ANALYTICAL CHEMISTRY, VOL 51, NO 5, APRIL 1979
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Pharmaceuticals and Related Drugs R. K. Gilpin Department of Chemistry, Kent State University, Kent, Ohio 44242
This review surveys pharmaceutical analysis and related methodology that has appeared in Anal.~ticalAbstracts (AA) or Chemical Abstracts ( C A ) from June 1976 to June 1978. Although in excess of 1800 entries have been cited, these cover only about 25 to 30% of the work reported during the time period of the review. An attempt has been made to report only those references which have appeared to be significant and have been published in easily accessible journals. T h e review has been divided into 11 major sections: General, Alkaloids, Antibiotics, Inorganics, Nitrogen- and Oxygen-Containing Compounds, Steroids, Sulfur Containing Compounds, Vitamins, Formulations and Mixtures, Techniques, and Miscellaneous. Most of the major sections have been divided further into subsections. The arrangement of the major sections is discussed below. T h e percent listed following each section title is the relative number of cited articles in that division. Each reported citation contains the complete title in English as provided by either A A or CA. For papers appearing in languages other than English, translated titles (AA or C A ) have been listed. Because of the large number of references cited, the titles are considered part o f t h e text and must be scanned t o obtain the full value of the review. General (2.0%). The section is arranged in alphabetical order by author. Alkaloids (10.3% ). The section is divided into nine major subdivisions, which are arranged in alphabetical order by alkaloid class. Within each subdivision. the individual compounds studied are alphabetized. Antibiotics (12.1 % ), T h e ten major subdivisions based on compound type are arranged alphabetically by author, except, iMiscellaneous, which is arranged alphabetically by compound. Inorganics ( 3 . 3 7 ~ ) .This section is subdivided into four parts. The single element analysis and radiopharmaceutical categories are arranged alphabetically by element. The multielement analysis and miscellaneous subsections are arranged alphabetically by author. Nitrogen- and Oxygen-Containing Compounds (40.1 7:). The section is arranged alphabetically by technique. Entries under each technique are in alphabetical order by author. Steroids (5.6% ). See Nitrogen- and Oxygen-Containing Compounds ( N - 0 ) . Sulfur (5.9%). See N--0. Vitamins ( 6 . 4 7 ~ ) .See N--0. Formulations and Mixtures ( 3 . 6 7 ~ ) .This section is arranged alphabetically by author. Techniques ( 9 . 1 7 ~ ) .See N-0. Miscellaneous ( 1 . 6 7 ~). This section is arranged alphabetically by author, BIBLIOGRAPHY GENERAL (1) "British Pharmacopoeia 1973-Addendum
1977"; Her Maiestv's . . Stationem Office: London, 1977, p 90. (2) "The European Pharmacopoeia"; Status as of April 1977 Auterhoff, H. D t S C h . ADOth.-ZtQ. 1977. 777(14). 489-491. (3). Compendium o i therapeutic and toxic concentrations of toxicologically significant drugs in human biofluids. Baselt, Randall C ; Cravey. Robert H. J . Anal. Toxicol. 1977, 7(2), 81-103. (4) "Practical Pharmaceutical Chemistry", 3rd ed.. Part 2, ' Physical Methods of Analysis"; Beckett. A. H.; Stenlake, J. B.; Athlone Press: University of London, 1976, p 552. ( 5 ) "Anaylsis of Drugs of Abuse": Berman, Eleanor; Heyden & Son: London, 1977, p 80. ( 6 ) Analytical approach to quantitation of known drugs in human biological samples by high-performance liquid chromatography. Bye, Alan; Brown, M. E. J . Chromatogr. Sci. 1977, 75(9). 365-371 (7) Chemical analysis in the pharmacy - necessity and possibilities Cohen, E. H. Pharm. Weekbl. 1977, 772(25). 605-613. 0003-2700/79/0351-257R$05 0010
Roger K. Gilpin is Assistant Professor of Chemistry at Kent State Unbersity. He received his B.S. degree in Chemistry from Indiana State University in 1969 and his Ph.D. degree in Analytical Chemistry from the University of Arizona in 1973. From 1973 to 1975 he was employed as Senior Scientist and from 1975 to 1978 as Group Leader of Analytical Chemistry in the Research Division of McNeil Laboratories. Dr. Gilpin's research interests are in fundamental and applied gas, liquid and thin-byer chromatography and pharmaceutical analysis. He has published in the areas of organometallic surface reactions, the application of aas and hiah Dressure liouid chromatography in pharGaceutical analysis and the development of chemically modified stationary phases for TLC, GC and HPLC use Before leaving the Philadelphia area he served as Executrve Committeeman for the Delaware Valley Chromatography Forum and Executrve Officer for the Analytical Chemistry Group He is also a member of The American Chemical Society
18) "The Quality Control of Medicines"; Deasy, P. B.; Timoney. R. F., Ed; Elsevier Scientific: Amsterdam, 1976, p 398. (9) "Handbook of Drug Analysis"; Ebel, S.: Verlag Chemie: Weinheim, Germany, 1977, 417 pp, (10) Prog. Med. Chem. 1977, 7 4 , 308. (1 1) [Analysis in] clinical chemistry. Evenson, Merle A. Anal. Chem. 1977, 49(5).16R-34R. (12) Current aspects of pharmaceutical analysis. Fairbrother. J. E Pharm. J , 1977, 279(5938). 291-293. (13) Current aspects of pharmaceutical analysis. Fairbrother, J. E. Pharm. J , 1977, 219(5951), 573-576. (14) Analvsis of druas in the solid state. Florence, A Pract. Pharm. Chem , 3rd ed: 1976, 2,-41-74. (15) "Analytjcal Profiles of Drug Substances". Vol. 6; Fiorey, Kbus. Ed.: Academic: New York, 1977. (16) "The Quantitative Analysis of Drugs", 3rd ed.; Garratt. Donald Clarence et al.; Chapman and Hall: London, England, 1976, 925 pp. (17) Toxicology: quantitative aspects. Horncastle, D C J. Med. Sci. Law 1977, 77(1) 37-52. (18) Saliva in therapeutic drug monitoring. Horning. Marjorie G.: Brown, Linda; Nowlin, Jean; Lertratanangkoon, Khing; Kellaway. Peter: Zion. Thomas E. Clin. Chem. ( Winsfon-Salem, N C . ) 1977, 23(2), 157-164. (19) Variabilty of AOAC methods of analysis as used in analytical pharmaceutical chemistry. Horwitz, William J Assoc. O f f . Anal Chem. 1977, 60(6), 1355-1 363. (20) Drug testing in pharmaceutical laboratories. Huenerbein. H.; Kiefer, S. K.; Schmail, H. Pharm. Ztg. 1978. 723(3), 105-107. (21) [Analysis of] pharmaceuticals and related drugs. Janicki. Casimir A,; Giipin. Roger K.: Moyer, Ernest S.; Almond, Harold R., j r . ; Ehrlich. Ronald H Anal. Chem. 1977, 4 9 ( 5 ) , llOR-133R (22) "Jenkins Quantitative Pharmaceutical Chemistry". 7th ed.. Jenkins, Glen Liewellyn; Knevel, Adelbert M.; DiGangi. Frank E. McGraw-Hill: New York, 1977, 518 pp. (23) Guide to urine testing in drug abuse prevention and multi-modality treatment programmes. Kaistha, K. K. J , Chromatogr. 1977. 74 7(2), Chromatogr. Rev 1977. 27(2), 145-196. (24) Drugs and drug analysis according to the Pharmacopeia European 111. Mechler, E. Dtsch. Apoth.-Ztg. 1977, 7 77(26), 1024-1029 (25) Comparative determination of volatile oils in drugs according to the European and German pharmacopeias. Mechier. E ; Kovar. K. A Dtsch Apoth. Ztg. 1977, 777(26), 1019-1023. (26) Automatization of drug testing. Legal consequences and personal experiences. Messerschmidt, Wolfgang Krankenhaus- Apotheke 1976, 26(2). 9-12; published in Dtsch. Apoth -Ztg. 776(28). (27) The stability of pharmaceuticals. Nielsen, Lis Smed Oesterr Apoth.-Zfg. 1977. 37(47). 943-946. (28) Drug analysis-guarantee of drug safety. Oelschlaeger. Herbert Pharm. Zfg. 1977, 722(22). 905-91 1 (29) Comparison of assay methods of the D.A B VI1 and the European Pharmacopoeia. I . Barbiturates. Otto, H.-H ; Mrosek, S.: Weber, I . Dtsche. Apofh-Zfg. 1976, 776(46), 1785-1787 (30) Quality of me anawical methods and regulatory standards for drugs. Pesez, M. Acta Pharm. Techno/., Suppl. 1976, 2, 73-86. (31) "Organic Analysis with Special Regard to Drugs' ; Pohlovdek-Fabini, Roland; Beyrich, Theodor; Akad Verlagsges: Leipzig. East Germany, 1975, 608 pp. (32) "Assay of Drugs and other Trace Compounds in Biologicai Fluids"; Reid, Eric, Ed.; North-Holland: Amsterdam, 1976, 254 pp. (33) "Pharmaceutical Analysis"; Roth, Hermann J : Blaschke, Gottfried. Thieme: Stuttgart, Germany, 1978, 444 pp. 1979 American Chemical Society
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(34) "Handbook of Pharmaceutical and Clinical Measurement and Analysis": Thomas, Harry Elliot Reston Publishing Co.: Reston, Va.. 1977, 320 pp. (35) "Practical Clinical Biochemistry, Voi. 11. Hormones, Vitamins. Drugs and Poisons", 5th ed.; Varley, Harold; Gowenlock, Alan H : Bell, Maurice: Williarll Heinemann Medical Books: London, 1976, p 402. (36) "Martindale--The Extra Pharmacopoeia". 27th ed.: Wade. Ainley, Ed.: The Pharmaceutical Society of Great Britain, The Pharmaceutical Press. London. 1977, p 2077. (37) Tabulation of therapeutic, toxic and lethal concentratiorls of drugs and chemicals in blood Winek, Charles L. Clin. Chenr. [ Winstori-Saleni. N.C.) 1976, 22(6), 832-836.
ALKALOlDS
General (1A) Citric acid-acetic anhydride reagent for determining some alkaloids and organic bases. Beltagy, Y . A. Pharmazie 1976, 37(7), 483-484. (2A) Value of tetraphenylborate(lI1) complexes in the identification of alkaloids and other organic bases in pharmaceuticals by infrared spectroscopy. Casy. A. F. Proc. Anal. Div. Chem. SOC.1977, 74(10), 292-294. (3A) Comparison of stability-indicating assay methods: ultraviolet, high-pressure liquid chromatography and acid dye [procedures]. Das Gupta. V.; Shek, 0. H. Am. J . Hosp. Pharm. 1976, 33(10), 1086-1088. (4A) Liquid chromatography of dansyl derivatives of some alkaloids and the application to the analysis of pharmaceuticals. Frei, R. W.: Santi, W.; Thomas. M. J . Chromatogr. 1976, 116(2), 365-377. (5A) Recovery of alkaloids after their location on thin-layer chromatograms Holdstock. Thelma M.; Stevens, H. M. Forensic Sci. 1975, 6(3). 187-195. (6A) Thin-layer chromatography of steroidal aikalokls. Hunter, lwing R.; Walden. Mayo K.; Wagner, Joseph R.; Heftmann, Erich. J. J. Chromatcgr. 1976. 7 18(2), 259-262. (7A) Alkaloids in whole plant material: direct analysis by kinetic energy spectrometry. Kondrat, R. W.: Cooks, R. G.; McLaughlin. J L. Science 1978, 199(4332). 978-980. (8A) Combined thin-layer and gas-chromatographic detection procedures for basic materials with a nitrogen-selective flame ionization detector I1 Alkaloids and synthetic morphine derivatives [and tranquilizers], Kroeger, H.; Bohn, G.; Ruecker, Gerhard Dtsch. Apoth.-Ztg., 1977, 117(46). 1923-1925. (9A) Chromatographic behaviour of alkaloids on thin layers of cation exchangers. 11. Alginic acid, Rexyn 102, Dowex 50-X4, and CMCNa [sodium carboxvmethvlcellulosel. LeDri. L.: Desideri. P. G.: Leoori. M. J . Chromatoar. 1976. 1 2 3 ( l j , 175-184. ' (10A) Chromatographic behaviour of alkaloids on thin layers of aniori and cation exchanoers. I . lBioRad1 AG 1-X4 and Cellex-D IDEAE-cellulnsel. LeDri. L.: DesGeri, P. G.: Lepori. M. J . Chronfatogr. i976, 776(1), 131-140. (1 1A) New polarimetric measurement possibilities and results according to the European Pharmacopoeia, Messerschmidt, Wolfgang Dtsch Apoth -Ztg 1977, 117(12). (12A) New methods of separation, and behavior of alkaloids during [thin-layer] chromatography on unmodified silica gel in very polar neutral or acidic media I . Munier, R . L.; Drapier, A. M. Chromatographia 1977, 70(5), 226-232. (13A) New methods of separation, and behavior of alkaloids on unmodified silica gel in very polar, neutral or acidic solvents. 11. Munier, R . L.; Drapier, A. M. Chromatographia 1977, 70(6), 290-297. (14A) Comparison of assay methods of the D.A.B. VI1 and the European Pharmacopoeia. 11. Alkaloids and analogous nitrogen compounds. Otto, Hans-Hartwig; Rossbach. Dieter: Rohde, Guenter Dtsch. Apoth -Ztg. 1977, 177(12). 418-421. (15A) Chromatography of alkaloids on titanium arsenate papers and quantitative separation of some alkaloids from nicotine on titanium arsenate coiumris. Qureshi, Mohsin; Nabi, Syed Ashfaq; Zehra, Nighat. Talanta 1976, 23111. 31-34. (16A) High-speed ion-pair partition chromatogra hy in pharmaceutical analysis. [Separation of ergot and tropane alka1oids.j) Santi, W.; Huen, J. M : Frei, R . W. J . Chrornatogr. 1975, 115(2). 423-436. (17A) Use of x-acceptors for detection of aikaloids on thin layers Ruecker, G.: Taha, A. J . Chromatogr. 1977. 132(1), 165-167. (18A) Analysis of alkaloid mixtures by charge-transfer complexation. Taha. Aly M.; Gomaa, Camelia S J . Pharm. Sci. 1976, 65(7), 986-991. (19A) Spectrophotometric analysis of alkaloids with picrolonic acid. Taha, Aly M.; Gomaa. Camelia S . J . Assoc. Off. Anal. Chem. 1976. 59(3).683--688 (20A) Utility of a-acceptors in alkaloid assay. Taha, Aiy: Ruecker. Gerhard Arch. Pharm. 1977, 310(6), 485-494 (21A) Thin-layer chromatographic procedure for the detection, isolation. and identifiration of basic psychotropic drugs in urine lhunell. Stig J . Chrornatcgr. 1977, 730. 209-228. (22A) Thin-layer chromatography of some quaternary alkaloids and alkaloid N-oxides. Verpoorte, Robert; Baerheim, Svendsen, A. J . Chromatogr-. 1976, 124(1), 152-156. (23A) Rapid screening procedures for some street drugs by thin-layer chromatography: an evaluation. Woodford, Warren Jatmes J. Chromatogr. 1975, 175(2), 678-68 1 (24A) Acid-base equilibria in ethanediol. 111. Selection of titration cor?ditions in ethanedioi medium: protolysis constants of alkaloids in ethanediol and its mixtures. Zikdov, P.:Zikolova. T.; Budevski. 0. Tabnta. 1976. 23(8), 587-590.
Cinchona Alkaloids (25A) Application of the TAS method in analysis of the drug cortex chinae [cinchona]. Chmel, Karel; Chmelova-Hlavata, Viasta J . Ghromatogr. 1976, 118(2), 276-279. (26A) Determination of total alkaloid content of cinchona bark. Haznagy, A Pharmazie 1976, 37(10), 713-715. (27A) Simple thin-layer chromatographic method for separation of cii ichona alkaloids. Wijesekera, Rahula 0.B.; Rajapakse. Lakshnii S , Chelvarajan,
Doris W. J , Chromatogr. 1976. 727(2), 388-389. (28A) Serum quinidine concentrations: comparison of fluorescence, gaschromatographic and gas-chromatographic/mass-spectrometric methods. Huffman, David H.: Hignite, Charles E. Clin. Chem. ( Winston-Salem, N.C.) 1976, 22(6), 810--812. (29A) Comparison of two spectrofluorimetric procedures for quinidine determination in biological fluids. Huynh-Ngoc. Tho: Sirois. Gerard J . Pharm Sci. 1977, 66(4). 591-592. (304) Colorimetric assay of quiriine arid quinidine in taw rriateriais, formulations and biological fluids. Karawya. Mohamed S.; Diab, Aly M. J . Pliarm. Sci. 1977. 66(9). 1317-1319. (31A) Novel quinidine metabolism in a suicide case with quinidine sulfate detected by gas chromatography-mass spectrometry, Leferink. J. G.: Maes. R . A. A,, Sunshine, Irving: and Forney. R. B., Jr. J . ,Ana/. Toxicol. 1977, 1(2), 62-65. (32A) Comparison of a spectrofluorimetric method with a gas-liquid chromatographic procedure for determination of quinidine plasma levels. Midha, Kamal K.: McGiiveray, Jain J.; Charette. Claude; Rowe, Mary L. Can. J . Pharnr. Sci. 1977, 12(2), 41-44. chromatographic and thin-layer chromatographic ne and quinine and related alkaloids in pharmaceuticals. Pound. N. J.; Sears, R. W. Can. J . Pharm. Sci. 1975. 70(4). 122-126. (34A) Spectrophotometric determination of quinine, emetine, and ephedrine in ptiai maceutical preparations with tetrabromophenolphthalein ethyl ester by sobent extraction. Sakai, Tadao; b r a , Itsuko: Tsubouchi, Masahiro Chem. Pharm. Bull. 1976, 24(6), 1254-1259. (3%) Direct determination of quinine ethylcarbonate with monoprotic acid dye by solvent extraction. Sakai, Tadao; Tsubouchi. Masahiro Chem. Pharm. Bull. 1976, 24(11). 2883-2886. (36A) Non-aqueous titration of sulfates of quinine and quinidine using barium acetate. Soliman, Sobhi A,; Abdine. Hassan; Zakhari, Nashaat A. J . Pharm. Sci. 1976, 65(3), 424-427. (37A) Assay of quinine hydrochloride according to the European Pharmacopeia. Surborg, K . - H Dtsch. Apoth.-Ztg. 1976, 7 16(5), 121-122. (38A) Gas-liquid chromatographic determination of quinidines in human plasma. Valentine, J. L., Driscoll, Patricia; Hamburg. Ellen L.; Thompson. Everett D. J Pharnr. Sci.. 1976, 65(1), 9 6 - 9 8 (39A) Leguminous alkaloids. XXIX. Gas-chromatographic Identification of qiiinolizidine akaloids from crude alkaloid extracts. Steinegger. E.: Schlunegger, U. P.; Fallert, H. Pharm. Acta Helv. 1976, 51(6), 170-171. Ergot Alkaloids (40A) Lysergic acids. 11. Separation of ergot alkaloids by reversed-phase chromatography. Dolinar, J. Chromatographia 1977. 70(7),364-367. (4 1A) Information concerning the proteowic activity of ergot. Poehm, M.; Kobssa. H.: Jentzsch, K Sci. Pharrn 1976, 44(1). 32-39 (42A) Quantitative fluoridensitometric determination of ergot alkaloids. Prosek, M.; Kucan, E.; Katic. M.; Bano. M Chromatographia 1976. 9(6), 273-279. (43A) Quantitative fluoridensitometric determination of ergot alkaloids. 11. Deterniination of hydrogenated ergot alkaloids of the ergotoxin group. Prosek. M.; Kucan. E.; Katic. M.; Bano, M. Chrornatographia 1976, 917). 325-327. (44A) Quantitative fluorodensitometric determination of ergot alkaloids. 111. Total assay of the alkaloids Prosek, M.: Kucan. E.; Katic, M.: Bano. M. Chroma tographia 19 7 7, 10 (3), 14 7- 150, (45A) Trace-enrichment techniques in reversed-phase high-perfnrmance liquid chromatography. Schauwecker, P.: Frei, R. W.: Erni. F. J , Chron~tcgr.1977, 736(1), 63-72 (46Al Identification of ergotpeptide alkaloids. based on gas-liquld chromatography of the peptide moiety Van MansveR, Franc J. W.; Greving. Jan E.; De Zeeuw, Rokus A. J . Chroniatogr. 1978, 157(2), 113-120, (47A) Quantitative thin-layer chromatographic analysis of ergotanline tartrate and caffeine in the nanogram range [in plasma and pharmaceutical preparations]. Amin. M.: Sepp. W. J . Chromatogr. 1976, 718(2). 225-232. (48A) Determination of the content arid purity of ergotamine preparations by means of high-pressure liquid chromatography. Bethke. H.; Delz, B.: Stich, K . J . Chrornatogr 1976, 723(1). 193-203. (49A) The NF dissoiutton test for ergotamine tartrate and caffeine tablets. Hossie, R D ; McGilveray. 1. J.; Brien, R. Can J . Pharm. Sci. 1977, 12(2),50-52. l50A) Quantitative analysis of dihydroergotoxinealkaloids by gas chromatography and gas chromatography-mass spectrometry Plomp, T. A , ; Leferink, J. G.; Maes, R. A. A. J Chromatogr. 1978. 751(2). 121-132. (51A) Chromatographic method for detection of LSD [lysergide] in biological liquids. Christie, John; White, Michael William: Wiles. Jennifer Mary J . Chrornatogr. 1976, 720(2), 496--501. (52A) Direct quantitative analysis of lysergic acid diethylamide (LSD) [lysergide] and 2.5dimethoxy-4-methylamphetamine (STP) on thin-layer chromatograms Niwaguchi. Tetsukichi; Ionue, Takako J , Chromtogr. 1976, 727(l), 165-169. (53A) Lysergic acids. 11. Isolation and separation of lysergic acids Rucman. Rudolf J . Chromatogr. 1976, 121(2), 353-360. Opium Alkaloids (54A) Gas-chromatographic determination of apomorphine in plasma. Baaske. 0 . Michael; Kaiser, Jeffrey E.; Smith, Robert V. J . Chromatogr. 1977. 740( 1). 57--64. (55A) Thin-layer chromatography of apomorphine and its analogues. Erhardt. Paul W.; S m h , Robert V : Sayther. Teny T : Keiser. Jeffrey E. J . Chromqtogr. 1976. 776(1), 218-224. 156A) Quantitative determinations of codeine phosphate, yuaifenesin. pheriiramine maleate, phenylpropanolamine hydrochloride. and pyrilamine maleate in an expectorant by high-pressure liquid chromatography. Das Gupta, V.: Chanekar. A G. J Pharm Sci. 1977, 66(6), 895-897. (57A) Rapid determination of ethylmorphine in analgesic tablets by gas-liquid chromatography. with special regard to "content uniformity" requirements. Gaidag, Maria; Nyiredy, Szabolcs Pharmazie 1977, 32(11), 724.
A N A L Y T I C A L CHEMISTRY. VOL. 51, NO. 5, APRIL 1979 (58A) Determination of nanogram amounts of aromatic [pharmaceirticall compounds by spectrophotometry on thin-layer chromatograms. Haefelfinger, P. J . Chromatogr. 1976, 724(2), 351-358. (59A) Mass screening and confirmation of codeine and morphine in urine by radio-immunoassay and gas-liquid chromatography. Jain. Naresh C.: Sneath, Thomas C.: Leung, Wai J.; Budd, Robert D. J Pharm Sci. 1977. 66(1). 66-69. (60A) Quantitative gas-liquid chromatographic determination of codeine in plasma. Zweidinger, Ruth A,: Weinberg. F, M.; Handy, R. W. J Pharm. Sci. 1976, 65(3), 427-429. (6 1A) Identification of diacetylmorphine [diamorphine] metabolites in humans Yeh, S. Y.; McQuinn R L.; Gorodetzky, C. W . J . Phann. Sci. 1977. 66(2). 201-204. (62A) he gaschrcfnatcgraphic determination of hydrocodone in serum. Barnhart. J. W.; Caldwell, W. J J . Chromatogr. 1977, 730, 243-249. (63A) Urinary excretion of hydromorphone and metabolites in humans. rats, dogs, guinea-pigs, and rabbits. Cone, E. J.: Phelps, E. A ; Gorodetzky, C. W. J . Phann. Sci. 1977, 66112). 1709--1713. (64A) Radi@immunoassay of hydromotphone in plasma. Hongberg. I. L.: Stewart, J. T.; Brown, W. J.: Jun. H. W.: Needham. T E.: Vallner. J. J. .I Anal. Toxicol. 1977.. 112). ,-/. 70--72 (65A) Polymorphism o f heroin [diamorphine] and its forensic aspects. Borka. Laszlo Acta Pharm. Suec. 1977, 74(2), 210-212 (66A) Plasma chromatography of heroin [diamorphine] and cocaine with mass-identified mobility spectra. Karasek. F. W.: Hill, 11. H., Jr.: Kim, S H. J , Chromatogr. 1976, 7 7712). 327-336. (67A) Comparative studies on the thin-layer chromatographic limits of detection or semiquantitative determination of heroin (diacetylmorphine). Thislemann. Horst Sci. Pharm. 1977, 45(3). 240-241. (68A) A single thin-layer chromatography system for foreign alkaloids in morphine. codeine and papaverine. Barrett. P. C. Proc. Anal Div Chem. SOC.1975, 72(10). 271-273. (69A) Improved recovery of morphine from biological tissues using siliconized glassware. Bhargava. Hemendra N. J. Pharn? Sci 1977. 66(7), 1044--1045 (70A) Application of the extractive alkylation technique to the pentafluorobenzylation of morphine (a heroin metabolite) and surrogates, with special reference to the quantitative determination of plasnia morphine levels using mass fragmentography. Cole. W. J.; Parkhouse. J.. Yousef. Y . Y . J . Chromatogr. 1977, 736'(3). 409-416. (71A) General procedure for the isolation and identification of 6ck- and 6,jhydroxy-metabolites of narcotic agonists and antagonists with a hydromorphone structure. Cone, Edward J. J . Chromatogr. 1976. 729, 355-361. (72A) Quantitative determination of morphine in paregoric U.S.P by high-pressure liquid chromatography. Das Gupta, V J . Pharm Sci. 1976. 6 5 ( 1 l ) . 1697- 1698. (73A) Rapid gas-liquid chromatographic method for Separation of picogram quantities of morphine and codeine. Kogan, M. J : Chedekel. M. A. J . Pharm. Pharmacol. 1976, 28(3), 261 (74A) Improved detectioii of morphine on thin-layer chromatography plates McIntyre, Joyce A,: Armandi. Arlene E. Clin. Chem. ( Winston-Salem, N C.) 1976, 22(3). 396. (75A) Vottammetric determination of morphine on stationary phtinum and graphite electrodes. Proksa. E.; Molnar. L. Anal. Chim. Acta. 1978, 97(1). 149--154 (76A) Quantitative morphine assay by means of gas-liquid chromatography and on-column silylation. Rasmussen. Knut E . J Chromatogr. 1976, 720(2). 491-495. (77A) Comparison of the EMIT (enzyme-multiplied immunoassay technique) opiate assay and a gas-chromatographic/mass-spectrometric determination of morphine and codeine in urine. van der Slooten, E. P J,, van der Helm. H. J. Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(7), 1110-1111 (78A) Detection and identification of morphine in aduiterated opium samples by thin-layer chromatography. Tewari, S N.:Sharma. D. N. freseniius' 2 Anal. Chem. 1976, 287(5), 381. (79A) Separation of frve major akalods in gum opium am3 quatititaton of morphine, codeine, and thebaine by isocratic reversed-phase high-performance liquid chromatography. Wu, C. Y.; Wmick, J. J Anal. Chem. 1977, 49(3), 359-363 (80A) Isolation and identification of morphine 3- and 6-glucuronides, morphine 3,6-diglucuronide, ethylmorphine sulfate, normorphine. and normorphine 6-glucuronide as morphine metabolites in humans Yeh, S . Y.;Gorodetzky. C. W.; Krebs, H. A. J . Pharm. Sci. 1977. 66(9). 1288- 1293. (81A) Analytical possibilities of phase-resolved phosphorimetry [of morphine and codeine]. Yen, E Lue: Winefordner. J. D Anal Chern 1977, 49(6). 1262-1263. (82A) Identification of opium by chemical-isonization mass spectrometry. Zitrin. Shmuel: Yinon, Jehuda Anal. Lett. 1977, 70(3), 235-241 (83A) Quantitative determination of naltrexone and naltrexone prodrugs by electron-capture gas-liquid chromatography. 5urce. Gary L., Rhat. H 5.; Sokoloski. Theodore J Chromatogr. 1977. 737121, 323--332. (84A) &termination of naloxone and nabexone as perfluoroalkyl ester derivatives by [nickei-63] electron-capture gas-liquid chromatography. Sams. Richard A.; Malspeis, Louis J . Chromatogr. 1976, 725(2), 409-420. (85A) Visualization of opium alkaloids on thin-layer Chromatography plates by Gibbs reagent spray. Baggi. T. R.; Rao, N. V. Rama; Murty. H. K. R. Forensic Sci 1976, 8(3), 265-267. (86A) Gas-liquid chromatographic determination of opium aikaloids in papaveretum. Fisher, G.: Gillard, R. J . Pharrn Sci. 1977, 66(3). 421-423. (87A) Chemistry of opium alkaloids. V l l i . Separation of opiuni alkaloids and related compounds by ion-pair high-performance liquid chromatography Olieman, C.; Maat, L.; Waiiszewski, K.; Beyerman. H. C J Chromafogr. 1977, 733(2), 382-385. (88A) Application of a mixed anhydride reagent for detection of some opiurn alkaloids on thin-layer plates. Rao. N. V. Rama; Tandon, S. N forensic Sci 1977, 9(2). 103-104 (89A) Use of sodium cobattinitrite as spray reagent for detection of some opiuni alkaloids on thin-layer chromatography plates. Rao. N V . Rama; Murtv. H. R . K . ; Baggi. T R . Curr. Sc!. 1976, 45(9), 332.
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(9OA) Detection of opium alkaloids in the urine of morphine addicts. Vu Duc. T.; Vernay. A,; Nicole, C. Pharm. Acta Helv. 1976. 57(5),126-128. (9 1A) Separation of five trajw akalods in gum opium and quanttaton of morphine. codeine. and thebaine by isocratic reverse phase high performance liquid chromatography. Wu, C Y . :Wittick. J J. Anal. Chem. 1977, 49(3), 359-363. (92A) Determination of papaverine in blood samples by gas-liquid chromatography and mass fragmentography. De Graeve, Jean; Van Cantfort, Jacques; Gieien. Jacques J . Chromatogr. 1977, 733(1), 153-160. (93A) Comparative assays according to DAB 7 and Ph Eur. 2. Alkaloids and analogous nitrogen compounds. Otto, Hans Hartwig: Rossbach. Dieter; Rohe, Guenter Dfsch. Apoth.-Zfg. 1977, 777(12), 418-421. (94A) Analysis of Papaver bracteaturnfor alkaloids. Cheng, Ping C.: Doorenbos. Norman J. J . M s s . Acad. Sci. 1976, (21), 13-15. (95A) Direct spectrophotometric determination of thebaine in arya 11 population capsules of Papaver bracteaturn L i d / . Maghssoudi. Rostam H.: Fawzi, Ahmad B. J . Phamt. Sci.. 1978, 67(1). 32-35. (96A) Thebaine content of selections of Papaver bracteaturn Lindl. at different ages. Vincerit. P G.; Bare, C. E.: Gentner, W. A. J . pharm. Sci. 1977, 66(12), 1716--1719. (97A) Quantitative determination of thebaine in Papaver bracteaturn by high-pressure liquid chromatography. Wu, Fen-Fen: Dobberstein. R . H. J . Chromatogr. 1977, 140(1). 65-70 Rauwolfia Alkaloids (SPA) Collaborative study of a spectrofluorimehic assay for Rauwolfia serpentina tablets and powdered roots. Smith, William M.: Clark. Charles C. J , Assoc. Off Anal. Chem. 1976, 59(4). 811-816. (99A) Collaborative study of a spectrofluorimetric assay for Rauwolfia serpentina tablets and powdered toot, usirig a vanadium pentoxide-phosphoric acid determinative step. Smith, William M. J . 4ssoc. Off. Anal. Chern. 1977, 60(5), 1018-1021. (100A) Use of ferric hydroxaniate complexes for photometric determination of medicinals. 111. Quantitative detection of reserpine in substance and in tablets. Dryanovska. L : Iovchev, I . fharinazie 1976, 37(2), 130 (101A) Colorimetric assay of reserpine in formulations and biological fluids. Karawya. Motiamed S ' Sharaf, Abdel-Aziz A,: Diab, Aly M. J . Assoc. Off. Anal. Chem. 1976, 59(4), 795-798. (102A) Collaborative study of a semi-automated fluorimetric method for the determination of reserpine in tablets. Kreienbaum, Mary A J Assoc. Off. Ana/. ChenJ. 1976, 5 9 ( 2 ) , 289-292. (103A) New gas-chroniatographic method for estimation of reserpine and rescinnamtne Settirnj. Guido; Di Simone, Luciano; Dei Giudice, Maria Rosaria J . Chroniatogr. 1976, f76(2), 263-270. (104A) Fluorimebtc analysis of alkaloids. Determination of serpentine. yohimbine, and boldine. Gurkan, Ti.irkan Mikrochin?. Acta 1976. 112-3). 173-180
Tropane Alkaloids (1058) Ion-pair high-performance liquid chromatographic method for the determination of atropine sulfate and tropic acid. Brown. Nesbitt D : Sleenlan, t i . Kenneth J Chromatogr. 1978, 750(l), 225-228. ( 106A) Gas.chiomatographic determination of tropane alkaloids in organs of Atropa belkdonna. Wiims. J.: Roeder. E.: Kating, H. Pbiita M d . 1977. 37(3), 249-256. ( 1 07A) Gas-liquid chromatographic assay of belladonna extracts Wyatt Dorothy K.. Richardson. William G., McEwan, Bruce; Woodside. John M.: Grady, Lee T. J , Pharrn Sci. 1976, 6515). 680-684. (106A) Gaschromatographic determination of cocaine in whole blood and plasma using a nitrogen-sensitive flame ionization detector. Dvorchick. Barry H.; Miller, Stephen H., Ckaham, William P. J . Chromatcgr 1977. 13511). 141-148. ( 1 09A) Analysis of benzoylecgonine in urine by high-performance liquid chromatography and gas chromatography-mass spectrome:ry. Graffeo. Anthony P.: I.in. Denis C K ; Foltz. Rodger L J . Chromafogr. 1976. 726. 7 17- 722 ( 1 10A) Simultaneous gas-chromatographic determination of cocaine, methadone, methaqualone. phencyclidine, and [dextrolpropoxyphene. Jain, Naresh C ; Chinn. Dennis M : Sneath. T. C : Budd. R D. J Anal Toxicoi. 1977, f(4). 192-194. ( 1 11A) Thin-layer chromatographic screening and confirmation of basic drugs of abuse in urine. Jain. Naresh C.; Leung, Wai J ; Budd. Rohert D.: Sneath. Thomas C. J Chromatogr 1975. 775(2), 519-526. (1 12A) Single- and two-step extraction and thin-iayer detection procedures for benzoylecgonine (a cocaine metabolite) alone or in combination with a wide variety of commonly abused drugs in urine-screening programmes. Kaistha, K. K..Tadrus. Rahmeh J . Chromatogr.. 1977, 735(2!. 385-393. (1 13A) Evaluation of selected methods for determining cocaine and benzoylecgonine in urine. Wallace, Jack E.; Hamilton, Horace E.; Christenson, James G.: Shimek. Eugene L.. Jr : Land, P a m Harris, Steven C. J . Anal. Toxicol 1977. [ t i ) , 20-26. ( 1 14A) Gas~-liqud chromatographic determination of cocaine and benzoylecgonine in urine. Wallace, Jack E.,Hamilton, Horace E.;King, David E.: Bason. Diana J : Schwertner. Harvey A,: Hans, Steven C Anal. Chem. 1976, 48(1), 34--41 ( I 15A) Analysis of homatropine methylbromide dosage forms. Hanna. S.: Rosen M.; Rasero, L.; Lachman. L. J . Pharm. Sci 1977, 66(1), 123-124. (1 16A) High-performance liquid chromatography of some tropane alkaloids. Verpoorte. Robert Baertieim Svendsen, A J Chrornatogr 1976. 72O(l ) , 203--205 Vinca Alkaloids (1 17A) Fluorinietric assay and pharmacokinetics of vincamine in rats. Iven, H.; Siegers. C.-P Arzneim - f o r s c h . 1977, 27(1) (6ai, 1248-1254. (1 16A) Gas-ciironiatographic method for determination of vincamine in blood. Kinsun. H.: Moulin, M. A . J , Chromatogr 1977, 744(1), 123-126. (1 19A) Radio~immviloassayof vinblastine and vincristine Teale. J. D.: Clough,
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Jacqueline M.; Marks, V. Br. J . Clin Pharmacol. 1977, 4(2), 169-172. Xanthine Alkaloids (120A) Identification, kinetic and quantitative study of [2-%]- and [lmethyl-"C]-caffeine metaboliies in rat urine by chromatographic separations. Arnaud, Maurice J. Biochem. Med. 1976, 16(1), 67-76. (121A) Coulometric bipotentiometric tiation of bases and their mixtures in acetic anhydride in the presence of two pretreated metal (gold, palhdiumhuinhydrone electrodes. Bjeiica, Luka J.; Vajgand, Vilim J.; Velimirovic, Dobrinka L. Mikrochim. Acta 1976, 11(3-4), 241-246. (122A) Micro-method for determination of caffeine [in blood]. Feldheim, Walter; Reimerdes, Emst Harbnut; Storm, GemotRainer Z. Lebensm.-Unters,-Fch. 1977, 165(4), 204-206. (123A) High-performance liquid-chromatographic and mass-spectrometric identification of dimethyl-xanthine metabolites of caffeine in human plasma. Midha, K. K.; Sved, S.; Hossie, R. D.; McGiheray, I. J. Biomed. Mass Spectrom. 1977, 4(3), 172-177. (124A) Determination of caffeine in pharmaceutical raw material. Stanisias, E.; Fouraste, I . J . Pharm. Belg. 1976, 31(6), 599-606. (125A) More sensitive high-pressure liquid-chromatographic determination of theophylline in serum. Adams, Reginald F.; Vandemark, Frank L.; Schmidt, Gary J. Clin. Chem. ( Winston-Salem, N.C.) 1976, 22(11), 1903-1906. (126A) Improved theophylline serum analysis by [use of] an appropriate internal standard for gas chromatography. Bailey, D. G.; Davis, H. L.; Johnson, G. E. J . Chromatogr. 1976, 121(2), 263-268. (127A) Rapid and sensitive gas-chromatographic determination of theophylline in plasma and saliva. de Boer, A. G.: Breimer, D. D. Pharm. Weekbl. 1977, 172(31-32), 764-767. (128A) Quantitative determination of theophylline in pharmaceutical dosage forms by differential spectrophotometry. Chae, Young Soon: Sheiver, William H. J . Pharm. Sci. 1976, 65(8), 1178-1181. (129A) Interference by butyl rubber stoppers in gas-liquid chromatographic analysis for theophylline. Chrzanowski, Francis; Niebergaii, Paul J.; Mayock. Robert; Taubin, Joel; Sugita, Edwin T. J. Pharm. Sci. 1976, 65(5), 735-736. (130A) Rapid micro-method for high-performance liquid-chromatographic determination of theophylline in human serum, Copper, M. J.; Mirkin. B. L.: Anders, M. W. J . Chromatogr. 1977, 143(3): Biomed. Appl. 1(3), 324-326. (131A) Therapeutic and toxic drug concentrations: correction. Dasta, Joseph; Slaughter, Richard Clin. Chem. ( Whston-Salem, N.C.) 1976, 22(10), 1751. (132A) Separation and spectrophotometric determination of theophylline and hydroxyethyitheophylline in a pharmaceutical sirup. De Fabrizio, Fabrizio J . Pharm. Sci. 1970, 67(4), 572-573. (133A) Serum theophylline analysis by high-pressure liquid chromatography. Evenson, Merle A,; Warren, Brenda L. Clin. Chem. ( Winston-Salem. N . C . ) 1976, 22(6), 851-855. (134A) Determination of theophylline in plasma ultra-filtrate by reversed-phase high-pressure liquid chromatography. Franconi. L. C.: Hawk, G. L.: Sandmann, E. J.; Haney, W. G. Anal. Chem. 1976, 48(2), 372-375. (135A) Retention behavior of a bonded phase in a high-performance Iiquidchromatographic assay of serum theophylline. Hili, R. E. J . Chromatogr. 1977, 735(2), 419-425. (136A) Comparison of two methods used to determine theophylline concentrations in Dlasma. Hossie. R. D.: Sved. S.; McEriane. K.: McGilverav. Iain J. Can. J.'Pharm. Sci. 1977, 12(2), 39-41. (137A) Gas-chromatographic miao-scale procedure for [determining] theophylline, with use of a nitrogen-sensitive detector. Least, Charles J., Jr.; Johnson, George F.; Solomon, Harvey M. Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(6), 765-768. (138A) Micromethod for gaschromatographicdetermination of serum theophylline utilizing an organic-nitrogen-sensitive detector. Lowry, James D.; Williamson, Lorna J.; Raisys, Vidmantas A. J . Chromatogr. 1977, 143(1); Biomed. Appl. 1(1), 83-88. (139A) Theophylline and dyphyiiine [diprophylline] levels in serum by liquid chromatography. Maijub. A. G.; Stafford. D. T.; Chamberiain. R. T. J . Chromatogr. Sci. 1976, 14(11). 521-525. (140A) Spectrophotometric determination of theophylline, dyphyiline [diprophylline], and khellin in some pharmaceutical preparations. Moussa. Abdei-Fattah A. Pharmazle 1977, 32(4), 242-243. (141A) Simplified micro-scale procedure for preparing samples for theophylline determination by liquid chromatography. Nelson, J. W.; Cordry, A. L.; Aron, C. G.; Bartell, R. A. Clin. Chem. (Winston-Salem. N.C.)1977. 23(1). 124-126. (142A) Gas-chromatographic quantitation of theophylline in small volumes of plasma. Perrier, Donald; Lear, Evangeline Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6), 898-900. (143A) Determination of theophylline in plasma by [nickel-631 electron-capture gas chromatography. Schwertner, Harvey A,; Ludden, Thomas M.; Wallace, Jack E. Anal. Chem. 1976, 48(13), 1875-1878. (144A) Rapid gas-chromatographic determination of underivatizedtheophylline in whole blood. Sheehan, Michael: Haythorn, Patricia J . Chromatogr. 1976, 117(2), 393-398. ( 145A) Gas-chromatographicimass-spectrometricdetermination of theophylline in whole blood. Sheehan, Michael; Hertel, Robert H.; Keiiy, Christopher, T. Clin. Chem. ( Winston-Salem, N . C . ) 1977, 23(1), 64-68. (146A) Rapid miao-method for measwing theophylline in serum by reversed-phase highperformance liquid chromatography. Soldin, S. J.; Hill, J. G. Clin. Biochem. 1977, 10(2), 74-77. (147A) Modified ultraviolet spectrophotometric method for determination of theophylline in serum in the presence of barbiturates. Vasiiiades, John; Turner, Tameia Clin. Chim. Acta 1976, 69(3), 491-495. (148A) Rapid determination of theophylline in human plasma by high-pressure liquid chromatography. Weddle, Orville H.; Mason, William D. J . Pharm. Sci. 1976, 65(6), 865-868. (149A) Specific thin-layer chromatographic method for determination of theophylline in plasma in the presence of some other drugs. Wesley-Hadzija, 6.;Mattocks, A. M. J . Chromatogr. 1975, 115(2), 501-505.
(150A) Separation of caffeine, theophylline, and theobromine by high-pressure liquid chromatography. Wildanger. Werner J . Chromatogr. 1975, 7 14(2), 480-482. (151A) Gas-liquid chromatographic determination of theophylline in biological fluids. Zuidema, J.; Licht, J. E. C. P. M.; Prins, J.; Merkus, F. W. H. M. Pharm. Weekbl. 1976, 111(23), 570-571. (152A) Use of high-pressure liquid chromatography and mass spectrometry for identification of xanthones. Hostettmann. Kurt; Jacot-Guiliarmod, Andre J . Chromatogr. 1976, 124(2), 381-387. Miscellaneous Alkaloids (153A) Colorimetric determination of aconitine in galenicals and in biological samples. Karawya, Mohamed S.; Sharaf, Abdei A. A,: Diab, Aly M. J . Assoc. Off. Anal. Chem. 1976, 59(4), 799-801. (155A) Selective estimation of aconitine in presence of aconine and benzoylaconine. Karawya. Mohamed S.: Diab, Aly M. J . Pharm. Sci. 1977. 66(9), 1331-1332. (156A) The gas-chromatographic-mass-spectral characteristics of aporphine and tetrahydroprotoberberine alkaloids. Cashaw, Jesse L.; McMurtrey, Kenneth D.; Meyerson, Laurence R.: Davis, Virginia E. Anal. Biochem. 1976, 74(2), 343-353. 157A) Exbaction-spectropometic determination of berberine in pharmaceutical preparations with 2,6dichiorophenolindophenol. Sakai, Tadao: Hara, Itsuko: Tsubouchi, Masahiro Chem. Pharm. Bull. 1977, 25(9), 2451-2455. 158A) Indirect atomic-absorption spectrophotometric determination of several organic bases using molybdophosphoric acid. Simon, Stephen J.; and BoRz, D. F. Microchem. J . 1975, 20(4), 468-475. 159A) Gas-liquid chromatographic determination of capsaicin. DiCecco, Joseph J. J , Assoc. Off. Anal. Chem. 1976, 59(1), 1-4. 160A) Highperformance liquid chromatography of catharanthus alkaloids. Gorog, Sandor; Herenyi, Bulcsu; Jovanovics, Karola J . Chromafogr. 1977, 139(l ) , 203-206. 161A) Quantitative gas chromatography and gas chromatography-mass spectrornetiy of Cephabtaxwalkabds. Spencer, G. F.; Phttner, R. D.; Powell, R. G. J . Chromatogr. 1976, 120(2), 335-341. (162A) Quantitative thin-layer chromatography of the principal Chelidonium alkaloids. Scholz, Claus: Haensei, Rudolf: Hilie. Caroia Pharm. Ztg. 1976, 121(42), 1571-1574. (163A) High-performance liquid chromatographic determination of colchicine and coichicoside in colchicum (Colchicum autumnale L . ) seeds on a homemade stationary phase. Forni, G.; Massarani, G. J . Chromatogr. 1977, 13 1 , 444-447. (164A) Determinationof emetine in the presence of its decomposition products. Schuijt, C.; Beijersberger van Henegouwen, G. M. J.; Gerritsma, K. W. Analyst (London) 1977, 102(1213), 298-301. (165A) Accurate determination of weak monofunctional bases and their base constants by means of pH-metric titration. Chakarova, P.; Budevski, 0. Nectroanal. Chem. 1976, 73(3), 369-372. (166A) Ultra-violet spectrophotometric determination of aminophylline, amylobarbitone, and ephedrine hydrochloride in an antiasthrna capsule preparation. De Fabrizio, Fabrizio J . Pharm. Sci. 1977, 66(6), 811-813. (167A) Fiuorodinitrobenzene as reagent in drug analysis. 11. Determination of ephedrine, metaoxedrine [phenylephrine], and isoprenaline in pharmaceutical preparations as dinitrophenyi derivatives. Tammiiehto. Seija Farm. Aikak 1975, 84(2), 53-59. (168A) Gas-chromatographic determination of hyoscyamine in tablets. Graf. Englebert: Luk. Erch Arch. pharm. (Weinkim, Ger.) 1976, 309(10). 861-863. (169A) Detection of ibogaine in organic liquids [e.g., urine]. Bertol, Elisabetta; Mari, Francesco; Froldi, Rino J . Chromatogr. 1976, 177(1), 239-241. (170A) Microchemical investigation of medicinal plants. XV. Quantitation of total alkaloid content in leaves of Ipomoea violacea (morning glory) via spectrophotofluorimetry. Weber, Jeffrey M.; Ma, T. S. Mikrochim. Acta 1976. 1(6), 581-588. (17 1A) Fielddesorption mass spectrometry of biogenic amines and isoquinoline alkaloids: some comparisons with chemical-ionization results. Wood, Gordon W.; Mak, Ning; Hogg. Alan M. Anal. Chem. 1976, 46(7), 981-984. (172A) [Methods used in] a fatal case involving ievorphanol. Turner, J. E.: Richards, Robert G. J . Anal. Toxicol. 1977, 1(2). 103-104. (173A) [Methods for use in] diagnosis and management of recreationai mescaline self-poisoning. Teiteibaum, Daniel T.; Wingeleth, Dale C. J . Anal. Toxicol. 1977, 1(1), 36-37. 174Aj Chromium-thiocyanate complexes with nicotine and the analytical determination of this alkaloid. Ganescu, I.; Varheiyi, C. Arch. Pharm. (Weinheim, Ger.) 1976, 309(4), 251-257. 175A) Rapid analysis of nicotine and cotinine in the urine of smokers by isocratic high-performance liquid chromatography. Watson, Ian D. J . Chromatogr. 1977, 143(2); Biomed. Appl. 1(2), 203-206. 176A) Thin-layer and gas-chromatographic evaluation of Petasites drug and extract. Wagner, Hiidebert; Giasl, H.; Huber, G. Dtsch. Apoth.-Ztg. 1976, 176(28), 1009-1012. 177A) Quantitative assay of physostigmine in human whole blood. @off, William A,; Eliin, Robert I.: Skalsky, Rickie L. J . Pharm. Sci. 1977, 66(3j. 389-391. 178A) Sub-nanogram assay for pilocarpine in biological fluids. Bayne, W. F.; Chu, L.-C.; Tao, F. T. J . Pharm. Sci. 1976, 65(12), 1724-1728. (179A) Gas-liquid chromatographic determination of pilocarpine. Dziedzic. Stanley W.; Wow, Stanley E.; Krohn. Dava L. J . pharm. Sci. 1976, 65(8).1262-1263. (180A) Chromium-thiocyanate complexes with pilocarpine and the determination of this alkaloid. Ganescu. Ion; Varheiyi, Csaba; Brinzan, Gheorghe Arch. Pharm. (Weinhelm. Ger.) 1976, 309(11), 887-892. (18 1A) High-speed liquid-chromatographic determination of pilocarpine in nharmaceotical rincnne forms
Khnlil S K Wahha , I Phnrm
S o 1977
ophthalmic formulations. Neville, George A.; Hasan, Fariza B.: Smith, Ian C. P. J . Pharm. Sci. 1977, 66(5), 638-642.
ANALYTICAL CHEMISTRY, VOL. 51, NO. 5, APRIL 1979 (183A) Study of basicity in aqueous phenol. Ttration of organic bases. Pellerin, Fernand; Baylocq-Quinault, Daniele Talanta 1977, 24(3), 182-184. (184A) Sensitive infrared measurement of pilocarpine-isopibcarpine isomerization. Ryan, James A. Anal. Chim. Acta 1976, 85(1), 89-93. (185A) Simultaneous determination of pilocarpine and isopilocarpine in pharmaceutical preparations by liquid chromatography. Urbanyi, T.; Piedmont, A.; Willis, E.; Manning, G. J . Pharm. Sci. 1976, 65(2), 257-260. (186A) Pilocarpine hydrochloride in ophthalmic solutions: modification of a high-pressure liquid-chromatographic determination and survey. Weber, John D. J . ASSOC.Off. Anal. Chem. 1976, 59(6), 1409-1415. (187A) Spectrophotometric determination of strychnine and brucine in liquid galenicals. El-Masry. Sawsan; Wahbi, Abdel Aziz M. J . Assoc Off. Anal. Chem. 1978, 67(1), 65-67. (188A) Thiocyanatochromium(II1) complexes in chemical analysis. Part 20. Indirect bdometric method for strychnine determination. Ganescu, I.: Oprescu, D.; Varhelyi, C. Pharmazie 1977, 32(8-9), 535-536. (189A) Potentiometric titration of ionizable compounds in two-phase systems. 1. Quantitative determination of organic ammonium ions [e.g., alkaloids] Gustavii, Klas; Johansson, Per-Arne; Brandstroem, Arne Acta Pharm. Suec. 1976, 13(5-6). 391-406. (190A) High-performance liquid chromatographic separation and quantitative determination of valepotriates in Valeriana drugs and preparations. Tittel, G.; Wagner, H. J . Chromatogr. 1978, 148(2), 459-468. ANTIBIOTICS
General (18) Radi+immunoassay of antibiotics and chemotherapeutic agents. Broughton, Alan; Strong, James E. Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(6), 726-732. (28) Titration of thioethers. Casalini, Claudio; Cesarano, Giulia, Mascellani. Giuseppe Anal. Chem. 1977, 49(7), 1002-1004. (38) Current aspects of pharmaceutical analysis. Analysis of antibiotics. Part 2. Chemical assay. Fairbrother, J. E. Pharm. J . 1977, 278(5924), 509-513. (48) Thin-layer chromatographic classification of antibiotics exhibiting antitumor properties. Issaq, H. J.: Barr, E. W.; Wei, T.; Meyers. C.; Aszalos A. J . Chromatogr. 1977, 733(2), 291-301. (58) Microbiologicalturbidimetric methods: linearization of antibiotic and vitamin standard curves. Kavanagh, F. J . Pharm. Sci. 1977, 66(11), 1520-1525. (68) Apparatus for uniform spraying of thin-layer chromatograms with reagents for quantitative thin-layer chromatography. Kreuzig, F. Fresenius' Z . Anal. Chem. 1976, 282(5), 457-458. (78) Application of quantitative high-performance thin-layer chromatography in the antibiotic industry. Kreuzig, F. J . Chromatogr. 1977, 742. 441-447. (88) Image-analysis system. Levy, Joel D. Int. Lab. 1976 (May-June), 81. (98) Principles and applications of isotachophoresis. Nagayanagi, Yutaka Int. Lab. 1977, 33. (1OB) Analysis of urinary tract antibacterial agents in pharmaceutical dosage form by high-performance liquid chromatography. Sondack, David L.; Koch. W. L. J . Chromatogr. 1977, 132(2), 352-355. (1 18) Reverse phase high speed liquid chromatography of antibiotics. 11. Use of high efficiency smaii particle columns, White, E. Roderick; Carrol, Margaret A.; Zarembo, John E. J . Antibiot. 1977, 30(10), 811-818. Penlcllllns and Cephalosporin (1 28) Electrochemical pH-stat and controlled-current coulometric acid-base analyzer. Adams, Robert E.: Betso, Stephen R.; Carr, Peter W. Anal. Chem , 1976, 48(13), 1989-1996. (138) Separation of degradation products of double-labeled benzylpenicillin on a cationexchange column. Adriaens. P.; Meesschaert, 6.; Eyssen, H.; Roets. E.: Vanderhaeghe, H. J . Chromatogr. 1977, 144(1). 93-99. (148) Separation of ninhydrin-positivecompounds on a single-column amino-acid analyzer using lithium buffers. Adriaens, P.; Meesschaert, 8 . ; Wuyts, W.; Vanderhaeghe, H.; Eyssen, H. J . Chromatogr. 1977, 740( l ) , 103-108. (158) Fluorimetric determination of cephalexin in urine. Aikawa, Renji: Nakano, Masahiro; Arita, Takaichi Chem. Pharm. Bull. 1976, 24(10), 2350-2355. (168) N-Bromosuccinimide assay of penicillins and cephalosporins. Alicino, Joseph F . J . Pharm. Sci. 1976, 65(2), 300-301. (178) Fluorimetric determination of cephalexin. Barbhaiya, R. H.; Turner, P. J . Pharm. Pharmacol. 1976, 28(10), 791-792. (188) Mercurimetric assay of penicillins. Bird, A. E.; Redrup. C. E. Proc. Ana/. Div. Chem. Soc. 1977, 74(10), 285-288. (19B) Spectrophotometric determination of cefapirin, a cephalosporin antibacterkl. Bodnar, J. E.; Evans, W. G.; Mays, D. L. J . Pharm. Sci. 1977, 6 6 ( 8 ) , 1108-1 11 1. (208) Preparation, identification, and quantitative nuclear magnetic resonance determination of silyl derivatives of 6-aminopenicillanic acid, 7-amino-3methyl-~3-cephem-4-carboxylicacid and 3-acetoxymethyl-7-amino-.13cephem-4-caroxylic acid. Bortesi. Fuivio: Cavalli, Silvano; Mangia, Albert0 J . Pharm. Scl. 1977, 66(12), 1767-1769. (218) Quantitative determination of aminopenicillins in the presence of their degradation and polymerization products. Bundgaard. Hans Arch. Pharm. Chemi, Sci. Ed. 1977, 5(5), 141-148. (228) Polymerization of pen ns. IV. Separation, isolation, and characterization of ampicillin polymers formed in aqueous solution. Bundgaard. Hans; Larsen. Claus J . Chromatogr. 1977, 732(1), 51-59. (238) Determination of cephradine and cephalexin by reversed-phase highperformance liquid Chromatography. Carroll, Margaret A,; White, E. Roderick; Jancsik, Zsuzsa; Zarembo, John E. J . Antlbiot. 1977, 3 0 ( 5 ) , 397-403. (248) Colorimetric estimation of ampicillin Choudhury, C Indian J . Pharm. 1976, 38(5), 124-126. (258) Contribution to the chromatographic examination of natural and semisynthetic penicillins. Cruceanu, 1.; Medianu, M.; Aiteanu. E.; Moldovan, A . Zentralbl. %arm. Pfwrrnakother. Laboratoriumsdngn. 1977, 116(3),25 1-258 (268) Simple chemical method for assay of amoxyciilin in serum and urine.
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Davidson, D. F. Clin. Chim. Acta 1976, 69(1), 67-71. (278) Simple fluorimetric assay for ampicillin in serum. Duerr, A.; Schatzmann, H. J. Experientia 1975, 37(4), 503-504. (288) Paper chromatography of semi-synthetic penicillins. Faith, L.; Novakova. L.; Georch, D.; Markovic, 0. Pharmazie 1977, 32(10), 593-594. (298) Coulometric titration of penicillins and penicillamine with mercury(I1). Forsman, Ulf Anal. Chim. Acta 1977, 93, 153-159. (308) Titration of 6-aminopenicillanic acid with mercury(I1) solution Forsman, U.; Kalberg, 8 . Anal. Chim. Acta 1976, 86(1), 87-91. (318) Microbiological assay of cephradine in blood and urine. Forster. Thomas C. Methodol. Dev. Biochem. 1976, 5, 227-230. (328) Iodimetric and spectrophotometric assays for cephradine after its hydrobsis with a @lactamase. Frantz, 8. May J . Pharm. Scl. 1976, 65(6), 887-891. (338) Analytical studies using iodine-luminol chemiluminescence. Hardy, William M.; Seitz, W. Rudolf; Hercules, David M. Talanta 1977, 24(5), 297-302. (348) Use of high-pressure liquid chromatography in the analysis of penicillins and cephalosporins. Hartmann, V.; Roediger, M. Chromatographia 1976, 9(6), 266-272. (358) Fluorimetric determination of cephradine in plasma. Heald, Anthony F.; Ita, Callixtus E.; Schrieber, Eric C. J . Pharm. Sci. 1976, 65(5). 768-769. (368) Detection of penicillin G and ampicillin as contaminants in tetracyclines and penicillamine. Herbst, Doris J . Pharm. Scl. 1977, 66(1 l ) , 1646-1648. (378) Chemical and physical analysis of antibiotics. 11. Penicillins and cephalosporins. Hughes, D. W.; Viiim, A,: Wilson, W. L. Can. J . Pharm. Sci. 1976, 11(4), 97-108. (388) Spectrophotometric method for specific determination of phenoxymethylpenicillin. Hughes, Alan S.; Poppiestone, Christopher R. Analyst(London) 1977, 102(1219), 759-763. (398) Specific determination of phenoxymethylpenicillin. Hughes, Alan S.; Popplestone, Christopher R . Proc. Anal. Div. Chem. SOC.1977, 14(10), 288-290. (408) Spectrophotometric determination of some penicillins with ammonium vanadate. Ibrahim, El Sebai A,; Beitagy, Y. A,; Abd El-Khalek. M. M. Talanta, 1977, 24(5), 328-330. (418) Chelatometric determination of epicillin. Ismaiel. Saad A.; Tawakkoi, Mostafa S.; Amer, Mohamed M. Pharmazie 1976, 31(11), 822. (428) Comparative studies of temporal changes in polarographic currents and ultraviolet absorption of benzylpenicillenicacid. Jemal, Mohammed; Knevel, Adelbert M. Anal. Chim. Acta 1978, 96(1). 143-151. (438) Determination of penicillins by titrations with mercury(l1) solution. Karlberg. Bo; and Forsman, Ulf Anal. Chim. Acta 1976, 83. 309-316. (448) A new colorimetric method for the determination of 6-aminopenicillanic acid. Kornfeld. Joseph M. Anal. Biochem. 1978, 86(1), 118-126. (458) Quantitative analysis of some pen ns using the differentiaihydrolysis-tate method. Koprivc, Ljerka; Polla, Eugenio; Hranilovic, Janko Acta h a r m . Suec. 1976, 13(5-6). 421-426. (468) Antigens in penicillin allergy. I . A radioimmunoassay for detection of penicilloylatedprotein contaminants in penicillin preparations. Kristofferson. A.; Ahistedt, S.; Pettersson, E.; Svard, P. 0. In!. Arch. AlkrgyAppl. fmmunol. 1977, 55(1-6), 13-22. (478) Automated system for determination of cephalosporins and penicillins using hydroxylamine reagent. Kulo, Arvo Ensio f a r m . Aikak. 1976, 85(1). 1-7. (488) A sensitive spectrophotometric method for determination of mecillinam or pivmecillinam in the presence of degradation products. Larsen, Ciaus; Bundgaard. Hans Arch. Pharm. Chemf, Sci. Ed. 1977, 5 ( l ) , 1-7. (498) Polymerization of penicillins. V. Separation, identification, and quantitative determination of antigenic polymerization products in ampicillin sodium preparations by high-performance liquid chromatography. Larsen. Claus; Bundgaard, Hans J . Chromatogr. 1978, 147. 143-150. (508) Gas-chromatographicdetermination of carboxylic acd chlordes and residual carboxylic acid precursors used in the production of some penicillins. Lauback. R . G.; Balitz. D. F.; Mays, D. L. J . Chromatr. Sci. 1976, 14(5), 240-245. (5 18) Determination of dimethylaniline in ampicillin formulations. LeBelie. M. J.; Lauriault, G.; Vilim, A,; Wilson, W. L. Can. J . Pharm. Sci 1977, 12(2). 32-33. (528) Stability-test analysis of cephalexin. Magnem, Tone Morek; Villmo. Per H.; Karlsen, Jan Medd. Nor. Farm. Selsk. 1977, 39(3), 221-226. (538) Gas-liquid chromatographic determination of N.N-dimethylaniline in penicillins. Margosis, Michel J . Pharm. Sci. 1977, 66(1 l ) , 1634-1636. (548) Electrophoretic separation of semi-synthetic penicillins. Markovic. 0 . ; Faith, L.; Novakova, L. Pharmazie 1977, 32(10). 594-595. (558) Thin-layer bioautographicai detection of d-lactam contaminants in pharmaceuticals. May, E. M.: Sefton, G. V Proc. Anal. Div. Chem. SOC 1977, 74(10), 290-292. (568) Gas--liquid chromatography of methyl esters of natural penicillins. Messchaert, B.; Adriaens, P.; Eyssen, H. J . Chromatogr. 1977, 136(1), 162- 164. (578) High-perfotmance liquid chromatography of natural products. I. Separation of cephalosporin C derivatives and cephalosporin antibiotics: isolation of cephalosporin C from fermentation broth. Miller, Roger D.; Neuss, Norbert J . Antibiot. 1976, 29(9). 902-906. (588) Fluorimetric determination of amoxicillin. Miyasaki Katsumi; Ogino, Osamu; Sato, Hiroyuki; Nakano. Masahiro; Arita, Takaichi Chem. Pharm. Bull. 1977. 25(2), 253-258. (598) Photometric extraction method for determination of cephalexin. Papazova, P.; Bonchev, P.; Kacharova, M. Mikrochim. Acta 1976, f1(1-2), 185-194. (60B) Photometric extraction method for determination of cephalothin. Papazova. P.; Bontchev, P.; Kacarova, M. Pharmazie 1977, 32(8-9~,486-488. (618) Ampicillin and amino-acid analysis Perrett, D. Clin. Chim. Acta 1975, 64(3), 343-346. (628) Detection of cephalosporins with chioroplatinic acid on thin-layer chromatoplates. Pokorny, M.: Vitezic, N.; Japelj, M.: Vaicavi, U. farmaco Ed. Prat. 1976. 37iI). 23-26. (638) A colorimetric method for the estimation of ampicillin. Rao, G. Ramana; Kanjilal, Geeta; Mohan, K. R a n e Curr. Sci. 1977, 46( 18), 636-637.
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(648) Electrochemical analysis of the cephalosporin cephamandole sodium "nafate". Richard, Eugene C.; Cooke, Gary G.J . Pharm. Sci. 1977, 66(3), 379-384. (656) Pyrolysis/gas-liquid chromatographic identification of food and drug ingredients. 11. Qualitative and quantitative analysis of penicillins and cephalosporins. Roy, Timothy A,; Szinai. S. S. J . Chromatogr. Sci. 1976, 74(12), 580-584. (666) Immobilized-enzyme-based flowing-stream analyzer for measurement of penicillin in fermentation broths. Rusling, J. F.; Luttreli, G. H.; Cullen, L. F.; Papariello, G.J. Anal. Chem. 1976, 48(8), 1211-1215. (678) Extraction of carboxylic acids as adducts with trioctylphosphine oxide. Schroeder-Nielsen. Merete Acta Pharm. Suec. 1976, 73(2), 133--144. (688) Gas-liquid chromatographic determination of 6-aminopenicillanic acid and 7-amino-3-methyi-~-cephem-4-carboxylicacid. Silingardi, Silvestro; Di Bitetto, Mauro; Mangia, Albert0 J . Pharm. Sci. 1977, 66(12), 1769-1771. (698) Salt effects in reversed-phase thin-layer chromatography [of, e,g., antibiotics] on silica gels. Thijssen, H. H. W. ,I. Chromatogr. 1977. 733(2). 355-358. (708) Chromatography of cephalosporins on DEAE Sephadex. Tortoiani, G.; Romagnoli, E. J . Chromatogr. 1976, 720(1), 149-153. (716) Comparison of methods for determining probenecid in tablets and flavored oral suspensions containing ampicillin. Vollmer, Paul J.; Chastonay, Richard; Haneke, Carol; Kantor, Nathan; Biyth, Robert J , Assoc. Off. Anal. Chem. 1977, 60(6), 1345-1349. (728) Spectrophotometric determination of some cephalosporins. Wahbi, A. M . ; Unterhalt, B. Fresenius' 2. Anal. Chem. 1977, 284(2), 128. (736) Application of proton and carbon-13 nuclear magnetic resonance spactroscopy to estimation of diastereoisomer ratio in phenethicillin [potassium]. Wilson, W. L.; Avdovich, H. W.; Hughes, D. W.; Buchanan, G. W. J . Pharm. Sci. 1977. 66f6). 1079-1083. (748) Determination of cephaloridine in serum and tissue by high-performance liquid chromatography. Wold, J. S.; Turnipseed, S. A. J . Chromatogr. 1977, 736(1), 170-173. (756) Application of tributyttin chloride to separation and column chromatography of thiols. Wronski, Mieczyslaw J . Chromatogr. 1976, 7 77(1), 47-52. (768) Gas-chromatographic and gas-chromatographic/mass-spectrometric analysis of ampicillin. Wu. Hsin-Lung; Masada. Mikio: Uno, Toyozo J . Chromatogr., 1977, 737(1), 127-133. (778) Analysis of diastereomeric 7-ureidoacetamidocephalosporins by highperformance liquid chromatography. Young, Marian G. J . Chromatogr. 1978, 750(1), 221-224. (786) Rapid sensitive fluorimetric analysis of cephalosporin antibiotics. Yu, A. B. C.; Nightingale, C. H.; Flanagan, D. R . J . Pharm. Sci. 1977, 66(2). 213-216. Polyene (79B) Colorimetric determination of nystatin. Chowdhry, 8 . Z. Talanta 1976, 23(1). 79. (808) 'Analysis of candicidin and related polyene antibiotics by means of the coil planet centrifuge. Lightbrown, J. W.; Newland, P.; Sutherland. I . A.; Dymond, J. W. A. Proc. Anal. Div. Chem. Soc. 1977, 74(2), 34-37 (816) Assay of nystatin based on measurement of potassium released from Saccharomyces cerevisiae. Ndzinge, I.; Peters, Susan D.; Thomas, A. H. Analyst (London) 1977, 102(1214), 328-332. (828) Analysis and assay of polyene antifungal antibiotics: a review. Thomas, A. H. Analyst (London) 1976, 707(1202), 321-340. (836) Microbiological assay of the polyene antifungal antibiotics amphotericin. candicidin, and nystatin. Thomas, A. H.; Peters, Susan D. Analyst(London) 1977, 702(1214), 333-339 Polypeptides (846) High-performance liquid-chromatographic analysis of gramicidin, a polypeptide antibiotic. Axeisen, K. S.; Vogelsang. S H. J , Chromatogr. 1977, 740(2), 174-178. (856) The quantitative nature of the reaction between amirioglycoside and polymyxin class antibiotics with polyanionic detergents. Edberg, S . C.; Savino. D.; Singer, J. M. Ewperientia 1977, 33(3), 323-324. (86B) High-pressure sample cell for circular dichroism studies. Harris. R D.; Jacobs, M.; Long, M. M.; Urry, D. W. Anal. Biochem. 1976, 73(2), 363-368. (878) Determination of bacitracin by differential pulse polarography. Jacobsen. E.; Pederstad, J. H.; Oystese, B. Anal. Chim. Acta 1977, 97(2). 121-128, (886) Determination of gramicidin by quantitative high-performance thin-layer chromatography. Kreuzig, F Fresenius' Z Anal. Chem. 1976, 28215). 447-449. Slreplomycln and Related Antibiotics (898) Spectrophotometric studies of neomycincopper complex and determination of neomycin sulfate using an auxiliiary ligand. Agrawal, J. K.: Harmalkar, S. G.; Vijayavargiya, R. Microchem. J . 1976, 27(2). 202-208. (906) Determination of doxorubicin [adriamycin] hydrochlorkle in pharmaceutical preparations using high-pressure chromatography. Barth. Howard G.; Comer. Albert 2. J , Chromatogr. 1977, 737, 375-381. (91B) New determination of two antibiotics belonging to the lincosanide group: lincomycin and clindamycin. Eaudet, Michele J . Pharm. Belg, 1976, 3 1(3), 247-254. (928) Tropaeolin 000 [C.I. Acid Orange 71 as an organic precipitant for determining streptomycin, meciozine. and isoniazid. Beltagy. Y. A,; Issa, A,; Rida, S. M. Pharmazie, 1976, 37(4). 258. (936) Thin-layer chromatography of some amino-glycosidic antibiotics: rapid method for identification of neomycins 8 and C from the culture broth. Chatterjee, Nithar Ranjan Indian J . Chem. 1975, 73(12). 1282-1284. (948) Chemical spectrophotometric method for determination of neomycin sulfate and polymyxin 8 sulfate in ophthalmic preparations. Doulakas. J. Pharm. Acta Helv. 1976, 57(12), 391-392
(958) Modificationsto the thiobarbituric acid assay of streptomycin. Duda. Erno; Marton. L.; Kiss, G. Biochem. Med., 1976, 75(3), 330-332. (966) Radioenzymic assay techniques for [antibiotic] aminoglycosidps. Forrey, Arden W.; Blair, Andrew D.; O'Neill, Michelle A,; Cutler, Ralph E. Methodol. Dev. Biochem. 1976, 5, 235-240. (976) A radio-immunoassay for clindamycin. Giibertson, Terry J ; Stryd. R. P. Clln. Chem. (Winston-Salem. N . C . ) 1976, 22(6). 828-831. (988) Simple thin-layer chromatographic identification method for erythromycin stearate. &aham, K. C.; Wilson, W. L.; Vilim, A. J . Chro,mtcgr. 1976, 725(2). 447-450. (996) Comparison of candicidin, levorin, and trichomycin [hactiimycin] by means of high-performance liquid chromatography. Hansen, Steen Honore; and Thomsen. Mogens J . Chromatogr. 1976, 723(1), 205-21 1 (1006) Fluorescence densitometric method for simultaneous determination of siomycins using a silica gel sintered plate. Hirauchi, Kazumasa; Masuda, Sachiko Chem. Pharni. BUN. 1977, 25(6). 1474-1478. (1018) Determination of gentamicin-complex components in fer nietitatiori broth by in-situ fluorimbic measurements of 4-chlorc-7-n%robenzofurazan derivatives. Kabasakalian, Peter: Kailiney, Sami; Magatti. Anita W. Anal. Chem. 1977. 49(7), 953-955. (1028) Electrophoretic, chromatographic, and mass spectrometric procedures for the identification and isotopic assay of amino ackl coristtuents in ntamycin. Kamal, Fatemah; Katz. Edward; Mauger, Anthony B J . Chrornatogr. 1978. 757(2), 245-248. (1038) Simultaneous determination of vancomycin, anisotnycin. and tririiethoprim lactate by high pressure liquid chromatography. Kirchmeier. R L.; IJptoti, R. P. Anal. Chem. 1978. 50(2), 349-351. (1046) Chromatography of reduction products of spectinoniycin. Knight. John C. J . Chromatogr. 1977, 736(3), 432-436. (1058) Erythromycin series. I V . Thin-layer chromatography of erythroniyciii, erythromycin oxime, erythromycylamine, and their acyl derivatives. Kobrehel. Gabrijeh; Tamburasev, Zrinka; Djokic, Slobodan J . Chromtogr , 1977. 133(2). 4 15-41 9. (106B) Maridomycin, a new macrolide antibiotic. XII. Simple quantitative anaiysis of 9-propionyimaridomyciri components. Kunishige, Nobuo: Kawatnura, Kunio; Muroi, Masayuki; Kishi. Toyokazu Chem. Pharni. Bull. 1975, 23(12), 3075-3080. (1078) Erythromycin series. V. Quantitative determination of ciadinose and methylcladinoside by densitometry of thin-layer chromatograms. Lazarevski, Tomislav; Tamburasev, Zrinka; Djokic. Slobcdan J . Chromtcgr. 1977, 732(2), 309-313. (1088) High-performance liquid-chromatographic determination of kananiyciti. Mays, David L.: Van Apekloorn, Richard J.; Lauback, Ronald G. J Chr-orwtcgr. 1976, 720(1), 93-102. (1098) Reversed-phasehigh-performance liquid chromatography of bleornycin. Rzeszotarski, W . J.; Eckelman, W. C.; Reba, R. C. J . Chrornatogr. 1976, 724(1), 88-91 (11OB) Rapid acetylation of a dihydroxy-compound by 4-(dinlethylamino)pyridine catalysis: application to gas-liquid chromatographic determination of clindamycin palmitate hydrochloride. Rowe, Englebert L.: Machkovech. Siisari M. J . Pharm. Sci. 1977, 66(2), 273-275. (1 1 18) Reversed-phasehigh-performance liquid chromatography of bleomyciti. Rzeszotarski, W. J.; Eckeiman, W. C.; Reba, R. C. J Chrornatogr. 1976, 724(1), 88-91. (1 128) Total systematic noise reduction in Fourier-transform nuclear magnetic resonance spectrometry. Santini, Robert E.: Grutzner, John 6 . Anal Chem 1976, 48(6), 941-943. ( 1138) Analysis of erythromycin. 11. Determination of erythromycin in human blood serum by competitive displacement of ''C-iabeled erythrornycin from Eschrichia coliribosomes. Smith, Robert V.; Harris, R. Gregg; Maness, Dale D.; Martin, Alfred Anal. Lett, 1977, 70(9). 719-731. (1 148) Analysis of erythromycin. I . A study of eqhhromycin-acid dye complexes. Smith, R. V.; Harris, R. G.; Sanchez, E.; Maness, D. D.;Martin. A , , Microchem J . 1977, 22(2), 168--175. ( 1158) Differential pulse polarographic analysis of adiiamycin [doxorubicinl in plasma. Sternson. Larry A , ; Thomas, George Anal Lett. 1977, 70(2), 99-109. (1168) Preliminary evaluation of Iurninescent techniques for the deterniination of bleomycin. Thompson, M.; Williams, C. R. Anal. Lett 1976. 9(6),179-185. (1178) Fluorimetric determination of erythromycin and erythromycin propionate in whole blood or plasma and correlation of results with microbiological assay. Tserng, Kou-yi: Wagner, John G. Anal. Chem. 1976, 4 8 ( 2 ) . 348-353. (1186) High-performanceliquid chromatographic determination of erythrumycrn. Tsuji, Kiyoshi; Goetz, John F. J , Chromatogr. 1978, 147. 359-367 (1198) Simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate, and ethyisuccinate. Vilim, A,, LeBelie, M.J.; Wilson, W. L.; Graham, K . C. J . Chromatogr. 1977, 133(1), 239-?44. (1208) Spectrophotometric determination of streptomycins. Wahbi, 4 M: Abdirie, H.; Sadek. A,; Rafik, H. Pharmazie 1977, 32(11). 690 692 (1218) Improvement of the efficiency of ion-exchange cellulose colunins. and their application. van der Wal. S.: Huber, J. F. K . J . Chrornatogr. 1977, 735(2). 287-303. ( 1228) Separation of bleomyciris by high-pressure liquid chromatography Williams, C. R.; Gifford, L. A,; Scanlon. 8 . Anal. Len. 1977, 1015). 407-413 ( 1 238) Polarization fluoro-immunoassay of gentamicin [in seruni] . Watson. R. A. Amina: Landon. J,: Shaw, Elizabeth J.; Smith, D. S. C/in. Chim. Acta 1976, 73(1), 51-55. (1248) Colorimetric method for the determination of kanamycin. Yassa. Dawoud A,; Gad Ei Rub, Laiia N. Pharmazie 1976, 37(4). 257- 258. Sulfonamides (1258) Gas-liquid chromatographic determination of suifadiazine and its major metabolite in human plasma and urine. Bye, A , , Land, G. J Chrornatogr. 1977, 739(1), 181-185. (1268) Contaminants in commercial dapsone. Cheung, Andrew P.; i-im, Peter
ANALYTICAL CHEMISTRY, VOL. 51, NO. 5, APRIL 1979 J . Pharrn. Sci. 1977, 66(12), 1723-1726. (1278) High-performance liquid chromatography of some sulfonamides. Cobb, P. H.; Hill, G, T. J . Chromatogr. 1976, 723(2), 444-447. (1288) Use of metal ions for selective separations in high-performance liquid chromatography. Cooke, N. H. C.; Viavattene, R. L.; Eksteen, R.; Wong, W. S.; Davies, G.; Karger, 8 . L. J . Chromatogr 1978, 749, 391-415. (1298) Separation and determination of a quaternary mixture of sulfonamides by liquid--liqL!id partition chromatography on columns. Crommen, Jacques J Pharm. Belg 1977, 32(2). 128-142. 11308) Rapid qualitative identification of sulfonamides by mass spectrometry. Davis, Reg; Hurst. Derek T.; Taylor, Albert R . J . Appl. Chem. BiOteChnOl. 1977. 27(10). 543-548. (1318) Evaluation and optimal combination of thin-layer chromatography systems for qualitative identification. I. Sulphonamides. De Clercq, H.: Massart, D. L : Dryon, L. J . Pharm. Sci. 1977, 66(9), 1269-1275. (1328) Direct spectrophotometric determination of sulfathiazole in presence of sulfadiazine and sulfamerazine. Dombrowski, Lawrence J.; Brown, Robert S.; Pratt, Edward L. J . Pharm. Sci. 1977, 66(10), 1413-1415. (1338) New method of linearization of the relaxation between the instantaneous temperature and the fraction of the mixture that has melted in differential microcalorimetry. Draguet-Erughmans, M,; Bouche, R.; Bontemps, R. Mikrochlm. Acta 1977, 1(1-2), 93-104. (1348) New paper-chromatographic technique for quantitative determination of sulfacetamide and sulfanilamide in liquid pharmaceuticals. Elsabbagh, H. M.; Sakr, A. M.; Kassem. A. A,; Ibrahim, E. H. Pharm. Ind. 1976, 38(11), 1002- 1005. ( 1358) Determination of dapsone and pyrimethamine in tablets by high-pressure liquid chromatography. Girgis-Takla, Pamela; Shirsat, Pandurang J . Assoc. Public Anal. 1977, 75(4), 135-140. (1368) High-performance liqud-chromatographic determinabon of trimethoprim and sulfonamide combinations. Helboe, Per; Thomsen. Mogens Arch pharm. Chemi, Sci. E d . 1977, 5(2), 453--460. (1378) Studies on the phosphorimetric determination of amines with halonitro-compounds. I . Phosphorimetric determination of 4homosulfanilamide [ rnafenide] with 1-fluoro-4-nitrobenzene. Hirauchi, Kazumasa: Amano, Tameyuki Chem. Pharm. Bull. 1977, 25(6). 1326-1329. ( 1388) Pyrolysis gas chromatographic-mass spectrometric study of medicinal sulfunamides. Irwin, W. J.: Slack, J. A J. Chromatogr. 1977, 739(2). 364-369. (1398) Multiple sulfa compounds: high-pressure liquid chromatographic assay and mobile phase correlation. Jennings. E. C.; Landgraf. W. C. J . Pharm. 5 c i . 1977, 66(12). 1784--1786. ( 140B) The reversed-phase liquid-chromatographic separation of sulfonamides a i d barbituric acids as acids and ion-pairs. Johansson, 1. Monika: Wahlund. Karl-Gustav Acta Pharm. Suec. 1977, 74(5-6). 459-474. (14 16) Quantitative determination of ambazone. Kuhnke. G.: Goeckeritz. D.; Pohloudek-Fabini, R . Pharmazie 1976, 37( 1 l ) , 820-821 (1428) Commentary on the standard instructions for the D.A.B. VI1 of the DDR. Detection of sulfonamides in body fluids. Lauermann, I.; Mueller, R. K ; Wehran, H.-J. Zentralbl. Pharm.. Pharmakother. Laboratoriumsdiagn. 1976. I75( 1 l ) , 1171-1 174. (1436) Investigation of Schiff bases of medicinal sulfonaniides. 11. Polarographic determination of some sulfonamides by Schiff-base reaction. Lehtinen, M.; Halmekoski, Jaakko Farm. Aikak. 1976, 85(2), 35-43. ( 1448) High-speed liquid-chromatographic analysis of dapsone and related compourids. Mannan, C. A,; Krol, G. J.; Kho, Boen T. J . Pharm. Sci. 1977, 66(11), 1618--1623 (14581 Gas-liquid chromatographic determination of sulfonamdes. Nose, Norihide; Kobayashi, Susumu: Hirose, Akiko: Watanabe, Akinobu J , Chromatogr. 1976, 723(1), 167-173. ( 1468) Separdtion of organic acids on Amberlite XAD copolymers by reversed-phase high-pressure liquid chromatography. Pietryzyk. Donald J., Chu, Ching-Hong Anal. Chem. 1977, 49(6). 860-867. ( 1478) Nuclear-magnetic-resonance determination of trimethoprim and SUIfamethoxazole in tablets and powders. Rodriguez, Maria R.; Pizzorno, Maria T.; Albonico. Sem M. J . Pharm. Scl. 1977, 66(1), 121-123. (1488) Determination of prothionamide and Its sulfoxide metabollte in physiological fluids by quantitative thin-layer chromatography. Rossi, Michael; Ruebsamen, Klaus J . Chromatogr. 1977. 732(3). 562-565. ( 1498) Vanadametric determination of sulfanilamide. Sastry. C. S. Prakasa; Ramdkrishna. R . Curr. Sci. 1976, 45(13), 494-495. (1508) tiigh-pressure liquid-chromatographic separation, identification and determination of sulfa drugs and their metabolites in urine. Sharma, J. P.; PerKins. E. G.; Bevill, R . F. J . Pharm Sci. 1976, 6511 1). 1606- 1608. (1518) Analysis of sulfonamides and their metabolites by pyrolysis-gas chromatography-mass spectrometry. Slack, J A,: Irwin, W. J. Proc Anal Div. Chem. SOC.1977, 74(9), 249--251. ( 1520) Thin-layer chromato raphic determination of mafenide [4-(aminomett1yl)benzenesulfonamide~in human serum. Steyn, J M. J . Chromatogr. 1977, 143(2): Biomed. Appl 7(2), 210-213 (1538) Assay of 4-aminobenzenesulfonamides wfth chloramine T. Trieff, Norman, M.; Ramanujam. V M Sadagopa; Cantelli Forti, G Talanta 1977, 24(3), 188- 190 (1548) Nuclear magnetic resonance analysis of pharmaceuticals. Part XV. Determination of sulfamethoxazole and trimethoprim in combination in tablets. Turczan. ,John W Ana/ Chim. Acta 1977, 92(1), 123-128.
Tetracycllne (1556) Direct-current polarographic assay of tetracyclines. Chatten, L. G.; Moskalyk, R . E.; Locock, R . A . ; Huang. K.-S. J . Pharm. Sci 1976, 65(9). 1315-1319. (1568) Study of panimocycline by high-performance liquid chromatography. Chevalier, Gerard; Bollet. Claude; Rohrbach, Philippe; Risse, Claude; Caude. Marcel: Rosset, Robert J Chromatogr 1976, 124(2). 343-349. ( 1578) Evaiuation of chemical assay for analysis of tetracycline in human p h s m . Christophersen, Asbjoerg Solberg; Jahren, Grete; Salvesen. Bjarne; Karlsen, Jan Medd. Nor Farm Selsk 1976, 38(1). 1-10,
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(1588) Thiocyanatcchromium(II1)complexes in chemical analysis. XXXII. Indirect volumetric determination of tebacycline. Ganescu, Ion; Braun, Marilena: Gavrib. Emil Arch. Pharm. (Weinheim, Germany) 1977, 370(7), 544-548. (1598) Fluorimetric assay of tetracycline mixtures. Hall. D. J . Pharm. pharmacal. 1976, 28(5), 420-423. (160B) Determination of anhydrotetracyclines in tetracycline by high-pressure liquid chromatography. Lindauer, Richard F.; Cohen. David M.; Munnelly, Kevin P. Anal. Chem. 1976, 48(12), 1731-1734. (16lB) Replacement of biological methods by chemical and physical methods. Tetracyclines. Lightbown, J. W. Proc Anal. Div. Chem. SOC.1976. 13(5), 137- 139. (1628) A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities. Mack, George D.; Ashworth, Raymond 8 . J . Chromatogr. Sci. 1978, 76(3), 93-101. (1638) Alternating-current polarography for tetracycline analysis. Oiliff, Cedric, J.: Chatten, Leslie G. J . Pharm. Sci. 1977, 66(11), 1564-1566. (1648) Fluorimetric determination of tetracyclines in biological materials. Poiger, H.; Schlatter, C. Analyst (London) 1976, 107(1207), 808-814. (1658) Simple method for the quantitative analysis of tetracyclines by direct fluorimetry after thin-layer chromatography on cellulose plates. Ragazzi, Enrico; Veronese, Giovanni J . Chromatogr. 1977, 732(1), 105-1 14. (166B) Gel chromatography of tetracycline antibiotics. Ragazzi, Enrico, Veronese, Giovanni J . Chromatogr. 1977, 734(1), 223-229. (1678) Fluorimetric determination of the active forms of tetracycline, chlortetracycline, and oxytetracycline in partially decomposed solutions. Regosz, A. Pharmazie 1977, 32(1 l ) , 681-683. (1688) Determinatlon of active form of doxycycline and methacycline in partially decomposed solutions by fluorimetry. Regosz, A. Fresenius' Z . Anal. Chem. 1976, 280(5), 383-384. (1698) High-pressure liquid-chromatographic determination of te!racyciines in urine. Sharma, J. P.: Koritz, G. D.; Perkins, E. G.; Bevili, R. F. J . Pharm. Sci. 1977, 66(9), 1319-1322. (1708) Reversed-phase high-performance liquid-chromatographic determination of tetracyclines in urine and plasma. Sharma. J. P.; Perkins, E. G.; Bevili, R. F. J . Chromatogr. 1977, 734(2), 441-450. (1718) Thin-layer chromatographic assay of tetracyclines. Szabo, Antal: Nagy, Margit Kovacs; Tomorkeny. Endre J . Chromatogr. 1978, 75 7(2), 256-258. (1728) Analysis of tetracycline in pharmaceutical preparations by improved high-performance liquid-chromatographic method. Tsuji. Kiyoshi: Robertson, John H. J . Pharm. Sci 1976, 65(3), 400-404. (1738) Rapid and sensitive direct thin-layer chromatographic fluorimetric method for evaluation of impurities in oxytetracycline. Wiilekens, Gilbert J. J . Pharm. Sci. 1977, 66(10), 1419--1422. Chloramphenicol (1748) Comparative studies on the determination of chloramphenicol and its hydrolysis product. Polarographic method after separation by thin-layer chromatography and high pressure liquid chromatography. Ali. Syed Laik Pharm. Ztg 1977, 722(41). 1816-1822 (1758) Quantitative gas-chromatographic flame ionization method for chloramphenicol in human serum. Least, Charles J., Jr.; Wiegand. Noreen. J.: Johnson, George F.; Solomon, Harvey M. Clin. Chem. ( Winston-Salem. N.C ) 1977, 23(2). 220-222. (1768) Separation of chloramphenicol intermediates by high-performance liquid chromatography on Micropak-NH, columns. Vigh, G.; Inczedy. J. J . Chromatogr. 1976, 729, 81-89. ( 1 778) Separation of some chloramphenicol intermediates by high-pressure liquid chromatography. Vigh, G.; Inczedy, J. J . Chromatogr. 1976, 7 76(2), 472-474.
Isoniazid (1788) High-performance liquid-chromatography analysis of isoniazid and its dosage forms. Bailey, Leonard C.; Abdou, Hamed J . Pharm. Sci. 1977, 66(4), 564-567. [ 179B) The therincdynamic determination of isonicotinic acid hydrazide in isonlazid tablets Bark. L. S ; Kershaw, L. Proc Eur. Symp. Therm. Anal.. Ist 1976, 139-142. ( 18OB) Electrolytic generation of siiver(I1) ions Application to the determination of organic substances and nitrite ions in water. Chateau-Gosselin. M ; Patriarche, G. J. Analusfs 1977, 5(7), 3111-313. (18 18) Coulometric determination of organic slubstances using electrogenerated dipositive silver. Chateau-Gosselin, M.; Patriarche, G. J.: Christian. G. D. Fresenius' Z Anal. Chem. 1977, 285(5), 373-376. (1828) Repetitive deterinination of isonicotinic acid hydrazide [isoniazid] in flow-through systems by series reactions. Dutt. V. V . S . Eswara: Mottola. Horacio A. Anal. Chem 1977, 49(6), 776-779. ( 1838) Specific rapid gas-chromatographic assay for determination of [extent of] isoniazid N-acetylation: observation in rats with induced constant urine flow. Frater-Schroeder, M.: Zbinden. G. B h h e m Med. 1975. 74(3), 274-284. (1848) Chromium(l1lphiocyanate complexes in chemical anatysis. Determination of isowid. Ganescu, I . ; Vahtyi. C.; Papa, I. Zentralbl. pharm., Pharmakother. Laboratoriumsdiagn. 1976, I75(5), 515-521. (1858) Quantitative determination of hydrazines derived from isoniazid in man. Iguchi, Sadao: Gofomaru, Tsuyoshi; No%, Atsuko; Matsuyama, Kenji; Sogabe, Keizo Chem. Pharm. Bull. 1977, 25(10), 2796-2800 (1868) Gasornetric determination of isonicotinic acid hydrazide [isonlazid]. Sawar. M.; Yaqub. M.: Naeem, I ; Kazi. A. A Fresenius' 2.Anal. Chem. 1977, 285(3-4), 269. (1878) Liquid chromatography in pharmaceutical analysis. VI11 Determination of isoniazid and its acetyl derivative in plasma and urine samples. Saxena S J.: Stewart, J T.; Honigberg, I L.; Washington, J G.; Keene. G R J . Pharm. Sci. 1977, 66(6), 813-816 (1888) Hydrazones of isoniazid for colorimetric analysis. Shah, P. R ; Raje. R . R. J Pharm. S o . 1977, 66(2). 291-292.
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(1898) Liquid chromatography in Pharmaceutical analysis. V . Determination of isoniazid-pyridoxine hydrochloride mixture. Stewart, J. T.; Honigberg, I. L.; Brant, J. P.; Murray, W. A,; Webb, J L.; Smith, J. B. J . Pharm. Sci. 1976, 65(10), 1536-1539. (1908) Determination of hydrazine metabolites of isoniazid in human urine by gas chromatography. Timbrell, John A.; Wright, James M.; Smith, Clare M. J . Chromatogr. 1977, 138(1), 165-172. Miscellaneous (1918) Liquid-solid chromatographic determination of 6-demethylgriseofulvin in urine. Papp, E.; Magyar, K.; Schwarz, H. J. J . Pharm. Sci. 1976, 65(3), 441-443. (1928) Determination of doxorubicin hydrochlwide in pharmaceutical preparations using high-pressure liquid chromatography. Barth, Howard G.; Conner. Albert 2. J . Chromatogr. 1977, 131, 375-381. (1938) Determimition of ethambutol hydrochloride. Amer Mohamed M.; Tawakkoi, Mostafa S.; Ismaiel, Saad A. J . Pharm. Belg. 1976, 31(1), 80-88. (1948) Determination of ethambutol in plasma and urine in chemical-ionization gas chromatography/mass spectrometry using a deuterated internal standard. Blair, Andrew D.; Forrey. Arden W.; Christopher, T. Graham; Maxwell, Barbara; Cutler, Ralph E. Methodol. Dev. Biochem. 1976, 5 , 231-234. (1958) Analysis of (+)-ethambutol by circular dichroism of its copper chelates. Kitagawa, Tsunehiro; Oie, Shigeharu; Taniyama, Hyozo Chem. Pharm. Bull. 1976, 24(12), 3019-3024. (1968) Indirect atomic absorption analysis of ethambutol. Kovatsis, A. V.; Tsougas, M. A. Arzneim.-Forsch. 1978, 28(2),248-250. (1978) Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey. Lee, Ching S.; Benet, Leslie 2. J . Chromatogr. 1976, 128(1), 188-192. (198B) Sensitive assay procedure for ethambutol hydrochloride via chargetransfer-complex formation. Tan, Henry S. I.; Geriach, Eric D.; Dimattio, Anthony S. J . Pharm. Sci. 1977, 66(6), 766--769. (1998) Gas-chromatographic determination of 5-fiuorocytosine [fiucytosine] in human serum. Harding, Sally A.; Johnson, George F.; Solomon, Harvey M. Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6), 772-776. (2008) Quantitation of an antibacterial agent in a dentifrice by thin-layer chromatography. Olson, Byron L. J . Dent. Res. 1977, 56(4)), 443. (2018) Determination of furazolidone in the presence of other materials in powder mixtures. Curtze, A.; Eschwe, E. Dtsch. Apoth. 1977, 29(9), 440-442. (2028) Colorimetric method for the determination of griseofuivin using 2,4dinltrophenylhydrazine. Amer, M. M.; Habeeb, A. A. J. Drug Res. 1975, 7(3), 123-128. (2038) Reaction for the determination of griseofutvin with potassium dichromate in sulfuric acid. Auterhoff, Harry; Kliem, Michael Arch. Pharm. ( Weinheim, Ger.) 1976, 309(4), 326-329. (2048) Gas-liquid chromatographic determination of griseofukin in human pbsma. Schwarz, H. J.; Waidman, 8. A.; Madrid, V. J , Pharm. Sci. 1976, 65(3), 370-372. (2058) Potentiometric determination of griseofuivin in pure and tablet form. Shafik. Ragab M.; Elnenaey, Elsayed A. Pharmazie 1977, 32(2), 126-127. (2068) Volumetric determination of hexamine in some pharmaceutical preparations containing piperazine. Ismaiei, Saad A,; Yassa, Dawoud A. Pharmazie 1976, 3 1(1l ) , 821-822. (2078) Gas-liquid chromatographic determination of methenamine [hexamine] in tablets. Strom, J. G., Jr.; Jun, H. W. J . Pharm. Sci. 1977, 66(4), 589-590. (2088) Analytical profile of pure hexetidine. Satzinger. G.; Herrmann. W.; Zimmermann, F. Arzneim.-Forsch. 1975, 25(12), 1849-1853. (2098) Quantitation o i the antimalarial mefloquine in blood, plasma, and urine using highpressure liquid chromatography. Grindel, J. M.; Tihon, P. F.; Shaffer, R. D. J . Pharm. Sci. 1977, 66(6), 834-837. (21OB) Analysis of urinary tract antibacterial agents in pharmaceutical dosage form by high-performance liquid chromatography. Sondack, David L.; Koch, William L. J . Chromatogr. 1977, 132(2), 352-355. (211B) Ubravioiet-spectral and polarographic study of nitrofurantoin, a urinary-tract antibiotic. Burmicz, J. S.; Smyth, W. Franklin; Palmer, R. F. Ana/yst(London) 1976, 101(1209). 986-991. (2128) Determination of nitrofurantoin in urine by reduction at rotating platinum electrode. Mason, William D.: Sandmann, Beverly J . Pharm. Sci. 1976, 65(4), 599-601. (2138) Colorimetric determination of nitrofurantoin in dosage forms. Rao. G. Ramana; Raghuveer. S.; Murty, S. S. N.; Bajrangrao, B. Indian J . Pharm. 1977, 39(4), 83-85. (2 148) Identificationof 8-aminc-6-methoxyquinoline as a metabolee of primaquine in man. Baty, J. D.; Evans, D. A. Price; Robinson, P. A. Biomed. Mass Spectrom. 1975, 2(6). 304-306. (2158) Metabolism of piromidic acid, a new antibacterlal agent. 111. Determination of pwomidic acid and its metabolites in blood, urine, and bile of rats and humans. Sekine, Yutaka; Miyamoto. Mie; Hashimoto, Masahisa; Nakamura. Kiyoshi Chem. Pharm. Bull. 1976, 24(7), 1433-1438. (2168) Analysis of rifampicin and of its hydrogenated derivatives by highperformance liquid chromatography. Vlasakova, V.; Benes, J.; Zivny K. J . Chromatogr. 1978. 151(2), 199-205. (2178) Thin-layer chromatographic identity and purity test for rifampin. Wilson W. L.; Graham, K. C.; Lebelle, M. J. J . Chromatogr. 1977, 144(2), 270-274. (2188) Separation, determination, and pharmacokinetics of rifampicin and its metabolites. Winsel, K.; Iwainsky, H.; Werner, E.; Eule, H. Pharmazie 1976, 31(2), 95-99. (2198) Characterization of impurities in sulfasaiazine. Zalipsky, J. J.; Patel. D. M.; Reavey-Cantwell, N. H. J . Pharm. Sci. 1978, 67(3)). 387-391. (2208) Preparation of trimethylsilyi derivatives of thiamphenicol. Janssen, G.; Vanderhaeghe, H. J . Chromatogr. 1977, 134(2), 365-374. (2218) Rapid gas-chromatographic determination of thiamphenicol in plasma and amniotic fluid. Plomp, T. A.; Maes, R. A. A.; Theiry, M. J . Chromatogr. 1976, 121(2),243-250. (2228) Determination of tinidazole in tablets by direct-current polarography.
Slamnik, Marjan J . Pharm. Sci. 1976, 65(5),736-737. (2238) Fluorimetric determination of WR-148,946 {the hydrochloride of 1[ 2,6-bis-(a.a,a-trifluoro-p-tolyl~4-pyridyi] -2dibutylaminoethanol\ in biological fluids. Bouwsma, Otis J.; Stewart, James T. Anal. Lett. 1976, 9(11). 1003-1013. INORGANICS Single Element Analysis (1C) The pH-stat titration of aluminum hydroxide gel. Kerkhof, Nicholas J.; Vanderlaan, Roger K.; White, Joe L.; Hem, Stanley L. J . Pharm. Sci. 1977, 66( 11), 1528- 1533. (2C) Micro- and sub-micro-scale iodimetric determination of antimony(II1) in antibilharzial compounds by use of amplification reactions. Gawargious, Y. A.; Bouios, L. S.; Besada, Amir Analyst(London) 1976, 701(1203), 458-462. (3C) Thiosulfate complexometric determination of bismuth in some organic pharmaceutical chemicals and in pharmaceutical formulations. Amer, M. M.; Stahlawska, A.; Ahmed, A. S.;Tawakkol, M. S. Egypt. J . Pharm. Sci. 1976, 16(3), 367-382. (4C) New semi-quantitative limit test for carbonate [in pharmaceuticalproducts]. Wolimann, H.; Doege, E.-M.; Graeser, K. Zentralbl. Pharm., Pharmakother. Laboratoriumsdiagn . 1976, 1 15(11), 1 13 1- 1 137. (5C) Calcium determimition of hemoditysis solution with an ion selective electrode. Praniic-Anusic, Zeliko; Cimerman, Zviezdana; Stefanac, Zlata Acta Pharm. Jugosl. 1977, 27(1), 55-61. (6C) Rapid and sensitive colorimetric determination of cobalt(I1). Eldawy, M. A.; Tawfik, A. S.; Elshabouri, S. R. J . Pharm. Sci. 1976, 65(5), 664-666. (7C) . , ReDlacement of carcinoaenic and aileraenic amines in the Aldridoe determination of cyanide. Nakrstedt, A. DtscTh. Apoth.-Ztg. 1977, 117(32), 1357- 1359. (8C) Automated fluoride-ion determination. Determination of serum fluoride-ion levels. Cowell, David C. Ann. Clin. Biochem. 1977, 14(5), 275-278. (9C) Automated fluoride-ion determination. Determination of urine fluoride-ion levels. Cowell, David C. Ann. Clin. Biochem. 1977, 14(5), 269-274. (1OC) Methods for the determination of fluoride ions in toothpaste. 1. Study of the separation of the ions to be determined by microdiffusion. Hanocq, M.; Schmitz-Masse, M. 0.; Herpoi-Borremans, M. J . SOC.Cosmet. Chem. 1976, 27(11), 533-541. (1 1C) Detection of traces of fluoride in inhalation aerosols by photon-activation analysis. Sadek, Hani; Starke, Kurt; List, P. Heinz Arch. Pharm. ( Weinheim, Germany) 1977, 310(4), 299-305. (12C) Determination of elemental fluorine in organic compounds by fluorine-19 nuclear magnetic resonance spectroscopy. Staiger, David B.: Warren, Richard J.; Zarembo, John E. Microchem. J . 1977, 22(4), 557-560. (13C) Determination of fluorine in organic and inorganic pharmaceutical compounds by high resolution nuclear magnetic resonance spectrometry interfaced with a computer system. Warren, Richard J.; Bender, A. Douglas; Staiger, David 8.; Zarembo, John E. Anal. Chem. 1978, 50(3), 426-428. (14C) Determination of gold in tissue by carbon-furnace atomic-absorption spectrometry. Kamel, H.; Brown, D. H.; Ottaway, J. M.; Smith, W. E. Talanta 1977, 24(5), 309-313. (15C) The use of aromatic carbonyl derivatives in pharmaceutical analysis, Part 1. Belal, S.; Chaaban, I. Pharmazie 1977, 32(11), 704-706. (16C) Single-dose assay of iron(I1) ions in pharmaceuticals. Juneau, Richard J . Pharm. Sci. 1977, 66(1). 140-141. (17C) Controlled-potential iodimetric determination of iron after extraction with isopropyl ether. Karlsson, Ronald; Gorton, Lo Tabnfa, 1976, 23(9), 672-674. (18C) Radiometric evaluation of iron dextran complexes used in medicine. Majali. M. A,; Mani, R . S. Radiochem. Radioanal. Lett. 1976, 25(3), 143-151. (19C) Serum-iron determination in patients receiving therapy with iron dextran (Imferon). McIntosh, Max E.; Lynn, Jerry K.; Meyerriecks, Norma; Contant, Irene Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(4), 524-527. (2OC) Spectrophotometric and chelatometric determination of iron(II1) with 2',4'-dihydroxyvalerophenone. Singh. Jai; Lal. Keemti; Gupta, S. P. S. Afr. J . Sci. 1976, 72(12), 378-379. (21C) Determination of iron in pharmaceutical preparations. Stankovic, B.; Dugandzic, M.: Jelikic, M. Pharmazie 1977, 32(7), 414. (22C) Spectrophotometric determination of iron(II1). iron(II), and total iron in drugs by reaction with Z,Z'-bipyridyl. Sullivan, Daniel, J. J . Assoc. Off. Anal. Chem. 1976, 59(5). 1156-1161. (23C) Coibboratve study of a spectrophotometric determination of ferric, ferrous, and total iron in drugs by reaction with 2,2'-bipyridyl. Sullivan, Daniel J. J . Assoc. Off. Anal. Chem. 1977, 60(6), 1350-1354. (24C) Application of an atomic absorption spectrophotometric method for the determination of organomercurial preservatives in eye-drops. Calder, I.T.; Miller, J. H. McB. J . Pharm. Pharmacol. 1976, 28, Suppl. 25P. (2%) A rapid method fw the microdeterminationof nitrogen in organic compounds using a flushed-oxygen combustion tube. Baba, Yoshiko Microchem. J . 1976, 21(3), 315-324. (26C) Potentiometric determination of sodium in electrolyte infusion solutions. Peirihardt, G. Zentraibl. Pharm. Pharmakother Laboratoriumsdiagn. 1977, 116(2), 157-161. (27C) Determination of sulfite in pharmacopoeial solutes, gelatin, and wines. Trublin, F.; Robert, H.; Guyot-Hermann, A.-M.: Baiatre, P. Ann. Falsif. Expert. Chim. 1976, 69(748). 907-921. (28C) Rapid spot test for stannous tin levels in technetium-99in kits. Hambright, P.; Adabi, A,; Reid, J.; Maitland, D.; Press, H, C.. Jr.; Cherry, M. J . Nuci. Med. Techno/. 1977, 5(2). 88-89. (29C) Tin(I1) ion quantitation in pyrophosphate and poiyphosphate radiopharmaceutical kits using differential pulse polarography. McBride, Martin H. D.; George, Robert E.; Kessler, Wayne V.; Shaw, Stanley M. J . Pharm. Sci. 1977, 66(6). 870-871. Multiple Element Analysis (30C) Thiosulfate compleximetric determination of bismuth in some organic
ANALYTICAL CHEMISTRY, VOL. 51, NO. 5, APRIL 1979 pharmaceutical chemicals and in pharmaceutical formulations, Amer, M. M.; Stahlawska, A.; Ahmed, A. S.;Tawakkol, M. S. Egypt. J . Pharm. Sci. 1976, 16(3), 367-382. (31C) Polarographic microdetermination of iron, manganese, lead, copper, bismuth, and tin in organic compounds. Application to analysis of pharmaceuticals. Bishara, S . W.; El-Samman. F. M. Microchem. J . 1977, 22(4). 442-450. (32C) Determination of minerals in commercial pharmaceutical preparations by atomic-absorption spectrophotometry. I. Determination of zinc, iron, and magnesium in some multivitamin and mineral preparations. El-Kinawy. S. A.: Walash, M. I.; Abou-Bakr. M. S.; Diaie, I. Z . J. Drug. Res. 1975, 7(2), 15 1-158. (33C) Determination of organically bound halogens, with particular reference to hydrochlorothiazide. Freidrich, F.; Kottke, K. Zenfralbl. Pharm., Pharmakofher. Laboratoriumsdiagn. 1976, 775(3), 235-241, (34C) Activation analysis of rare-earth elements in opium and cannabis samples. Henke, G. J . Radioanal. Chem. 1977, 39(1-2), 69-83. (3%) Determination of cobalt, copper, manganese, and zinc in multivitamin preparations by atomic-absorption spectrophotometry after anion-exchange separation. Kwklsch, J.; Huebner, H. Mikrochlm. Acta 1976, II(3-4), 31 1-316. (36C) Application of hydropyrolysis procedure for determination of the halogen content of organic compounds. Mazor, Laszlo Acfa Chim. Hung. 1976, 89(4), 289-295. (37C) The analysis of heavy metal ions in drugs. Messinger, P.; Meyer, H. Msch. Apoth.-Ztg. 1976, 176(27), 976. (38C) Detection and rapid determination [by atomic-absorption spectroscopy] of cadmium, copper, lead, and zinc in dyes and antioxidants authorized for use in drugs and foodstuffs. Pelierin, F.; Goulie, J. P. Ann. Pharm. Fr. 1977, 35(5-6), 189-195. (39C) Assay of sodium and potassium by using macrocyclic polyethers (polyoxadiaza-macrobicyclicreagents). Van Poucke, M.; Resibois, 6.; Bertrand, J. Ann. Pharm. Fr. 1977, 35(5-6), 205-217. (40C) Flame-photometric and atomic-absorption determination of calcium. potassium and sodium in Ringer's solution and injection and in bctated Ringer's solution. Weeks, John F., Jr. J . Assoc. Off. Anal. Chem. 1977. 60(4), 929-934. (41C) Detection of contamination of drugs by heavy-metal ions. 11. Evaluation of selectivity and sensitivity Wollmann, H.; Roethig, J.; Kottke. Dagmar; Senf. H.J.; Stark, A. Zentralbl. Pharm., Pharmakother. Laboratoriumsdiagn. 1976, 7 75(3), 243-249. Radiopharmaceuticals (42C) Radionuclidic purity of an injectable solution of tritiated water. Besnard, M.; Cohen, Y. J . Radioanal. Chem. 1978, 42(2), 469-475. (43C) Radiochemical quality-control of short-lived radiopharmaceuticals. Krohn, Kenneth A.; Janshoit, Anne-Line Int. J . Appl. Radiat. Isot. 1977, 28( 1-2), 213-227. (44C) [Highperfotmance liquid chromatography for] radioanalytical quality control of carbon-1 1-, fluorine-l8-, and iodine-123-labeled compounds and radiopharmaceuticals. Machulla, H.-J.; Laufer, P.; Stoecklin, G. J . Radioanal. Chem. 1976, 32(2), 381-400. (45C) Quick spectrographic method for semi-quantitativeanalysis of radioactive iodine. About El-Nour. F. Isofopenpraxis 1975, 7 f ( 1 l ) , 393-395. (46C) Assay of iodine-123. Hudson, F. R.; Glass, H. I.; Waters, S. L. J . Nucl. Med. 1976, 77(3). 220-222. (47C) Separation of labeled iodine, iodoprotein, iodotyrosines. and iodothyronines in serum from patients treated with iodine-131, using an improved chromatographic method. Olsen. K. J.; Hansen, H. Hvid Scand. J . Clin. Lab. Invest. 1976, 36(3), 269-272. (48C) Chromatography of sodium iodide labeled with iodine-125 on Sephadex gels. Wilson, Nadine; Greenhouse, Veronica Y.J. Chromatogr. 1976, 7 78(l), 75-82. (49C) Paper chromatography of radiopharmaceuticalshbeled with indium-1 13m. Singh, M. V.; Dass, R. S.: Nayyar, C. P.; Singh, Bikram J. Chromafogr. 1976, 724(1), 145-146. (50C) Determination of radiochemical purity of [2a3Hg]chiormerodrinby an electrophoretic method. Jovanovic, V.; Zmbova, B.; Bzenic, J. J . Radioanal. Chem. 1977, 35(2), 383-387. (5 1C) Determination of optical purity of L-selenomethionine labeled with selenium-75. Otto, P. P. H. L.; van Veen-van Staalduinen. G. F. J . Radioanal. Chem. 1977, 35(1), 37-44. (52C) Gel chromatographic quality control of technetium-99m-radiopharmaceuticals. Johannsen, B. Radiobml.. Radiother. 1976, 77(1), 91-95. (53C) Factors influencing the radiochemical analysis of technetium-99m radiopharmaceuticals b y paper chromatography. Owunwanne, Azu; Weber, David A.; O'Mara. Robert; Wilson, George J . Labelled Compd. Radiopharm. 1977. 7312). 261-262. (54C) Rapid miniaturized chromatographic quality control procedures for technetium-99m radiopharmaceuticals. Zimmer. A. Michaei; Pavel. Dan G. J . Nucl. Med. 1977, 78(12), 1230-1233. Mlcellaneous (5%) Infrared spectrophotometricanalysis of medicinal gases for trace impurities. Brannon. Wilson L.; Benson, Walter R.; Schwartzman, George J . Assoc. Off. Anal. Chem. 1976, 59(6). 1404-1408. (56C) Spectrophotometric determination of sodium nitroprusside and its photdegradatin products. Frank, M. J.; Johnson, J. B.; Rubin, S. H. J . Pharm. Sci. 1976, 65(1), 44-48. (57C) Quanttake hwpressure liquic!4-vomatcgraphic determinatbn of thimerosal [thiomersai] in pharmaceutical formulations. Fu. Cherng-Chyi; Sibiey, Murray J. J . Pharm. Sci. 1977, 66(5), 738-739. (58C) Differential pulse polarography of cacodylate injections. Holak, Walter J . Assoc. Off. Anal. Chem. 1976, 59(6), 1401-1403. (59C) Cdorime'uk m e w for determining hydrogen peroxide in emulsions. James, K. C.; Tsirivas, E. J , Soc. Cosmet. Chem. 1977, 28(10), 615-820. (60C) Estimation of carbon dioxide concentration in the presence of nitrous
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oxide using a Lloyd-Haldane apparatus. Owen-Thomas, J. B.; Meade. F. B r . J . Anaesth. 1975, 47(1), 22-24. (61C) Direct complexomewic tiation of calcium phosphates. Tuckerman, Murray M.; Sanchez de Ramos, M. Eleanor J. Pharm. Sci. 1977, 66(9), 1341-1344.
NITROGEN AND OXYGEN CONTAINING COMPOUNDS General (1D) Identification of some analogues of the hallucinogen phencyclidine. Bailey, Keith; Gagne, Denise R . ; Pike, Richard K. J . ASSOC.Off. Anal. Chem. 1976, 59(1), 81-89. (2D) Relative merits of some methods for amphetamine assay in biological fluids. Bost, Robert 0.; Sutheimer, Craig A,; Sunshine, Irving Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(6),789-801 (3D) Assay of methaqualone in blood. Brown, Stanley S . Mefhodol. Dev. Biochem. 1976, 5, 179-184. (4D) Isolation and identification of some metabolites of phenyramidol in human urine. Goenechea, S.;Eckhardt, G.; Goebel, K.-J. Z . Klin. Chem. Klin. BiOChem., 1977, 75(9), 489-498. (5D) Assessment of interference by aspirin with some assays commonly done in the clinical laboratory. Routh, Joseph 1.; Paul, William D. Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6),837-842. (6D) Detection and quantitative determination of aminosalicylic acid and some components of its mixtures. Wesolowski, Marek Sci. Pharm. 1977, 45(4), 321 -334. Gas Chromatography (7D) Micromethod for simultaneous determination of phenobarbitone, phenytoin, carbamazepine, and primidone in blood. Abraham, C. V. Microchem. J . 1976, 27(3). 272-278. (8D) Simuttaneous gas-chromatographic analysis for the seven commonly used a n t i i l e p t i c drugs in serum. Abraham, C. V.; Gresham, Denise J. Chromatcgr. 1977, 736(2), 332-336. (9D) Simuttaneous gas-chromatographicanalysis for phenobarbitone, phenytoin, carbamazepine, and primidone in serum. Abraham, Chempithera V.; Joslin. Harry D. Glin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6), 769-771. (1OD) Simultaneous gas-chromatographic analysis for the four commonly used antiepileptic drugs in serum. Abraham, Chempithera Varughese; Joslin, Harry Douglas J . Chromafogr. 1976, 728(2), 281-287. (1 1D) Gas-chromatographic determination of traces of acetylsalicylic anhydride and acetylsalicylsalicylicacid in acetylsalicylic acid. Ali, Syed Laik Fresenius' 2. Anal. Chem. 1976, 278(5), 365-366. (12D) Three alkylation methods for determination of indomethacin in plasma by electron-capture gas chromatography. Arbin. Astrid J. Chromatcgr. 1977, 744(1), 85-92. (13D) Gas-chromatographic determination of the laxative 1.8-dihydroxyanthraquinone in urine and feces. Baars, A J.; Vermeulen. R. J.; Breimer. D. D. J . Chromatogr. 1976, 120(1), 217-220. (14D) Gaschromatographic analysis for therapeutic concentrations of imipramine and desipramine in plasma, with use of a nitrogen detector. Bailey, David N.; Jatlow, Peter I . Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(10), 1697- 1701. (15D) Gaschromatographic analysis for therapeutic concentrations of amitriptyline and nortriptyline in plasma with use of a nitrogen detector. Bailey, David N.; Jatbw, Peter 1. C/in. Chem. ( Winston-Sabm, N . C . )1976, 22(6). 777-781. (16D) Simplified gas-chromatographic method for determination of chlorpheniramine in serum. Barnhart, James W.; Johnson, James D. Anal. Chem. 1977, 49(7), 1085-1086. (17D) Toxicological determination of benzodiazepines in biological fluids and tissues by flame ionization [detection after] gas chromatography. Basalt, Randall C.; Stewart, Constance B.; Franch, Serafino J. J . Anal. Toxicol. 1977, 1(1), 10-13. (18D) Plasma concentrations and excretion of zipeproi in man under acidic urine condiins. Beckett, A. H.; Achari, R J . Pharm. pharmacol. 1977, 29(10), 589-592. (19D) Direct gas-liquid chromatographic analysis of N-hydroxyamphetamine, a metabolite of amphetamine. Beckett, A. H.; Achari, R . J . Chromatogr. 1977, 735(1), 200-204. (20D) Derivatization to stabilize some aliphatic primary hydroxylamines for gas-liquid chromatographic anaiysis. Beckett, A H.; Achari. R J . Pharm Pharmacol 1977, 29(4), 212-216. (21D) Extraction of diazepam and metabolites from biological material and their gas-chromatographic estimation. Besic, Josip; Grims, Milan; SernhorstStaresinic, Ivana; Beus, Ivan; Rulnjevic. Juraj Acta Pharm. Jugosl. 1976, 26(2), 99-105. (22D) Gas-chromatographic determination of acenocoumarin (nicoumalone] in human plasma. Bianchetti, G.; Latini, R . ; Morseili, P. L. J . Chromatogr. 1976, 724(2), 331-335. (230) Determination of the anthelmintic diethylcarbamazine in tissue [e.g., veal] and plasma by gas-liquid chromatography. Bogan. J. A. Analyst(iondon). 1977, 702(1210). 56-59. (24D) Sensitive and specific method for detection of phenylbutazone in biological samples. Bogan, J. A. J , Pharm. Pharmacol. 1977. 29(2), 125-126. (25D) Gas-chromatographic analysis for succinimide anticonvulsants in serum: macro- and micro-scale methods. Bonitati, James Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(3), 341-345. (26D) Specific method for determination of phenazone in biological fluids. Brinkmann, H. J.; Hengtsmann, J. H. Arzneim.-Forsch. 1976, 26(4), 483-484. (27D) Quantitative determination of sodium [ 2-(2,6dichloroanilino)phenyl]acetate (diclofenac sodium) in human blood plasma or serum. Brombacher, P. J.: Cremers, H. M. H. G.; Verheesen. P. E.; QuanjeCSchreurs, R . A. M. Arzneim.-Forsch. 1977, 27(11)(8), 1597-1599. (28D) Determination of clorazepate and its major metabolites in blood and urine by electron-capture gas-liquid chromatography. Brooks, M. A,; Hackman, M. R.; Weinfeld, R. E.; Macasieb. T. J . Chromatogr., 1977, 735(1), 123-131. (29D) Gas-liquid chromatographic method for the analysis of diphenoxylic
266R ANALYTICAL CHEMISTRY, VOL. 51, NO. 5, APRIL 1979 [ 1-(3-cyano-3,3diphenylpropyl)-4-phenylpiperidlne-4-carboxylic~acid in urine. Brownsill, R. D. A.; Palmer, R . F.; Tidd, M. J. Chromatographia 1976, 9(3), 127- 129. (30D) Simultaneous determination of phenobarbitone, primidme, arid phenytoin in small samples of blood by gas-liquid chromatography. Bruce, A. M.; Smith, Hamilton Analyst (London) 1977, 102(1210), 35-41. (3 1D) Gas-liquid chromato raphic determination of [the centrai tiervous system stimulant] 3-phenylspirofphthalan-1.4'-piperidine] (HP 505) in bioiogical fluids using a nibgen-specific detector. Bryce, T. A,; Burrows, J. L J. Chromtogr. 1977, 136(3), 401-407. (32D) Nitrogen-phosphorus detector and its applications in gas chronlatography. Burgett, Charles A.; Smith, Douglas H.; Bente, H. Bryan J . Chromalogr. 1977, 134(1), 57-64. (33D) Gas-liquid chromatographic determination of the optical isomers of fenfluramine and norfenfluramine in biological samples. Caccia. S.; Joim A. J . Chromatogr. 1977, 144(1), 127-131. (34D) Gas-liquid chromatographic determination of lidocaine [lignocaine] in human plasma. Caille, G.; Lelorier, J.; Latour, Y.;Besner, J. G. J . PhXnJ. Sci. 1977, 66(10), 1383-1385. (350) Indirect determination of phenelzine in urine Caddy, 8.; Stead, A H. Analyst (London) 1977, 102(1210), 42-49. (360) Decompositiin of 1,3dirnethylphenobarbdoneirl trimethyhniliniuinhydroxide. Gallery, Patrick S.; Leslie, James Clin. Chem. ( Winston-Salem. N.C.) 1976, 22(6), 926--927. (37D) Determination of fiunitrazepam, demethylflunitrazepam, and cionazepam in plasma by gas-liquid chromatography with an internal standard. Cano, J. P.; Guintrand, J.; Aubert, C.; Viala, A. Arzneinl-Forsch 1977, 27(1)(2), 338-342. (38D) 2Dimethyiamincsethariol (deanol) in body fluids. Ceder, Gunnel; Schuberth Jan J . Pharm. Pharmacol. 1977, 29(8), 373-374 (39D) Quantitative gas-liquid chromatographic method for determination of neostigmine and pyridostigmine in human plasma. Chan, K.; Williams, N E.; Baty, J. D.; Calvey, T. N. J , Chromatogr 1976, 120(2), 349-358. (40D) Gas-chromatographic determination of clioquinol and its conjugates in biological fluids. Chen, Ching-Tan; Samejima. Keijiro; Tamura, Zenzo Chzm. Pharm. Bull. 1976, 24(1), 97-101. (4113) Quantitative determination of isosorbide dinitiate [sorbide nitrate] and two metabolites in plasma. Chin, David A.; Pure, David G ; Michelucci, John; Kho, B. T.; Warner, Charles R. J . Pharm. Sci. 1977, 6 6 ( 8 ) , 1143-1 145. (42D) Gas-chromatographic determination in bbiogical fltkis using electronapture detection. Chu, Sou-Yie: Sennelb, Lawrence T. J. Chromatogr. 1977. 137(2), 343-350. (43D) Gas-chromatographic determination of dextropropoxyphene and nordextropropoxyphene in plasma. Cleemann, Marianne ./. Chromtogr . 1977, 132(2), 287-294. (44D) Analysis of isomeric impurities in a synthesis of the iiwel antcinflamniatory drug benoxaprofen. Cockerill. Anthony F.; Hall, Martin; Malien. David N B.: Osborne, David J.: Prime, Diana M. J . Chromatogr., 1976. 129. 339--345. (45D) Quantitative gas-chromatographic flame ionization method for p chiorophenoxyisobutyric acid in human serum and saliva. Connor, John N , Johnson, George F.; Solomon, Harvey M. C&. Chem. ( Winston-Salem. N . G . ) 1976, 22(6), 884-888. (46D) Quantitation of amitriptyline and nortriptyline in human serum Connor. John N.;Johnson, George F.; Solomon, Harvey M. J Chromatogr 1977, 143(4); Biomed. Appl., 1(4), 415-421. (47D) Simultaneous determination of therapeutic levels of amitriptyline arid nwb-iptyline in plasma by gas-liquid chromatography. Corona, G. t. : Bonferoni, B. J . Chromatogr. 1976, 124(2), 401-404. (48D) Quantitative determination of underivatized anticonvuisant drugs [in serum] by high-resolution gas chromatography with support-coated open-tubuiar columns. Cramers, C. A.; Vermeer, E. A,; van Kuik, L. G.; tiulsrnari. J. A , ; Meijers, C. A. Clin. Chim. Acta, 1976. 73(1), 977107 (49D) Deterniination of tolmetin [ (l-methyl-5-p-toluoyl-2-pyrrolyl)acetic acid] in human plasma by gas-liquid chromatographic and spectrophotometric procedures. Cressrnan, William A.; Lopez, Barbara; Sumner, Darrell ./. harm. Sci. 1975. 64(12), 1965-1967. (500) GasGhrornatographicdetermination of carnyiofine dihydrochioride in tabiats and suppositories. Crombez, E.; Van den Bossche, W.; De Moerloose, P J . Chromatogr. 1976, 117(1), 161-166. (51D) Gas-chromatographic method for [determining] acetaminophen [paracetamol] based on sequential alkylation. Dechtiaruk, Walter A ; Jotisnon, George F.; Solomon, Harvey M Clin. Chem. (Winsfori-Saiem. N.C) 1976, 22(6y, 879-883. (52D) Determination of phanquone in biological material by gas-liquid chromatoaraohv. Deaen. P. H.: Brechbuehler. S . : Schaeublin. J.: Riess. W.. J Chromaiogr. 1 9 f 6 , '1 18(3j, 363-370. (53D) Simplified method for determination of oxprenulol and other ,?-receptor blocking agents in biological fluids by gas--liqud Chromatography. Degen, P. H.; Riess, W. J , Chromatogr. 1976, 121(1), 72-75. (54D) Determination of 4-amino-3-(4-chlorophenyl)butyric acid (baclofen) in biological materials by gas-liquid chromatography. Degen, P. H.; Riess, W J . Chromatogr. 1976, 117(2). 399--405. (55D) Determination of clioquinol in bioiogical imaterials by extractive alkylation and gas-liquid chromatography. Degen, P. H.; Schneider. W.; Willard. P.; Geiger, U. P.; Riess. W. J . Chromatogr. 1976, 717(2), 407--413. (56D) Simultaneous determination of methylated barbiturates and other anticonvulsant drugs by high-resolution gas chromatography. De Graeve, J ; Vanrov. J. J . Chromatow 1976, 129, 171 -179 (57D) Quantitative gas-liquid chromatography of iproniazid and iprociozide. De Sagher, Roland M.; De Leenheer, Andre P.; Claeys, Albert E. J Chromatogr Sci. 1976, 14(6), 302-304. (58D) Improved COlUmn systems for gas-liquid chromatography of iproniazid and lproclozide. De Sagher, R . M.; De Leenheer. A P.; Claeys, A . E. J . Chromatogr. Sci. 1976, 14(4), 206-21 1. (59D) Relative electron-capture response of the 2-chloroethyl derivatives of some barbituric acids and anticonvulsant drugs. Diili, Seryio; Piilai, Dilranjan N. J . Chromatogr. 1977, 737(1). 111-117.
(60D) Evaluation of 2-benryiidenecyclohexanones and 2,6-bis(benzylidene)cyclohexanones for antitumor and cytotoxic activity and as inhibitors of mitochondrial function in yeast: metabolism studies of (E)-2-benzylidenecyclohexanone. Dimmock, J. R.; Hamon, N. W.; Hindmarsh, K. W.; Sellar, A. P.: Turner, W. A.; Rank, G. H.; Robertson, A. J. J , Pharm. Sci. 1976, 65(4), 538-543. (61D) Rapid gaschromatographic measurement of anticonvtilsarit drugs in serum. Dorrity, Floyd, Jr.; Linnoih, Markko Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6), 860-862. (62D) Reflux reactions for chromatography. Duengas, W. Chromatographia 1976, 9(11). 571-572. (63D) Interference in [serum] dilantin [phenytoin] assays. Dusci, L. J.; tiackett, L. P. Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(7), 1236. (64D) Gas-chromatographic determination of valproic [a-propylpentanoic] acid in human plasma. Dusci, L. J.; Hackett, L. P. J . Chromatogr. 1977, 132(1). 145-147. (65D) Quantitative gas-chromatographic determination of nefopam in plasma. Ehrsson, Hans; Eksborg, Staffan J . Chromafogr. 1977, 136(1), 154-158. j66D) Gas-liquid chromato raphic microanalyses of phenacetin and acetaminophen [paracetamoig plasma levels. Evans, M. A,; Harbison, R. D. J . Pharm. Sci. 1977, 66(11), 1628-1629. (67D) Gas-liquid chromatographic method for measurement of methylurea in blood and urine. Evans, Robert Trevor J . Chromatqr. 1976, 7 18(3), 357-362. (68D) Micro-method for determination of meperidine in plasma. Evans, M. A,; Harbison, R. D. J . Pharm. Sci. 1977, 66(4), 599-600. (690) Quantitative gas-chromatographic analysis of flunitrazepam in human serum with electron-capture detection. Faber, D. B.; Kok, R. M.; Rempt-van Dijk, E. M. J . Chromatogr. 1977, 133(2), 319-326. (70D) Rapid quantitative determination of tetrahydrocannabinol in marihuana by gas chromatography. Fairlie, Kathryn; Fox, B. Lawrence J Chromatogr. Sci. 1976, 74(7). 334-335. (71D) Electron-capture gas chrornatogiaphy of benzodiazepines and metabolkes Ferguson, James L.; Couri, Daniel J . Anal. Toxicoi. 1977, 1(4), 171-174. (72D) Routine analysis of barbiturates and some other hypnotic drugs in blood plasma as an aid to diagnosis of acute poisoning. Flariagan, R. J.; Berry, D. J. J . Chromatogr. 1977, 137, 131-146. (73D) Rapid micromethod for the measurement of ethchlonynol in blood plasma and urine by gas-liquid chromatography. Flanagan, R . J.; Lee, T. D. J . Chromatogr. 1977, 137(1), 119-126. (74D) Determination of methaqualone in hurnan plasma. Frederichsen, Per Medd. Nor. Farm. Seisk. 1977, 39(1), 16-21. (75D) Separation and detection of phencyclidine [and one of its metabolites] in urine by gas chonutography Froehlich, Peter M.; Ross. Gail J . Chromatogr. 1977, 137(1), 135-143. (76D) Stereochemistry of metabolism of amphetamines: use of (-)-ctmeMoxy-n-(bifluoromethyl)phenyhcetylchloride for gas -liquid Chromatographic resolutiinof chiral amines. Gal, Joseph J. Pharm. Sci. 1977, 66(2), 169-172. (77D) Gas-chromatographic determination of barbiturates [in body fluids] by extractive alkylation and support-coated open-tubular coiumn separation. Garle, Mats; Petters, Inga J . Chromatogr. 1977, 740(2), 165-169. (76D) 8-Methoxypsoralen, isolation from aqueous solutions and serum and gas-chromatographic determination. Gazith, J.; Schaefer, H. Biochem. Med. 1977, 18(1), 102-109. (79D) Simple and sensitive gas-chromatogiaphic method for determination of clonazepam in human plasma. Gerna, M.; Morselli, P. L. J . Chromatogr. 1976. 176(2), 445-450 (80D) Gas-liquid chromatographic determination of carbamazepine suitable for pharmacokinetic studies. Gerardin, Andre; Abadie, Francoise; Laffont. Joeile J . Pharm. Sci. 1975, 64(12), 1940-1942. (81D) Sirnuitaneous isothermal determination of phenytoin and phenobarbitone serum levels by gas-liquid chromatography following flash-heater hexylation. Giovannielio. Thomas J.; Pecci, Joseph Clin. Chim. Acta 1976, 67(1), 7-13. (82D) Rapid gas.-liquid chromatographic determination of therapeutic plasma-glycerol levels. Goehl, Thomas J ; Pitlick, William H.; Shiu, Gerald K.; Pirakitikuir, Pichai J . Pharm. Sci. 1977, 66(7), 1027-1029. (83D) Microdetermination of phsma diphenyl-hydantoin [phenytoin] by gas-liquid chromatography. Gordos, J.; Schaeublin, J.; Spring, P. J . Chromafogr. 1977, 743(2); Biomed Appi. 1 ( 2 ) , 171-181. (84D) Gas-liquid chromatography of methyCpentynol carbamate and its metabolde 3-methylpent-4-yne-2,3diol. Grove, J.; Martin, B. K. J . Chromatog. 1977, 133(2), 267-272. (85D) Gas--liquld chromatographic determination of primidone in plasma. Gupta, R . N.; Dobson, K.; Keane, P. M. $1. Chromatogr 1977, 132(1),140-144. (86D) Quantitative gas-chromatographic method for determining p-chlorophenoxyisobutyric acid (clofibric acid) in human plasma. Haeselbarth. V Arzneim.-Forsch. 1976, 26(11). 2076-2080. (87D) Gas-chromatographic separation of isomers of benoxaprofen using liquid crystals. Hall, M., Mallen, D. N. B. J . Chromatogr. 1976, 118(2), 268-269 (88D) Head-space gas-chromatographic analysis of paraldehyde in toxicological specimens. Hancock. Joseph P.: Harrill, Joan C.; Solomons. Everett T. J Anal. Toxicol. 1977. 1(4), 161-163. (89D) Collaborative study of gas-liquid chromatographic determination of methaqualone in pharmaceutical and clandestine preparations. Hanel, Harold F. J . ASSOC. Off. Anal. Chem. 1977, 60(4). 935-939. (90D) Simple GLC determination of ethylene oxide and its reaction products in drugs and formulations. Hartman, P. A,; Bowman, P. B. J . Pharm. Sci. 1977, 66(6), 789-792. (9 1D) Electron-capture gas-chromatographic determination of sub-nanogram amounts of emepronium bromide in serum. Hartvig. Per: Nasiund, Barbro; Vessman, Joergen J Pharm. S o . 1976, 65(11), 1707-1709. (92D) Electron-capture gas chromatography of tertiary amines as pentafluorobenzyl carbamates. Hartvig, Per; Handl, Wolfgang; Vessman, Joergen; Svahn, Carl Magnus Anal. Chem. 1976, 48(2). 390-393. (930) Determination of pethidine in plasma by electron-capture gas chromatography after reaction with trichioroethyl chloroformate. Hartvig. Per; Karlsson, Kari-Erik; Johansson, Lena; Lindberg, Claes J . Chromatogr. 1976, 121(2). 235-242.
ANALYTICAL CHEMISTRY, VOL. 51, NO. 5, APRIL 1979 (94D) Extractive alkylation of biological samples of clioquinol or chlorquinaidol and determination by eiectron-capture gas chromatography. Hartvig, Per; Fagerlund, Christina J . Chromatogr. 1977, 140(2), 170-173. (95D) Determination of plasma amitriptyline by electron-capture gas chromatography after oxidation to anthraquinone. Hartvig, Per; Strandberg, Sten; Naslund, Barbro J . Chromatogr. 1976, 1 18(l ) , 65-74. (96D) Electron-capture gas chromatography of nanogram amounts of tertiary amines as trichloroethyl carbamates. Hartvg, Per; Ahnfek, Nils Otto; Karlsson, Karl Erik Acta Pharm. Suec. 1976, 13(2), 181-189. (97D) Simultaneous determination of plasma amitriptyline and nonriptyline as trichloroethyl [esters of the] carbamates by electron-capture gas chromatography. Hartvig, Per; Naslund, Barbro J . Chromatogr. 1977, 733(2), 367-37 1. (98D) Determination of indomethacin in serum and urine by electron-capture gas-liquid chromatography. Helleberg, Lars J . Chromatogr 1976, 7 17( 1). 167-1 73. (99D) Accumulation of acetylmethadoi [methadyi acetate] and actlve metabolites in plasma following chronic administration [of methadone]. Henderson, Gary L.; Weinberg, J. Arthur; Hargreaves, William A,: Lau, Derick H M.; Tyler, Joan; Baker, Barbara J . Anal. Toxicol. 1977, 7(1). 1-5. (1000) Simultaneous determination of anticonvulsant drugs by gas-liquid chromatography. Hill. R . E.; Latham, A. N J . Chromatogr. 1977, 737. 341-346. (101D) Gas-liquid chromatographic determination for ftorafur in biological fluids Hills, Elliott B.; Godefroi, Viviane C.; Q'Leary. Irving A,; Burke, Matthew; Andrzejewski, Denis; Brukwinski, Waiter; Horwitz, Jerome P. J . Pharm. Sci. 1977, 66(10), 1497-1499. (102D) Gas-liquid chromatographic determination of free triclocarban in blood. Hoar, D. R.; Bowen, M. H. J , Pharm. Sci. 1977, 6 6 ( 5 ) , 725-726 (103D) Rapid gas-liquid Chromatographic determination of ibuprofen in serum. Hoffman, D. J. J . Pharm. Sci. 1977, 66(5),749-750. (104D) Rapid, sensitive gas-liquid chromatographic method for determination of amltriptyline and nortriptyline in plasma using a nitrogen-sensitive detector. Hucker, H. B,;, Stauffer, S. C. J , Chromatog 1977, 138(2). 437--442. (105D) Gas-liquid chromatographic determination of cyclobenzaprine [3(5Hdibenzo [ad]cyclohepten-5-ylene)-N,Ndimethylpropyiamine] in piasma and urine. Hucker, Howard B.; Stauffer, Susan C. J Pharm. S o . 1976, 65(8), 1253- 1255. (10613) Gas-liquid chromatographic arialysis for lidocaine [lignocaine] in plasma using a novel nitrogen-sensitive detector. Hucker, H. 8.; Stauffer, S. C J . Pharm. Sci. 1976, 65(6),926-927. (107D) Gas-liquid chromatographic determination of nanogram amounts of cyclobenzaprine in plasma using a nitrogen detector. Hucker, H 8.; Stauffer, S. C. J . Chromatogr. 1976, 124(1), 164-168. (108D) Gas-liquid chromatographic analysis of lidocaine [lignocaii~e]in blood using an alkaliflame ionization detector. Irgens, T. R . ; Henderson, W. M.; Shelver, W . H. J . Pharm. Sci. 1976, 65(4), 608-610, 39D) Determination of hydralazine in plasma by gas-liquid chromatography Jack, D. B.; Brechbuehler, S.; Degen, P. H.; Zbinden. P.: Riess, W. J Chromatogr. 1975, 115(l ) , 87-92. 10D) Gas-chromatographic separation of allylbarbituric acid [butalbital] and butabarbitai [secbutobarbitone] . Jain, N C.; Sneath. T.; Budd. R . ; Chinn, D.; Leung, W.; Olson. B. J . Chromatogr. 1976. 776(1), 194-196. 11D) Sensitive gas-liquid chromatographic method for determination of vaiproic acid in biological fluids. Jensen, Chris, J.: Gugler, Roland J . Chrornatogr. 1977, 737(1), 188-193. 12D) Gas-chromatographic method for quantitative determinbtion of glyceryl guaiacolate [guaiphenesin], of methyl 4-hydroxybenzoate and o f propyl 4-hydroxybenzoate in cough mixture Jensen Fred Medd Nor Farm Selsk 1977. 39111. 38-48 (113D) Gas chromatographic-mass spectrometric identification and determination of residual by-products in clofibrate preparations. Johansson, E., Ryhage. R. J . Pharm. Pharmacoi. 1976, 28(12), 527-929. (114D) Interference by endogenous 4-hydroxypherlylaceticacid with estimation of N-acetyl-p-aminophenol [paracetamol] in urine by gas chromatography. Kaka, J.; Mamer, 0. A , ; Gregory, B.; Gault, M. H. J . Pharm. Pharmacoi 1977, 29(2), 127-128. (1 15D) Comparison of two gas- liqiiid chromatographic methods for the determination of nitrazepam in plasma Kangas. Laiiri J Chrornatogr. 1977, 136(2), 259-269. (1 16D) Rapid gas-liqud chromatographic determinatior,of propranolol in hunian plasma samples. Kates, Robert E.;Jones, Catherine L. J . Pharrn Sci 1977, 66( lo), 1490-1492. (1 17D) Solvent suppression of decomposition of phenobarbitone during on-column methylation with trimethyianilinium hydroxide Kelly, Raymond C ; Valeiitour , James C ; Sunshine, Irving J . Chromatogr. 1977, 738(2), 413-422 (1160) Gaschromatographi determimtion of an antifibrinolyk drug, aminocaproic acid. Keucher, Thomas R . : Solow. Elizabeth E.: Metaxas, John; Campbell, Robert L. Glin. Chem. ( Winston-Salem, N . C . ) 1976, 22(6), 806-809 (119D) Gas-liquid chromatographic determination of ethinamate and its hydroxy derivative in biological fluids. Kleber, J. W.; Bechtol. L. D : Brunsori, M K ; Chernish, S. M. J . Pharm. Sci. 1977, 66(7). 992-994. (120D) Direct analysis of salicylic acid in keratolytic plaster by gas-solid chromatography. KO, Pak H. J . Pharm. SCI 1977, 6 6 ( 5 ) , 731L733. (121D) Rapid gas-liquid chromatographic determination of serum levels uf phenobarbitone and phenytoin. Kumps, A.; Mardens, Y . Ciin. Chim. Acta 1975, 62(3). 371-376. (122D) Comparative shdy on the derivatization of (-!-methadyl acetate metabolites for electroncapture gas-lquid chromatography. Lau, Derick, H. M ; Henderson, Gary L. J , Chromatogr. 1976, 129. 329-338. (123D) Capillary gas ckomatography of hypnotics, methyprylone. and pyrithyMione (Persedon), after derivatization in all-glass solid injector. Lauwereys. M.; Vercruysse, A. Chromatographia 1976, 9(10), 520-522. (124D) Quantitative analysis of phenytoin in serum by gas chromatography-mass spectrometry Lehrer. Michael; Karmen, Arthur Blochem. h t d . 1975, 74(2). 230-237.
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(125D) Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame ionization and nitrogen-selective detection. Lennard, M. S.; Siias, J. H.; Smith, A. J.; Tucker, G, T. J . Chromatogr. 1977, 133(1), 161-166. (126D) Gas-liquid chromatographic determination of nyldrin [buphenine] in human urine samples. Li. Herschel; Cervoni, Peter J . Pharm. Sci. 1976, 65(9), 1352-1356. (127D) Radiochemical gas-liquid chromatographic assay for nortriptyline in human plasma. Loh, Arthur; Zuleski, Francis R . ; Di Carlo, Frederick, J. J . Pharm. Sci. 1977, 66(7), 1056-1058. (128D) Gas-chromatographic determination of lofepramine and desipramine in plasma. Lundgren, R.; Olsson, A,; Forshell, G. Plym Acta Pharm. Suec 1977, 74(1), 81-94. (129D) New gas-chromatographic assay for the quantification of methadone. Application in human and animal studies. Lynn, R. K.: Leger, R. M.; Gordon, W. P.; Olsen, G. D.: Gerber, N. J . Chromatogr. 1977, 131. 329-340. (130D) Simple device for gas-liquid chromatographic separations of cannabinoids using a surface-coated open-tube column without stream spliing. McCailum, N. K.; Cairns, E. R. J , f h a r m . Sci. 1977, 66(1). 114-116. (1310) Quantition of ethchiowynol by ws chromatography. MLCurdy, H. Horton J . Anal. Toxicol. 1977, 7(4), 164-165. (132D) Simultaneous quantitative gas-liquid chromatographic determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in a cold-tablet preparation. Madsen, R. E.; Magin, D. F. J . Pharm. S o . 1976, 65(6),924-925. (133D) Electron-capture gas-liquid chromatographic deternlination of nanogram to picogram amounts of isosorbide dinitrate. Malbica, J. 0.; Monson. K.; Neilson, K.; Sprissler. R. J . Pharm. Sci. 1977, 66(3), 384--386. (134D) New and expedient determination of atenolol in biological samples. Malbica. J. 0 . ; Monson, K. R. J . f h a r m . Sci. 1975, 64(12), 1992-1994. (135D) Extraction and gas-ii uid chromatographic analysis of pyrithyldione [3,3-die*ylpyridine-2,4-dioneg in highly putrefied human post-mortem samples. Martens, Frank K.; Martens, Mark A,; Demeter, Johan; Heyndrickx, Aubin J . Pharm. Sci. 1976, 65(9), 1393-1395. (136D) Studies on formation of cyclohexylamine and N-methylcyclohexylamine from bromhexine in animals and man, and simultaneous determination of cyclohexylamine and N-methylcyclohexylamine by gas chromatography. Matsumura, Riichiro: Kohei, Hiroshi J . Chromatogr. 1976, 7 77(2), 383-391. (137D) Gas-chromatographic analysis of dialkyl-barbituric acids. Menez, J. F.; Berthou, F.; Picart, D.; Bardou, L.; Floch, H. H. J . Chromatogr. 1976, 729, 155-169. (138D) Gas-liquid chromatographic determination of plasma concentrations of phenprocoumon. Midha, K. K.; Hubbard, J. W.; Cooper, J. K.; McGilveray, I . J. J . Pharm. S o . 1976, 65(3), 387-391. (139D) Rapd and simple gas-liquid chromatographic procedure for determinations of plasma concentrations of ibuprofen. Midha, Kamal K.; Cooper, J. K.; Hubbard, J. W.; McGilveray, Iain J. Can. J . Pharm. Sci. 1977, 12(2). 29-31 ( 140D) Gas-liquid chromatographic determinations of plasma acenocoumarol [nicoumalone] levels. Midha, K. K., Cooper, J. K. J Pharm. Sci. 1977, 66(6), 799-802. (141D) Sensitive gas-liquid chromatographic protiedure for sirnultaneous determination of phenytoin and its major metabolite from plasma following single doses of phenytoin. Midha, K. K.; McGilveray, I J ; Wilson, D. L. J . Pharm Sci. 1976, 65(8), 1240-1243. (142D) Gas-liquid chromatographic identification and determination of 3 , d methylenedbxyamphetaminefrom pksma and urine. Midha, K. K., McGiberay, I. J.; Bhatnagar, S.P.; Cooper, J K . J . Pharm. Sci. 1976, 65(2), 188-197. (143D) Gas chromatographic analysis of pharmaceuticals based on pyrimidine and purine substances. Miller, V.; Pacakova, V.; Smolkova. E. J. Chromtcgr 1976. 12311). 216-219. (144D) +,e ps chromatographic analysis of the diastereoisomeric forms present in some phenylalkanolamines. Munro. G.; Hunt, J. H.; Rowe, L. R.; Evans, h4. B. J . Pharm. Pharmacol. 1976, 28. Suppl. 27P. (145D) Gas-chromatographic method for the quantitative determination of lidocaine [lignocaine] and its metabolite monoethylglycinexylidide (2-ethylamino2',6'-acetoxylidide] in plasma. Nation, R . L.; Triggs, E. J.; Selig, M. J . Chromatogr. 1976, 176(1). 188-193. (146D) Electron-capture gas-liquid chromatographic determination of phenyipropanolamineas a pentafluorophenyloxazolidinederivative. Neelakantan, L ; Kostenbauder. H. B J Pharm. Sci. 1976, 65(5),740-742. (147D) Gas-liquid chromatographic deierrnination of nikethamide in injectable preparations. Newton, John M. J Assoc Off. Anal. Chem. 1976. 59(1), 93-97. (148D) Determination of therapeutic levels of bcitriptyline in plasma by gas-liquid chromatography Norman, Trevor R . ; Maguire. Kay P ; Burrows, Graham D. J . Chromatogr. 1977, 134(2), 524-528. (149D) Quantitative analysis of tricyclic antdepressants in serum from psychiatric patients. Nyberg, Gosta; Martensson, Erik J Chromatogr. 1977, 743(5); Biomed. Appl.. 7(5), 491-497. (150D) Gas-liquid chromatographic determination of doxepin plasma levels. O'Brien, J. E., Hinsvark, 0 N. J . f h a r m . Sci. 1976, 65(7), 1068-1069. ( 15 1D) Determination of ibuproxam [ 2-(4-isobutylphenyl)propiohydroxamicacid] and its metabolites in the plasma and urine of rats. Orzalesi, G.; Selleri, R ; Caldini, 0.; Volpato, I.; Innocenti, F.; Colome, F Sacristan. A,; Varez, G.; Pisaturo, G. Arzneh-Forsch. 1977, 27(1)(5). 1012-10 15. (152D) Gas-chromatographic determination of dirnethophrine [ d-hydroxy3,5-dimethoxy-cr~methylamino)methylbenzenealCOhOi in biological specimens of rabbit. Pantarotto, C.; Belvedere, G.; Frigerio, A Arzneim.-Forsch. 1976, 26( l o ) , 1857 -1860. (153D) Analysis of medazepam. diazepam, and metabolites in plasma by gas--liquid chromatography with electrolytic-conductivity detection. Pape, Brain E.; Ribick, Michael A. J . Chromatogr. 1977, 136(1), 127-139. (154D) Rapid gas-chromatographic method for the determination of clonazepam in serum and cerebrospinal fluid. Parry, G. J. G.: Ferry D. G. J . Chromatogr 1976, 128(1). 166-168. (155D) Determination of methaqualone in urine by metabolite detection via gas ~
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chromatography. Permishon, R. C.; Hilpert, L. R.; Kazyak, Leo J . Forensic Sci. 1976, 21(1), 98-107. (156D) Simuhneous gas-liquid chromatographic determination of acetaminophen [paracetamol] , dichloralantipyrine [dichloralphenazone] and isometheptene mucate. Plakogiannis, Fotios M.; Saad, Ahmed M. J . Pharm. Sci. 1977, 66(4), 694-605. (157D) Gas-liquid chromatographic determination of sorbide nitrate in tablets. Pure, David G.; Johnson, Raymond N.; Kho, Boen T. J . Assoc. Off, Anal. Chem. 1977, 60(6), 1341-1344. (158D) Determination of 5-(2-fluorophenyl)-l,3-dihydro-7-iodo-l-methyl-2H1,4-benzodizepin-2~ne(Ro 7-9957) and its major bio-transformation products in blood and urine by electron-capture gas-liquid chromatography. Puglisi, Carl V.: de Silva, J. Arthur F.; Leon. Arthur S. J . Chromatogr. 1976, 118(3), 371-386. (159D) Diazepam abuse: incidence, rapid screening and confirming methods. Rejent, Thomas A.; Wahl, Kenneth C. Clin. Chem. (Winston-Salem, N . C . ) 1976, 22(6), 889-89 1. (160D) Separation of cannabinoids. Repetto, M.; Lopez-Artiguez, M.; Martinez, D. Bull. Narcot. 1976. 28(4), 69-74. (161D) Simultaneous measurement of plasma isosorbide dinitrate [sorbide nitrate], isosorbide 2-nitrate, and isosorbide 5-nitrate by gas-liquid chromatography. Richard, L.; Klein. G.; Orr. J. M. Clin. Chem. ( Winston-Salem, N . C . ) 1976, 22(12), 2060-2061. (162D) Forensic toxicology of some orphenadrine-related deaths Robinson, Ann E.: Holder, Ann T.; McDowall, R. D.; Powell, R.; Saltar, H. Forensic Sci. 1977, 9(1), 53-62. (163D) Rapid gas-liquid chromatographic estimation of doxapram in plasma Robson, R. H.: Prescott, L. F. J . Chromatogr 1977, 143(5); Biomed. Appl. 1(5), 527-529. (164D) Gas-chromatographic method for the analysis of butyrophenones based on the Hofmann degradation reaction. Rosenfeld. J.; Kawai, M ; Rigg, J. R. A,; Khandeiwal, J K. J . Chromatogr. 1976, 129, 387-392. (165D) Gas-liquid chromatographic determination of aprindine: quantitation and stabili?, measurement. Rutherford, Bonnie S.; Bishara, Rafik H. J . Pharm. Sci. 1976, 65(9), 1322-1325. (166D) Quantitative determination of propranolol. propranolol glycol [3-( 1naphthyloxy)propane-1,2-diol], and N-deisopropylpropranolol [ l-amino3-( l-naphthyloxy)propan-2-ol] in Drain tissue by electron-capture gas chromatography. Saelens, David A.; Walle, Thomas; Privitera, Philip, J. J . Chromatogr. 1976, 123(1), 185-192. (167D) Rapid micro method for measurement of diazepam and demthykiiazepam in blood plasma by gas-liquid chromatography. Rutherford, D. M. J . Chromatogr. 1977, 137(2), 439-448. (168D) Identification and quanttative gas-liquid chromatographic determination of iproniazid in human urine. de Sagher. R . M.; De Leenheer, A. P.; Claeys, A. E. J . Pharm. Sci. 1976, 65(6), 878-882. (169D) Improved column systems for gas-liquid chromatography of iproniazid and iproclozide. de Sagher, R. M.; De Leenheer, A. P.; Claeys, A. E. J . Chromatogr. Sci. 1976, 74(4), 206-21 1 (170D) Quantitative gas-liquid chromatography of iproniazid and iproclozide. de Sagher, Roland M.; De Leenheer, Andre P.; Cbeys, Albert E. J. Chromtcgr. Sci. 1976, 14(6), 302-304. (171D) Bio-availability of diphenhydramine from some commercial tablets and suppositories. [Determination of diphenhydramine in urine.] Satvesen, Bjarne: Groenningsaeter, Helge Medd. Nor. Farm. Selsk. 1977, 39(2). 110-127. (172D) Rapid gaschromatographic determination of underivatized phenprocoumon in plasma. Schmitt, Karl-Friedrich; Jaehnchen, Eberhard J . Chromatogr. 1977, 130, 418-421. (173D) Solubility and ionization characteristics of phenytoin. [Application to its determination.] Schwartz, Peter A,; Rhodes. C. T.; Cooper. J. W.. Jr. J . Pharm. Sci. 1977, 66(7), 994-997. ( 174D) Quantitative gaschromatographic analysis of barbiturates and hydantoins [in serum] with quaternary ammonium hydroxides. Serfontein. Willem J ; de Villiers. Louis S. J . Chromatogr. 1977, 130, 342-345. (175D) Gas-chromatographic procedure, based on nitrosation, for simultaneous determinatlon of [dextro] propoxyphene and [its Ndemethylated derivative] norpropoxyphene in biological material. Serfontein, Willem J.; de Viliiers. Louis S. J . Pharm. Pharmacol. 1976, 28(9). 718-719. (176D) Gas-liquid chromatography of eight anticonvulsant drugs in plasma. Sengupta, Alokananda; Peat, Michael Allan J . Chromatogr. 1977, 137(1), 206-209. (177D) Gas-liquid chromatographic determination of underivatizec carbamazepine in whole blood. Sheehan, Michael; Beam, Raymond E. J . Pharm. Sci. 1975, 64(12), 2004-2006. (178D) Determination of 1,4-benzodiazopines and diarepin-2-ones in blood by electron-capture gas-liquid chromatography. de Silva, J. Arthur F.; Bekersky, Ihor; Puglisi, Carl V.; Brooks, Marvin A,; Winefeld, Robert E Anal. Chem. 1976, 48(1), 10-19. (179D) Gas-liquid chromatographic determination of procainamide in biological fluids. Simons, K. J.; Levy, R . H. J . Pharm. Sci. 1975, 64(12), 1967-1970. (18OD) Potential problem in gas-liquid chromatographic determination of ibuprofen caused by solid support. Slattery, John T., Yacobi, Avraham; Levy, Gerhard; Kaiser, David G. J . Pharm. Sci. 1976, 65(11), 1710. (181D) Estimation of chlorbutol by electron-capture gas chromatography. Smith, Hamilton; Thorpe, J. W. J , Chromatogr. 1977, 134(1), 178-181. (182D) Determination of hydrallazine in tablets by gas chromatography. Smith, Karen M.; Johnson, Raymond N.; Kho, B. T. J . Chrornatogr. 1977, 137(2), 43 1-437. (183D) Comparison of esterification methods for the gas-chromatographic determination of indoprofen in phsma and urine. Smith, R. V.; EscabnaCastillo, H. J. Microchem. J . 1977, 22(3). 305-327. (184D) Gas-liquid chromatographic determination of indoprofen { ( f ) - 2 - [ 4 (1-oxoisoindolin-2-yl)-phenyl]propionic acid1 in plasma. Smith, Robert V.; Humphrey, David W., Escalona-Castillo. Henry J . Pharm. Sci. 1977, 66(1). 132- 134. (185D) Micro-method for determination of clonazepam in serum by elec-
b-oncapture gas-liquid chromatography. Sobw, Elizabeth B.; Kenfield, Caroline P. J . Anal. roxicol. 1977, i(4), 155-157. (186D) Gas-liquid chromatographic determination of degradation of two related amine-uptake inhibitors. Souter, Rex W.; Dinner, Alan J . Pharm. Sci. 1976, 65(3), 457-459. (187D) Gas-liquid chromatographic determination of acetaminophen [paracetamol] in blood plasma. Stavchansky, s.; Wu. P.; Kostenbauder, H. G. Anal. Len. 1977, 70(11), 845-856. ( 188D) Gas-chromatographic determination of hexobarbitone and its metabolites in biological material. Steinbach, Heinz; Gielen, Wilhelm J. Chromtogr. 1977, 139(1), 191-194. 189D) Use of trimethylanilinium hydroxide-tetramethylammonium hydroxide as on-column methylating agent for gas-liquid chromatographic analysis of phenytoin. Stella, V. J. J . Pharm. Sci. 1977, 66(10), 1510-1511 190D) Limitations of pentafluorobenzyl chloroformate as a derivatizing reagent for the gas-liquid chromatographic analysis of tertiary amines. Sternson, Larry A.; Cooper, Aaron D. J . Chromatogr. 1978, 150(l). 257-258. 191D) Probenecid, a possible intwferent in the gaschromatographicdetermination of diphenylhydantoin [phenytoin]. Steyn, J. M.; Hunctt, H. K . L. J . Chromatogr. 1977, 143(2); Biomed. Appl., 1(2), 207-209. 192D) Minor components of cannabis resin. VI. Mass-spectrometric data and gas-chromatographic retention times of components eluted atter cannabinol. Stroemberg Lars J . Chromatogr. 1976, 121(2), 313-322. 193D) Determination of pentobarbitone in serum by electron-capture gas-liquid chromatography. Sun, Sy-Rong: Chun, A. H. C. J . Pharm. Sci. 1977, 66(4), 477-480. 194D) Simuttaneous determination of meperidine [pethidine] and normeperidine ~norpethiine1in biofluids. Szeto, Hazel H.: Inturrisi. Charles E J . C h r o m t w r . i 9 7 6 , i25(3j,503-510. 195D) Analytical studies on mepirizole and its metabolites. 111. Gas-chromatographic determination of mepirizole and its metabolites in biological fluids. Tanaka, Yoshiaki; Esumi, Yoshio; Sano, Mitsuji Chem. Pharm. Bull. 1976. 24(4), 808-812. 196D) Gas-chromatographic method for determination of methadone and its metabolites in biological fluids and tissues. Thompson. Bernard C ; Caplan, Yale H. J . Anal. Toxicol. 1977, 7(2), 66-69. (197D) Determination of salicylates by gas-liquid chromatography. Tischio, John P . J . Pharm. Sci. 1976, 65(10), 1530-1533. (198D) Simultaneous determination of acetyimethadol [methadyl acetate] and its major metabolaes by gas-liquid chromatography. Tse, Francis L. S.; Welling, P. G. J . Chromatogr. 1977, 135(1), 205-207. (199D) Determination of the anticonvulsant [sodium] dipropylacetate (Epilim) [sodium valproate] in human plasma by gas chromatography. U-Schulz. H.; Toseland, P. A . Ann. Clin. Biochem. 1977, 14(4), 240-242. (200D) Gas-liquid chromatographic determination of therapeutic and toxic levels of amitriptyline in human serum with a nitrogen-sensitive detector Vasiliades. John; Bush, Kerry C. Anal. Chem. 1976, 48(12), 1708-1711. (201D) Gas-chromatographic determination of pemoline as 5-phenyloxazolidine-2,4dione in human urine. Vermeulen, N. P. E.; de Roode, D.; Breimer. D. D. J . Chromatogr. 1977, 137(2), 333-342. (202D) Gas-chromatographic determination of pemoline, as 5-phenyloxazolidine-2.44ione, in human urine. Vermeulen, N. P. E.; de Roode. D ; Breimer, D. D. Pharm. Weekbl. 1977, 712(26), 637-638. (203D) Determination of tranexamic acid in biological material by electron-capture gas chromatography after direct derivatization in an aqueous medium. Vessman, Joergen; Stroemberg, SgnhiM Anal. Chem. 1977. 49(3). 369-373. (204D) Determination of intact oxazepam by electronaptwe p s chromatography after an extractive alkylation reaction. Vessman, Jorgen; Johansson, Margareta; Magnusson, Per; Stromberg, Signhild Anal. Chem. 1977, 49(1 l ) , 1545--1549. (205D) Sensitive thin-layer chromatographic method for screening of urine for barbiturates. Vinson, J. A,; Hooyman, J. E.; Koharcheck. H.; Holmes, M. M. J . Chromatogr. 1977, 140(1), 71-76. (206D) Gas-liquid chromatographic assay for fenclorac [ ci,3-dichloro-4cyclohexylphenylacetic acid]. Visalli. Anthony J.: Patei, Dahyabhai M., Reavey-Cantwell, Nelson H. J . Pharm. Sci. 1976, 65(1 l), 1686-1688. (207D) Rapid determination of 4-hydroxybutyric acid (Gamma OH) and isopropyl pentanoate (Depakine) in human plasma by means of gas-liquid chromatography. Vree, T. B.; van der Kleijn, E ; Knop, H. J J . Chromatogr. 1976. 721(1), 150-152. (208D) Determination of primidone [in blood plasma] by electron-capture gas chromatography. Wallace, Jack E.; Hamilton, Horace E.; Shimek. Eugene L., Jr.; Schwertner, Harvey A. Anal. Chem. 1977, 49(7), 903-906. (209D) Selective GLC determination of epinephrine, isoproterenol, and phenylephrine in pharmaceutical dosage forms. Watson, J. R.: Lawrence, R . C. J . Pharm. Sci. 1977, 66(4), 560-564. (2 10D) Gas-liquid chromatographic determination of (-)-N-cyclopropylmethylmorphinan-2-01in plasma and urine. Weinfeld, Robert E : Hoiazo, Aiice; Kaplan, Stanley A. J . Pharm. Sci. 1976, 65(12). 1827--1831 (21 1D) Rapid determination of diazepam and demethyldiazepam in plasma by electron-capture gas-liquid chromatography. Application in clinical pharmacokinetic studies. Weinfeld, Robert E.; Posmanter. Howard N ; Khoo, KO-Chin; Puglisi, Carl V J . Chromatogr. 1977. 143(6); Biomed. Appl , r(6). 581-595. (2 12D) Microdetermination of 4-hydroxybenzoic esters in pharmaceuticals and cosmetics. Weisenberg. Emil; Gershon. Baruch; Schoenberg. Judith J. Assoc. Off. Anal. Chem. 1977, 60(1). 56-59. (213D) Methylation artifacts in the as chromatography of serum extracts. Competitive suppression with [2H~trimethylaniiinium hydroxide. Wong, Lan K.; Costello, Catherine E.; Biemann. K . J . Chromtogr. 1976, 116(2).321 -331 (214D) Use of capillary columns for detection of barbiturates in clinical chemistry. Wu, Anthony: Pearson. M. Lynn Anal. Lett. 1977, 10(5), 381-393 (215D) Gas-liquid chromatographic determination of p-chloroacetnnilide in acetaminophen. Wyatt, Dwothy K.; aady, Lee T J . Assoc Off Anal. Chem. 197d, 61(1), 68-71.
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Gas Chromatography-Mass Spectrometry (216D) Conversion of biguanides into substituted 1,3,5-triazines assayable by gas chromatography or mass fragmentography. Alkalay, David; VoIk, Joseph; Bartlett, M. Fred J . Pharm. Sci. 1976, 65(4). 525-529. (2 17D) Single- and multiple-ion recording techniques for analysis of phenytoin and Its major metabolite [5-(4-hydroxyphenyl)5-phenylhydantoin] in plasma. Baty, J. D.; Robinson, P. R. Biomed. Mass Spectrom. 1977, 4(1), 36-41 (218D) Estimation of acetanilide, paracetamol, and phenacetin in plasma and urine using mass fragmentography. Baty, J. D.: Robinson, P. R.; Wharton, J. Biomed. Mass Spectrom. 1976, 3(2), 60-63. (219D) Determinationof ketocaine blood concentrations following brachial plexus block and epicutaneous administration. Berlin-Wahlen, A , : Hogberg, K.; Lindgren. J.-E. Acta Pharm. Suec. 1977, 14(5-6), 425-434. (220D) Electron-beam ionization mass-fragmentographic analysis of tricyclic antidepressants in human plasr a. Biggs, John T.; Holland, William H.; Chang, Sidney; Hipps, Paul P.; Sherman, William R. J . Pharm. Sci. 1976, 65(2), 26 1-268. (22 1D) Gas-chromatographic/mass-spectrometric detection of amphetaminil. Bohn, G.: Audick, W.; Hoeltzenbein, P. Z. Rechtsmed. 1977, 79(3), 189-192. (222D) Determination of bupivacaine in human fetal and neonatal blood samples by quantitative single-ion monitoring. Caklwell, John; Moffatt, John R.: Smith, Robert L.; Lieberman, Brian A,; Beard, Richard W.; Snedden, Watter; Wilson, Barrie W. Biomed. Mass Spectrom. 1977, 4(5), 322-325. (223D) Gas chromatography-mass spectrometry of the major metabolites of flurazepam. Ciatworthy, A. J.; Jones, L. V.; Whitehouse, M. J. Biomed. Mass Spectrom. 1977, 4(4), 248-254. (224D) Simultaneous measurement of imipramine and desipramine [in plasma] by selected ion recording with deuterated internal standards. Claeys. M.; Muscettola, G.; Markey. S. P. Biomed. Mass Spectrom. 1976, 3(3). 110-1 16. (225D) Measurement of clomipramine. Ndemethylclomipramine. imipramine, and dehydroimipramine in biological fluids by selective ion monitoring, and pharmacokinetics of clomipramine. Dubois, Jean-Pierre; Kueng, Werner; Theobald, Walter; Wirz, Bernard Clin. Chem. ( Winston-Salem, N.C.) 1976, 22(6), 892-897. (226D) Simuitaneous determination of (-)- and (+)-propranolol by gas chromatography-mass spectrometry using a c!elrteriun*beiing technique. Ehrsson, Hans J . Pharm. Pharmacol. 1976, 26(8). 662-663. (227D) Synthesis of deuteriumbbeled drugs of abuse for use as internal standards in quantification by selected-ion-monitoring. I. Methylamphetamine, 2.5dimethoxy-4-methylamphetamine (DOM), phencyclidine (PCP), and methaqualone. Fentiman, Allison F., Jr.; Foltz, Rodger L. J , Labelled Compd. Radiopharm. 1976, 12(1), 69-78. (228D) Measurement of the propantheline ion in biological fluids after administering propantheline bromide to man. Ford, G. C.; Grigson, S J W.; Haskins. N. J.; Palmer, R . F.; Prout, M.; Vose, C. W. Biomed. Mass Spectrom. 1977, 4(2), 94-97. (229D) Measurement of diphenoxylic [ 1-(3-cyano-3,3-diphenyipropyl)-4phenylpiperidine-4-carboxylic) acid after administration of [its ethyl ester] diphenoxylate. Ford, G. C.; Haskins, N. J.: Palmer, R. F.; Tidd. M. J.; Buckley, P. H. Biomed. Mass Spectrom. 1976, 3(1), 45-47. (230D) Chemical-ionization mass-spectrometric measurenlent of ci-methyldopa and dopa metabolites in rat-brain regions. Freed, Curt R.; Weinkam, Robert J.; Melmon, Kenneth L.; Castagnoli, Neal Anal. Biochem. 1977, 78(2). 319-332. (231D) Quantitative determination of doxepin and demethyldoxepin in rat piasma by means of gas-liquid chromatography/mass fragmentography. Frigerio, A.; Pantarotto, C.; Franco, R.; Gomeni, R . ; Morselli, P. L. J . Chromatogr. 1977, 130, 354-360. (2320) Fieid desorption. field ionization, and electron impact mass spectrometry of barbiturates. Games, D. E.: Jackson, A H.: Taylor, K. T.; Haskins. N. J. Adv. Mass Spectrom. Biochem. Med., 1976, 1 , 383-390. (233Dj Quantitative determination of amitriptyline and its principal metabolite, nortriptyline, by gas-liquid chromatography and chemical-ionization mass spectrometry. Garland, W. A. J , Pharm. Sci. 1977, 66(1), 77-81. (234D) Quantitative determination of phenacetin and its metabolite acetaminophen [paracetamol] by gas-liquid chromatography-chemical-ionization mass spectrometry. Garland, W. A . ; Hsiao. K . C.; Pantuck, E. J.; Conney. A. H J . Pharm. Sci. 1977, 66(3), 340-344. (235D) Quantitative analysis for methadone in biological fluids using deuterium-labeled methadone and gas-liquid chromatography-chemical-ionization mass spectrometry. Hachey, D. L.; Kreek, M. J.; Mattson. D. H. J . Pharm. Sci. 1977, 66(1 l ) , 1579-1582. (2361)) Determination of hydrallazine and its metabolites by gas chromatography-mass spectrometry. Haegele, Kiaus D.; Skrdlant, Harold B.; Robie, Norman W.; Lalka. David; McNay, John L., Jr.; J Chromatogr. 1976, 726, 517-534. (237D3 Characterization of butyl homologues of A'-tetrahydrocannabinol. cannabinol, and cannabidiol in sampies of cannabis by combined gas chromatography and mass specb-ometry. Harvey, D. J. J , Pharm Pharmacol. 1976, 28(4), 280-285 (238D) Cyclic alkaneboronates as derivatives for the characterization of cannabinolic acids by combined gas chromatography and mass spectrometry, Harvey, D. J. Biomed. Mass Spectrom. 1977, 4(2j, 88-93. (239D) Mass-fragrnentographic determination of diphenylhydantoin [phenytoin] and its main metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, in human pbsma. Hoppel. Charles; Garle, Mats; Ebnder. Magnus J. Chromatcgr. 1976, 116(1), 53-61. (240D) Mass-fragmentographicdetermination of prednimustine and chlorambucil in plasma Jakhammer, Tommy: Olsson, Arne; Svensson, Leif Acta Pharm. Suec. 1977, 14(5-6). 485-495. (241Dj Cyclic alkaneboronates as derigatives for the characterization of cannabinolic acids by combined gas chromatography and mass spectrometry. Harvey, D. J. Biomed. Mass Spectrom. 1977, 4(2), 88-93. (242D) Gas chromatographic-mass spectromeb-ic identification and determination of residual by-products in clofibrate preparations. Johansson, E.; Ryhage,
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R. J , Pharm. Pharmacol. 1976, 28(12), 927-929. (243D) Determination of N-hydroxy- and phenolic metabolites of drugs derived from acetanilide by 0-alkylation and selected-ion monitoring. Kapetanovic, Izet M.; Dutcher, John S.; Strong, John M. Anal. Chem. 1977, 49(12), 1843- 1846. (244D) Analysis of impurities in ethchlorvynol by gas chromatography-mass spectrometry. Kochhar, Man M.; Needham, Larry L. J , Chromatogr. 1976, 118(3), 418-424. (2460) Gas chromatography-mass spectrometry assay for ketamine and its metabolites in plasma. Lau, Serrine S.; Domino, Edward F. Biomed. Mass Spectrom. 1977, 4(5), 317-321. (246D) Analysis of terbutaline in plasma and urine at therapeutic levels using mass fragmentography. Leferink, J. G.; Wagemaker-Engels. I . ; Arendse. W. M.; Maes, R. A. A,; Van Der Sb-aeten. M. Biomed. Mass Spectrom. 1976, 3(5), 255-256. (247D) Quantitative analysis of terbutaline in serum and urine at therapeutic levels using gas chromatography-mass spectrometry. Leferink, J. G.; Wagemaker-Engels, I . ; Maes, R. A. A,; Lamont, H.; Pauwels, R.; Van Der Straeten, M. J . Chromato r 1977, 143(3); Biomed. Appl., 1(3). 299-305. (248D) Comparative study of gpaper and] thin-layer chromatographictechniques for separation of lanatoside glycosides. Lenkey, Beia; Bondar, Elek; Nanasi, Pal Acta Biol. Debrecina 1976, 13, 7-10. (249D) Preparation of deuterium-labeled catecholamines, catecholamine precursors, and metabolites for use as internal standards in mass-fragmentographic determination and for turnover studies. Lindstroem, 8.; Sjoequist, €3.; Anggard, E. J . Labbelled Compd. 1974, 10(2), 187-194. (250D) Determination of debrisoquine and its 4-hydroxymetabolite in plasma by gas chromatography-mass spectrometry. Malcolm, Susan L.: Marten, Timothy R. Anal. Chem. 1976, 48(6), 807-809. (251D) Determination of salbutamol in plasma, as either its trimethylsiiyl or tert-butyldimethylsilyl ether, using a stable-isotope multiple-ion recording techique. Martin, L. E.; Rees, Janet; Tanner, R. J. N. Biomed. Mss Spectrom. 1976, 3(4), 184-190. (252D) Quantitative determination of enantiomeric compounds. I. Simuitaneous measurement of the optical isomers of amphetamine in human plasma and saliva using chemical-ionization mass spectrometry. Matin, Shaikh B.; Wan, Suk Han: Knight, James B. Biomed. Mass Spectrom. 1977, 4(2), 118-121. (253Dj Identification of urinary catechol and methylated catechol metabolites of phenytoin in humans, monkeys, and dogs by gas-liquid chromatography and gas-liquid chromatograpy/mass spectrometry. Midha, K. K.; Hindmarch, K. W.; Mdjitveray, 1. J.; Copper, J. K. J. pharm. Sci. 1977, 66(11), 1596-1602. (254D) Evidence for lack of carrier effect in solvent extraction and determination of octopamine by gas chromatography-mass spectrometry. Millard, B. J.; Tippett, P. A,: Couch, M. W.; Williams, C. M. Biomed. Mass Spectrom. 1977, 4(6), 381-384. (255D) Determination of clonazepam and its 7-amino-metabolite in piasma and blood by gas chromatography-chemical ionization mass spectrometry Min, B. H.; Garland, W. A,: J . Chromatogr. 1977, 139(1). 121-133. (256D) Mass-fragmentographic determination of (+tand (-kchlorpheniramine with aid of the stabie-isotope technique. Miyazaki, Hiroshi; Abuki. Hideo Chem. Pharm. Bull. 1976. 24(10), 2572-2574. (257D) Mass-fragmentcgraphic quantitatbn of ethotoin and some of its metabolites in human urine. Naestofl, Joergen; Larsen, Niels-Erik J . Chromatogr 1977, 143(2); Biomed. Appl.. 7(2), 161-169. (258D) Analysis of marihuana samples from different origins by high-resolution gas-liquid chromatography for forensic application. Novotny, Milos; Lee, M. L.; Low, Chow-Eng; Raymond, Alain Anal. Chem. 1976, 46(1). 24-29. (259D) Analysis of drugs by pyrolysis. I. Selected-ion monitoring combined with a pyroiysk method for the determination of carpronium chloride in biological sampies. Ohya, Kazumi; Sano, Mitsuji Biomed. Mass Spectrom. 1977, 4(4), 241-247. (260D) Detection and quantitation of phencyclidine in blood by use of ['H5] phencyclidine and selected-ion monitoring applied to nonfatal cases of phencyclidine intoxication. Pearce. Dan S. Clin. Chem. ( Winston-Salem, N C.) 1976. 22(10), 1623-1626. 1261D) Mass-hagmentographic assay of nanogram amounts of the antidepressant drug mianserin hydrochloride in human plasma. de Ridder. Johannes J.; Koppens, Paul C. J. M.; van Hal, Henk J. M. J . Chromatogr. 1977, 14313); Biomed. Appl.. 1(3), 289-297. (262D) Use of high-performance iiquid chromatography for sample clean-up in mass-fragmentographic assays. de Ridder. Johannes J.; Koppens. Paul C. J. M., van Hal, Henk J. M. J . Chromatogr. 1977, 143(3); Biomed. Appl.. 1(3), 281-287. (263D) Mass-fragmentation assay for 1 1-hydroxy-A9-tetrahydrocannabinol from plasma. Rosenfeld, J. M.; Taguchi, V Y . Anal. Chem. 1976, 48(4), 726-728. (264D) Electron-capture and multiple-ion detection of benzodiazepine esters in pharmacokinetic studies. Sanchez, M. C.; Colome, J.; Gelpi, E. J . Chromatogr. 1976, 126, 601-613. (265D) Role of pyrolysis-gas chromatography-mass spectrometry in the analysis of drugs. Slack. J. A.; Irwin. W. J. R o c . Anal. Div. Chem. SOC.1977, 14(8j. 21 5-21 7. (266D) Determination of verapamil in human plasma by mass fragmentography by using stableisotopeiabeled verapamil as internal standard. Spiegelhalder, B.; Eichelbaum, M. Arzneim-Forsch. 1977, 27(1)(1). 94-97 (267D) Simultaneous estimation of dextropropoxyphene and dideuterodextropropoxyphene levels by quantitative mass fragmentography. Potential utility in muttihse investigations. Sullivan, Hugh R.; Wood, Paul G., McMahon. Robert E. Biomed. Mass Spectrom. 1976, 3(5). 212-216. (268D) Analytical studies on mepirizole and its metabolites. 11. Identification of the human urinary metabolites of rnepirizole with [use of] stable-isotope labeling. Tanaka. Yoshiaki; Sano, Mitsuji Chem. Pharm. Bull. 1976. 24(4), 804-807. (269D) Analytical studies on me irizole and its metabolites. IV. Quantitative determination of mepirizole ~4-methoxy-2-(5-methoxy-3-methylpyrazol-lylk8methylpyrimidine] in human serum by mass fragmentography, and isotope effect on drug metabolism. Tanaka, Yoshiaki; Sano, Mitsuji Chem. Pharm. Bull. 1976, 24(6), 1305-1309.
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(270D) Amylobarbitone metabolism in man. Determination of N-hydroxyamylobarbitone and 3'-hydroxyamylobarbitone in urine by gas chromatography-chemical-ionization mass spectrometry. Tang, E. K.: Inaba, T.; Kalow. W. Biomed. Mass Specbom. 1977, 4(2), 73-76. (271D) The combined gas-liquid chromatographic/mass-spectrometricanalysis of pemoline in biological samples. Van Boven, M.: Daenens, P J . Chromatcgr. 1977, 734(2), 415-421. Liquld Chromatography (272D) Simultaneous determination of lidocaine [lignocaine] and piocainamide in serum by use of high-pressure liquid chromatography. Adams, Reginald F.; Vandemark, Frank L.; Schmidt, G. Clin. Chim. Acta, 1976,69(3), 515-524. (273D) A laboratory experiment in pharmaceuticalanaiysis: analysis of dkzepam tablets by high pressure liquid chromatography. Bailey, Leonard C. Am. J . Pharm. Educ. 1978, 42(1), 63-66. (274D) Liquid chromatographic analysis of analgesics on Amberlie XAD7. b u m , Robert G.; Cantwell, Frederick F. Anal. Chem. 1976, 50(2), 280-285. (275Dj Determination and characterization of gallotannin [tannic acid] by high-performance liquid chromatography. Beasley, Thomas H., Sr.: Ziegler. Howard W.: Bell, Alexis D. Anal. Chem. 1977, 49(2). 238-243. (276D) High-performance liquid-chromatographic analysis of methadone hydrochloride oral solution. Eeasley. Thomas H., Sr.; Ziegler, Howard W. J . Pharm. Sci. 1977, 66(12), 1749-1751. (277D) High-pressure liquidchromatographic anaiysis of ftwafur and its rnetabolites in biological fluids. Eenvenuto, J. A.; Lu, K.; Loo, Ti Li J . Chromatogr. 1977, 134(1), 219-222. (278D) Column chromatography of tricyclic antidepressants [in serum]. van den Berg, J. H. M.; de Ruwe, H. J. J. M.; Deelder, R. S. J . Chromatogr. 1977, 138(2), 431-436. (279D) High-pressure liquid chromatographic determination of chlorphenesin carbamate and the 3-isomeric carbamate [in formulations], Beyer. William F. J . Pharm. Sci. 1976, 65(12), 1802-1805. (280D) High-performance liquid chromatographic determination of warfarin. Billings, Toby J.; Hanks, Alan R.; Colvin, Billy M. J . Assoc. Off. Anal. Chem. 1976, 59(5), 1104-1 108. (28 1D) High-pressure liquid chromatographic analysis of drugs in biological fluids. I. Warfarin. Bjwnsson. Thorir D.; Blaschke, Terrence F.; Meffin. P. J. Pharm. Sci., 1977, 66(1), 142-144. (282D) High-pressure liquidchromatographic analysis of drugs in biological fluids. I V . Determination of clofibrinic acid [the active metaboiite of clofibrate]. Bjornsson, Thorir D.; Elaschke, Terrence F.; Meffin, Peter J. J . Chromatogr., 1977, 137(1), 1455152. (283D) Separation and measurement of tricyclic antidepressant drugs in plasma by high-performance liquid chromatography. Brodie, R. R ; Chasseaud, L F.: Hawkins. D. R; J . Cluomatogr. 1977, 743(5); Biomed. Appl., 1(5),535-539. (284D) Determination of allopurinol and oxypurinol in human plasma and urine. Brown, Martin: Bye, Alan J , Chromatcgr. 1977, 143(2); Biomed. Appl., 1(2), 195-202. (285D) Quantitative determination of the glutathione, cysteine, and N-acetylcysteine conjugates of acetaminophen [paracetamol] by high-pressure liquid chromatography. Euckpitt, A. R.; Rollins, D. E.; Nelson, S. D.; Franklin, R E.; Mitchell, Jerry R. Anal. Biochem. 1977, 83(1), 168-177. (286D) Quantitative high-performance liquid chromatography of diazepam and N d e r n e ~ y l d l z e p a min blood. Bugge, Andreas J . Chromatogr 1976, i28( 1).
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(287D) High-pressure liquid chromatographic determination of immunogenic contaminants of acetylsalicylic acid preparations. Bundgaard. Hans Arch Pharm. Chemi. Sci. Ed. 1976. 4(61. 103-113. (288D) Separation and quantitation of possible degradation products of procarbazine hydrochloride in its dosage form. Burce, Gary L.; Boehlert. Judy P. J , Pharm. Sci. 1976, 67(3), 424-426. (289D) Highperformance liqud-chromatographic determination of chlordlazepoxide and major related impurities in pharmaceuticals. Butterfield, A G ; Matsui, F. F.; Smith, S. J.; Sears, R. W. J . Pharm. Sci., 1977, 66(5), 684-687 (290D) Simultaneous quantification of procainamide and N-acetylprocainamide wfih highperformance liquid chromatography. Carr, K.; Woosley, R. L.: Oates, J. A. J . Chromatogr. 1976, 129, 363-368. (291D) Determination of pemoline by high-pressure liquid chromatography Cartoni, G. Paolo; and Natalizia, Franco: J . Chromatogr. 1976, 723(2), 474-478. (292D) Isolation and quantitation of picomole quantities of digoxin, digitoxin and their metabolites by high-pressure liquid chromatography. Castle, M. C. J Chromatogr. 1975, 7 15(2). 437-445. (293D) High-pressure liqukkhromatographic anaiysis of methotrexate in presence of its degradation products. Chatterji, Dulal C.; Gailelli, Joseph F. J , Pharm. Sci. 1977, 66(9), 1219-1222. (294D) Identification and quantitation of impurities from benoryiate (Salipran) by high-performance liquid chromatography. Chevalier, G.; Rohrbach, P.: Bollet, C.; Caude, M. J . Chromatogr. 1977, 138(1), 193-201 (295D) Quantitative determination of methyl and propyl 4-hydroxybenzoates by high-performance liquid chromatography. Clarke, G.: Rashid, I.A. Ana/yst (London), 1977, 102(1218), 685-687. (296D) Application of high-performance liquid chromatography to the separation of cardenolides and the assay of digoxin in Digitalis lanata leaf. Cobb, Paui, H. Analyst (London) 1976, 70 1(1207), 768-776. (297D) Polyamides in highperformance liquid chromatography. Collet, G.: Rocca, J. L.; Sage, D.; Berticat, P. J . Chromatogr.. 1976, 721(2), 213-226 (298D) [Determination of] niflumlc acid in plasma and urine. Cowen, T.: Salmon. J. R. Methodol. Dev. Biochem. 1976, 5 , 211-216. (299D) High-performance liquid chromatographic determination of halogensubstituted salicylanilides. Cukor, P.; Persiani, C . ; Woehler, M.; Eischak, N. J . Chromatogr. 1978, 147, 496-500. (300D) Quantitative determinations of phenol and resorcinol in pharmaceutical dosage forms by high-pressure liquid chromatography. Das Gupta, V. J Pharm. Sci. 1976, 65(11), 1706- 1707.
(30 1D) Quantitative determination of benzoic acid and salicylic acid in ointments by high-pressure liquid chromatography. Das Gupta, V. J . Phdrm. Sci. 1977, 66(1), 110--111. (302D) Quantitative determinations of antipyrine [phenazone] and benzocaine in ear-drops by high-pressure liquid chromatography. Das Gupta. V.; Sachanandani, S. J , Pharm. Sci. 1977, 66(6),897- 898. (303D) Separation of some tricyclic antidepressants by high-performance liquid chromatography. Detaevernier, M. R.: Dryon, L.; Massart. D. L. J Chromatogr 1976, 728(l),204-207. (304D) Phenacetin estimation from biological sanipies by high-performance liquid chromatography. Duggin, Geoffrey G. J . Chromatogr. 1976. 72 l ( l), 156- 160. (305D) High-pressure liquid-chromatographic determination of allopurinol and oxypurinol in serum. Endele, R.; Lettenbauer, G. J , Chromatogr 1975, 7 15(1), 228-231. (306D) Comparison of reversed-phase and partition high-performance liquid chromatography of some digitalis glycosides. Erni, F.; Frei. R . W. J . Chromatogr. 1977, 130, 169-180. (307D) Biochemical applications of a quantitative high-pressure liquid-chromatographic assay of warfarin and its metabolites. Fasco, Michael J.; Piper, Lawrence, J.; Kaminsky, Laurence S . J. Chromatogr. 1977, 137, 365-373. (308D) Quantitative analysis of methyl- and propyl-paraben I methyl and propyl hydroxybenzoates] by high-performance liquid chromatography Fitzpatrick, F.A.; Summa, A. F.; Cooper, A. D. J . SOC. Cosmet. Chem 1975,26(8). 377- 387. (309D) Determination of diminazene in plasma by high-performance liquid chromatography Fouda, Hassan G. J . Chromatogr. Sci. 1977. 75(1l ) , 537-538. (3 10D) Post-column fluorescence derivatization of peptides. Probiems and potential in high-performance liquid chromatography. Frei. R . W , Michel, L.; Santi, W. J . Chrornatogr. 1976, 726, 665-677. (311D) Quantitative high-pressure liquid chromatographic determination of epinephrine in pharmaceutical formulations. Fu. Cherng-Chyi: Sibley, Murray J. J . Pharm. Sci. 1977. 66(3). 4255426. (3 120) Post-column derivatization in high-performance liquid chroniatography using the air segmentation principle: application to digitalis glycosides Gfeller. J. C.; Frey. G.; Frei, R. W. J . Chromatogr. 1977, 742, 271- 281. (313D) Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography. Ghanekar. A. G.: Das Gupta, V. Am. J . Hosp. Pharm. 1977,34(6), 651-653 (314D) High.pressure liqiiid chromatographiL methud for survayiiig the purity of tolmetin sodium dihydrate. Gilpin, R. K.: Janicki. C. A. ,/ Chromatogr 1976, 147, 501-506. (3 15D) Quantitative deterrriination of pinaLeparn and its rnetabolites in blood and urine by high-performance liquid chromatography. Grass!, E.; Passetti, G. L ; Trebbi, A. J . Chromatogr. 1977, 144(1), 132- 135. (3 16D) High-pressure liquid chromatography of derivatives and micl-obiai metabolites of withaferin A. Gustafson, Mark E : Nicholas, Allan W.; Rosazza, John P. J . Chromatogr. 1977, 737(2). 4 6 5 4 6 7 . (3 17D) Determination of imipramine N-oxide and its degradation products by HPLC. Hansen, Steen Honore; Madsen. Jens Hardy Arch. Pharm. Chemi, Sci. Ed. 1977, 5(5), 157-162. (3 18D) Dihydroergotoxine: separation and determination of four components by high-performance liquid chromatography. Hartmann, V., Rodiger. M.; Ableidinger, W.; Eethke. H. ./. Pharm. Sci., 1978, 67(1). 98-103. (319D) Separation and detection of some common analgesics by high-pressure liquid chromatography. Harzer, Klaus; Barchet, Reinhold Dtsch Apoth.-Ztg. 1976, 116(34). 1229-1231. (320Dj Analysis of benzcdiizepines and their hydrolysis products, banzoptienones. by reversed-phase high-performance liquid chromatography and its application to biological material. Harzer, Klaus: Barchet. Reinhold ,/. Chromatogr 1977, 132(1), 83--90. (321D) Assay of the major [5
