1963, 627 (Pub. 1964); C . A . 62, 7591a (1965). \ - - - - I

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(429) Covello, &I. and Schettino, O., Farmaco (Pavia) Ed. Prat. 19 (l),38 (1964); C.A. 60,118485 (1964). (430) Cox, W. H. and Greenwell, B. E., J . Pharm. Sci. 54 (7), 1076 (1965). (431) Craig, J. C., Mary, N. Y. and Roy, S.K., ANAL.CHEM.36, 1142 (1964). (432) Crepy, O., Judas, 0. and Lachese, B., J . Chromatog. 16 (2), 340 (1964). (433) Cresta, L. A., Rev. Assoc. Bioquim Arg. 29,48 (1964);A n d . Abstr. 13, 2172 (1966). (434) Crevar, G. E. and Goettsch, R. W., J . Pharna. Sei. 55 (4), 446 (1966). (435) Crevar, G . E. and Slotnick, I. J., J . Pharm. Pharmacd. 16 (6), 429 (1964). (436) Cross, A. I).,Landis, P. W. and Murphy, J. W., Ste:oids 5 ( 5 ) , 655 (1965). (437) Cruceanu, 31.,Andele. Stiint. Univ. A. I . Cuza," Sect. I , 11 (1) 55 (1965); Anal. Abstr. 13,2628 (1966). (438) Cruceanu, &I. and Dima, &I., Analele Sliinl. Univ. "A. I . Cuza," Iasi, Sect. I C . Chem. 10 (2), 217 (1964); C.A. 6 3 , 1 7 7 9 8 ~(1965). (489) Crummett, u'. B., Simek, J. and Stenger, V. A . , ANAL. CHEM.36, 1834 (1964). (440) Cuiko, I. V. and Elernshtein, V.N., Peredovye Metody h7hina. Tekhnol. i Kontrolya Proizu. Sb. 1964, 264; C.A. 63, 8124b (1965). (441) Cunha, A. P. da, 1301. Escola Farm., L'niv. Coimbra. Ed. Cient. 22. 72 (1962); C . B . 61,'533d (1964). (442) Cunha, A . P. h1. A. da, Ibid., 23, 1 (1963), C.A. 62,1515d (1965). (443) Cunha, 0. It. P. da and Gomes, Ibtd.. 22. 129 (1962): C.A. 31. E. B., Ibid.. 61, l 7 l l d (1964). (444) Curry, A. S., Brzt. Med. J. 1 (5379), 354 (1964); C . A . 60, 11347e (1964). (445) Czlonkowaka, H. rind Gradecka, I., Farmacja Pol. 20, 7XI (1964); Anal. Abslr. 13,914 (1966). (446) Cqszewska, S., Lliul. Inst. Roslin Lecznzczych 9 (1-2), 1 2 (1963); C.A. 60, 13094f (1964). (447) D"'Alberti, A., Ram. China. 16 (2), 77 (1964); C.A. 61,10534f (1964). (448) Dal Pozzo, A., B(>Ll.Chim. Farm. 104,55 (1965);C.A. 6 3 , 4 3 1 ~(1965). (449) Uanek, A., Dtssertcitiones Pharm. 16 ( 3 ) 3 2 3 (1'364); C.A. 62, 15993h (1965). (4503 Ibid., 339 (1964): Anal. Abstr. 13. ' 37i (1906). (451) Danek, A., Farm. .Polsku 21 (9-lo), 326 (1965); C.A. 63,11247f (1965). (452) Daiiek, A. and Brandys, J., Dissertaliones Pharm. 15 (4), 427 (1963); C . A . 61,2910e (1964). (453) Danek, A,, and liniek, J., Ibid., 16, 359 (1964); Anal. Abstr. 13, 373 (1966). (454) Danek, A., AIadej, A. and Sztark, W., Ibid., 17 (3), 329 (1965); C.A. 64, 1103Og (1966). (45:) Danel'yants, 1.. A. and Nushins'ka, b. Kh., Farmatsevt. Zh. (Kiev) 19 (j), 34 (1964); C.A. 64,486;'h (1966). (456) Danhier, A,, J. I'harm. Belg. 19 (9-10), 385 (1964); C.A. 62, 14424b (1965). (457) Dariilova, E. X. and Shemyakin, F. AI., ilptechn. Delo 13 (5), 38 (1964); C . A . 6 2 , 2 6 6 9 ~(1965). (458) l h i d o v a , V. N:, Ukr. Khim. Zh. 30 (6), 651 (1964); C.A. 61, 9360b (1964). (459) Danilovic, 31. and Naumovic-Stevanovic, O., J. Chromutog. 19 (3), 613 ( 1965). (460) Danilovic, AI. and Nikolic, K., Acta Pharm. Jugoslao. 15 (3), 107 (1965))C.A. 64,14024h (1966). (461) llanos, B., Acta Pharm. Hung. 34, 221 (1964), Anal. Abstr. 13,347 (1966). I

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(462) Daoust, R. A., J . Pharm. Sci. 52 (7), 642 (1963). (463) Darlington, D., Knights, B. A. and Thomas, G. H., J . Gas Chromatog. 1, 21-23 (1963). (464) Das, S. and Dutta, B. N., J . Proc. Inst. Chemists (India) 36 (3), 152 (1964); C . A . 61,9352h (1964). (465) Das Gupta, V.,Texas J . Pharm. 5 (4), 137 (1964). (466) Datta, D. D. and Ghosh, D., Indian J. Pharm. 26 ( l l ) , 292 (1964); C.A. 62, 116279 (1965). (467) Datta, D. D. and Ghosh, D., Ibid., 27 (9), 265 (1965); C.A. 63, 16129f (1965). (468) David, S. and Hirshfield, H., Bull. SOC.Chim. France 1963 ( 5 ) , 1011; Anal. Abstr. 11, 2830 (1964). (469) Davidova, A., and Quercia, V., Rend. Ist. Super. Sanita. 26, 881 (1963); C.A. 61, 1713h (1964). (470) Davies, D. and Nicholls, P. J., J. Chromatog. 17, 416 (1965). (471) Deavin, J. C. and Mitchell, D. H., J. Pharm. Pharmacol., Suppl. 17, 56s (1965). (472) Dechene, E. B., J . Pharm. Pharnaacol 16, 158 (1964). (473) Deckers, W. and Mueller, A., J . Chromatog. 17 ( 3 ) ,618 (1965). (474) Dedneva, A4. L., Aptechn. Delo 9 (3), 39 (1960); C.A. 60,15680~(1964). (475) Dega-Szafran, Z., and Mitura, W Bull. $cad. Polon. Sci., Ser. Sci. Ch&n. 13 (9), 591 (1965); C.A. 64, 8000e (1966). (476) De Guiseppe, L. and Rindi, G., Int. Z. Vitaminforsh. 34, 21 (1964); Anal. Abstr. 12, 2457 (1965). (477) DeGroot, L. J., Pretell, F., Garcia, 34. E., A7ew Eng. J. Med. 274, 133 (1966). (478) DeJongh, D. C., Shrader, S. R. and Cava, hl. P., J . Am. Chem. Soc. 88 ( 5 ) , 1052 (1966). (479) De Leo, A. B. and Stern, hl. J., J. Pharm. Sci. 53 (8),993 (1964). (480) DeLeo, A. B. and Stern, M. J., Ihid.. 55 - - ( 2 ) . 173 (1966). (481) Delonca, H., Puech, A., and Tirat, P., Trav. Soc. Pharm. Montpellier 23 (3),271 (1963); C.A. 6 2 , 8 9 3 9 ~(1965). (482) Deltombe, J. and Dutrieux, F., J. Pharm. Belo. 17 (9-10). 331 11962): C.A. 61, 6861f(1964). (483) Deltombe, J., Leboutte, G. and Rosier, N., Ibid., 17 (7-8), 236 (1962); C . A . 61, 5453d (1964). (484) Deltombe, J. and Stainier, R., Ibzd., 17 (7-8), 239 (1962); C . A . 61, 5461a (1964). (485) Demetrescu, E., Grintescu, P., Florea, V., and Ivan, C., Rev. Chzm. (Bucharest) 15 (2), 113 (1964); C.A. 61, 1712h (1964). (486) Demina, L. G., Labenskii, A. S., and Romanchuk, >I. A., Teorzya a Prakt. Ionnogo Obmena, Akad. Nauk Kaz. SSR, Tr. Resp. Soveshch. 1962, 182 (Pub. 1963); C.A. 61, 13125f I

119641 \----,.

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(487) Denisov, M. D., Farmatsevt. Zh. (Kiev) 19 ( 3 ) ,60 (1964); C.A. 64, 3286a (1966). (488) Denoel, A., J. Pharm. Belg. 19 (11-12), 505 (1964); C.A. 62, 15992e (196.5). (489) Denoel, A. and van Cotthem, B., Ibid., 18 (7-8), 346 (1963); C.A. 62, l512h (1965). (490) Denoel, A., Nihoul-Ghenne, L. and van Cotthem, B., Ibid., 17 (11-12), 343 (1962); C.A.61,6864f(1964). (491) Deppeler, H. and Becker, A., 2. Anal. Chem. 199 (6), 414 (1963); Anal. Abstr. 1 2 , 744 (1965). (492) Deptula, S. and Robel, A., Acta Polon. Phurm. 21 ( l ) , 71 (1964); C.A. 62, 7588h (1965).

(493) Derlikowski, J., Narbutt-hlering, A. B., Perkowski, E., Weglowska, W. and Potajalo-Gulinska, J., Acta Pobn. Pharm. 21 (l),9 (1964); C . A . 62, 8935a (1965). (494) Derlikowski, J. and Perkowski, E., Ibid., 21 (6), 537 (1964); C. A. 62, 12984b (1965). (495) Detter, A., Deul. Apotheker-Ztg. 104 (35), 1185 (1964); C.A. 62,399e (1965). (496) Detter, A., Phurm. Ztg. 109 (19), 694 (1964); C.A. 63,9750e (1965). (497) Deutsch, M. J., Duffy, D. and Weeks, C. E., J . Assoc. Ofic. Agr. Chemists 47,762 (1964). (498) Deutsch, M. J., Jones, S. W., Wilkie, J. B., Duffy, D. and Loy, H . W., Ibid., 47,756 (1964). (499) Devyatnin, V. A. and Kuznetsova, L. A., Med. Prom. SSSR 18 (3), 58 (1964); C.A. 61,2908s (1964). (500) Devyatnin, V. A. and Moizhes, M. Y., Ibid., 18 (6), 50 (1964); C.A. 61, 11854f (1964). (501) Devyatnin, V. A. and Solunina, I. A., Molekul. Khromatogr., Akad. Nauk SSSR, Inst. Fiz Khim. 1964, 112; C.A. 62, 7589e (1965). (502) Devyatnin, V. A., et al., TT. Vses. h'auchn. Issled. Vitamin. Inst. 7. 44 (1961); C.A. 60,13098b (1964). (503) Deyl, Z., Rosmus, J. and Pavlicek, X, J . Chromatog. 11,556 (1963). (504) Dew. H. P., Pharm. WeekSlad 99 (28). 737 (1964): C.A. 61. 118490 (1964). (505) Dibbern, H. W. and Scholz, G., Arch. Pharm. 298 ( 3 ) , 175 (1965); C . A . 62, 159939 (1965). (506) DiCarlo, F. J., Hartigan, J. M., Jr., and Phillips, G. E., ANAL.CHEM. 36, 2301 (1964): (507) Dittert, L. W. and Higuchi, T., J . Pharm. Sci. 52,852 (1963). (508) Dmitrieva, V. S. and Semenov, S. ht., Antibiotiki 9 ( l ) , 84 (1964); C.A. 61, 11851c (1964). (509) Dobrowolska, B. and Twardowska, K.. Dissertationes Pharm. 17 (4), . .. 537 (1965); C.A. 64,17358~(1966). (510) Doerge, R. F., Ravin, L. J. and Caldwell, H . C., J . Pharm. Sci. 54 (7), 1038 (1965). (511) Doluisio, J. T. and Swintosky, J. V., Ibid., 53, 597 (1964). (512) Dominguez, 0. V., Seely, J. R. and Gorski. J.. ANAL. CHEM. 35 1243 (1963): ' (513) Doorenbos, H. J., et al. Pharm. Weekblad 98 (23), 1037 (1963); C . A . 61, l l h (1964). (514) Dowd, N. E., Killard, A. M., Pazdera, J. and Ferrari, A., Ann. N . Y . Acad. Sei. 130 (2), 558 (1965). (515) Dragulescu, C. and Florea, I., Acad. R.P.R., Baza Cercet. Stiint. Timisoara, Stud. Cercet. Stiint. Chim. 9, 219 (1962); Anal. Abstr. 11, 3944 (1964). (516) Ibid., p. 247; Anal. Abstr. 11, 3587 (1964). (517) Drebentsova, N. F., Kadyrov, Y. K. and Gengrinovich, A . I., Dokl. Akad. .Vauk Uz. S S R 22 (l),39 (1965); C.A. 63,1661h (1965). (518) Ibid., (6), 38 (1965); C . A . 63,14639h (1965). (519) Drozdov-Tikhomirov, L. N., Optika i Spektroskopiya 17 (5), 683 (1964); C.A. 62,51429 (1965). (520) Dryanovoska-Noninska, L., and Mitsev, V., Farmatsiya (Sofia) 14 ( 5 ) , 22 (1964); C.A. 62,6343h (1965). (521) Dryon, L., J . Pharm. Belg. 19 (1-2), 19 (1964); C.A. 61, 5460h (1964). (522) Duchene, M. and Lapiere, C . L., Ibid., 20 (7-8), 275 (1965); C . A . 64, 7970d (1966). ~

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(523) Uuchleiter, L., Ilver, K. and Madsen, Aa., Dansk Tidsskr. Farm. 38, 127 (1964); C.A. 6 1 , 1 1 8 5 5 ~(1964). (524) Dugan, R. E., Frigerio, N. A. and Siebert, J. M., ANAL. CHEM.36, 114 (1964). (525) Dumazert, C., Ghiglione, C. and Pugnet, T., Ann. Pharm. France 21, 227 (1963); Anal. Abstr. 11, 1069 (1964). (526) Dunagin, P. E., Jr., and Olson, J. A., ANAL.CHEM.36,756 (1964). (527) Dupcza, K., Kelemen-Kuettel, I., Vastagh, G. and Zabrak, E., Pharm. Zentralhalle 103 (4), 237 (1964); C.A. 61, 93549 (1964). (528) Dusinsky, G., Abhandl. Deut. Akad. Wiss. Berlin, Kl. Chem., Geol. Biol. 1964 (l),176; C.A. 62,5141d (1964). (529) Dusinsky, G. and Faith, L., Farm. Obzor 33, 296 (1964); Anal. Abstr. 12, 6068 (1963). (530) Dutkiewicz, Z., Kucharska, 11. and hianikowski, W., Poznan. Towarz, Przviaciol Nauk. Wvdzial Lekar.. Prace KoGisji Farm. 3, 155 (1965); C:A. 63, 8126e (1965). (531) Dutt, M. C. and Chua, T. H., J . Pharm. Pharmacol. 16 (lo), 696 (1964). (532) Dworschak, E., Enelmiszervizsgalati Koezlemenyek 10, 12 (1964); C.A. 63, 17801d (1965). (533) Dykhovichnaya, D. E., Antibiotiki 8 (lo), 939 (1963); C.A. 61, 15930b (1964). (534) Dzhalilov, D. R., Sazonova, R. N. and Goryaev, 11. I., Aptechn. Delo 12 (3), 34 (1963); C.A. 61,9354d (1964). (535) Dzierkacz, At. and Zommer, S., Farm. Polska 19 (23-24) 507 (1963): . C.A. 61,5458h (1964). (536) Dzottsoti, S. Kh., Materialy Ztog. Nauchn. Konf. Farmatsevt. Fak. Azerb. Med. Inst. po Probl. Izyskanie iVovykh Sposobov Zzgotovl. Lekarstv i Metodov ikh Analiza, Baku, Sb. 1963, 18; C.A. 61, 14471b (1964). (537) Eberhardt, H. and Norden, O., Arzneitmittel-Forsch. 14, 1354 (1964); Anal. Abstr. 13,1971 (1966). (538) Eckschlager, K., Cesk. Farm. 12 ( 8 ) , 419 (1963); C.A. 62,159949 (1965). (539) Eckschlager, K., Ibid., 14, 82 (1965); Anal. Abstr. 13,3163 (1966). (540) Eckschlager, K., and Fidlerova, J., Zbid., 13, 371 (1964); Anal. Abstr. 12, 6093 (1965). (541) Eckschlager, K. and Vachek, J., Zbid., 13, 379 (1964); Anal. Abstr. 12, 6080 (1965). (542) Efimova, G. V. and Markovich, A. V., Antibiotiki 9 ( 7 ) , 592 (1964); C.A. 61,8131f(1964). (543) Egerts, V., Latvijas PSR Zinatnu A k a d . Vestis, Kim Ser. 1963 ( 5 ) , 519; C.A. 62,402e (1965). (544) Egerts, V., Hillers, S., Lielgalve, A. and Shimanskaya, M. V., Ibid., 1963 (51. 531: C.A. 6 2 . 4 0 2 ~(1965). (545)' Egerts, V. and Jurka, A., Aptechn. D e b 11 (51, 43 (1962); C.A. 60, 11846~ (1964). (546) Egger, K., Planta Med. 12 (3), 265 (1964); C.A. 62,26709 (1965). (547) Egger, K . and Keil, M., 2. Anal. Chem. 210 (3), 201 (1965); C.A. 63, 1654e (1965). (548) Egger, K . and Kleinig, H., Zbid., 21 1 (3), 187 (1965); C.A. 63,545Oh (1965). (549) Egorov, N. V., Elgazin, S. A. and Shemyakin, F. M., Izv. Vysshikh Uchebn. Zavedenii, Khim. i Khim. Tekhnol. 7 (l), 66 (1964); C.A. 61, 5454d (1964). (550) Egorova, E. I., Farmatsevt. Zh. (Kiev) 19 (2), 76 (1964); C.A. 61, 6861h (1964). I

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(551) Egorova, E. I., Subdeno-Med. Ekspertiza, Min. Zdravookhr. SSSR 8 (2), 24 119651: C.A. 64.11029d (1966). (552) Eichhorn, 8. and Rutenberg, A., Clin. Chem. 11 (5), 563 (1965). (553) Eid, A. I., Amer, M. M., AbuShady, H. and El-Mangoury, H., J . Pharm. Sci. U . Arab Rev. 4. 157 (1963) (Pub. 1965); C.A. 63, l7800d (1965). (554) Eiden, F. and Nagar, B. S., Deut. Apotheker Ztg. 104 (lo), 281 (1964); C.A. 62, 402b (1965). (555) Eidus, L. and Hamilton, E . J., Clin. Chem. 10 (7), 581 (1964). (556) Eisenbrand, J., Deut. ApothekerZlg. 103 623 (1963); Anal. Abstr. 11, 2796 (1964). (557) Eisenbrand, J., Pharm. Acta Helv. 39 (4/5), 232 (1964); C.A. 61, 4154b (1964). (558) Eisenbrand, J., 2. Naturwiss.-Med. Grundlagenforsch. 2 (a), 132 (1964); C.A. 62, l5407e (1965). (559) Eisenbrandt, K., Pharmazie 19 (6), 406 (1964); C.A. 61,5455f(1964). (560) Elbanowska, A., Bad. Inst. Roslin Leczniczych 9 (3), 102 (1963); C.A. 61, 1711e (1964). (561) El Gendi, S., Kisser, W. and Machata, G., Mikrochim. Ichnoanalt. Acta 1965, 120; Anal. Abstr. 13, 2633 (1966). (562) El'kin, G. E., Samsonov, G. V., and Klikh, S. F., Ionoobmen, Tekhnol., Akad Nauk SSSR, Inst. Fiz. Khim. 1965, 146; C.A. 63,67845(1965). (563) Ellert, H., Ceglarski, R. and Regosz, A., Chem. Anal. (Warsaw) 10 (6), 1217 (1965); C.A. 64, 14031a (1966). (564) Ellert, H. and Pawelczak, I., Gdanskie Towarzyst. Nauk., Wydzial Nauk Mat. Przyrodniczych, Rozprawy Wydzialu ZZZ No. 1, 323 (1964); C.A. 64, 14032d (1966). (565) Emmerson, J. L., and Anderson, R. C., J . Chromatog. 17 (3), 495 (1965). (566) Endraszka, J., and Szyrmulewicz, R., Dissertationes Pharm. 15 (3), 275 (1963); C.A. 61, 2911b (1964). (567) Enriquez, 0. ,and Kuback, V., Rev. Fac. Farm. Unav. Central Venezuela 3 ( 8 ) , 249 (1962); C . A . 61, 10535f (1964). (568) Ercoli, A,, Vitali, R. and Gardi, R., Steroids 3 (4), 479 (1964). (569) Eremeeva. V. S.,Poroikova. L. N.. Petrova, R. I., Morunova, 2. S., and Sivitskava. 0. K.. Amtechn. D e b 9 (3). ,, 60 (1966); C.A. 60; 15'SSOg (1964). (570) Eremina, Z. I. and Gurevich, V. G., Zh. Analit. Khim. 19 (4), 519 (1964); C.A. 61, 3698a (1964). ' (571) Eriksen, S. P. and Stelmach, H., J . Pharm. Sci. 54 (7). 1029 (1965). (572) Eriksson, S. ' O., Acta Pharm. Suecica 2 (4), 305 (1965); C.A. 64, 545a 1966). (573) Eriksson, S. 0. and Holmgren, A., Ibid., 2 (4), 293 (1965); C.A. 64, 5449 (1966). (574) Ermakov, V. I., Latyshev, E . V. and Antraptsev, F. I., Zavodsk. Lab. 31 ( 7 ) ,889 (1965); C.A. 63,8126d (1965). (575) Esche, J. and Wojahn, H., Deut. Apotheker Ztg. 105 (12), 379 (1965); C.A. 63, 1661b (1965). (576) Everhard. M. E.. Dickcii.IS, D. A. and Goodhart. F. W..'J. Pharm. Sei. 53 (2), 173 (1964). (577) Evrard, E., Claesen, M. and Vaderhaeghe, H., Nature 201 (4924), 1124 (1964). (578) Fagard, J., J . Pharm. Belg. 16 (3-4), 128 (1961); C . A . 61, 6870e (1964). (579) Fagerstrom, R., J . Pharm. Pharmacol. 15, 479 (1963). I

(580) Fairbairn. J. W..Planta .Wed. 12 __ (3), 260 (1964);C.A. 62,2665b (1965). (581) Fairbairn, J. W. and Simic, S., J . Pharm. Pharmaeol. 16 ( 7 ) , ' 450 (1964). (582) Faith, L., Farm. Obzor 32, 53 (1963); C.A. 64,15676d (1966). (583) Fang, C., Yao Hsueh Hsueh Pao 10 (12), 712 (1963); C.A. 60, 11845f (1964). (584) Farkas, E. and Bridicska, bl., Gyogyszereszet 8 (4), 137 (1964); C.A. 61, 415Od (1964). (585) Farkas, S., Magy. Kem. Folyoirat 70 (4), 150 (1964); C.A. 61, 1715d (1964). (586) Farmilo, C. G. and Jervis, H. E., Proc. Can. SOC.Forensic Sei 4, 197 (1965); C.A. 63, Yi42e (1965). (587) Faucennet, L. and Waldesbuehl. M., Pharm. Acta Helv. 38 (7/8), 423 (1963); C.A. 60,11848a (1964). (588) Faure, F. and Blanquet, P., Clin. Chim. Acta 9 (3), 292 (1964). (589) Fecko, J., dcta Polon. Pharm. 20 (3), 225 (1963); C.A. 62,1518b (1965). (590) Fecko, J., Ibid., 21 (21, 155 (1964); C.A. 62. 8942d (19653. (591) Federal Register 29,4119-33 (hiarch 28, 1964). (592) Ibid., 7625-57 (June 13, 1964). (593) Ibid., 11670-82, 11683-5 (Aug. 14, ~

1964).

(594) Zbid., 16911-14 (Dec. 10,1964). (595) Feher, T., ;\'aturwissenschaften 52 ( 7 ) , 160 (1965); C.A. 63,432f (1965). (596) Feigl, F. and Ben-Dor, L., Talanta 10. 1111 (1963). (597j Feigl,'F., Ben-Dor, L., and Jungreis, E., Chemist-Analyst 52, 113 (1963). - -J, F., Jungreis, E. and Ben(598) v& Dor, L., Israel J. Chem. 1 (4). 351 (1963); Anal. Abstr. 12, 1192 (196Sj. (599) Feigl, F., Jungreis, E. and Lipetz, V..Chemi~t-~4nalwst 53. 9 (19641. (600) Feigl, F. andl'kari;, S.:-A&. Chim. Acta 29 (6), 580 (1963). (601) Felmeister, A. and Discher, C. A., J . Pharm. Scz. 53 ( 7 ) , 756 (1964). (602) Felmeister, A., Schaubman, R. and Howe, H., Ibid., 54 ( I l ) , 1589 (1965). (603) Feltkamp, H., Deut. ApothekerZtg. 104 (4), 99 (1964); C.A. 60, 118479 (1964) --- - -,. (604) Ferguson, D. R., J . Endocrinol. 32, 119 (1965). (605) Few, J. D., Analust 90 (1068). 134 (1965). (606) Fey, L., Schwartz, I. and Beceanu, A., Rev. Chim. (Bucharest) 16 (9), 447 (1965); C.A. 64,11030~(1966). (607) Fiebig, A., Janicki, S. and Wasiak, H., Dissertations Pharm. 17, 81 (1965); Anal. Abstr. 13, 3157 (1966). (608) Fiebig, A., Janicki, S., and Wasiak, H., Farm. Polska 19 (23), 491 (1963); C.A. 61. 686% 11964). (609) Fike, Weu W. and Sunshine, I., ANAL.CHEM.37, 127 (1965). (610) Finholt. P.. Himchi.' T.. J . Pharm. Sii. 51, 656 (1962)(611) Finholt, P., Jurgensen, G. and Kristiansen, H., Ibid., 54 (3) 387 (1965). (612) Finnegan, R. A., Ibid., 54, 928 ( 1965). (613) Fischer, R., Fischer, G. and Kren, G., Pharm. Zentralhalle 105 (2), 73 (1966); C.A. 64,14025b (1966). (614) Fisher, W. T., Edwards, N. &I.and Lehman, R. W., J . Pharm. Sci. 53 (3), 294 (1964). (615) Fishman, W. H., Harris, F. and Green, S., Steroids 5 (3), 375 (1965). (616) Floderer, I. and Horvathy, V., Acta Pharm. Hung. 35 (3), 98 (1965); C.A. 63, 16160e (1965). (617) Florea, T., Aiteanu, E., RIedianu, M. and Bucur, I., Rev. Chim. (Bucharest) ~

15 (9), 575 (1965); C.A. 63, 16127g (19651. (6f8)ibid., 16 (6), 347 (1965); C.A. 63, 12972d (1965). (619) Florea, V., G:-intescu, P. and Medianu. M.. Ibid., 15 (6), . 359 (1964): . C.A. 61,’9359f (1964). (620) Florea, V. and Moldovan, A., Farmacza (Bucharest) 8 ( l l ) , 691 (1965); C.A. 64, 7967h (1966). (621) Florey, K., Personal Communication, June 8,1965, Stluibb Institute for Medical Research, New Brunswick, N.J. (622) Floris, G., Acta Pharm. Hung. 36 ( 1 ) . 10 (1966): C.A. 64.14030a 119661. (623j’ Fldris, G., Gyog2/szereszet 9 (ll), 430 (1965); C.A. 64, E512h (1966). (624) Flueck, H., Pharm. Weekblad 100 (47). 1361 (1965); C.A. 64, 95076 ( 1966). (625) Fo g A. G. and Reynolds, G. F., Anal.m .ih!( Acta 32 (6), 582 (1965). (626) Fogg, A. G. and Wood, R., J . Chromatog. 20 (3), 612 (1965). (627) Fondarai, J., Grand, J. L., and Dubouloz,, P.,, Anal. Chim. Acta 31, 97 (1964). (628) Fontan, C. R., Jain, N. C. andKirk, P. L., Mikrochim. Icimoanal. Acta 1964 ( 2 4 ) , 326; C.A. 61,3700g (1964). (629) Fontan, C. R., Smith, W. C. and Kirk, P. L., ANAL. CHEM. 35, 591 (1963). (630) Fontan, P. a n 1 Corradini, C., Ann, Fac. Agrar., Univ. Cattolica Sacro Cuore 1 (l), 5:3 (1961); C.A. 61, 8124d (1964). - -, (631) Foppiano, R. and Brown, B. B., J . Pharm. Scz. 54,20€1(1965). (632) Ibid., pp. 12-14. (633) Forist, A. A., Exown, L. W. and Rover. 11.E., Ibid., 5.1 (31,476 (1965). (634)*Fdrist, A. A. and Judy, R. W., Ibid., 53 (lo), 1244 (1964). (635) Formanek, I., Fulop, L. and Szantho, C., Rev. Med. (Targu-Mures) 10 (3), 312 (1964); (?.A. 62, 144239. (1965). (636) Franchi, G. and Gorgeri, L., Boll. Chim. Farm. 102, ti93 (1963); Anal. Abstr. 11, 3942 (1964). (637) Frauendorf, H. and Vogel, H., 2. Anal. Chem. 205 (l), 460 (1964); C.A. 62, 1059b (1965). (638) Frei, R.W. and Frodyma, 1%. M., Anal. Bzochem. 9, 310 (1964). (639) French. W. N..’ J. Pharm. Sci. 53 ‘ (7 j, 842 (1664). (640) French, W. N., Ibid., 54 (12), 1726 (1965). (641) French, W. N. and Morrison, J. C., Ibid., 54 (8), 1133 (1E65). (642) Ibid., (2), 306 (1965). (643) French, W. N. and Wehrli, A., Can. Pharm. J . 98 (5), 174 (1965); C.A. 63, 5451e (1965). (644) French, W. N. and Wehrli, A., J . Pharm. Sci. 54 (lo), 1515 (1965). (645) Frerejacque, X. :tnd Graeve, P. de; Ann. Pharm. Franc 21, 509 (1963); Anal. Abstr. 11, 3325 (1964). (646) Fresen, J. A., Pharm. Weekblad 99 (31-32), 829 (1964); C.A. 61, 11850b (1964). (647) Ibid., (49), 1373 (1964); C.A. 62, 7590h (1965). (648) Fresen, J. A., Ibid., 100 (16), 532 (1965); C.A. 63, 6783f (1965). (649) Freundt, K. J. and Schwinger, G., Arch. Toxikol. 20 (4) 257 (1964); C.A. 62, 5141b (1965). (650) Friedenberg, R., Univ. hiicrofilms (Ann Arbor, Mich.), Order No. 64-3531, 343 p p ; Dissertatzon Abstr. 25 (4), 2246 (1946). (651) Friedenberg, R. 2nd Jannke, P. J., J . Pharm. Sci. 54 (4), (657 (1965). (652) Frischauf, H., Wien. 2. Inn. Med. Grenzg. 45 (4), 121 (1964); C.A. 61, 6860f (1964). . I

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(6.53) Frodyma, SI. >I., Lieu, V. T. and Frei, R. W., J . Chromatog. 18 (3), 520 (1965). (654) Frost, E. and Seidlein, H. J., Pharm. Praxis, Beilage Pharmazie 1964 (2), 28; C.A. 61,535d (1964). (655) Fuerst, W., Arch. Pharm. 298 ( l l ) , 795 (1965); C.A. 64,4865f(1966). (656) Fuerst, W., Pharm. Zentrahalle 102, 496 (1963); Anal. Abstr. 11, 4517 (1964). (657) Fuerst, W., Ibid., 103 (5), 341 (1964); C.A. 61, 10536c (1964). (658) Ibid., ( i ) ,475 (1964); C.A. 61, 1 4 4 6 9 ~(1964). (659) Fujii, &I. and Takahashi, S., Yakugaku Kenkyu 35 (2), 39 (1963); C.A. 64, 95088 (1966). (660) Ibid., pp. 45 (1963); C.A. 64, 950% (1966). (661) Fukueawa, H. and Shiizu, K., Yakuzaigaku 23, 294 (1963); C.A. 61 17169 (1964). (662) Fulop, L., et al., Rev. Med. (TarguMures) 11 (3-4), 425 (1965); C.A. 64, 17360b (1966). (663) Fumagalli, U., Ambrogi, V. and Balestra, G., Boll. Chim. Farm. 103 (12), 911 (1964); C.A. 62, 89369 (1965). (664) Furtig, W. and Pohloudek-Fabini, R., Pharmazie, 19, (3), 209 (1964); Anal. Abstr. 12, 3495 (1965). (665) Fuwa, T., Kido, T. and Tanaka, H., Iakuzaigaku 24, 123 (1964): C.A. 61. 15924f (19641. -----, (666) Gabor, M., Matkovics, B. and Gondos, G., Pharmazie 19 (12), 785 (1964); C.A. 6 2 , 7 5 9 0 ~(1965). (667) Gadret. M. and Bregere, C., Bull. SOC. P h a r k Bordeauz -103’ (3), 153 (1964); C.A. 62,12981d (1965). (668) Gadsden, R. H. and McCord, W. M., J . Gas Chromatog. 2 (l), 7 (1964). (669) Gaenshirt, H. C. and Polderman, J., Ibid., 16 (3), 510 (1964). (670) Gaind, K. X., Dar, R. N. and Bapna, S. C., Indian. J . Pharm. 26 (9), 248 (1964); C.A. 6 2 , 6 3 4 4 ~(1965). (671) Gaind, K . N., Dar, R. N. and Kaul, R. N., Ibid., 25, ( i ) ,225 (1963); Anal. Abstr. 11, 3328 (1964). (672) Gajdos, ?VI.,Ceskosl. Farm. 14, 70 (19651: Anal. Abstr. 13. 3173 (1966). (673) Gallelli, J. F. and Kostenbauder, H. B., J . Pharm. Sci. 52,649 (1963). (674) Gallo, G. G., Pasqualucci, C. R. and Radaelli, P., Farmaco (Pavia) Ed. Prat. 14, 146 (1959); Anal. Abstr. 11, 3929 (1964). (675) Gana, R. I. M., Anales Fac. Quim. Farm. Univ. Chile 15, 112 (1963); C.A. 62,14426s (1965). (676) Gantes, P., Barat, J. and Garinot, J. C., ilnn. Pharm. Franc. 23,41 (1965); Anal. Abstr. 13, 2639 (1966). (677) Gantes, P., Garinot, J. C., Barat, J. and Juhasz, J. P., Ibid., 23 (Z), 137 (1965); C.A. 62, 15992a (1965). (678) Garcia, R:E. G., Rev. Fac. Farm. Univ. Central Venezuela 3 (8), 224 (1962): C.A. 61,13130h (1964). (679) Garrett, E.. R., Sajybi 4 (13), 3 (1964); C.A. 62, 8944e (1965). (680) Garrett, E. R., Chemburkar, P. B. and Suzuki, T., Chem. Pharm. Bull. Tokyo 13, 1113 (1965); C.A. 64, 530e (1966 1. (681) Garrett, E. R. and Notari, R. E., J . Org. Chem. 31 (2), 425 (1966). (682) Garrett, E. R. and Notari, R. E., J . Pharm. Sci. 54 (2), 209 (1965). (683) Ibid., (4), 561 (1965). (684) Garrett, E. R. and Schroeder, W., Ibid., 53 (8), 917 (1964). (685) Gasco, M. R. and Gatti, G., Boll. Chim. Farm. 104 (lo), 639 (1965); C.A. 64, 4865d (1966). I

\-

I

(686) Gasparic, J., Cesk. Farm. 9, 514 (1960); C.A. 61,4154e (1964). (687) Gaudiano, A. and Sciarrone, M. P., Bull. SOC.Ital. Biol. Sper. 39, 1874 (1963); Anal. Abstr. 12, 1446 (1965). (688) Gavrila, E. and Braun, M., Farmacia (Bucharest) 14 (Z), 111 (1966); C.A. 64, 15676g (1966). (689) Gawrych, Z. and Pomazanska, T., Acta. Polon. Pharm. 22 (6), 497 (1965); C.A. 64, 17355~(1966). (690) Gawrych, Z. and Wilczynska, I., Ibid., 22 (l), 1 (1965); C . A . 65, 81269 (1965). (691) Gecgil, S., Eczacilik Bulteni 7 (8-lo), 100 (1965); C.A. 64, 1403% (1966). (692) Geczy, G., Elelmiszervizsgalati Kozlem. 10 ( 3 4 ) , 100 (1964); C.A. 64, 3285e (1966). (693) Genest, K. and Farmilo, C. G., J . Pharm. Pharmacol. 16 (4), 250 (1964). (694) Genest, K. and Farmilo, C. G., Proc. Can. SOC.Forensic Sci. 2 (Z), 421 (1964); C.A. 61,6862b (1964). (695) Genest, K. and Farmilo, C. G., Ibid., 3,85 (1963) (Pub. 1964); C . A . 61, 14468a (1964). (696) Gengrinovich, A. I., hluratova, F. S. and Mel’Kumova, Z. V.,Med. Prom. SSSR 19 (l),41 (1965); C.A. 62, 11631h (1965). (697) Genkina, G. L., Sharipov, A. Kh., and Abubakirov, N. K., Ibid., 18 (9), 40 (1964); C.A. 62, 5142b (1965). (698) Georgacopoulos, P. P., Pharm. Deltion Epistemonike Ekdosis 1 (Z), 96 (1961); C.A. 60, 15679c (1964). (699) Georgievs’kii, V. P. and Dzyuba, N. P., Farmatsevt. Zh. (Kiev) 20 (6), 19 (1965); C.A. 64, 14027h (1966). (700) Georgievs’kii, V. P., Dzyuba, N. P. and Izmailov, N. A., Ibid., 18 (4), 27 (1963); C.A. 61, 4156d (1964). (701) Gerali, G., Lugaro, G. and Ferrari, L., Farmaco, (Pavia), Ed. Sci. 20 (Z), 148 (1965); C.A. 63, 1825s(1965). (702) Gerdes, H. and Staib, W., Steroids 6 (6), 793 (1965). (703) Gerecke, K., Arzneimitlelstandardisier., Inform.-Dienst 3 (Z), 83 (1962); C.A. 61, 6860e (1964). (704) Ibid., (4), 225 (1962); C.A. 62, 1514h (1965). (705) Gerlach, H., Pharm. Zentralhalle 102 (ll), 708 (1963); C.A. 60, 11850a (1964). (706) Gerlach, H., Grundmann, W. and Giessner, R., Pharmazie 20 ( i ) , 450 (1965); C.A., 63, 9743h (1965). (707) Gerlach, H. and Senf, H. J., Pharm. Zentralhalle 105 (2), 93 (1966); C.A. 64, 14029f (1966). (708) Ghiglione, C., Lebourhis-Sauer, J. and Fondarai, J., Bull. SOC.Pharm. Marseille 14 (55), 183 (1965); C.A. 64, 14968c (1966). (709) Ghitulescu, F. and Dragusin, I., Rev. Chim. (Bucharest) 15, 163 (1964); Anal. Abstr. 12, 3500 (1965). (710) Ghosh, D. and Roy, S. C., Ann. Rev. Biochem Allied Res. India 33, 23 (1962); C.A. 60,15679e (1964). (711) Giacobbo, H. and Simon, W., Phurm. Acta Helv. 39, 162 (1964); C.A. 61, 1710c (1964). (712) Giebelmann, R., Pharmazie 19 ( l l ) , 703 (1964); C.A. 62, 10295g (1965). (713) Giebelmann, R. and Gibb, B., Arch. Tozikol. 20, 253 (1964); Anal. Abstr. 12, 5979 (1965). (714) Gil-Av, E., Charles, R. and Fischer, G., J . Chromalog. 17,408 (1965). (715) Gioia, G. and Festa, A., Farmaco, (Pavia), Ed. Prat. 20 (l), 3 (1965); C.A. 62, 89399 (1965). (716) Girard, M. L., Prod. Probl. Pharm. 19,47 (1964); C.A. 60,14334b (1964). VOL. 39, NO. 5 , APRIL 1967

219 R

(717) Gittner-Mindermann, A., Leupin, K. and Baumgartner, R., Pharm. Acta Helv. 39, 390 (1964); C.A. 61, 4154d (1964). (718) Glasner, A. and Avinur, P., Tahnta 11, 761 (1964). (719) Gloesener, E., J . Pharm. Belg. 16 (6), 379 (1961); C.A. 61,17138 (1964). (720) Godyatskii, 5’. E. and Bernshtein, V. N., Aptechn. Deb 13 (l),39 (1964); C.A. 61, 9354h (1964). (721) Goettsch, R. W., J . Pharm. Sci. 54 (2), 317 (1965). (722) Goldel, L., Zimmermann, W. and Lommer, D., 2. Physiol. Chem. 333, 35 (1963); Anal. Abslr. 11,5072 (1964). (723) Golebiowka, A., Zeszyty Nauk. Uniw. Jagiel., Prace Chem. N o . 8 , 17 (1963); C.A. 62, 6342a (1965). (724) Golkov, J’. A. and Kas’yanenko, Aptechn. Delo 13 (5), 67 (1964); C.A. 62, l519a (1965). (725) Golovina, A. P., Alimarin, I. P. Kuznetsov, D. I., and Filyugina, A. D., Zh. Analit. Khim. 21 (2), 163 (1966); C.A. 64, 16596d (1966). (726) Golovkin, V. O., Farmatsevt. Zh. (Kjeu) 20 (5), 47 (1965); C.A. 64, 79,le (1966). (727) Zbid., (6), 34 (1965); C.A. 64, 140309 (1966). (728) Gondos, I. G., Matkovics, B. and Kovacs, O., Nicrochem. J . 8 (4), 415 (1964). (729) Gonnard, P., Camier, M. and Boigne, N., Bull. SOC.Chim. Biol. 46 (2/3), 407 (1964); C.A. 61, 6867d (1964). (730) Gopal, N. G. S., Intern. J . Appl. Radiation Zsotopes 17 (l), 75 (1966); C . A . 64, 1 7 3 5 9 ~(1966). (731) Gorczyca, M. and Zejc, A., Disserlationes Pharm. 15 (3), 349 (1963); C. A . 61,29079 (1964). (732) Gorog, S., Acta Chim. Acad. Sci. Hung. 47 ( l ) , 1 (1966); C.A. 64, 1 1 0 3 0 ~(1966). (733) Gorog, S., Acta Chim. Acad. Sci. Hung. 47 ( l ) , 7 (1966); C.A. 64, 11030a (1968). (734) Gorog, S., Magy. Kem. Folyoirat 70 (4), 161 (1964); C.A. 61, 17119 ( 1964). (735) Gorog, S. and Folodes, 5’., Zbid., 72 ( l ) ,1 (1966); C.A. 64, 11030b (1966). (736) Goryacheva, K.A. and Korchagina, V. A., Aptechn, Delo 9 (3), 33 (1960); C.A. 60, 11849e (1964). (737) Goto, M. and Toei, K., Talanta 12, 124 (1965). (738) Gough, G. R. and Silberman, H., Australasian J. Pharm. 44 (522), S69 (1963); C.A. 61, 536d (1964). (739) Gower, D. B., J . Chromalog 14 (3), 424 (1964). (740) Grab, K., Deut. Apolheker-Ztg. 103, 1424 (1963); Anal. Abstr. 12, 329 (1965). (741) Grabowicz, W., Chem Anal. (Warsaw 9 (4), 697 (1964); C.A. 62, 1517d (1965). (742) Grabowicz, W. and Kania, K., Ibid., 9 (4), 661 (1964); C.A. 62, 38879 (1965). (743) Grabowska, I., Gdanskie Towarzyst. Nauk., Wydzial Nauk Mat. Przyrodniczych, Rozprawy Wydzialu I11 (1) 193 (1964); C.A. 64, 14029b (1966). (744) Zbid., pp. 207-21 (1964); C.A. 64, 1567% (1966). (745) Zbid., pp: 223-33 (1964); C.A. 64, 1736% (1966). (746) Graefe, G., Deut. Apotheker-Ztg. 104 (40), 1412 (1964); C.A. 62, 3887h (1965). (747) Ibid., (50), 1763 (1964); C.A. 62, 10296e (1965). (748) Graf. E., Pharmazie 20 ( 5 ) , 331 (1965); C.A. 63, 6788a (1965).

220 R


(749) Graichen, C. and Molitor, J. C., J . Assoc. Ofic. Agr. Chemists 46, 1022 (1963). (750) Gramberg, K . and Blagojevic, Z., Acta Pharm. Jugoshv. 14, 17 (1964); C. A . 63,9748b (1965). (751) Grandolini, G., et al. Thin-Layer Chromatog., Proc. Symp., Rome 1963, 155 (Pub. 1964); C . A . 62,63409 (1965). (752) Graner, R. F. and Garcia-Marquina, J. M.,Circ. Farm. 22 (203), 75 (1964); C.A. 62,1514h (1965). (753) Grau, W. and Endres, H., J. Chromatog. 17 (3), 585 (1965); C.A. 62, 15993d (1965). (754) Grecu, I., and Curea, E., Rev. Chim. (Bucharest)16 181. . 389 (1965): . . , C.4. 64. i1031a (1966). (7.55) Grecu. I. I . and Curea, Curea. E., E.. Stud. (755) Grecu, ’ Circet. Cercet. Chi;., Chim., C h j , 13, ‘29 29 ’(1962); (1962); Anal. Abstr. 11, 2505 (1964). (766) Grecu, I., Curea, E., and Pitis, M., Acad. Rep. Populare nomine, Filiala Cluj Studii Cercetari Chem. 13, (2) 219 (1962); C.A. 61, 100279 (1965). (757) lbid., p. 225 (1962); C.A. 61,100279 I I , ,

I1 96.5). \ - - - - I -

(758) Greeley, V. J., Holl, W. W., Illichaels, T. P. and Sinotte, L. P., Ann. N . Y . Acad. Sci. 130 (2). 657 (1965). (759) Ibid., pp. 545-9 (1965). (760) Green, A. R., Australasian J . Pharm. 45, S88 (1964); C.A. 62, 8932e (1965). (761) Grier, N., J . Pharm Sci. 53, 1208 ( 1964). (762) Grimmett, M.R . and Richards, E. L., J . Chromatog. 18 (3), 605 (1965). (763) Grintescu, P., Calafeteanu, I. and Dumitrescu, E., Pharm. Zentralhalle 105 (3), 141 (1966); C.A. 64, 17356f (1966). (764) Grintescu, P., Calafeteanu, I. and Ivan, C., Rev. Chim, Bucharest 15, 424 (1964); Anal. Abstr. 12, 6114 (1965). (765) Grlic, L, Bull. Narcotics, U.hT.Dept. Soczal Aflairs 16, 29 (1964); Anal. Abstr. 13,919 (1966). (766) Grlic, L. and Tomic, N., Ezperientia 19, 267 (1963); Anal. Abstr. 11, 2785 (1964). (767) Grochmalicka, J., Poznan. Towarz. Przyjaciol Nauk Wydzial Lekar. Prace Komisji Farm. 1 (4), 45 (1963); C.A. 61,1712e (1964). (768) Grochmalicka, J., Zeszyty Probl. Postepow Nauk Rolniczych 53, 57 (1965); C . A . 64,58135(1966). (769) Groebel, W., Z. Lebensm.-Untersuch.Forsch. 129 (3), 153 (1966); C.A. 64, 173599 (1966). (770) Groeger, D. and Erge, D., Pharmazie 29 (2), 92 (1965); C.A. 62, 129819 (1965). (771) Groeger, D. and Stolle, K., Arch. Pharm. 298 (4), 246 (1965); C.A. 63, 1655h (1965). (772) Grundenmeier, E. W. and Andrews, A. C., Trans. Kansas Acad. Sci. 68 (l), 62 (1965); C.A. 63, 6790a (1965). (773) Grunewald, R., Ziemer, P. L. and Christian, J. E., ANAL. CHEM. 36, 1138 (1964). (774) Grzybowska, J., Acta Polon, Pharm. 22 (2), 185 (1965); C.A. 63 12975f (1968). (775) Gstirner, F. and Baveja, S. K., Mitt. Deut. Pharm. Ges. 35 (2), 29 [Pub. in Arch. Pharm. 298 (2), (1965)l; C.A. 63, 4349 (1965). (776) Guadagnini, G. and Sekules, G., Boll. Chim. Farm. 103 (6), 438 (1964); C. A . 62,401e (1965). (777) Gudzinowicz, B. J., J . Gas Chromatog. 4 (3), 110 (1966). (778) Gudzinowicz, B. J., Martin, H . F. and Driscoll, J. L., Ibzd., 2 (8), 265 (1964).

(779) - - Guilbault, ---. G. G., ANAL.CHEM.35, 8% (l%a). (780) Guilimova, T. E., Aptechn, Delo 14 (3), 31 (1965); C.A. 63, 6790b (1965). (781) Gulubova, T. and Iliev, M., Farmatsiya (Sofia) 15 (2), 116; C.A. 63, I

11 _ 256n - _ _ _ (1 96.5).

( 7 8p ) Gupta, R. C. and Koford, J., ivature 198 - -384 , (1963). (783) Gurevi ch, V. G. and Gol’tman, A. D.. Zh. Analit. Khim. 20 (12). \ - - - - /

(784) Gkiseva,’ A. R.,’ Paseshnichenko, V. A., Borikhina, AI. G., and hloiseev, R. K., Biokhimiya 30 (2), 260 (1965); C.A. 63, 1656c (1965). (785) Guheva, L. X., Aptechn. Delo 12 (4), 62 (1963); C . B . 61, ll850e (1964). (786) Gutowska, A., Chem. Anal. (Warsaw) 9 (3), 597 (1964); C.A. 61, 15357c (1964). (787) Guven, K. C., Eczacilik Bulteni 6 (11-12), 117 (1964); C . A . 62, 12981h ,( 1 a -w ., ,.\ (788) Guven, K . C., Altinkurt, T., Zbid., 7 (11-12), 119 (1965); C.A. 64, 14033h (1966). (789) Gvoidyak, P. I . and Kolesnikov, D. G., Farmatsevt, Zh. (Kiev) 18 (4), 70 (1963); C.A. 61, 2904s (1964). (790) Gyarmati, Laszlo, .David, G., Acta Pharm. Hung. 34 (6), 273 (1964); C.A. 62. 116266 11965). (791) Gye‘nes, I. and Laszlo, .4.,Talanta 10.567 (1963). (792) Hadjiioannou, T. P. and Hadjiioannou, S. I., Pharm. Deltion, Epistemonike Ekdosis 4 (2), 58 (1964): C . A . 62,129769 (1965); (793) Haedicke, AI. and hleyer, H., Pharm. Praxis, Beil. Pharmazie 1964, 263; C.A. 62,6345g (1965). (794) Haefelfinger, P., Schmidli, B. and Ritter, H., Arch. Pharm. 297 ( l l ) , 641 (1964); C.A. 62, 2672a (1965). (795) Haertelt, AI., Boll. Chim.Farm. 103 (2). 140 11964): C.A. 61. 171% (1964). (796y Zbid.,’ (9),”673 (1964); C.A. 62, 1516c (1965). (797) Hagerman, D. D. and Spencer, J. M., Steroids 4, 547 (1964). (798) Hajdu, I. P. and Haeussler, A., Arzneimittel-Forsch. 14. 709 (1964): ,, C.A. 61,9359h (1964). (799) Hakanson, R., J . Chromatog. 13, 263 (1964). (800) Hakkesteegt, Th. J., Pharm. Weekblad 99 (35’1. 922 (1964); C.A. 61. 144679 (1964). (801’1 Hall. A.. J . Pharm. Pharmacol. Suppl. 16,9 (1964). (802) Halmekoski, J., Farm. Aikakauslehti 73, 295 (1964); C.A. 64, 79749 (1966). (803) Halmekoski, J. and Hannikainen, H., Ibid., 75 (l), 3 (1966); C.A. 64, 140335(1966). (804) Hamilton, E. J., Eidus, L. and Lee, Y. S., Clin. Chim. Acta 8 , 763 (1963); Anal. Abstr. 11, 2343 (1964). (805) Hamlin, W. E. and Higuchi, W. I., J. Pharm. Sci. 55 (2), 205 (1966). (806) Han, T., Chang, Y. and Yuan, C., Acta Chim. Sinica 31, 12 (1965); Anal. Abstr. 13. 3176 11966’1. (807) Hanna, J. G. and Siggia, S., Encycl. Znd. Chem. Anal. 1, 561 (1966). (808) Hanna, J. G. and Siggia S., J . Pharm. Sci. 55, 541 (1966). (809) Hannema, H. I. and Faber, J. S., Pharm. Weekblad 100 ( 5 ) , 153 (1965); C. A . 63,54468 (1965). (810) Hannig, E. and Heyroth, H., Pharm. Zentralhalle 103 (11/12), 810 (1964): C.A. 62 10394e (1965). (811) Hansen, IT. J. and Miller, 0. K., Bull. Tulane Univ. M e d . Fac. 22, 75 (1963’1; Anal. Abstr. 11, 2338 (1964). (812) Hansen, R., iVord. Vetcrinarmed. 17 (3), 164 (1965); C.A. 63, 437a (1965). & ”

~

~

(813) Hara, S. and Tikeuchi, >IJ.., Chromatog. 11, 565 (1963). (814) Harris, W. G., liniv. Microjilms (Ann Arbor, Mich.), Order No. 65-8690, 75 pp.; Dissertation Abstr. 26 (3), 1360(1965) (815) Harris. W. G.. Kessler. W. V.. ' Christian, 'J. E. and Knevei, A. M.: J . Pharm. Sci. 55 (4),448 (1966). (816) Hashmi, M. H., Ayaz, A. A. and Rashid, A., Talanta 1.1, 1121 (1964). (817) Hata, S., Yamakavra, M., Tomioka, . S. and Sano, H., Chem: Pharm. Bull: (Tokyo) 13 (l), 96 (1965); C . A . 62, 14426a (1965). (818) Hattori, T., Kawai S. and Nishiumi & Bunsekz I., Kagaku 1 L t ( 7 ) , 586 (1965); C.A. 6 3 , 1 6 1 3 2 ~(1965). (819) Hauck, G., Deut. Apotheker-Zfg. 105, 209 (1965); Anal. Abstr. 13, 3148 (1966). (820) H'auck, G., Dtsch. Z. Ges. Gerichfl. Med. 54 (l),98 (1963); Anal Abstr. 11, 5011 (1964). (821) Hauser, W., hleyer, W. and Kartnig T.. Sci. Pharm. 31. 124 (1963): . . . Anal. A&. 11, 2774 (1964). (822) Haussler. A . and Haidu. P.. Z. ' Anal. Chem Chem.' 195, 277' (1663); Anal. Ahnfr. 1' Absfr. 11,2776 (1964). (823) (823)' Hayden, Ha) A . L., J . Pharm. Sci. 54 ( l ) ,151 (1965). (824) Hayden, A. L. and Brannon, W. L., J . Assoc. OJic. Agr. Chemists 48 (3), 616 (1965). (825) Haznagy, A., Szondrei, K . and Toth, L., Pharmazie 20 (9), 541 ((1965); C.A. 63, 16125d (1965). (826) Heacock, R. A. antl Mahon, ht. E., Anal. Biochem. 8, 401 (1964). Heath, H. B. et al., Analyst 89 (827) Hea (1059). 377 S ( i (1964). 11YO41. 11059). (828) Heaysman, L: T. and Sawyer, E. R., Ibid., 89 (1061), 529 (lE64) (829) Hefferren, J. J., J . Pharm. Sci. 52, 1090 (1963). (830) Heftmann, E., Chromatog, Rev. 7, 179 (1965); C.A. 64, 7337e (1966). (831) Heftmann, E., KO, S. T., and Bennett, R. D., J . Chromcztog. 21 (3), 490 ilSG6). (832) H'eisey, H. O., J . Pharm. Sci. 53 (12), 15.53 (1964). (833) Hellstrom, V., Anilersson, R. and Hegedus, L., V a r Foda N o . 8, 57 (1964); C.A. 62, 514611 (1965). (834) Helou. J. H.. Anais Farm. Quim. Suo ' Paulo 14, i7-7O,'93-10eJ 118-2k, 161-74 (1963); C.A. 61 5458d (1964). (835) Hentrich, artd Pfeifer, S., Pharmazie 19, 630 (1964); Ana?. Abstr. 13, 910 (1966). (836) Hernandez, F. A. Ordenes, R. B. and. Marquez, A. V., Rev. Fac. Farm. Unzv. Central Venezuela 2 (4), 32 (1961); C.A. 61, 11847d (1964). (837) Hernandez, R. I . , Anales Fac. Quim. Farm., Univ. Chile j.5, 180 (1963) (Pub. 1964); C.A. 62, 15996b (196.5) (838) Hesse, O., Bel. lJ, 1517 (1880); J . Chem. SOC.dbstrs. Papers 40, 63 (1881). (839) Hetman, J. S., Abhandl. Deul. Akad. Wiss. Berlin, Kl. Cht>m., Geol. Biol. 1964 ( l ) , 169; C . A . 64, 4866h (1966). (840) Hetman, J. S., Anal. Chim. Bcta 30 (3), 313 (1964). (841) Hetman. J . S.. Chem. Zvesti 18. ' 422 11964):'C.A. 61. 10538d (1964).' (842) Hetman, J. S., Lab. Pract. 14 (2), 157 (1965). (843) Heusser, D., Pharm Tijdschr. Belg. 42 (12), 263 (1965); C . A . 64, l7355f

k,

~I

f1SBR) \ - - - - I -

(844) Heusser, D., Planfz Med. 12 (3), 237 (1964); C.A. 62, 2f869e(1965). (845) Heusser, D. and Jackwerth, E., Deut. Apotheker-Ztg. 105 (4), 107 (1965); C.A. 62, 14422b (1965).

(846) Heyndrickx, A., Schauvliege, $1. and Blomme, A., J . Pharm. Belg. 20 (3-4), 117 (1965); C.A. 63, 11256b (1965). (847) Higuchi, T., Eriksson, S. O., Uno, H. and Windheuser, J. J., J . Pharm. Sci. 53 (3), 280 (1964). (848) Higuchi, T. and Shefter, E., Sei. Sect. Am. Pharm. Assoc., Preprint Papers, Las Vegas, Nev. 1962, A-111, 9 PP: (849) Hill, D. W., Hook, J. R. and hlable, S. E. R., J . Sci. lnstr. 39 ( 5 ) ,214 (1962); C. A . 60,14333b (1964). (850) Hiller, K., Pharmazie 19 (3), 167 (1964); C.A. 60, 14331e (1964). (851) Hoerhammer, L. and Wagner, H., Pharm Deltion Epistemonike Ekdosis 3 ( l ) ,18 (1963); C.A. 61, 1709e (1964). (852) Hoerhammer, L., Wagner, H., Bittner. G. and Graf. E.. Deut. AvothekerZfg: 105 (25), 827 (1965); C . A . 63, 1125lg (1965). (853) Hoerhammer, L., Wagner, H. and Hein, K., J . Chromatog., 13, 235 (1964). (854) Hoerhammer, L., Wagner, H., Richter, G., Konig, H. W. and Heng, I., Deut. Apotheker-Ztg. 104, 1398 (1964); Anal. Absfr. 13, 952 (1966). ( 8 5 5 ) Hoffman, D. R., J . Org. Chem. 31 (3), 792 (1966). (856) Hoffman, H., Arch. Pharm., Berlin 296, (11)(1963); 197 Mitt. Dtsch. Pharm. Ges. 33, (11) (1963); Anal. Abstr. 12, 907 (1966). (857) Hofmann. H.. Mehler. A. and ' Deeken, C., Deut.' Apotheker-Ztg. 105, 139 (1965); Anal. Abstr. 13, 3167 (1966). (858) Hoffmann, R. W., Sieber, W. and Guhn, G., Chem. Ber. 98 (ll), 3470 (1965); C.A., 64, 12499b (1966). (859) Hofmann, K., Naturwissenschajten 52 (14), 428 (1965); C.A. 63, 14046a (1965). (860) Hohmann, J. R. and Levine, J., J . Assoc. OJic. Agr. Chemists 47 (3), 471 (1964). (861) Hohmann, T. and Rochelmeyer, H., Arch. Pharm. 297 (3), 186 (1964); C.A. 60,13095d (1964). (862) Holbrook, A., Bailey, F. and Bailey, G. XI., J . Pharm. Pharmacol. Suppl. 15,270T (1963). (863) Holl, W. R., Michaels, T. P. and Sinotte, L. P., J . Pharm. Sci. 52, 817 (1963). (864) Holl, W. W., Tufekjian, J. H., Michaels, T. P. and Sinotte, L. P., Ann. ,V.Y. Acad. Sci. 130 (2), 525 f1QG.i) ,- - - ,. (865) Hollifield, H. C. and Winefordner, J. D.. Talanta 12 (9), 860 (1965). (866) Hollos, J. and Horvath-Gabai, I., Gyogyszereszet 8 (8), 305 (1964): C.A. 61,1447221(1964). (867) Hollos, J. and Horvath-Gabai, I., Pharmazie 20 (4), 207 (1965); C.A. 63, 16619 (1965). (868) Hollos, J. and Szuchovsky-Misik, A,, Gyogyszereszet 9 (8), 299 (1965); C.A. 63, 1297% (1965). (869) Holobut, W. and Kolataj. A., Acta Physiol. Polon. 16 (6), 903 (1965); C.A. 64, 17357e (1966). (870) Hopes, T. XI., J. Assoc. Ofic. Agr. Chemists 48 (3), 585 (1965). (871) Homing, E . C. and T'andenHeuvel, W. J. A., Riv. Ital. Sostanze Grasse 42 (9), 418 (1965); C.A. 64, 11028b (1966). (872) Horak, P., Cesk. Farm. 12, 398 (1963); Anal. Abstr. 12, 306 (1965). (873) Horak, P. and Zyka,'J., Ibid., 12, 286-93 (1963); C.A. 61, 4151h (1964). (874) Ibid., pp. 359-62 (1963); C.A. 62, 8936b (1965). (875) Ibid., pp. 394-8 (1963); Anal. Abstr. 12, 299 (1965).

(876) Horii, S., Hitomi, H. and Miyake, A., Takeda Kenkyusho iVempo 23, 8 (1964); C.A. 63, 16127h (1965). (877) Horvath, G. and Milch, G., Pharm. Zentralhalle 104 (9-lo), 647 (1965); C.A. 66,32879 (1966). (878) Hossein, A. hf. and Kassim, A. A., Bull. Fac. Pharm. 1, 33 (1961-62); C . A . 60,13100b (1964). (879) Howorka, K. and Beckert, S., Pharm. Zentralhalle 102 ( l l ) , 715 (1963); C.A. 60,118469 (1964). (880) Hradsky, E. and Barna, K., Chem. Zvesti 18, 542 (1964); Anal Abstr. 12, 5973 (1965). 1881) Hrdv. 0. and Veselv. P.. Cesk. Farm. i o (3), 126 (196lji CIA. 61, 14466e (1965). (882) Hruban, L. and Santavy, F., Pharmazie 20, 357 (1965); C.A. 63, 8127a (1965). (883) Hsi, N. and Chao, S., Yao Hsueh Hsueh Pao 11 ( 5 ) . 346 (1964): C.A. 61. . 8137h (1964). (884) Hiu, L: and Chou, T., Ibid., 12 (3), 171 (1965); C.A. 63, 2388a (1965). (885) Huang, C. and Chang, C., Ibid., 11 (12), 837 (1964); C.A. 62, 71188 (1965). (886) Huan, W.. Ibid., 11 (7), . ., 459 (1964); . ,, . C.A. 62, 1518f (1965). (887) Huber, C.O. and Stapelfeldt, H. E., A N A L CHEM. 36.315 11964). .-. - (888) Huber, J., Rueckbeil, I. and Kieszig, R., Pharm. Zentralhalle 102 (12), 783 (1963); C.A. 60, 14334c (1964). (889) Hubicka, K., Dissertationes Pharm. 15, 449 (1963); Anal. Abstr. 11, 5083 (1964). (890) Ibid., pp. 453457 (1963); Anal. Abstr. 11, 5118 (1964). (891) Hubicka, K., Ibid., 16 (4), 561 (1964); C.A. 62, 11632h (1965). (892) Hubicka, K. and Sawicki, B., Ibid.. 16 (3). 317 (1964): C.A. 62. 6339g (1965)." (893) Hubik, J., Cesk. Farm. 12 (6), 316 (1963); C.A. 61, 6857c (1964). (894) Hudanick, J., J . Pharm. Sci. 53 (3), 332 (1964). (895) Hudson, H. E., Mjg. Chemist Aerosol News 37 (2), 40 (1966); C.A. 6 4 , 1 7 3 6 2 ~(1966). (896) Huettenrauch, R., Pharmazie 19 (lo), 678 (1964); C.A. 62, 7592d (1965). (897) Huettenrauch, R., Ibid., 20 (6), 395 (1965); C.A. 63, 81209 (1965). (898) Huettenrauch, R., and Doell, A., Ibid., 17 (lo), 596 (1962); C.A. 61, 8132c (1964). (899) Huettenrauch, R. and Keiner, I., Pharm. Zentralhalle 104 (6), 392 (1965); C.A., 63,9747b (1965). (900) Huettenrauch, R. and Keiner, J., Ger. (East) Patent 34,175 (Dec. 5, 1964); C . A . 63, 6798c (1965). (901) Huettenrauch, R., and Klotz, L., J . Chromatog. 12, 464 (1963). (902) Huettenrauch, R., and Klota, L. and Muller, W., 2. Chem. 3,193 (1963); Anal. Abstr. 11,2784 (1964). 1903) Huettenrauch. R. and Schulze. J.. ' Phzrmazie 19 (5),'334 (1964); C.A.'61; 2903b (1964). (904) Huettenrauch, R. and Schulze, I., Pharm. Zentralhalle 104 12). ,, 85 (1965): C.A. 62, 116309 (1965). (905) Huisman, J. W. and Dek, 31. C., Pharm. Weekblad. 99. 1121 (1964); . Anal. Abstr. 13,811 (1966). (906) Hull, D. A., Shepp, J. M., Weaver, W. J., Reschke, R. F. and Bomstein, J., ANAL.CHEM.36, 599 (1964). (907) Hull, R. L. and Biles, J. A., J . Pharm. Sci. 53, 869 (1964). (908) Hyatt, R., J . Assoc. OJic. Agr. Chemists 47 (3), 475 (1964). (909) Ibid., 48 (3),594 (1965). ~

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(1347) Malspeis, L. and Gold, D., .I. Pharm. Sci. 53 (lo), 1173 (1964). (1348) Malsmis. L. and Hung. X . G. M., Ibid., 53 (5), 506 (1964). (1349) Malspeis, L., Turner, J. R. and Lachman, L., Ibid., 54 (2), 253 (1965). (1350) Malyshkina, XI. A., Morgunova, A. F. and Sannikov, V. A., Materialy d-oi (Vtoroi) Konf. Molodykh Uchmykh Leningr. Inst. Antibiotikov, Leningrad, Sb. 1964, 54; C.A. 63, 8122b (1965). (1351) Malysz, D. and Walicka, T., Acta Polon. Phurm. 22 (2). 15.5 (1965); C.A. 63, 1655a (1965). 11352) Mandak, M. and Struhar, M., Cesk. Farm. 10 (9), 456 (1961): P.,4. 60, 156819. (1964). (1353) Mandak, M., Struhar, M. and Zekuciova, V., Farm. Obzor 33 (3), 112 (1964); Anal. Abstr. 12, 3484 (1965). (1354) Manikowski, W. and Niezgodzki, L., Farm. Polska 20 (21-22), 822 (1964): C.A. 62.129800 (1965). (1355) Manikowiki, W: and Niezgodzki, L., Ibid., 21 (7-8), 261 (1965); C.A. 63,14637h (1965). 11356) Manova, I., Dolezal, V. and Kacl, K., Z . Chem. 4, 187 (1964): Anal. Abstr. 12, 4762 (1965). (1357) Manthey, J. A. and Aniundson, M. E., J . Chromatog. 19 (31, 522 (1965): C.A. 63,17798j (1965).

-

(1358) Marciszewski, H., Chem. Anal. (Warsaw) 9, 1011 (1964); Anal. Abstr. 13, 1966 (1966). (1359) Marciszewski, H., Trojanowska. Z. and Muszalska, A., Ibid., 10 13), 409 (1965); C.A. 64, 4868n (1966). (1360) Mares, V. and Stejskal, Z., Cesk. Farm. 11 (7), 354 (1962); C.A. 62, 10925b (1965). (1361) Margasinski, Z., Danielak, R., Pomazanska, T. and Rafalowska, H., Acta Polon. Phurm. 21 (l), 5 (1964); C.A. 62, 89419 (1965). (1362) Ibid., p. 253 (1964): Anal. Abstr. 12, 4821 (1965). (1363) Margasinski, Z., Danielak, R. and Rafalowska, H., Ibid., 22 (5), 423 (1965); C.A., 64, 9509c (1966). (1364) Mariani, A. and Vicari, C., Boll. Chim. Farm. 103, 23 (1965); C.A. 63, 1665a (1965). (1365) Mariano, 111. G. C. and Vieira da Silva, XI. J. J., Rev. Port. Farm. 14 (3), 242 (1964); C.A. 63, 434a (1965). (1366) Marini-Scotti, M., Farmaco (Pavia) Ed. Prat. 18, (6) 332 (1963); Anal. Abstr. 11, 4509 (1964). (1367) Marino, V. S., J. Assoc. O$c. Agr. Chemists 48, 582 (1965). (1368) Mario, E. and Gerraughty, R. J. J. Phurm. Sci. 54 (2), 321 (1965); C.A. 62, 12995h (1965). (1369) Markova, 1''. A., Aptechn. Deb 14 (2), 69 (1965); C.A. 63,67895(1965). (1370) Markovic, M. and Blagojevic, Z., Acta Phurm. Jugoslav. 15 (4), 197 (1965); C.A. 66, 15677e (1966). (1371) Martin, II. F. and Driscoll, J. L., ANAL.CHEM.38, 345 (1966). (1372) Martin, J. L. and Shaw, W. H. C., "Proceedings of the SBC Conference, Nottingham, 1965"; .4nal. Sbstr. 13, 2616 (1966). 11373) Martin, L., Genest, K., Cloutier, J. A. R. and Farmilo, C. G., Bull. Narcotics, li. AT. Dept. Social Affairs 15 ( 3 4 ) 17 (1963); C.A. 60, 13096.f (1964). (1374) Martin, R. San and Batllori, L., Kongr. Phnrm. Wiss., Vortr. Originalmitt., 93, Muenster (Westfalen), Ger. 1963, 179; C.A. 62, 5140d (1965). (1375) Martinek. R. G.. Clin. Chm. 10 (12), 1078 (1964); Anal. Abstr. 13, 1903 (1966). \----, 376) Martonfi, L., et al. Rev. Med. (Targu-Mures) 11 (2), 192 (1965); C.A. 63, 17798e (1965). 377) Martonfy, L., Szantho, C., Formanek, I. andyeumann, S., Ibid., 10 (I), 5 (1964): C.A. 61. 13127~(1964). (1378) Masiakowski, J. and Pawelczyk, K., Dissertationes Pharm. 17, 87 (1966); Anal. Abstr. 13, 3168 (1966). (1379) Xason, 31. E., Eager, 11.E. and Waller, G. R., A N ~ LCHEW . 36, 587 (1964). (1380) hfasse, J. and Paris, R., Ann. Phurm. Franc. 22 (.5), 349: ('.A. 61, 8130g (1964). (1381) Massingill, J. L., Jr., and Hodgkins, J. E., ANAL.CHEM.37,952 (1965). (1382) Matherne, M. J., Jr., J. Assoc. Ofic.Agr. Chemists 48 (3), 613 (1966); C.A. 63,6789~(1965). (1383) Mathis, C. and Garel, J. P., Prod. Probl. Pharm. 20 (9), 408 (1965); C.A. 64, 9507a (1966). 11384) Matolcsy, I., Acta Phurm. Hung. 36 (2), 90 (1966): C.A. 64, 15677d (1966). (1385) Xatta, G. and Lopes, E. S., Anazs Azevedos (Lisbon) 16 (3), 184 (1964): C.A. 63,17800~(1965). (1386) Matta, G. and Lopes, E. S., Rev. Port. Farm. 14 (3), 336 (1964); C.A. 6 2 , 8 9 3 6 ~(1965). (1387) Matta, G. and Lopes, E. S., Rev. Port. Farm. 15 (3), 384 (1965); C.A. 64, 11027~(1966).

(1388) Matta, G. and Silva, M. J., Ibid., 14 (31, 274 (1964); [‘.A. 62, 12977a (1965). (1389) Matta, G., Silva, I d . J. and Lopes, M. M. So, Ibzd., 15 (3) 341 (1965); C.A. 64,11027d (1966). (1390) Mattock, G. L., J . Chomatog. 16, 254 (1964). (1391) htatucha, &I.,Cesi.. Purrti. 14 (lo), 510 (1965); C.A. 64, 14031d (1966). (1392) blatveeva, R. A , Lapuk Y. I. and Stepanov, V. M., i‘zv. Akad. S a u l SSSR, Ser. Khim. 1964, (3), 501; Anal. Abstr. 12, 3470 (1965). (1393) Mauer, P., Mzkrochim. Ichnoanal. Acta 1964 12-4), 254; C.A. 61, 49348 ( 1964).

21 (l), 128 (1966); (’A. 64, 14032g (1966). (1396) Meier, J. and Beclrer, A., 2.Anal. Chem. 204, 427 (1964); Anal. Abstr. 12, 6698 (1965). (1397) hleijerman, G. L I . and van Lier, K. L., Bull. w7~rldHealth Organ. 33 (1). 27 (1965); C . A . 63, 16133f (1965). (1398) Rlellinger, T. J. artd Keeler, C. E., ANAL.CHEY.36, 1840 (1964). (1399) Menyharth, P., Seta Chim. dcad. Sci. Hung. 41 (1-2), 195 (1964): C . 9 . 62, 6343b (1965). 11400) Menyharth, P., .Ida Pharm. HWLY. 36 (l), 5 11966); C A . 64, 14033a (1966). (1401) Rtenziani, E., Sanciri, P. and Pertusato, G., Bull. Chim. Farm. 103, 825 (1964): Anal. 9 bstr. 13. 1475 (1966). 11402) Mercaldo, 0 , E. arid Pizzi, E. A., Ann. N. Y . Scad. Sti. 130 (2), 530 (1965). (1403) Merkau, J., Farm. Glusnik 21, 67 (1965); C.A. 63, 97!jlb (1965). (1404) Merkle, F. H. and Discher, C.A., Anal. Chem. 36, 1639 (1964). (1405) Merkle, F. €1. and Discher, C. A.. J. Pharm. Sri. 53 (6), 620 (1964). (1406) hlerkus, F. W. H. M., Phait~c. Neekblad. 98, 947 (1963); Anal. 9bstr. 12, 905 (1965). (1407) Uevkus, F. M . H. 11. and Sagel, J.. I W . , 99 140). 109%(1964): ,, C.A. 62. 7 5 9 1 ~(1965) ’ (1408) Mrrlevede, M., F’harm. Y‘ij’dschr. Be19 42 ( I ) , 1 (1965); C.A. 62, 159895 ~

(196.5’1.

(1469, hlrrrills, R. J., A i d . Biochern. 6, 272 (1963). (1410) Merz, K. W.,Knipes, H. and Lehnann, H., Pharmazia 20 (12), 764 (1965); C.A. 64,7967d (1966). (1411) Mesnard, P. and Crockett, K., Chim. Anal. (Paris) 42 (7), 346 (S), 381 (1960); C.A. 60, 1268lf (1964). (1412) Mesnard. P. and Devaux. G.. Ann. Pharm. Franc. 21, 223 (1963), Anal. Abstr. 11,1085 (1E64) (1413) Mesnard, P. arid Lhvaux, G.) Bull. Soc. Chim. France, 1964, (l), 43, Anal. Abstr. 12,2440 (1965) (1414) Mesnard, P. anc Devaux, (i., Bull. SOC.Pharm. Bordeaux 103 (2), 101 (1964); C.A. 61, 12123g (1964). (1415) Mesnard, P., Ijevaux, C,. a i d Fauquet, J., Ibid., 104 (1) 18 (1965). C.A. 63, 12975d (1965). (1416) Mestres, R.and B t ~ r o i s ,C., Trav. SOC.Pharm. Afontpellzer 23 ( 2 ) , 98 (1963); C.A. 61,6868h (1964). (1417) Mestres, R., Barlois, C. and Pech, M., Trav. Soc. Pharm. Montpellier 22 (4), 242 (1962); C.11 60, 14333h (1964). (1418) llestreb, K.and Martin, C., ‘L‘rau. Soc. Phmm. Montpellztvr 23 (2), 104 (1963): C.A. 61, 8136e (1964).

(1419) Metcalf, M. G., Lancet, 1964, i, 671; Anal. Abstr. 12, 2970 (1965). (1420) Meulenhoff, J., Pharm. Weekblad 100 (18), 583 (1965); C.A. 63, 1297% (1965). (1421) Xeulenhoff, V. J., Pharm. W e e k blad 100 (13), 409 (1965); C.A. 63, 5447e (19651. (1422) RfeyeGDulheuer, K. H. and Ritter, E., Phurm. Ztg. 110 (8), 260 (1965); C.A. 62, 15994h (1965). (1423) Meyniel, G., Berger, J. A., Arnaud, R. N. and Blanquet, P., Compt. Rend. 260 (ll),3065 (1965); C.A. 63, 4339 f196,5). (1424) &g. Cheitiist Aerosol hews 36 ( 8 ) , 30 (1965); C.A. 63, 12976d (1965). (1425) Ibid., (2), 40 (1965). (1426) Michalska, B., Zurkowska, J. and Ozarowski, A., Acta Polon. Pharm. 21, 365 (1964); C.A. 62, 10292d (1965). (1427) Zurkowska, M. J. and Ozarowski, A., Sci. Pharm. 32 (3), 201 (1964); C.A. 62, 15159 (1965). (1428) Michaud, J., Bull. SOC.Pharm. Bordeaux 104 ( l ) ,25 (1965); C.$. 63, 11257b (1965).

hlikhailova, J., Tr. NauchnoIssled. KhLm.-Farm. Inst. 4, 80 (1963): C.A. 61, 686311 (1964). 11431) hlikhailova, T. A. and KhromovBorisov, K. 1 ., Zhur. Anal. Khim. 19, 648 (1964); Anal. Abstr. 12, 4820 (1965). 1432) Mikhrlo, V., Farmatsevt. Zh. (Kiev. 20 (2), 26 (1965): C . A . 64, 11029e 11966 ). 1433) fbid., (K), 45 (1965); C.‘4. 64, 140269 (1966). 1434) Miki, T., Kikuchi, N., and Sahashi, Y., J . Vitaminol. (Kyoto) 8 (4), 279 (1962); C.A. 61, 12637h (1965). 1435) Milch, G., Magyar Kem. Lapja 18, 289 (1963); -4nal. Abstr. 12, 904 11965). (1436)-i\lilc~arska,A. and Petri, S., Actu Polon. Pharw. 22 (2), 163 (1965), C.A. 63, 9749h (1965). (1437) Milos, C’., J. Assoc. O$Lc. Agr. Chemists 48 ( X ) , 607 (1965); C.A. 63, 67889 (1965). (1438) Xnc\ev-Kalcaeva, AI., Gyogyszereszet 4, 181 11960); C.A. 60, 13096b (1964). ( 1439) llirlcsev-Kalcseva, M., Czeller, K. and Egie>sy, J., Ibid., 8 (lo), 352 (1964); C.A. 62, 38869 (1965). (1440) Mirkina, Y. N. and Kharlamov, V. T., Metady Analiza RadioaktaLn. Preparatov, Sh. StateL 1965, 155; C.A 63, 9774h 11965). (1441) Mironov, A. F., et al., Med. Prom. SSSR, 1964, ( 5 ) , 40: Anal. Abstr. 12, 6030 (1965). (1442) Mitchell, W., et al, Analyst 89 (1064), 689 (1964). (1443) Mitev, D., Farmatsiya (Sofia) 15 (4), 227 (1965); C.A. 64, 3284h (1966). (1444) Mitra, li. K. and Kay, G. K., Indian J. Pharm. 26, 172 (1964); C . A . 61,1053tia (1964). (1445) Mitta, .L E. A., Camin, L. L. and Fraga, A . I*., Arg. Rep. Com. Nacl. Energia At., lnforme No. 110, 7 pp (1964); C.A. 61, S137c (1964). 11446) Mitta, A. E. A., Troparevsky, A. and P. de Troparevsky, AI. L., Ibid., 123, 7 pp. 11964); C . A . 62, 2667b (1965). (1447) l\llttelIiidiiii, L. and >layer, d , , Pharm. Acta Helv. 36 (1/2/?), 153 (1961); C.A. 02, 3884d (1965). t 144 .A. 62, 89336 (1 (144 (1

(1450) Ibid., p. 389: C..4. 62, 8933b (1965). (1451) Mizgalski, W. and dmajkiewicz, A., Poznan. Towarz. Przyjaczol Nauk, Wydzial Lekar., Prace Komisji Farm. 3,35 (1965); C.A. 63,8127~(1965). (1452) Mizsei, A,, Igloy, A l . and Veress, M a g y . Kem. Lapja 19 (9), 503 E464); C.A. 62, 6344d (1965). (1453) hlizutani, S.,Nakajima, T., Matsumoto, A. and Tamura, Z., Chem. Pharm. Bull. Japan 12, 8.50 (1964), Anal. Abstr. 12, 5992 (1965). (1454) Modak, M. J. and Venkataraman, A., Indian J . Pharm. 27 (i),200 (1965); C.A. 63,9748f (1965). (1455) llohn, L., J . dssoc. 0 % ~Agr. . Chemists 48 (3). 590 (1965): C.A. 63, 6792c f196,5). (1456) Goiseev, R. K., Aptechn. Uelo 13 (6), 29 (1964); C.A. 62, 6341b (1965). (1457) Molle, L. Patriarche, G. and Gerbaux, A. A., J. Pharm. Belg. 20 (7-8), 263 (1965); C.-4. 64, 7972d (1966). (1458) kloniose, T., Matsukuma, T., Okura, Y., Yakugaku Zmshi 84 (8), 783 (1964); C.A. 61, 118489 (1964). (1459) Monden, K., Kauaku Keisatsu Kenkyusho H O ~ O 17 ~ U 357 (1064); C.A. 63,12253d (1965). (1460) Mondovi, B., m701f, A. M.,Turini, P. and Fanelli, A. R.,Gwrn. Biochim. 13 (6), 415 (1964); C.A. 62, 11637b (1965). (1461) Rlonforte, F. and Faraone, G., Atli Accad. Peloritana Pericolanti, Cl. Sci. Fis., Mat. Nut. 48 (2), 1 (1962); C.A. 61, l714a (1964). (1462) Pvlontequi, R., de Valderrama, E. F. and Collado, M. C. Anales Real Acad. Fmm. 30 (5), 281 (1964); C.A. 63. 434f 11965). (1463) M“ontgomery, K. O., Fleniming, C. V., Weinswig, M. H., Parke, R. F. and Swnrtz, H. A,, J. Pharm. Sci. 53 (3), 340 (1964). (1464) Moody, J. E., Ibid., 52,791 (1963). (1465) Morait, G. H., Coada, M., Turculet, V. and Clogolea, G. H., Farmacia (Bucharest) 12 (9), 521 (1964); C.A. 62,403d (1965). (1466) Moras, J. de, Parado, C. and Drevon, B., Bull. Trav. SOC.Pharm. Lyon 7, S8 11963); Anal. Abstr. 11, 5708 (1964). (1467) hIore&a, E. A., Tribuna Farm. (Brazil) 31 (3/4), 49 (1964); C.A. 63, 431a (1965). 11468) Moreira, E. A. and Cecy, C., Ibid., 32 ( 2 4 ) , 55 (1964); C.A. 63, 17798d (1965). 11469) Moretti, C., Boll. Chim. Farm. 103 (l), 69 (1964): C.A. 60, 11852~ (1964). (1470) Morita, M.,Eisei Shikenjo Kenkyu Hokaku 2Vo. 81, 1 (1963); C.A. 62, 8939b (1965). 11471) Monison, J. C. and Chatten, L. G.. J. Pharm. Sci. 53 (lo), 120.5 (1964). 11472) Rlorvay, J., Racz, I. and Gati, L., Gyogyszereszet 9 (12), 472 (1965); C.A. 64.7966f (1966). (1473) hlorvay; J. an’d Sinmi, L., Acta Pharm. Hung. 34 16), 252 (1964); C . A . 62, 1 2 9 7 6 ~(1965). (1474) Morvap, J. a i d Stajer, G., Ibid.. 35 (5), 194 (1965); c.1. 63, 14639b (1965). (1475) Mosmrii, L. aiid Lama, h.,Analyst 89 (1065), YO3 (1964). 11476) illosig, A., Quart. ,I. Crude Drug Res. 5 (11, 661 (1965); C.A. 64, 14024e (1966). (1477) l l o u g e ~ E. , H. and Rlatsuii, J. \\‘., ‘4nal. Biochem. 6, 223 (1963). (1478) Movrin, M. and Barkovic, b., d c t a Pha1.m. Jugoslao. 14, 29 (1965); C.A. 63,9746~(1965).

(a),

VOL. 39, NO. 5, APRIL 1967

227 R

(1479) Mshvidobadze, A. E., Chumburidze, B. I. and Sardzhveladze, 0. V., Aplechn. Delo 12 (3), 36 (1963); 61, 11853ax1964). (1480) Mshvidobadze, A. E., Chumburidze, B. I. and Sardzhveladze, 0. V., Trudy Nauchno-Med. Obshch. Gruz SSR 3, 73 (1963); Anal. Abstr. 12, 1376 (1965). (1481) Mueller, F. and Speiser, P., Pharm. Acta Helv. 40 (8-9), 449 (1965): C.A. 63, 12996e (1965). (1482) Zbid., ( l l ) , 620 (1965); C.A. 64, 3301e (1966). (1483) Ibid., (12), 671 (1965); C.A. 64,4886f (1966). (1484) Mueller, R. K., Pharm. Praxis, Beilage Pharmazie 1964 (4), 75; C.A. 61, 5452h (1964). (1485) Mukherjee, R. B. and Dutta, B. N., J. Proc. Znst. Chem. India 37 (l), 17 (1965); Anal. Abstr. 13, 2613 (1966). (1486) Mulder, F. J., de Vries, R. J. and Keuning, K. J., Pharm. Weekblad 100 (50), 1457 (1965); C.A. 64, 9511g (1966). \---->-

(1487) Mule, S. J., ANAL. CHEW 36, 1907 (1964). (1488) Munch, J. C., Franco, M. and Friedland, B., J. Pharm. Sci. 53 (7), 832 (1964). (1489) Muratova, F. S. and Gengrinovich, A. I., Aptechn. Delo 13 (4), 43 (1964); C.A. 61, 118535 (1964). (1490) Murea, L., Beral, H., Cuciureanu, E. and Madgearu, M., Rev. Chim. (Bucharest) 16 (11-12), 600 (1965); C.A. 64, 14031e (1966). (1491) Zbid., 17 (l), 46 (1966); C.A. 64, 17360e (1966). (1492) Murea, L. and Stoicescu, F. V., Ibid., 16 (4), 231 (1965); C.A. 63, 8125d (1965). (1493) durgu; N., Pharmazie 19 ( l l ) , 724 (1964); C.A. 62, 75919 (1965). (1494) Murtv, C. N. and Bauat, bI. G., 2. ‘Anal. Chem. 199, ( 5 ) , 367 (1963); Anal. Abstr. 12. 1448 (1965). (1495) Mustafaev, M. M., Aptechn. Delo 12 (6), 61 (1963); C.A. 62, 10295d (196.5). \____,.

”

(1496) Mustafaev, ill. M., Med. Prom. SSSR 18 (l), 44 (1964); C.A. 60, 11848~(1964). (1497) Muszalska. A.. Dissertationes ‘ Phclrm. 15 (4),’439 (1963); C.A. 61, 4155d (1964). (1498) Ibid., p. 445 (1963); [C.A. 61, 93589 (1964). (1499) Myers, E. and Smith, D. A., J. Chromatog. 14, 129 (1964). (1500) Myszkowska, K., Tautt, J. and Tuszynska, S.,Acta Polon. Pharm. 22 (5), 465 (1965); C.A. 64,951221 (1966). (1501) Nadim, A. It.and Hassan, M.-ul-, Pakistan J. Sei. Ind. Res. 8 (3), 141 (1965); C.A. 64, 140275 (1966). (1502) Yagami, H., Awazu, S., and Kanakubo, Y., Chem. Pharm. Bull. (Tokyo) 11, 13 (1963); C.A. 58, 12372h (1963). (1503) Nagasawa, K., Koshimura, E. and Kimura, T., Eisei h‘hikenjo Kenkyu Khokoku No. 81,. 36 (1963): . . . C.A. 62. 8937c (1965). (1504) Nagasawa, K., Tsuchiya, M., Kawamura. J. and Kashima. T.. Eisei Shikenjo Hokoku 79, 241 (1963); C.A. 61, 5082q (1964). (1505) Nagase, Y., Kanaya, Y., Sugiyama, A., and Hoshida, H., Yakugaku Zasshi 85 (2), 119 (196j); C.A. 62, 12982a (1965). (1506) Naik, R. X., Deb, M. M. and Agrawal, S. R., Indian J. Pharm. 25, 412 (1963); C.A. 60, 11846e (1964). (1507) Nair, P. P., Sarlos, I. J., Solomon, D. and Turner, D. A,, Anal. Biochem. 7,96 (1964). (1508) Nair, P. P. and Turner, D. A., J. Am. 011Chemists’ Soc. 40,353 (1963).

2281

(1509) Nakaji, Y., Bitamin 26 (6), 417 (1962); C.A. 60, 15682e (1964). (1510) Nakano, M., Yakuzaigaku 24, 49 (1964); C.A. 61, 41555 (1964). 11511) Nambara, T., Imai, R. and Sakurai S., Yakugaku Zasshi 84, 680 11964): Anal. Abstr. 12, 6035 (1965). (1512) Nambara, T. and Kato, M., Chem. Phurm. Bull (Tokyo) 13 (l),78 (1965): C.A. 62, 13197e (1965). (1513) Nanda J. N. and Bera, B. C., “LABDEV” (Kanpur, India) 3 (l), 81 (1965); C.A. 63, 11679e (1965). (1514) Narasimhachari, N. and Rao, G. R., Hindustan dntibiot. Bull. 6 (3), 114 (1964); C . A . 63, 16134~ (1965). (1515) Narasimhachari, N., Rao, G. R. and Tatke, J. V., Zbid., 7 (3), 127 (1965); C.A. 63, 16134d (1965). (1516) Narbutt-Mering, A. B. and Weglowska, W., Acta Pobn. Pharm. 22 (l), 13 (1965); C.A. 63, 81263 (1965). 11517) Nasierowska, Z., Rozynska, M. and Wojcik, Z., Chem. Anal. (Warsaw) 8, 593 (1963); Anal. Abstr. 11, 3943 (1964). (1518) Nazrullaev, S. N., Tr. Tashkentsk. Farmatsevt. Inst. 3, 351 (1962): C.A. 61, 534b (1964). (1519) Nazrullaev, S. N., Gengrinovich, A. I. and Murtazaev, A. M., Aptechn. Delo 12 (l),42 (1963); C . A . 61, 8873f (1964). (1520) Nedbal, J., Hach, V. and Libosvar, J., Ceslc. Farm. 11, 320 (1962); C.A. 61, 4159b (1964). (1521) Nedelkovltch, E. G., Kongr. Pharm. Wiss., Vortr. Originalmitt., 23., Muenster (Westfalen), Ger. 1963, 665; C.A. 62, 8944b (1965). (1522) Neher, R., Thin-Layer Chromatog., Proc. Symp. 1963, 75: C.A. 62, 6342h (1965). (1523) Neidlein, R., Kluegel, G. and Lebert, U., Pharm. Ztg. No. 20, 651 (1965); C.A. 63, 678% (1965). (1524) Nelson, D. F., Univ. Microfilms (Ann Arbor, Mich.), Order No. 64-5333, 130 DD.: Dissertation Abstr. 24 (12). 4952’(i964); C.A. 61,9359b (1964):(1525) Nelson, D. F. and Kirk, B. L., ANAL.CHEM.36,875 (1964). (1526) Netien, M. G., Bull. Trav. Soc. Pharm. Lwn 7 (4). 145 (1963): C.A. 60, 15681c“(1964). (1527) N e b , J. S. A,, Rev. Brasil. Farm. 44 (5), 259 (1963): C.A. 60, 15679~ ( 1964). (1528) Neumann, D. and Schroeter, H. B., J. Chromatog. 16 (2), 414 (1964); C.A. 63,81248 (1965). (1529) Neuninger, H., Sci. Pharm. 33 (4), 230 (1965); C.A. 64, 79689 (1964). (1530) Nevinskii, A. A., Materialy 2-0i (Vtqroi) Konj. Molodykh Uchenykh Lenangr. Inst. Antibwtikov, Leningrad, Sb. 1964,60; C.A. 63,545Od (1965). (1531) Nienstedt, W., Riochem .I. 92 (1)) 8 P (1964). (1532) Niezgodzki, L. and Manikowski, W., Poznan. Tozoarz. Przyjaciol Nauk. Wydzial Lekar. Prace Komisji Farm. 3, 149 (1965): C.A. 63, 11253e (1965). (1533) Nigam, R. K., Srivastava, K. K. and Tayal, J. N., Labdev (Kanpur, India) 2 (2), 148 (1964); C.A. 61, 6866c (1964). (1534) Nikelly, J. G., ANAL.CHEM.36, 2248 (1964). (1535) Nikiforova, I. S. and Mel’kanovitskaya, S. G., Dokl. Akad. Nauk uzbek. SSR, 1964, (3), 23; Referat. Zh., Khim., 19GDE, 1965, (9), Abstr. No. 9G181; Anal. Abstr. 13,950 (1966). (1536) Nikolaev., A. V., Tr. Vses. Inst. Eksperim Vet., Vses. Akad. Sel’skokhaz. Nauk 30, 271 (1964); C.A. 64, 1329b (1966).


”

(1537) Nikolic, K. and Blagojevic, Z., Farmacia (Bucharest) 12 (4), 211 (1964); C.A. 61, 6865e (1964). (1538) Nikolic, K . and Volasevic, K., Acta Phurm. Jugosluv. 14, 25 (1964); C.A. 63,9750j(1965). (1539) Nikolics, K., Phurm. Zentralhalk 102, 432 (1963); C.A. 59, 15121g (1963). (1540) Nikol’skaya, M. N., Gandel, V. G. and Popkov, V. A., Aptechn. Deb 14 (4), 63 (1965); C.A. 64, 1899g (1966). (1541) Nino, N., Farmatsiya (Sofia) 14 (6), 43 (1964); C.A. 62, 12980h (1965). (1542) Ninomiya, T., Takada, M. and Hashi, K., Yakuzaigaku 24, 114 (1964); C.A. 61, 15936a (1964). (1543) Nishinioto, Y. and Toyoshima, S., Yakugaku Zasshi 85, 327 (1965); C.A. 63, 1229% (1965). (1544) Nishina, T., Sakai, Y . and Kimura, M., Steroids 4 (2), 255 (1964); C.A. 61, 118519 (1964). 11545) Noirfalise, A., Acta Clin. Belg. 20 (4), 273 (1965); C.A. 64, 7971h (1966). 11546) Noirfalise, A., .I. Chromatog. 19 (l), 68 (1965). (1547) Noirfalise, A., Zbid., 20 (l), 61 (1965); C.A. 64,3283j (1966). 11548) Noirfalise, -4. and Buret, J., J. Pharm. Belg. 17 @-lo), 313 (1962); C.A. 61,6862f(1964). (1549) Noirfalise, A. and Grosjean, M. H., J. Chromatog. 16 (l),236 (1964). (1550) Nonclercq, M. and Nys, C., J . Pharm. Belg. 17 (7-8), 241 (1962); C.A. 61, 5454e (1964). (1551) Nonclercq, Yf. and Nys, C., Ibid., 19 (9-10), 421 (1964); C.A. 62, 14421f (1965). (1552) korman, A. W. and DeLuca, H. F., ANAL.CHEM.35, 1247 (1963). f.1553). Noujaim, A. A., Kessler, W. V., Christian. J. E. and Knevel. A. M.. J. Pharm: Sei. 53 (4), 455 (1964). (1554) Nour El-Din, H. M., J. Pharm. Sci. U . Arab. Rep. 3 (l), 193 (1962); C.A. 62,1517j (1965). (1555) Nouvel, G., Barthes, M. and Zoll, A., Bull. Trav. SOC. Pharm. Lyon 9 (l), 7 (1965); C.A. 64, 14029d (1966). (1556) Nouvel, G., Charpenne, F., Zoll, A. and Barthes, M., Zbid., 9 (l), 3 (1965); C.A. 64, 14029c (1966). (1557) Nowakqwska, Z., Wilczynska, I. and Zyzynski, W., Acta Polon. Pharm. 21 (2), 161 (1964); C.A. 62, 8939d (1965). (1558) Nussbaumer, P. A., Pharm. Acta Helv. 38, 24,i (1963); Anal. Abstr. 11, 1084 (1964). (1559) Nussbaumer, P. A., Zbid., 39 (lo), 647 (1964): C.A. 62,3886f (1965). (1560) Nussbaumer, P. A.,-Ibid., 40 (4), 210 (1965); C.A. 63,4378 (1965). (1561) Nussbaumer, P. A.,-Schweiz. Apotheker Ztg. 102 (3), 65 (1964); C.A. 60 14331c (1964). (1562) Nussbaumer, P. A. and Schorderet, M., Pharm. Acta Helv. 40 (4), 205 (1965); C.A. 6 3 , 4 3 2 ~(1965). (1563) Zbid., (8-9), 477 (1965): C.A. 63, 16136e (1965). 11564) Nygard, B., Abhndl. Deut. Akad. Wiss. Berlin, Kl. Chem., Geol. Bwl. 1964 (I),254; C.A. 62, 5140f (1965). (1565) Nyitrai, L., Acta Phdcrm. Hung. 34 (21, en m x ) ; C.A. 61, 29075 (1964). (1566) Zbid., p. 159; Anol. Abstr. 12, 6071 (1965). (1567) Nyitray, L., Ibid., 35 (5), 219 (1965); C.A. 63, 16130c(1965). (1568) Oakey, R. E., Stitch, S. R. and Eccles, S. S., J . Chromatog. 11, 355 (1963).

(1569) Oelschlaeger, €I., Arch. Pharm. 296, 396 (1963); Anal. Abstr. 11, 3945 (1964). (1570) Oelschlaeger, H., Volke, J. and Hoffmann, H., Collectzon Czech. Chem. Commun. 31 (3); C.A. 64, 15718~ (1966). (1571) Oelschlaeger, H., Volke, J. and Kurek, E., Arch. Pharm. 297 (7), 431 (1964); C.A. 61, 10536h (1964). (1572) Oelschlaeger, H., Volke, J. and Lim, G. T., Ibid., 298 (4), 213 (1965); C.A. 63, 4309 (1965). (1573) Oelschlaeger, H. and Welsch, C., Ibid., 297 (lo), 608 (1964); C.A. 62, 38850 (1965). (1574) "Oesterlhg, T. 0,. and Guttman, D. E., J . Pharm. Sa.. 53 (lo), 1189 (1964). (1575) Ogawa, S. and Xobayashi, T., J . Vitaminol. (Kyoto) 10 (l), 38 (1964): C.A. 62,7589~(1965). (1576) Ogawa, S., Morita, M., Koshimoto, A. and Dome, K., Bitamin 32 (4),369 (1965); C.A. 63, 16132h (1965). (1577) Ogawa, S., Morii,a, M., Nishiura K. and Fujiwara, K., Yakugaku Zasshi 85 (7), 650 (1965); C.A. 63, 9746e (1965). (1578) Oguchi, M. and Shimizu, Y., Sogo Igaku 19, 923 (1962); C . A . 63, 1 2 9 7 2 ~(1965). (1579) Ohrt, J. M. and Norton, D. A., Appl. Spectroscopy 18 (4), 110 (1964). (1580) Oi, N., Yakugaku Zasshi 85 ( l l ) , 996 (1965); C.A. 64,41170~(1966). (1581) Ibid., 1001; C.A. 64, 4870e (1966). (1582) Ibid., 1004; C.A. 64, 4870f (1966). (1583) Oi, N. and Umeda, I., Ibid., 85 ( l l ) , 998 (1965); C.A. 64, 4870d (1966). (1584) Oikawa, T. and Osawa, S., Kagaku Keisatsu Kenkyusho liokoku 15, 106 (1962); C.A. 63, 1637c (1965). (1585) OlechnowiczStepien, W., Dissertationes Pharm. 16 (4), ,547 (1964); C.A. 62, 12980e (19651. (1586) Olson, E. C., AUL. CHEX. 32, 1.545 (1960). (1587) Olszewski, Z., 13ujar, H. and Wendt, L., Acta Polon. Pharm. 18, 423 (1961); C.A. 60, 15684d (1964). (1588) Olszewski, Z. and Grabowska, J., Ibid., 21 (2), 175 (1964); C.A. 62, 8945a (1965). (1589) Omboly, C. and Derzsi, E., Acta Pharm. Hung. 33, 14!i (1963); Anal. Abstr. 12, 1366 (1965). (1590) Omboly, Cs. and Derzsi, E., Gyogyszereszet 8, 105 (1964); C.A. 61, 1714b (1964). (1591) Ono, S., Onishi, R and Kawamura, K., Yakugaku Zasshi 8:~ (3), 239 (1965); C.A. 63, 436f (1965). (1.592) Ibzd., p. 245: C.A. 63, 436f (1965). (1593) Ibid., p. 251; C.A 63, 436s (1965). (1594) Ono, S., Onishi, R. and Kawamura, K., Ibid., 86 ( l ) , 11 (1966); C.A. 64, 11032b (1966). (1595) 030, Y. and Sakaguchi, T., Bunseka Kagaku 14 ( 0), 891 (1965); C.A. 64, 1902g (1966). (1596) Onoda, H., Pakuzaigaku 24, 119 (1964): C.A. 61, 15936f (1964). (1597) O'Reilly, 1'. J., 'Australasian J . Pharm. 45, 5114 (1964); C.A. 62, 8931h (1964). (1598) Orlov, Y. E. and Dzyuba, N. P., Aptechn. Delo 14 (5), 52 (1965); C . A . 64, 1903f (1966). (1599) Orlov, Y. E. and Dzyuba, N. P., Farmutsevt. Zh. (Kzev) io (2), 36 (1965); C.A. 64, 7966h (1966). (1600) Orlov, Y. E. and Dzyuba, K'. P., Med. Prom. SSSR 19 (4), 44 (1965); C.A. 63, 1659f (1965). (1601) Orlov, Y. E., Ignatov, Y. I. and Shostenko, Y. V., Ibid., 18 (2), 44 (1964); C.A. 60, 15681d (1964).

(1602) Oswald, N. and Flueck, H., Pharm. Acta Helv. 39 (4/5), 293 (1964); C.A. 61, 2903f (1964). (1603) Oswald, N. and Flueck, H., Sci. Pharm. 32 (2), 136 (1964); C.A. 61, 14465e (1964). (1604) Otani, S., Yahgaku Zmshi 85 (6), 521 (1965); C.A. 63,9751h (1965). (1605) Otani, S., Yakuzazgaku 24, ,59 (1964); .C.A. 61, 4158a (1964). (1606) lbzd., p. 293; C.A. 63, 1663s (1965). (1607) Otani, S., Ibid., 25 (1) 36 (1965); C.A. 63, 16639 (1965). (1608) Ozaki, A., Inoue, Y. and Hashiguchi, N., Ibid., 25 (2), 157 (1965); C.A. 64,4872f(1966). (1609) Padron, J. L. and Shetlar, M. R., Intern. Arch. Allergy Appl. Immunol. 28 (6), 301 (1965); C.A. 64,9512~(1966). (1610) Palamaru, E. and Gondos, M., Sber. Dlsch. Akad. LandwWiss. 12, 31 (1963); Anal. Abstr. 12,4875 (1965). (1611) Pamplona, M. and Ramos, A. C., Anais Fac. Farm. Univ. Recife 617, 3 (1963-64); C.A. 64,11027e (1966). (1612) Panarin, E. F. and Solovskii, 31. V., Antibwtiki 10 (ll), 1000 (1965); C.A. 64,9568e (1966). (1613) Panier, R. G. and Close, J. A., J. Pharm, Sci. 53 (l), 108 (1964). (1614) Panma, 1'. V., Med. Prom. SSSR 19 (6), .55 (1965); C.A. 63, 6791c (1965). (1615) Pannerden, E. B., L. M. van Nispen tot, Pharm. Weekblad 99 (17). 414 (1964): C.A. 61.11849~(1964). (lGlG)'Pa&erden, E. B., L. M. van Nispen tot, Ibid., 100 (50), 1473 (1965); C.A. 64,11028g (1966). (1617) Pant, R. and Agrawal, H. C., 2. Phvswl. Chem. 335. 203 (1964): C.A. 61; 2164h (1964). ' (1618) Papariello, G. J., Letterman, H. and Huettemann, R. E., J. Pharm. Sci. 53 (6), 663 (1964). (1619) Paquin, R. and Lepage, M., J . Chromatog. 12,57 (1963). (1620) Paris, M., Prod. Probl. Pharm. 19, 281 (1964); C.A. 61,10532h (1964). (1621) Paris, R. R., Paris, M. and Poitoux, R., Bull. SOC.Chim. France 1963, 1597; Anal. Abstr. 11, 5081 (1964). (1622) Parissakis, G. and Issopoulos, P. B., Pharm. Acta Helv. 40 (12), 653 (1965); C.A. 6 4 , 4 8 6 9 ~(1966). (1623) Parrak, V., Radejova, E. and Machovicova, F., Chem. Zvesti 18, 369 (1964); C.A. 61,9363e (1964). (1624) Parrot, J. and Paty, M., Riv. Ital. Sostanze Grmse 41 (3), 143 (1964); C.A. 62, 9752h (1965). (1625) Pasalis, J. and Bell, N. H., J . Chromatog. 20 (2), 407 (1965). (1626) Pasich, J. and Lehmann, M., Diasertationes Pharm. 16 (2), 201 (1964); C.A. 61,15936~(1964). (1627) Pasich. J. and Lehmann. M.. Faim. Polsku 20 (19-20), 731 (1964): C.A. 62, 11631e (1965). 11628) Pasich, J. and Stawinska, H., Ibid., 20 (21-22), 829 (1964); C . A . 62, 12976g (1965). (1629) Pastor, J. and Raimondi, R., Bull. SOC.Pharm. Marseille 13 (51). 193-5, 197-201 (1964); C.A. 63, 16133d ( 196.i'1. 11630) Pastor, J. and Raimondi, R., Trav. SOC. Pharm. Montpellier 23 (3), 220 (1963); C.A. 62,11634b (1965). (1631) Pataki, G., J. Chromatog. 12, ,541 11462),. (1963). (1632) Pataki, G., Ibid., 17,327 (1965). (1633) Patel, R. P. and Soni, F. K., Indian J. Pharm. 26., 35 (1964): C.A. . 60, 156838 (1964). (1634) Patriarche, G., J. Pharm. Belg. 19 (7-8), 299 (1964); C.A. 63, 16125e (1965). ~

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(1635) Patriarche, G., Thesis, Univ. Libre de Bruxelles, 1963; Anal. Abstr. 11, 2767 (1964). (1636) Patrikeev, V. V., Sholin, A. F. and Nikiforova. I. A.. Izv. Akad. Nauk SSSR, Otdel. Khim. * Nauk, 1963 (6), 1031; Anal. Abstr. 11,4456 (1964). (1637) Patt, P., Arznezmzttel-Forsch. 15 (I), 90 (1965); C.A. 62,12980f(1965). (1638) Paulus, W., Goenechea, S., and Wienert, V., Arch. KTiminol. 135 (3-4), 84 (1965); C.A. 65,11257~(1965). (1639) Pavolovic, S., Acta Pharm. JugoSlav 14,21 (1964); C.A. 63,9747b (1965). (1640) Pawelczak, I., Gdanskie Towarzyst. Nauk., Wydzial Nauk Mat. Przyrodniczych, Rozprawy Wydzialu 111 No. 1, 235 (1964); C.A. 64, 14031h (1966). (1641) h i d . , pp. 263-94 (1964); C.A. 64, 1 4 0 3 2 ~(1966). (1642) Ibid., pp. 295-321 (1964); C.A. 64, 14032b (1966). (1643) Pawelczyk, E., and Dopierala, T., Farm. Polska 18, 565 (1962); C.A. 63, 6793b (1965). (1644) Pawelczyk, E. and Plotkowiakowa, Z., Chem. Anal. (Warsaw) 9 (6), 1109 (1964); C.A. 6 3 , 4 3 6 ~(1965). (1645) Pawelczyk, E. and Plotkowiakowa, Z., Dissertations Pharm. 17 (l), 75 (1965); C.A. 6 3 , 6 5 9 3 ~(1965). (1646) Pawelczyk, E., and Plotkowiakowa, Z., Poznan. Towarz. Przyjaciol Nauk, W-ydzial Lekar. Prace Komisji Farm. 1 (4),79 (1963); C.A. 61, 4157b (1964). (1647) Pawelczyk, E. and Przadka, T., Ibid., 87 (1963); C.A. 61,1716~(1964). (1648) Pawelczyk, E. and Zalac, M., Chem. Anal. (Warsaw) 10 (3), 387 (1965); C.A. 64,48739 (1966). (1649) Pawlaczyk, J., Poznan. Towarz. Przyjaciol Nauk Wydzial Lekar. Prace Komisji Farm. 1 (4), 38 (1963); C.A. 61, 5375 (1964). (1650) Pechenii, M. I., Aptechn. Delo 11 (2), 64 (1962); C.A. 60,11847h (1964). (1651) Pechtold, F., Arzneimittel-Forsch. 14 (9), 1056 (1964); C.A. 62, 3999 (1965). (1652) Peck, G. E., Christian, J. E., and Banker, G. S., J. Pharm. Sci. 53 (6), 632 (1964). (1653) Pedersen, K. E., Arch. Phurm. Chemi 71 (21), 693 (1964); C.A. 62, 75929 (1965). (1654) Pellerin, F. and Demay, D., Ann. Pharm. France 22 (4),307 (1964); C.A. 61, 9357h (1964). (1655) Pellerin, F., Gautier, J. A., CastilloPenna, M., Blanc-Guenee, J., J . Pharm. Belg. 20 (5-6), 181 (1965); C . A . 64, 1901c (1966). (1656) Pellerin, F., Gautier, J. A. and Conrad, A. M., Ann. Pharm. Franc 22 (11-12), 621 (1964); C.A. 63, 1 6 5 9 ~ (1965). (1657) Pellerin. F.. Gautier. J. A. and Demay, D.; Ibid., (8-9); 495-504 (1964); C.A. 62,12979s (1965). (1658) Ibid., pp. 559-565 (1964); Anal. Abstr. 13, 1459 (1966). (1659) Pellerin, F., Gautier, J. A., and Kiner. J. G.. Ibid.. 21. 355 (1963): C.A. 61,11854~ (1964): . (1660) PellerL, F.; Gautier, J. A., and Pineau, J., Prod. Probl. Pharm. 19, 195 (1964); C.A. 61, 6865f(1964). (1661) Pelloni, V. and Simionovici, R. Rev. Chzm. (Bucharest) 15 (6), 358 (1964); C.A. 61,9360e (1964). (1662) Peneva, A. and Ingilizov, S., Farmatsiya (SoJia) 14 (3), 18 (1964); C.A. 62. 116340 (1965). (1663) Pebna-Hkreros, A., J . Chromatog. 14 (3), 536 (1964). (1664) Penner, M. H., Talmage, J. and Geller, M., J . Pharm. Sci. 55 (4),429 (1966). ~I

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(1665) Pennington, G. W. and Smyth, D., Arch. Intern. Phurmucodyn. 152 ( 3 4 ) , 285 (1964); C.A. 62, 894ld (1965). (1666) Pentz, E. I., Anal. Biochem. 8, 328 (1964). 11667) Percheron. F.. Bull. SOC.Chim. Franc. 1963, 1684’; Anal. Abstr. 11, 5021 (1964). (1668) Ibid., 1965 (I), 255; C.A. 62,14422e (1965). (1669) Perel’man, Y. 31. and Evstratova, K . I., Sptechn. Delo 12 (I), 45 (1963); C.A. 61. 9360h 11964). (1670) Ibid., ( 5 ) , 27‘(1963); C.9. 62, 401d (1965). (1671) Perel’man, Y. X., Ibid., 72 (1963); C.A. 61, 81259 (1964). (1672) Perel’son, 31, E. and Sikonov, G. K.. Med. Prom. S S S R 19 13). 42 (1965)’;C.A. 63,434d (1965). (1673) Perrin, D. D., “Dissociation Constants of Organic Bases in Aqueous Solution,” Butterworths, London, 1965, 473 pp. (1674) Perry, H. M . and Sheppard, M. L., J . Pharm. Pharmacol. Suppl. 16, 136 (1964). (1675) Pesakhovich, L. V., Aptechn, Delo 11 (6), 42 (1962); C.A. 60, 14335s (19641. (1676) Pesez, 31. and Bartos, J., Ann. Pharm. Franc. 22 (8-91. 541 11964): C.A. 6 2 , 7 5 8 9 ~(1965). (1677) Ibid., 675 (1964); Anal. Abstr. 13, 3177 (1966). (1678) Ibid., 23, 65 (1965); $nul. Abstr. 13, 2426 (1966). 1 16791 Pesez. M. and Bartos. J.. Bull. SOC. Chim. France, 1964; (5j, 912; Anal. Abstr. 12,4777 (1965). (1680) Petricic, J. arid I h z i n , V., ;Icta Pharm. Jugoslao. 13, 117 (1963); C.A. 63,9749e (1965). (1681) Petrova, R. I., Sb. Sauchn, Tr., Tsentr, dptechn, iYauchn.-Issled. Inst. 3, 125 (1962); C . A . 61, 171Of (1964). (1682) Petrova, R. I. and_ Zaitsev., T7. A., Aptechn. Delo 12 (l), 17 (1963); C.B. 61,13127b (1964). (1683) Petzold, J. A., Cairip, TT. J. R. and Kirch. E. R.. J . Phurm. Sci.. 52 ( l l ) , 1106 (’1963). ’ (1684) Pfeifer, S. and Heydenreich, K., Naturwissenschaften 48, 223 (1961); C.A. 61,29039 (1964). (1685) Pfordte, K., J . Chromatog. 21 (3), 495 (1966). (1686) Phadke, H. S., Hindustun Antibiot. Bull. 6 (2), .54 (1963); C.A. 64, 48689 (1966). (1687) Phokas, G., Phurnr. Deltion Epistemonike Ekdosis 1 ( l ) , 2.5 (1961): C.A. 60,15679b (1964). (1688) Pierzchalski, T., Chem. Anal., Warsaw,8,443 (1963); Anal. Abstr. 11, 3322 (1964’1. (1689) Pijck,’ J., J . Piiarm. Belg. 17 (9-lo), 323 (1962); (‘A. 61, 8136h (1964). (1690) Pijck, J., Ibid., 19 (7-8): 324(1964) C.A. 62,14424d(1965). (1691) Pijck, J., and Clac-ys, A., Ibid., 19 (7-8), 327 (1964); C.A. 62, 15992h (1965). (1692) Pilet, G., Nang, L. Si, and Perret, C., Prod. Probl. Phnrm. 19, (12), 565 (1964); C.A. 6 2 , 7 5 8 8 ~(1965). (1693) Pinxteren, J. A. C. van, and Veiloop, M. E., Pharm. ilcta Helv. 38, (7/8), 437 (1963): C..4. 60, 118498 (1964). (1694) Pinxteren, J. A. c‘. van, and S’erloop M . E., Pharm. T I eekblad 99 (41), 1125) (1964): C.A. 63, 1659a (1965). (1695) Pinsteren, J. A. ( > .van and S’erloop, AI. E., Ibid., 100, 189 (1965): Anal. Abstr. 13, 3175 (1966). (1696) Ibid., (36), 1037 (1965): (,‘.A. 63, 17799b (1965). ~I

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1697) Pinyazhko, I. R. M., Farmatsevt. Zh. (Kiev) 18 (6), 28 (1963); C.A. 61, 1705d (1964). 1698) Pinyazhko, I. R. M., Ibid., 19 (5), 17 (1964); C.A. 64, 4871a (1966). 1699) Ibid.. 16). 12 (1964): C.A. 64 67oih (i966j. 1700) Pinyazhko, I. R. M., Ibid., 20 ( l ) ,17 (1965); C.A. 64, 9514c (1966). 1701) Ibid., (2), 18 (1965); C.il. 64, 7969e (1966). (1702) Ibid., (5), 17 (1965); C.A. 64, 7969h (1966). (1703) Pinyazhko, I. R. M. and Kramarenko, V. F., Ibid., (6), 13 (1965): C.A. 64,140269 (1966). (1704) Pinvazhko, I. R. AI. and Turkevich, M.” M., Ibid., 19 (3), 44 (1964): C.A. 64, 13564e (1966). (1705) Pinzon, R. and Kapetanidis, I., Mikrochim. Ichnoanal. Acta 1965 (2), 269; C.A. 62, 14421d (1965). (1706) Pinzon, R., Mirimanoff, A. and Kapetanidis, I., Phurm. Acta Helv. 40 (3), 141 (1965); C.A. 62,11633f(1965). (1707) Piotrowska, A., Acta Polon, Pharm. 20(5), 379(1963); C.A.62,1517~(1965). (1708) Ibid., (6), 429 (1963); C.A. 62, 6342d (1965). 11709) Piotrowska, A., Ibid 21,29 (1964); Anal. Abstr. 12, 2451 (1965). (1710) Pitel, G. and Luce, Th., Ann. Pharm. Franc. 23 (9-10). 569 11965): C . A . 64. 79710 (1966). (l’ill)Pitra, J., “Collection Czech. Chem. Commun. 31 (3), 1402 (1966); C.A. 64, 15675d (1966). (1712) Plat, M. and Poisson, J., Ann. Pharm. Franc. 22 (10) 603 (1964): C.A. 62,3885ei1965). (1713) Platt, T. B., Gentile, J. and George, M. J., Ann. N . Y . Acad. Sci. 130 (2), 664 (1965). (1714) Pligin, S. G., dptechn. Delo 13 (5), 44 (1964); C.A. 62, 1516h (1965). (1715) Ploettner, D., Deut. Lebensm.Rundschuu 59, 259 (1963); C.A. 63, 9751c (1965). (1716) Poethke, W. and Behrendt, H., Plzarm. Zentralhalle 104 ( l ) , 4 (1965); C.A. 62,8940d (1965). (1717) Poethke, W. and Hoffmann, J., Ibid., 103 (lo), 731 (1964); C.A. 62, 6339h (1965). 11718) Poethke, W. and Jaekel, C., Pharmazie 19 (3), 203 (1964); C.A. 60, 1 4 3 3 3 (1964). ~ (1719) Poethke, W. and Kinze, W., Arch. Pharm. 297 (lo), 593 (1964); C.il. 62,2669h (1965). i 1720) Poethke, W. and Kinze, W., Phurm. Zentralhulle 102 (11). 692 i1963): C.il.60,11846f(1964). f 1721) Poethke, W. and Kinze, W., Ibid., 103 (2), 95 (1964); C.A. 61, 4152b (1964). (1722) Ibid., (8), 577 (1964); C.A. 62, 26699 (1965). (1723) Poethke, W. and Kinee, W., Ibid., 104 (7), 489 (1965); C . A. 63, 16130g (1965). 1724) Poethke, W. and Koehne, H., Ibid., (9-lo), 630 (1965); C.A. 64, 48708 (1966). 1725) Poethke, W. and Preussler, &I., lbid., (7), 464 (1965); C.A. 63, 16126h (1965). 1726) Poethke, W., Wigert, R. and Beckert, S., Phurmazie 19 (5), 318 (1964); C . A . 61, 2902e (1964). 1727) Ibid., 322 (1964); C.A. 61, 2902e (1964). 728) Poetter, H., Pharmazie 20 ( l l ) , 737 (1965); C . A . 64, ?511b (1966). 729) Pohorsky, J., Vaachek, J. and Konecny, J., Cesk. Farm. 12 (lo), 532 (1963); C.A. 61, 93625 (1964). 730) Pol, H. J. van der, Phurm. W e e k hlad 99 (19), 504 (1964); C.A. 61, 11847s( 1964). I ,

”

f 17311 Polaczek. L. and Grzeszkiewicz. A . , ’ Acta Poion Pharm. 21 (11, 19 (1964); C.A. 62, 10296b (1965). \ -

(1732) Polaczek, L. and Grzeszkiewicz, A., Chem Anal. (Warsaw) 9 (6), 1045 (1964); C.A. 63, 18d (1965). (1733) Polonia, J. and Martinez, F., Anais. Fac. Farm. Porto 22. 43 (1962): C.A. 61,54609 (1964). (1734) Polotebnova, N. A., Krtil, J., Ravitskaya, F. K. and Krachun, S. V., Uch. Zap. Kishinevsk. Gos. Cniv., 1963 68, 71; C.A. 63, 8122d (1965). (1735) Poltorak, V. A., Antzbiotzki 8 (7), 638 (1963); C.A. 61,15935b (1964). (1736) Pominov, I. S., Khamidullina, F. K. and Shamova, A . A., Zh. Prikl. Spektroskopii 1 (a), 182 (1964); C.A. 63,17800g (1965). (1737) Pons, J. A., Rev. Farm. (Buenos Aires) 107 (5-6), 103-6, 109-12, 115-18 (1965); C.A. 63, 1 6 1 3 3 ~(1965). (1738) Pontvianne, B., Mededel. Landboutvhogeschool Opsoekingssta. Staat Gent 29 (3), 1208 (1964); C.A. 63, 17152d (1965). (1739) Poonawalla, F. AI. and Iyengar, 13. R. S., Appl. Microbial. 13 ( 5 ) , 755 (1965). (1740) Popa, G., Ciurea, I. C., Lazar, C,. and Cristescu, C., An. Cniv. Bucurestz, Ser. Stiint. iYat., Chin!. 11, 91 (1962); Anal. Absbr. 11, 4515 (1964). 11741) Popa, I., Bors, G., Armasescu, L,., Stan, T. and Ioanid. N., Farmacza (Bucharest) 10 (6), 347 (1962); C.A. 61,5379 (1964). (1742) Popa, I. and Voicu, A., Ibid., (7), 399 (1962); C.A. 62, 1517d (1965). (1743) Popa, I., s’oicu, A,, Armasescu, L., Stan, T and Ioanid, N., Ibid., 13 (5), 287 (19;s); C.A. 63, 6792a (1966). (1744) Popescu, D. and Vaeni, M., Rea. Chim. (Bucharest) 16 ( i ) ,321 (19653; C . A . 63, 17802~(1965). (1745) Popov, K. and Popova, Y., iVauchni Tr., Sauchnoizsled. Inst. Konservna Prom., Ploadiz, 2, 73 (1964): C.A. 63,1657b (1965). ( 1746) Popova, Y., POPOV, K. aud Ilieva, RI., J . Chromatog. 21 (l), 164 (1966). (1747) Popova, Y. and Popov, K., Sauchni Tr., ,Vauchnoitsled. Inst. Ronservna Prom., Ploadiz~ 2 , 67 (1964); C.A .63,6316g (1965). (1748) Popova, Ya. G., .Yauchni Tr., Vissh. Inst. Kranifelnn Vkusova Prom. Plovdiv 10, 289 (1963); C.A. 61, 9354c (1964). (1749) Popovic, K. B., Sikolic, K. and Blagojevic, Z., Glasnik H e m . Drustva, Beograd 29 (1-2), 1 11964); C.A. 64, 14032f( 1966). (1750) Popovici, S’., Schn-eiger, A., and Spiher, A4.,Farmacia (Bucharest) 13 (9). 569 (1965’3: C.A. 64,3283d (1966). (1751) Popovici, ’ V., Schweiger, B. and Spitzer, E., Acta Pliarm. Hung. 35 C.A. 64.4869e (1966). (6). 252 (1965): . (1752) Porges, E., Bratkav. Lekarske Listy 44-I (l), 3 (1964); C.A. 60, 11847~(1964). (1753) Poroikova, L. N. and Tarasenko, 31.I., Sb. Nauchn. Tr., Tsentr. Aptechn. .Tauchn.-Issled. Inst. 3, 120 (1962): C.A. 60,130979 (1964). (1754) Porter, G. S., J . Pharm. Phurmacol. Suppl. 16,24 (1964). (1755) Portnov, ill.A , , Zazosov, A., T‘eselitskaya, T. A., l\likhalev, T . A., Med. Prom. SSSR 18 ( a ) , 36 (1964); C.8.61,2911e(1964). 11756) Posgay-Kovacs, E,, Acta Pharm. Hung. 34 (4), 152 (l964); C.A. 61, 1593ia (1964). ( 1757) Posgay-Iiovacs, E., Ibid., 35 (2), 68 (1965); C.A. 65, 1655, (1965) (1758) Ibzd., p. 75; ( ‘ . A . 65, 1655e (1965). I

,

v.

(1i5!)) Posgny-Kovscs, E., and Bayer, I., Ibitl., 33, 0-14 (lE163); Anal. Abstr. 12, 1349 (1965'1. (1760) Posg:Ly-Kovacs, E., arid Bayer, I., Pharinntie 20 ( l ) , 46 (1965); C.A. 62, 1162!)d (196,:). (1761) Potapov, T-. AI., T'estn. Mask, [-nit'., Ser. l < h f m . 19'53, 3 ; Anal. d b s t r . 11,3131 (1964). (1762) Potapov, V. AI., Ikm'yanovich, 1.. A t . and Terenl'ev, A. P., Zh. Analit. K h i m . 19 ( 2 ) , 254 11964): C . A . 60, 14:334f ( 1!164). 1763) Potter,W. P. de, \.ochten, R . F. and de Schnepdryver, A. F., Esperientia 21 ( S ) , 482(1!165): C.;1.63,11256~(1965). 1764) Pozdnvakovn, 1- T. aiid Golovkin, 1.. A,, .Lpt&hn. De20 14 (,5)) 60 (1965); C.,'i. 64, :i28$7 (lo(%). 1765) Pozdliy:ikova, 1. T. and Rozovrkii 11. Y., Farniatsett. Z h . ( K i e c ) 18 (6), ,53 (1'363): C.;l. 61, 6 8 6 4 ~(1964). 1766) Pozdiiy:ikovn, 1 . T., llogovs'kii, 11. \-. m d Golovkiii: I-.0.. Ihicl., 20 f:3). 3 3 (1965): C . d . 64. 11025f 11966'1. 767) POLO,A. del ,tiid Salamr, I?,, Galenica *lcta ( . l I n d . ? t l ) 16 ( 3 ) , 195 (1!)63), C.,l 61, 1713d (1964). 768) Pozo, A . del and Salazar. I?., Jlcditat??trLta (Jlatlr~ii)25 (13), (206), 131 (1061); C.=l. 61, 6S65b (1964). 76')) Pieiiis. F. R and Knecht. A , .

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. N . , de Silva, A . H.and I,

IT.. -1nai.y Fac. Farni.

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ihb) ll:idovic,

r

l

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Phuriii. Ueltion EpistetTionike Ekdosis 2 (4), 187 (1962): C.d 61, 2008e (1'364).

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~

~~

. .

- ..

U. b. Patelit' 3:178,451, April 13, 1965:(1819) Rich. N. TV. and Chatten, L. G., J . Z'harnz. Sei. 54 ( 7 ) , 995 (1'365).

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232 R


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1908) Sammitl, 0. €I., Brannon, IT. L. aiid ITagden, A. L., J . Assoc. 0 8 c . A g r . Chemists 47, 918 (1964). 1909) Sanchez, F. hl. E., IZeu. Fac. Fartie. r n i i . Central Venezuela 3 ( i )31 , (1962); C. A . 61.14475d (1964). (1910) Sai;cliez, F. 11. E., Ibld., 5 (12), 69 (1964): C.A. 62, 11633h (1965). (1911) Sandberg, D. €I., Bock, S. X. and Turner, D. A, Anal. Biocizem. 8, 129 (1964). (1912) Sandri-Cavicchi, G . and Quaglio, 11. P., Boll. Chiin. Farin. 104 (5)j 300 (196-5); C . A . 63, 6790d (1965).

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(1'388) dchettino, O., Fumiaco, Pacia), Ed. Prat. 20 (1). 40 (1965): C' , X93.5f (196.5). (1039) Schieser, 11. JY.,J . Phnrin. Sci. 53 (8), 90'3 (1964). (1940) Schilcher, II., Deut. ;lpotiieker-Ztg. 104 (XI), 1019 (1964); C..1. 61, 10.53.5e .I

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(1941) Schill, G., Acta Phnrni. Suecica 1 ( 3 ) , 101 ,(1964j; C..1. 63, 1657g (1963). 118421 Ibzd., 1 3 ) , 169 (1964); C.A. 62, 124klh (19651. (1943) Schill, G.>Ibitl., 2 (l)! 13 (196,5); C..1. 63, 812,311 (196.5). (1944) l b i d . , ( 2 ) , 99 (1963); C.;I. 63, 16;i7h ( l < K ) . (1943) Ibicl., 109 (1965); C. .I 63, 1657h (196,ij . (1946) Ibitl., (3)j 177 (1965); C.;l. 65, 11233s ( 1965) . ~

(1947) Schill, G., and Jcnsson, T. E., Ibid., 1 (l), 13 (1964); C.S. 61, 5453h (1964). (1948) Schill, G., Lennart, AI., and Johansaon, M., Ibicl., 2 (1964); C.A. 61, 8138d (1964). (1949) Schiller. P.. Kerneneraie 6 (9). . 514' (1963);' c.A. 61, 144f2e (i96'4j: (1950) Schiller, P., anc. Majer, J., Cesk. Farm. 11, 286 (1962); C.A. 61, 6860d (1964).

(1931) Schilt, A. A., and Sutherland, J. W., AKALCHEM.36, 1805 (1964). (1952) Schmandke, II., Ernaehrungsforschung 10 (l), 66 (1965); C.A. 63, 6316h (1965). (1953) Schmid, E., Hoppe, E., Meythaler, C. Jr., and Zicha, L., ArznemittelForsch., 13 ( l l ) , 969 (1963); Anal. Abstr. 1 2 , 1368 (1965). (1954) Schmidt, G. C., Fischer, C. and McOw-en, J. AI., J . Pharm. Sci. 52, 468 (1963). (1955)' Schneider, G. a id Schneider, C., 2. Physiol. Chem., 332, 316 (1963); Anal. Abstr. 11, 3869 (1964). (1956) Schnekenbuiger, J., Planta Med. 12 ( 3 ) , 321 (1964); C.A. 62, 2669f (1965). (1957) Schnekenbnrger, J., and Hartikainen, I., Deut. dpotheker-Ztg. 104 (lo), 1402 (1964); C.A. 62,2666b (1965). (1958) Schreiber, K., Kulturpjanze 11, 502 (1'363); C . A . 60. 13095h (1964). (1959) Schreiber, K., and Anrich, O., Zbzd., 1 2 , 473 (1964); C . 9 . 63, 14636h (1H65). (1960) Schreiber, K . , Aurich, 0. and Osske C;.) J . Chromatog. 12, 63 (1963). (1961) Schulek, E., Lzsztity, A4.,and Rempoi t-Horvath, 2 ., .letu Pharm. Huno. 34 (1)., 1 (1964). . . , C A . 61 2906d ( 1964 ) . (1962) Schulek, E., l l a r x j L. and Perl, I., Talanta 10,561 (1063). (1963) Schulte, K . E., Kassem, hl. A. and Hobl, R., Z. I.naZ. Chem. 195, 196 (1963). (1964) Schultz, 0. E., Planta M e d . 12 ( 3 ) ) 371 (1964); C.A. 62, 3883d (1965). (1965) Schultz, 0. E., and LIohrmann, H. L., Pharmazie 20 (7),441 (1965); C . A . 63, 9744e (1963). (1966) Schaltz, 0. E . and Schriekenburger, J., Arch. Pharm. 298 ( 8 ) , 548 (1965); C . A . 64, 4867g (1966). (1967) Schulz. E. P.. J . Pharm. Sci. 54 11). 144 (1'363). (1'368) SchulL, E. P. a i d Diaz, 31. A , , Z b ~ d . 53 , (9j, 1115 (1964). (1969) Schulz, E. P., Iliaz, AI. A. and Guerrero, L. l l . , Ihid., (9),'1119 (1964). (1970) Schulz, E . P., et al.. ANALCHEM. 36, 1624 (1964). (1'371) S c h i d e r , R.,Fortschr. Gebiete Roentgenstrahlen A\'ctk8'earmed. 98, 762 (1963); d n a l . Abstr. 11, 3952 (1964). (1972) Schute, J . B., Pharm Weekblad 99 (39), 1033 (1964); C.A. 62, 7588d (1965). (1973) Ibid., p. 1253; Anal. Abstr. 13, 1460 (1966). (1974) Schwarts, 31. A., J . Pharrn. Sei. 54 ( 3 ) ,472 (1965). (10ij) Schwartz, AI. A., Bara, E., Rubycz I. and Granatek, A. P., Ibid., ( l ) , 149 (1'365). (1976) Schwartz, AI. A , Buckwalter, F. I€.,Zbid., 51,1119 (1962). (1977) Schwartz, 11.A., Granatek, A. P., Buckwalter, F. H., Ibid., 523 (1962). (19%) Schwarz, T. and Sarsunova, AI., Pharmazie 19 (4), 267 (1964); C . A . 61, 2906f (1964). (1979) Sciarra, J. J., Berosol Age 10, 40, 44 (1965). (1980) Scott,, N.,J . Phtzrm. Sci. 53 (9), 1121 (1964). (1981) Scotti, 11. Xarini, Boll. Chim. Farm. 104 (e), 356 (1965); C.A. 63, 9 7 X a (1965).

(1382) Sedam, R. L., Gennaro, A. R. and Osol, A., J . Pharm. Sci. 54 (2), 215 (1965). (1983) Seiler, N., and Wiechmann, RI., 2. Physzol, Chem. 337 (4-6), 229 (1964); C.A. 61, 11849e (1964). (1984) Sekhon, N. S., Dar, R. N. and Ram, J., Indian J . Pharm. 26, 174 (1964); C.A.61, 10534e (1964). (1985) Sekiguchi, K., Yotsuyanagi, T. and Mikami, S.,Chem. Phurm. Bull. (Tokyo) 12 (9), 994 (1964); C.A. 61, 13935b 11964). (1986) Sekules)' G., Boll. Chim. Farm. 102 (I), 2I. and Chichiro, V. E., Sb. -\-auchn. Tr . Tsentr . Sauchn.Issled. Aptechn. Inst. 3, 115 (1962); C.A. 60, 13681b (1964). (2031) Shinohara, T., Kagaku Keisatsu Kenkuusho Hokoku 18 ( l ) , 10 (1965): C.A. 63, 11256f (1965). (2032) Shiraeff, I).A., J . dssoc. Oflc. Agr. Chemists 47, 724 (1964). (2033) Shrivastava, S. K., Chakravarty, K. B. and Rav. G. K.. Indian J . Pharm., 25, 97 (1963); ilnhl. Abstr. 11, 2344 (1964). (2034) Shtol'ts, XI. G., Shtamm, L. K. and Bednyagina, S . P., Med. Prom. SSSR 19 (lo), 34 (1965); C.A. 64, 3284s (1966). 12035) Shvartsman. P. D.. Farmatsevt. Zh. (Kiev) 16 (l), 64 (1961); C.A. 61, 4155b (1964). (2036) Shvartsman. P. D. and Skal't. B. I., 'Aptechn. Del0 12 (6), 63 (1963); C.A. 62, 10394c (1965). (2037) Sidorova, A. I., Antibiotiki 8 (lo), 915 (1963); C.A. 61, l5930d (1964). (2038) Sidorova, A. I. and Chaikovskaya, S. M.,Ibid., 917 (1963); C.A. 61, l5930e (1964). (2039) Siedlanowska, H., Acta Polon. Phurm. 21 ( l ) , 33 (1964); C.A. 62, 14423h (1965). (2040) Siedlanowska, H., Ibid., 22 (l), 93 (1965); C.A. 6 3 , 8 1 2 4 ~(1965). ~

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(2041) Siedlanowska, H., Farm. Polska 20 (5-6), 160 (1964); C.A. 61, 8 1 3 3 (1964). (2042) Siedlanowska, H. and Krowczynski, L., Acta Polon. Phurm. 20 (6), 463 (1963); C . 9 . 6 2 , 15149 (1965). (2043) Siegel, F. P. and Ecanow, B., J . Pharm. Sci. 53 (7), 831 (1964). (2044) Siegel, F. P., Hiter, F. D., Susina, S.V. and Blake, M. I., J . Pharm. Sei. 53 ( 8 ) ,978 (1964). (2045) Sieper, H., Longo, R. and Korte, F., Arch. Pharm. 296, 403 (1963); Anal. Abstr. 1 1 , 3925 (1964). (2046) Siest, G., Bull Acad. SOC.Lorraine Sci. 3, 42 (1963); Anal. Abstr. 12, 1308 (1965). (2047) Siggia, S. and Stahl, C. R., AXAL. CHEhl. 35,1740 (1963). (2048) Sil, J., Agrawal, K. C. and Dutta, B. S . , Sei. Cult. (Calcutta) 28, 472 (1962); C.A. 61,6868b (1964). (2049) Silaev, A. B., Plakunov, T'. K . and Plakunova, V. G., Antzbiotzki 9 (41. 314 (1964):C.B. 61. 1711b (1964).

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31. 'T. C.,'Inacio, 11. hI. L. a n d Leal, A. M., Ibid., 295 (1965); C.A. 64, 9513f

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(2073) Sivitskaya, 0. K., Sb. iyauchn. Tr ., Tsent r. A ptechn. iVauchn .-Issled. Inst. 4, 123 (1963); C . A . 61, 8133d (1964). (2074) Sjogren, J. and Ervik, M., Acta Pharm. Sueczca 1 (6), 219 (1964); C.A. 62, 129859 (1965). (2075) Skarka, B., and Peciar, J., Chem. Zcestz, 17, 449 (1963); Anal. Abstr. 11 3904 (1964). (2076) Skelly, N. E. and Crummett, W. B., ANAL.CHEY.35, 1680 (1963). (2077) Skinner, W.A., Parkhurst, R. h l . and Alaupovic, P., J . Chromatog. 13, 240 ( 1964). (2078) Skolik, J., Prace Zakresu Towaroznawasl. Chem., Wyzsza Szokla Ekon. Poznan., Zeszyty S a u k . , Ser. I 17, 139 (1964); C.A. 63,16129h (1965). (2079) Skora, II.,Dissertationes Pharm. 15 (4), 433 (1963); C . A . 61, 2910b (1964). (2080) Slomp, G., Baker, R. H., Jr., and RIacKellar, F. A., A N ~ LCHEM., . 36, 375 (1964). 120811 Smith. B.. Persmark. U. and ' Edman, E'., Acta Chem. Scand. 17, 709 (1963);Anal.Abstr. 1 1 , 989,(1964). (2082) Smith, E., J . Pharm. Scz. 53 (8), 942 (1964). (2083) Smith, E., Univ. Microfilms (Ann Arbor. Rlich.) Order No. 63-444. Disse&tionAbslr. 23. 3139 (1963). (2084). Smith, T. C., J'. -4ppl: Physiol. 21 (2), 745 (1966); C.A. 64, 17359h (1966). (2083) Smoczkiewiczowa, A. and Sioda, R., J . Pharm. Pharmacol. 15, 486 119631. (2086) SIIatzke, G., 2. Anal. Chem. 209 (3), 412 (1965). (2087) Sobiczewska, M., Acta Polon. Pharm. 21 (6), 485 (1964): C.A. 62, 8936c ("Jfi;) (20881 S lbiczewska, LIS, Farm. Polska 20 '(1-Z), 35 (1964); C.A. 61, 6861b ( 1964). (2089) Sobko, 31. Y., Furmatsevt. Zh. (Kiev) 18 (4), 43 (1963); C.A. 61, 1710d (1964). (2090) Sobko, 11. Y., Jfaterialy I-oi (Pervoi) Sauchn. Konf. p o Khim. i Khim. Tekhnol (Lvov: L'vovsk. Cniv.) Sb. 1963,8; C.A. 61,144729 (1964). (2091) Soczewinski, E. and Szabelska, B., Dissertationes Pharm. 17 ( l ) , 53 (1965); C.A. 63, 9450a (1965). (2092) Soibel'man, B. I., and Ruzhitskii, I>. ll.,dptechn. Delo 14 ( 3 ) )43 (1965); C.A. 63, 12676b (196.5). (2093) Sokolski, W.T., Chidester, C. G., Carpenter, 0.S., and Kaneshiro, R.AI., J . Pharm. Sci. 53 (7), 826 (1064). (2094) Solodova, A. F., Aptechn. Delo 14 (6), 7 5 (1965); C.A. 64,4861f (1966). (2095) Sonanini, D., Pharm. Acta. Helv. 39. ( l l ) , 673 (1964); C . A . 62, 3989 (1965). (2096) Sonanini, D., and h i k e r , L., Pharm. Acta. Helv. 39 (81,518 (1964); C . A . 61, 9360d (1964). (2097) Sonanini, D., Hofstetter, R., Anker, L., and Muehlemann, H., Pharm. Acta Helv. 40 (5), 302 (1965); C . A . 63, 165% (1965). (2098) Spacu, P., Gheorghiu, C., and Cristurean, E., 2.Anal. Chem. 210 (6), 436 (1965); C.A. 6 3 , 3 6 2 2 ~(1965). (2099) Spanyar, P., Kevei, E. and Slazovich, M.,2. Anal. Chem. 195, 268 (1963);Anal. Abstr. 11, 2831 (1964). (2100) Spitzer, A., Schweiger, A., and Popvici, Y.,Farmacia (Bucharest) 12 (8),503 (1964); C.A. 62, 2671c (1965). (2101) Spitzer, A., Schweiger, A., and Popovici, V Pharm. Zenfralhalle 104, (2), 83 (1965); Anal. d b s t r . 13, 3190 (1966). (2102) Spratt, J. L., J . Chromatog. 16 (I), 253 (1964). LV"",.

\-

(2103) Sprenger, H. E., 2.Anal. Chem. 204 (4), 241 (1964); C.A. 61, 11337~ (1964). (2104) Springer, R. and Isak, H., 2. Anal. Chem. 199, 363 (1963); Anal. Abstr. 12, 1382 (1965). (2105) Springer, I-.,Karlicek, R., Najer, J., and Noskova, L., Farm. Obzor 33, 340 (1964); Anal. Abstr. 12, 6671 (1965). (2106) Springer, I-., and Majer, J., Cesk. Farm. 13 (l), 6 (1964); C.A. 61, 93600, (1964). (2107) Stahl, E., "Thin-Layer Chromatography,:: Academic Press, S e w York, 1965, a03 pp. (2108) Stahl, E. and Pfeifle, J., 2. Anal. Chem. 200, 377 (1964); Anal. Abstr. 12, 2947 (1965). 12109) Stahlavska. A. and Malat. 111. ' Cesk. Farm. 13 ( 3 ) , 89 (1964); C.A. 61; 1447Oh (1964). (2110) Stainier, C., Farmaco (Pauia), Ed. Prat. 20 (9), 427 (1965); C.A. 64, 2740f (1966). (2111) Stainier, C., Ibzd., (lo), 473 (1965); C.A. 64,4861e (1966). (2112) Stainier, It., J . Pharm. Belg. 18 (5-6), 223 (1963); C.A. 61, 6863h (1964). (2113) Stainier, R., Ibid., 20 (3-4), 89 (1965); C.A. 63, 1 1 2 0 3 (1965). (2114) Stakhorskaya, L. K., Aptechn. Delo 11 (a),44 (1962); C.A. 60, 11848d (1964). \ - -

- - I

(2113) dtancakova, A., Clin. Chint. Acta 10 ( l ) , 55 (1964); C.A. 61, 54568 (1964). (2116) Starka, L., Sulcova, J., Riedlova, J. and Adamec, O., Clan. Chzm. Acta., 9, 168 (1964), Anal. Abstr. 12, 2414 (1963 j. (2117) Stawowczyk, A., Farm. Polska 21 (9-lo), 340 (1965), C.A. 63, 12969~ ( 1965). (2118) Steagall, E. F., J . Assoc. Ofic. =Ig,. Chemzsts 48 (4),723 (1965). (2119) Steele, J. W., Can. Phaim. J., Scz., Sect. 97 ( 2 ) , 91 (1964), C A . 60, l5681e (1964). (2120) Steele, J. A., J . Chromatog. 19 (2), 300 (1965). (2121) Stefanescu, D., Tuchel, N. and iintonescu, Y.,FaTmacta (Bucharest) 12 (II), 465 (1964), C.A. 62, l520b (1965). (2122) SteinietL, E. P Bull. Soc. Pharm. .Yancy S o . 60, 15 (1964), C.A. 61, l4467d (196.5). (2123) Stein, H. H. and Ambrose, J. lI., Au IL. CIIEV.35, 550 (1963). (2124) Steinegger, E., and Gebistorf, J Sei. Pharni. 31 (4), 298 (1963); C . A . 60, 11850h (1964). (2125) Steinegger, E., Sonanini, D. and Tsingnridas, K., Pharm. A c t a Helv. 39 16), 450 (1964),C.d. 61,29049 (1964). (2126) Stekol'nlkov, L. I. and El'piner, I. E., Bmfizzka 10 (2), 232 (1965); C.A. 63, 8127s (1965). (2127) Stenszky, E., Meszaros, G., and LaLar, J., Gyogyszereszet 8, 257 (1964); C . A . 61, 10537g (1964). (2128) Sterba, B. and Kucerova, J., Cesk. FaTrn. 13 (4), 186 (1964), C.A. 61, 13129f (1964). (2129) Steiescu, AI., Mihalca, G. and Stoicescu, I-., Rev. Chzm. (Bucharest) 15 (B), 358 (1964), C.A. 61, 93619 ( 1964). (2130) Sterescu, lI. and Pelloni, V., Ibid., 12, 43 (1961); C.A. 61, 1 5 9 3 5 ~ (1964). (2131) Stevens, H. SI., JPed. Sci. Law 4 (3), 188 (1964); C . A . 61,13130f(1964). (2132) Stevens, H . AI., Proc. Can. SOC. Forenszc Sci. 4, 187 (1965); C.A. 63, 9745h (1965). (2133) Stevens, P. J., J . Chromatog. 14 (2), 269 (1964). ~

~

(2134) Stevens, P. J., Lab. Pract. 13 (4), 306 (1964); C.A. 61,4E831f(1964). (2135) Stevens, S. G. E. and Warren, B . - ’ J . Phurm. Pharsaacol. Suml. .. 16; 32 (1964). (2136) Stoicescu, V., Beral, H . and Ivan, C., Pharm. ZentralhaIle 104 (la), 776 (1965); C.A. 64, 14031b (1966). (2137) Storck, J., Ann. Pharm. Franc. 23 (2), 113 (1965); C.A. 62, 1 5 9 9 1 ~ (1966). (2138) Stowe, H. D., Arch. Biochem. Biophys. 103,42 (1963). (2139) Strack, E. and Kunz, W., 2. Physzo?. Chem. 333, 46 (1964); Anal. Abstr. 11, ,5068 (1964). (2140) Strickland, W.A , Jr., arid Robertson, L., J . Pharm. Scz. 54 (3), 452 (1963). (2141) Strohecker. R.. pharm. Zta.. Ver. ’ Apothekerztg. 109 ‘(14), 508 “(1964); C . A . 60, l5682d (1964). (2142) Struhar, AI., Acta Fac. Bohemoslov. 9, 99 (1964); Int. Pharm. Abstr. 2 1165, (1965). (2143) Struhar, AI., and Hirkova, AI., Farm. Obzor 32 (6), 249 119631: , ,, C.A. 61. 6870c (1964). (2144) Struhar, AT., Mandak, M., and Pobocikova, K., Farm. Obzor 32 (4), 153 (1963), C.A. 61,6862h (1964). (2145) Suchy, J., et al., Cesk. Farm. 12 (2), 107 (1963); C.A. 63, 6794a (1965). (2146) Sucker, H., A d z . Pharm. 297 (9), 543 (1964); C . A . 61, 1 4 4 7 0 ~ (1964). (2147) Sucker, H., Deut. Apotheker-Ztg. 104 (22), 727 (1964); C.A. 61, 14469f (1964). (2148) Ibid., (28), 947 (1964); C.A. 61, 14469g (1964). (2149) Ibid., 131), 1057 (1964); C.A. 61, 15932d (1‘364). (2150) Ibid., (34), 1160 (1964); C.A. 61, 13932e (1‘364). (2151) Ibid., (36), 1220 (1964); C.A. 61, 15933d (1964). (2152) Ibid., (37), 1254 (1964); C.A. 62, lt514f (1965). (2153) Ibid., (40), 1408 (1964); C.A. 62, 3886c (19651. (2154) Sbenaga, E., Murakami, H. and Omae, &I., Yakuzaigaku 24, 63 (1964); C.A. 61, 4157h (1964). (2155) Siigano, Y. and Wakazawa, T., iYippon i~ogezkagakuKaiski38, 1 (1964); Anal. d b s t r . 12, 6683 :1965). (2136) Sugii, A., Dan, ;&I.,and Fujihara, 11.,.Yzppon Daigaku r akugaku Kenkyu H O ~ O5-6, ~ O 13-16 c1963); C.A. 61, 144709 (!?64). (2157) Sugii, A. and Kabasawa, Y., Japan .Analyst, 13, 236 (1964); Anal. i l b s t r . 13, 2625 (1966). (2136) Sugii, A. and Kabasawa, Y., Yakzigaku Zasshi 84 ( l l ) , 1138 (1964); C . A . 62, 314,jc (1963) (2159) Sukhlitskaya, Y. 11.and Belevich, N. A., Aptechn. Delo 12 (a),75 (1963); C.A. 61, 81335 (1964). (2160) Sullivan; G. a n j Brady, L. R., Lloydia 28 (l), 68 (1965); C . A . 63, 8 1 8 0 ~(1965). (2161)vS~imma, A. F., Pharm. Sci. 54 ( 3 ) , 442 (1965). (2162) Summa, A. F., and Graham, J. H., I b i d . , (4),612 (1965). (2163) Sun, F. C., Hua. Hsueh 1963 (4), 141: C.A. 62. 31a 119e5). (2164) Sunshine, f., Ani. j.Clin. Pathol. 40, 576 (1963); Anal. Abstr. 11, 3239 (1964). (2163) Suprun, P. P., Aptechn. Delo 11 ( 3 ) ,34 (1962); C . B . 60 14333f (1964). (2166) Suprun, P. P., Ibid., 13 (2), 36 (1964); C.il. 62,4019 (1965). (2167) Suprun, P. P., Farmatsevt. Zh. (Kiec) 18 (6), 41 (1962); C.A. 61, 2907d (1964). I ,

~

L‘.

(2168) Ibid., 19 (4), 42 (1964); C.A. 64, 328% (1966). (2169) Suprun, P. P., Ibid., 20 (5), 39 (1965); C . A . 6 4 , 7 9 6 8 ~(1966). (2170) Surovi, Z., Ciigandzic, &I. and Blagojevic, Z., Arhiv Farm. (Belgrade) 13 (5-6), 299 (1963); C.A. 60, 1 3 0 9 5 ~ (1964). (2171) Suszko-Purzycka, A., and Trzebny, W., Chem. Anal. (Warsaw) 9 (6), 1103 (1964); C.A. 6 3 , 4 3 1 ~(1965). (2172) Suszko-Purzycka, A., and Trzebny, W.. J . Chroniatoa. 16 (1). 239 (1964). (2173) Suszko-Pnrzycka, A.,and Trzebny, W., Ibid., 17 (l),114 (1965). (2174) Suvorova, T. RI., Materialy I-go (Pervogo) T’seros. S’ezda Farmatsevtov (Jloscow: M e d . ) 1962. 258 (Pub. 1964): C..4. 62, 3145d (1965).‘ (2175) Siizuki, I. and Kato, S., Eisei Shzkenjo Kenkyu Hokoku 12‘0. 81, 51 (1963); C.A. 62, 129815 (1965). (2176) Suzuki, O., L. AI., Bo?. SOC. Quzm. Peru 29 (2), 75 (1963); C.A. 61, 13127g (1964). (2177) Svatek, E., Cesk. Farm. 12, 418 (1963);Anal.dbstr. 1 2 , 312 (1965). (2178) Svatek, E., Ibzd., 14 (S), 420 (1965); C.A. 64, 11029h (1966). (2179) Svatek, E., Capek, A. and Tadra, M., Ibid., 12, 383 (1963); Ana?. Abstr. 1 2 , 307 (1965). (2180) Svatek, E., and Tachek, J., Ibid., (lo), 309 (1963); C.A. 6 1 , 9 3 5 9 ~(1964). (2181) Svendsen, A. B. and Kolboe, T., Medcl. .\-orsk Farm. Selsk. 25, 117 (1963),Anal.Abstr. 11, 5082 (1964). (2182) Svetlaeva, V. 11. and Zhuravlev, S. I’.,Zh. Analit. Khzm. 19 (6), 761 (1064);C.A. 61,813if(1964). (2183) Svinhufvud, G., Ortengren, B. and Jacobsson, S. E., Scand. J . Clin. Lab. Intest., 17 ( 2 ) , 162 (1965)1 9nal. Abstr. 13, 3067 (1966). (2184) Svobodova-Leblova, S., Kostir, J. I’.and Hais, I. AI., J . Chromatog. 14, 451 (1964). (2185) Snagzdib, J. E., and Flanagan, T. L., Anal. Biochem., 7 (2)) 147 (1964). (2186) SSkulska, Z., and Gorzycka, AI., Acta Polon. Pharm. 22 (2), 133 (1965); C.A. 63, 9752c (1963). (2187) Synodinos, E., Kotakis, G., and Kokkoti-Kotaki, E., China. Chronzka 28, 77 (1‘363); Anal. I b s t r . 11, 5596 (1 \ -0641. ---,

(2188) Syper, L., Dissertationes Pharm. 17, 33 (1965): ilnal. Abstr. 13, 3027 (1966). (2189) Syper, L., and Wagner, E., Ibid., 16 (4), ,553 (1964); C . B . 62, 11634c (19651. (2190) Szabolcs, E., Acta Pharm. Hung. 34 (,?), 212 (1964); C . A . 61, 15936e (1964). (2191) Szarras, L., Zurkowska, J., and Ozarow3ki, 11.A, Ann. Pharm. Franc. 23 (9-10), 561 (1965); C.d. 64, 7973d (1966). (2192) Szasz, G., and Fazekas, E., Acta Pharm. Hung. 35 (6), 256 (1965); C.A. 64, 515lb (1966). (2193) Szasz, G., Szasz-Zacsko, ll.,and Polankay, V., I b i d (5), 207 (1965); C.A. 63, 14637s (19s5). (2194) Szasz, G., 1-amos, J., and T-egh, A., l b i d . , (6), 241 (1963); C.A. 64, 4870h (1666). (2193) S7epesy, A., and Placz, I., Gypgysrereszet 8, 245 (1964); C.,i. 61, 10o38b 11064). (2196) Szigetvary, AI., and Kuttel, D., Szoinbathely Gyogyszereszet 6, 51 (1962); C.A. 62. 5141a 11965). (2197) Szilagyi, I., Tal$-Nagy, T., Xature 205 (4977), 1223 (1965). (2196) Sztaricskai, F., and Uri, J., d4ikrochim. Ichnoanal. Acta, 1963, (3), 431;Anal. Abstr. 11, 3329 (1964).

(2199) Szucs, O., Gyogyszereszet 5 , 288 (1961); C.A. 62,399d (1965). (2200) Szulczewski, D. A., Shearer, C. M.. and Aguiar, A. J., J . ‘Pharm. ‘Sci. 53 (lo), 1156 (1964). (2201) Tagi-Zade, S. B., Lab. Delo 1964 (4),222; C.A. 61,4152h (1964). (2202) Takacsi-Nagy, G., and Balkav, A., Gyogyszereszet 9 (5), 190 (1965”); C.A. 63, 112605 (1965). (2203) Takahashi, K.. RIizumachi. S.. and Asahina, H:, Eisei Shikenjo Kinky; Hokoku 11-0. 81, 23 (1963); C.A. 62, 8936c (19651. (2204) Takahashi, T., Ann. Rept. Shionogi Res. Lab. 15, 152, 1965; Int. Pharm. Abstr. 3, 608d (1966). (2205) Takahashi, T., Yakugaku Zasshi 85 (9), 804 (1968); C.A. 63, 178029 (1965). (2206) Takebe, T., and Uzuks, &I., Tokyo Yakka Daigaku Kenkyu iYempo 13,59 (1963); C.A. 61,14472~(1964). (2207) Takeda, K., Hara, S.,Wada, A., and hlatsumoto, N., J . Chromatog. 11, 562 (1963). (2208) Takeuchi, AI., Chsm. Pharm. Bull. (Tokyo) 11, 1183 (1963); Anal. Abstr. 11, 5069 (1965). (2209) Talmage, J. M.,Penner, AI. H., and Geller, AT., J . Pharm. Scz. 54 (8), 1194 (1965). (2210) Tamura, Z., and Imanari, T., Chem. Pharm. Bull. ( T o k y o ) 12, 1386 (1964);Anal. Abstr. 13, 1403 (1966). (2211) Tan, Y. L. and Cole, D. R., Clin. Chem. 11, 58 (1965). (2212) Tanaka, I., Otani, S., Nakayashiki, J., and Fujita, S., Yakuzaigaku 24 (4), 303 (1964); C.A. 6 3 , 1 6 6 4 ~(1965). (2213) Tanay, I., J i a g y . Kem. Folyoirat, 69, 226 (1963); Anal. Abstr. 11, 4476 (1964). (2214) Tanker, >I., Istanbul Unzv. Tip Fak. Mecnauasi 26 (l),26 (1963); C.A. 61, 5437h (1964). (2213) Tarasova, ?VI. G., J i a f e r i a l y 1-go (Pemoyo) Vsesros. S’ezda Farmatsectov X o s c o w : Jledztsina Sb. 1962, 210 (Pub. 19G4), C.A. 62,13992~(1965). (2216) Tarasova, AI. G., Tr. Leningr. Khim.-Farmatsett. Inst. &Yo. 14, 41 (1962); C.A. 61, I Eisdorfer, ., I. B., Thompson, W. E., and Zarembo, J. E., J . Pharm. Sci. 55 (2), 144 (1966). (2414) Wartmann-Hafner, F., and Buechi, J., Pharm. Acta Helv. 40 (11), 592 (1965); C . A . 64, 3286d (1966). (2415) Wasiak, H., Acta Polon. Pharm. 21 (3), 297 (1964); C.A. 62, 11627h (1965). VOL. 39, NO. 5, APRIL 1967

237 R

(2416) Wasiak, H., Ibid., 22 (2), 141 (1965); C.A. 63,97529 (1965). (2417) Wasiak, H., Farm. Polska 16, 71 (1961); C.A. 60, 13100f (1964). 124:s) Wasickv, R.. Rev. Fac. Farm. Bioquim., cniv. duo Paulo 1 (l), 69 (1963); C.A. 61, l709e (1964). (2419) Ibid., 135 (1963); Anal. Abstr. 11, 4047 (1964). (2420) Wassermann, L., and Hanus, H., iVaturwissenschaften 50, 351 (1963); Anal. Abstr. 11,2186 (1964). (2421) Watanabe, H., J . Chem. Soc. Japan, Pure Chem. Sect., 83 (l), 51 (1962); Anal. Abstr. 12, 2990 (1965). (2422) Wayland, L., and Reiss, P. J., J . Assoc. Ojic. Agr. Chemists 48 (5), 965 (1965). (2423) Wegen, P. A. van der, Pharm. Weekblud 99 (22), 592 (1964); C.A. 61, 11850d (1964). (2424) Wegen, P. A. van der, Ibid., 100 (17), 555 (1965); C.A. 63, 5451a (1965). (2425) Wehrli, A . , Can. Pharmaceut. J . Sei. Sect. 97 ( 5 ) , 208 (1964); C.A. 61, 8135g (1964). (2426) Weichsel, H., Xikrochim. Ichnoanalyt. Seta. 1965, (2), 325; Anal. Abstr. 13, 3165 (1966). (2427) Weiner, N. D., and Felmeister, A , . ASAL.CHEM.38. 513 11966). ~ - - , (2428) Weiriatein, B., k i d Fenselau, A. H., J . Chromatog. 15, 149 (1964). (2429) Welsh, L. H., and Summa, A. F. J . Assoc. Ofic. d g r . Chemists 47 (3), 476 (1964). (2430) Weiidlandt, IT. W.,and Hoiberg, J. A., Anal. Chim. Acta 29, 539 (1963); Anal. Abstr. 12, 740 (1965). (2431) Westerink, D., and Glerum, J. H., Pharm. IYeekblud. 99, 657 (1964); Anal. Abstr. 12, 5978 (1965). (2432) Wettig, K., Gigiena i Sanit. 20 (12), 56 (1964); C.A. 62, 97549 (1965). (2433) TVhittet, T. D., Am. J . Hosp. Pharm. 21, 438 (1964). (2434) Whittet, T. D., and Robinson, A. E., Pharm. J . 193 (5254), 39 (1964). (243.5) Wilczynska, I., d c t a Polon. Pharm. 22 ( l ) , 89 (1965); C.A. 63, 8121c ( 1965). (2436) Rilkie. J. B.. ANAL. CHEM. 36. ' 896 11964).' (2437) 'Wilkinson, S., and Lowe, L. A,, J . Chem. Soc. 1964,4107. (2438) Williams, A. D., lleister, L., Faircloth, >I., and Florsheim, W. H., J . Phaim. Sci. 53 (11) 1415 (1964). (2439) JVilliams, H., J . Pharm. Pharmacol. Suppl. 16, 166 (1964). (2440) Wills, P. A,, Australasian J . Pharm. 44 (521) S50 (1963); C.A. 61, 538f (1964). (2441) Rimer, 1).C., Encycl. Ind. Chem. Anal. 1 , 30 (1966). (2442) Wimer, D. C., Theivagt, J. G., and Pawendick. Y. E.. ANAL. CHEM. \

(24433 \i7indheuser, 'J. J., Higuchi, T., J . Pharm. Sei. 52, 557 (1963). (2444) Winefordner, J. D., and Tin, AI., Anal. Chim. Acta 31 (3). 239 (1964): C . A . 61, 13130b (1964). ' (2445) m'inefordner, J. D., and Tin, AI., Z b z d , 32, 64 (1965); Anal. Abstr. 13, 2515 (1966). (2446) Winkler, E., Szabo, J., Varga, I., and Gaizer, F., Acta Pharm. Hung. 34 ( 3 ) , 103 (1964); C.A. 61, 54605 (1964). (2447) Wiseman, E. H., Chiaini, J., and Finson, E. R. Jr., J . Pharm. Scz. 53, 166 (1964). (2448) Wisniewski, W., Furmanczyk, Z., and Olszemka, T., Acta Polon. Pharm. 22 (G), 505 (1965); C.A. 64, 17358b (1966). (2449) Wisniewski, W.,and Golucki, Z., Farm. Pokka 21 (15-16), 557 (1965); C.A. 64, 3289a (1966).

238 R


(2450) Wisniewski, W., Jablonski, S., hlachala, K., and Szelagowska, M., Acta Polon. Pharm. 20 (l), 35 (1963); C.A. 61, 9 3 5 3 (1964). (2451) Winniewski, W., and Jablonski. S.. Ibid.. 22 (3). 243 (1965). C I A Farm. Polska 20 (19-20)

21 (I), 41 (1964j; C.A. 62, 12981e

(196,;). (2434) Ibid., (6), 489 (1964); C.A. 62, 10294h (1965). (2455) Wolf, L., and Karacsony, E. M., Plantahfed. 11 (4), 432 (1963); C.A. 61, 2094h (1964). (2456) R o o , C. H., Yakhak Hoeji 7 (2/3), 51 (1963); C.A. 62, 10297d (1965). (2457) Wrightman, K . B., and Holl., W. W., Ann. N. Y. Acad. Sei. 130 (2). . 516 (1965). (2458) Wysocka, B., Dissertationes Pharm. 17, 99 (1965); Anal. Abstr. 13, 3181 (1966). (2459) Yablochkin, 1'. D., Szidebno-Med. Ekspertiza, 6 ( 3 ) , 45 (1963) Ref. Zhur., Khim. 190DE, 1964; Anal. Abstr. 12, 1285 (1965). (2460) Yamaguchi, K., Oba, T., and Ito, H., Eisei Shikensho Hokoku N o . 80, 22 (1962); C.A. 61, 6535e (1964). (2461) Yamakawa, T., Kinumaki, T., Sugii, K., and Higashi, H., Tokaiku Suisan Kenkyusho Kenkyu Hokoku N o . 41 (Jan.), 33 (1965); C.A. 63, 11254h (1965). (2462) Yamnmoto, R., and Yamamoto, E., Yakuzaz'gakzi 24 (4), 309 (1964); C.A. 63, 1663e (1965). (2463) Yamamoto, R., and Yamamoto, E., Zbid., 25 (l), 42 (1965); C.A. 63, l7803e (1963). (2464) Yamana, T., et. al., Yakugaku Zasshi 84 (lo), 971 (1964); C.A. 62, 2 6 7 3 (1965). (2465) Yamana, T., and RIizukami, Y., IbCd., 85, 1057 (1965); C.A. 64, 6412d \ - - - - ,

I ,

(\ -1966 ). - - - /

(2466) .Yamana, T., i\Iizukami, Y., and Asahi, S.,Zbid., 84, (8), 696 (1964); C.A . 61, 13132f (1964). (2467) Ibid., 699 (1964); C.A. 61, 13132f i1964 ). (2468) Yamana, T., Mizukami, Y., and Ichimura, F., Ibid., 85 ( 7 ) , 6.54 (1965); C .1. 63, 11239h (1965). (2469) Yamaqhiro,. D.,, A'ature 201. 76 (1964). (2470) Yampol'skaya, &I.hl., Farmatsevt. Zh. (Kiev) 19 (6), 31 (1964); C.A. 64, 7969a 11966). (2471) uYanotovskii, R4. Ts., Zh. Analit. Khzm. 19 (2), 262 (1964); C.A. 60, 14336b (1964). (2472) Yao, K., and Chen, H., Hua Hsueh Tung Pao 1964 (5), 302; C.A. 61, 1130.3 (1964). (2473) Yashchenko, D. Y.,Farmatsevt. Zh. (Kiev) 18 (4), 46 (1963); C.A. 61, 1710e (1964). (2474) Yashchenko, D. 5'., Zbid., 20 (l), 42 (1965); C.A. 64,7972a (1966). (2475) Yaskina, D. S., and Hien, N. B., Aptechn. Delo 13 ( l ) , 69 (1964); C.A. 61, 9361a (1964). (2476) Yaskina, D. S., and Nguyen-Bah, H.. Zbzd.. 12 (1). 76 (1963): C.A. 61. 13131f(lb64). (2477) Yatabe. AI.. and Oki. H.. Kaoaku ' Keisatsu Kenkyhsho HoLoku ' 17 " (2), 167 (1964); C.A. 61, 15933f (1964). (2478) Yavors'kii, M. P., Aptechn. Delo 1 1 (2), 47 (1962); C.A. 60, 14334a (1964). (2479) Yavorskii, N. P., Aptechn. Delo 12 (Z), 56 (1963); C.A. 61, 8134e (1964). ~

\ - - - - I

I,

~

(2480) Yavorskii, N. P., Ibid., 13 (l), 81 (1964); C.A. 61,8126h (1964). (2481) Yavors'kii. N. P.. Farmatsevt. Zh.' (Kiev) 19 (i), 65 (1964); C.A. 61, 9361e 11964). (2482) Yavors'kii, N. P., Ibid., 20 ( l ) , 29 (1965); C.A. 6 4 , 7 9 7 1 (1966). ~ (2483) Zbid., (2), 22 (1965); C.A. 64, 79729 (1966). (2484) Yavors'kii, N. P., Babich, E. M., and Koren'kova, E. P., Ibid., 19 (4), 29 (1964); C.A. 64, 3287h (1966). (2485) Yavorskii. N. P.. and Fedusiv. ' RI.'hI.,Ibid., '18 (4), 34 (1963); C.A: 61, l708h (19f"). (2486) Yavorskii, N. P., Koval, 5'. S., and Starushchenko, hl. &I., Ibid., 20 (5), 31 (1965); C.A. 64,9512e (1966). (2487) Yavors'kii, N. P., and Starushchenko, 5'.I., Zbid., (3),28 (1965); C.A. 64, 1903c (1966). (2488) Yeargers, E., and Augenstein, L., J . Invest. Dermatol. 44, 181 (1965). (2489) Yoshida, D., and Mitake, T., Radioisotopes (Tokyo) 14 (6), 514 (1965); C.A. 64, 9512b (1966). (2490) Yurkevich, A. AI., Borodulina, 5'. I.. and Preobrazhenskii. N. A.. Zh. Obshbh. Khim. 35 (l),85 (1965); 'C.A. 62. 1.1223 - - - - - - (196.5). (2491) Zabrak, E., and Farkas, S.,Acta Pharm. Hung. 34 ( 5 ) , 207 (1964); C.A. 61, 159369 (1964). (2492) Zacek. H.. Pharmazie 18, 766 ' (1963); C.-A. 62; 12984h (1965). . (2493) Zadiraka, Y.Y., and Kurinna, N. V.. Formntswt. Zh. (Kiev) 19 13). 66 (1964); C.A. 64, 3286c j1966) (24!34) Zaduminski, AI., Wasilewska, I., Krowczynski, L., and Krepska, H., Acta Polon. Pharm. 20 (3), . . 399 (1963); . .. C.A. 62,404e (1965). (2495) Zafir, >I., Folia Pharm. (Istanbul) 5 (6), 704 (1965); C.A. 64, 3286c (1966). (2496) Zaidi, S. A. H., Husain, S. A., and blahdihassan, S., ArzneimitteG Porsch. 15 (6), 636 (1965); C.A. 63, 11257s (1965). (2497) Zaitsev, V. A., Aptechn. D e b 11 (4), 53 (1962); C.A. 61, 14465d (1964). (2498) Zaitsev, 5'. A Ibid., 12 (4), 45 (1963); C.A. 61, 1lkjOf (1964). (2499) Zaitsev, T. A. and Zorin, E. B., Zbid., 13 (3), 31 (1964); C.A. 61, 13129h (1964). (2500) Zaki, S. A., Mangoiiri, H. A., and AIachu, W.,Egyptian Pharm. Bull. 44, 257 (1962); C.A. 64, 1 2 4 6 3 (1966). (2501) Zarandi, A., Acta Pharm. Hung. 35, 34 (1965); Anal. Abstr. 13, 2612 (1966). (2502) Zarnack, J., Pharm. Praxis, Bed. Pharmazie 1965 (7), 163; C.A. 63, 146379 (965). (2503) Zarnack, J., and Pfeifer, S., Pharmazie 19 (3), 216 (1964); C.A. 60, lfi6ROe 11964). __._.. -, (2504) Zatula, E. I., and Bugrim, N. A., Jfed. Prom. SSSR 18 (12), 35 (1964); C . A . 62, 8944g (1965). (2503) Zelikson, Y. I., Aptechn. Delo 10 13). 68 11961): C.A. 60. 14336h (1964). (2g06) Zelikson,' Y. I., I&., 13 ( 3 ) , 42 (1964); C.A. 61, 8131a (1964). (2507) Zhantalai, B. P., Biokhimiya 29 (6), 1009 (1964); C.A. 62, 7590c (l96j). (2508) Zheltovskii, L. K., and Spirina, 31,S., Aptechn. D e b 14 (6), 70 (1965); C.A. 64, 9511a (1966). (2509) Zielinska-Sowicka, R., Szymanska, &I.,and Brancewicz, K., Dissertationes Pharm. 15 131, 313 (1963); C.A. 61, 29038 (1964). (2510) Zielinska-Sowicka, R., and Wojcik, E.. Ibzd.. 17 14). 555 11965): C.A. 64. 17355g (1966): (2511) Zimnukhov, T. Y.,Sudebnomed Ekspertiza, 1963, (2), 46 Ref. Zhur., Khim., 19GDE 1964 (2), Abstr. No. 20242; Anal. Abstr. 11, 5696 (1964). \ - - - - ,

--I

\

\ - -

~

"

1

,

I,

(2512) Zinser, hI., and Baumgaertel, C., Arch. Pharm. 297 (3), 158 (1964); C.A. 60, 13095f(1964). (2513) Zivanov, D., Blagojevic, Z., and Pllladenovic, M., Arh ‘v Farm. (Belgrade) 14 (5), 273 (1964); C.~1.62,2671h(1965). (2514) Zollner-Ivan, IC., Acta Pharm. Huna. 34 (2). 49 (1964): C.A. 61. 29119 (1964).” (2515) Zbid., (4), 145 (1964); C.A. 61, 15937h (1964). (2516) Zommer, S., and Lipiec, T., Chemia Anal. (R’arstcw) 9, 871 (1964); C.A. 62, 46058 (1965).

(2517) Zorin, E. B., Sb. Nauchn. Tr., Tsentr. Aptechn. A’auchn.-Zssled. Znst. 3 , 129 (1962); C.A. 61 , 1710h (1964). (2518) Zugaza, A., and Hidalgo, A., Rev. Real Acad. Cienc. Exact., Fis. iYat. Madrid 59, 221 (1965); C.A. 64, 6450g (1966). (2519) Zurkowska. J.. Budzvnska. &I.. and Ozarowski, A., Acta Pdon. Pharm: 20 (2), 109 (1963); C.A. 62, 1513e (1965). (2520) Zurkowska, J., Lukaszewski, IT., and Oearowski, A,, Ibid., 115 (1963); C.A. 62, l513e (1965).

(2521) Zurkowska, J., and Ozarowski, A., Zbid., 22 (I), 83 (1965); C.A. 63, 1 1 6 8 3 (1965). (2522) Zurkowska, J., and Ozarowski, A., PlantaMed. 12 ( 2 ) , 222 (1964); C.A. 61, 14469e (1964). (2523) Zurkowski, P., Clin. Chem. 10, 451 11964). (2524)‘ Zw&-zchowski, Z., Acta Polan. Pharm. 20 ( 5 ) , 383 (1963); C.A. 62, l518d (1965). (2525) Zwimpfer, G., and Buechi, J., Pharm. Acta Helv. 39 (4/5), 327 (1964); C.A. 61, 415lb (1964).

Rubber Coe W. Wadelin and Gordon S. Trick, Research Division, The Goodyear Tire and Rubber Co., Akron, Ohio

T

covers characterization and chemical analysis of rubber. While many methods, such as pyrolysis followed by gas chromatography, are appropriate for both rubbers and plastics, they are includei here only when they have been applied to rubber. There are a few exceptions to this rule where the references are particularly interesting or may be obviously extended t o rubber. hlethods for the identification or determination of rubber and materials in rubber ,are included, b u t methods for the analysis of rubber chemicals before they are added to rubber are omitted. The literature on chemical analysis which became availahle to the authors between September 1064, the end of the period covered by the last review in this series (222), and September 1966, is covered. In a few cmes, articles cited in the previous review have been repeated because they have now been translated into Englisi (29, 70, 7 8 ) . I n the section on polymer characterization by physical methods, a longer period of time is covered. Literature searching was done by the mechanized information retrieval center operated by the University of Akron under contract with the Division of Rubber Chemistry (of the American Chemical Society (67’) The abbreviations recommended in ASThl Designation D1418-65 have again been used (9). They are listed in Table I. HIS REVIEW

GENERAL 1NFC)RMATION

Working Group A of Technical Committee 45 of the International Organization for Standardization is compiling methods for analysis of rubber and rubber products which are involved in international trade. Recent progress toward agreement on methods for determination of e x t r w t , ash, carbon

black, zinc oxide, copper, manganese, and iron was reported (167). il survey of polymer analysis was published in “Encyclopedia of Polymer Science and Technology” (84). Information on analysis can also be found in the article about the polymer of interest. Haslam and J17illisJbook deals with analysis of plastics b u t much of i t is also applicable to rubber (95). h compilation of physical constants of rubbers has been published (254). POLYMER IDENTIFICATION

Pyrolysis-Gas Chromatography. Differences of opinion a b o u t t h e most desirable conditions for pyrolysis continue to be reported. A s t u d y of pyrolysis techniques indicated t h a t the fragments recombine if they are permitted to cool before being injected into the gas chromatograph (79). The method t h a t seems to be least sensitive to experimental conditions is pyrolysis of a small sample a t high temperature so t h a t very rapid fragmentation to monomer occurs. Some workers found t h a t temperatures above 500’ C cause monomers to crack further, thereby destroying the characteristic featurks of the gas chromatogram (128). However, other investigators found t h a t monomers are stable a t 1050’ C and concluded that i t is the best temperature (65). It was pointed out that rapid removal of the initial breakdown products from the pyrolysis zone is necessary to prevent secondary fragmentation (203). Differences in this feature may be the reason for different viewpoints on optimum temperature. Most of the pyrolysis is done thermally. I n addition to pyrolysis, there were preliminary reports on two other methods, electric discharge (205) and oxidative degradation (193). Neither of these has been thoroughly explored. If the column effluent is split and then simultaneously examined b y flame ioni-

443 7 6

zation and electron capture detectors, some surprising identifications can be made (55). For instance, emulsion SBR can be distinguished from solution SBR and IR can be distinguished from KR. Rubbers containing chlorine, nitrogen, sulfur, or oxygen have much more electron capture response than hydrocarbon rubbers. Gas chroniatography is more sensitive than infrared for detecting small amounts. This is useful for I I R (79). Any method which uses pyrolysis as the initial step is unable to distinguish cis-trans structures in the original sample (55, 7‘9). Therefore pyrolysisgas chromatography cannot completely supplant infrared examination of the unpyrolyzed sample. The ability to distinguish mixtures of polystyrene and polyacrylonitrile from styrene-acrylonitrile copolymers was reported (138). The chromatograms of many polymers were reported (33, 144). The pyrolysis products of SBR, BR, I R , and E P M were identified (239). Infrared. T h e long used Dinsmore a n d Smith method for degrading polymers by refluxing in lJ2-dichloro-

Table I. Abbreviations Recommended by ASTM (9) BR Butadiene rubber IR Isoprene rubber, synthetic CR Chloroprene rubber KR Isoprene rubber, natural IIR Isobutylene-isoprene rubber NBR Nitrile- butadiene rubber SBR Styrene-butadiene rrtbber T8i Silicone elastomers having both methyl and vinyl containing groups on the polymer chain 111 Polyisobutylene EPM Ethylene-propylene copolymer EPDM Terpolymer of ethylene, propylene, and a diene with the residual unsaturated portion of the diene in the side chain CSM Chloro-sulfonyl-polyethylene

VOL. 39, NO. 5, APRIL 1967

239 R

Pharmaceuticals and related drugs - Analytical Chemistry (ACS

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