Phototransformations of Bridgehead-Disubstituted Dibenzobarrelenes

D. Ramaiah, S. A. Kumar, C. V. Asokan, T. Mathew, S. Das, N. P. Rath, and M. V. George*. Photochemistry Research Unit, Regional Research Laboratory (C...
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J. Org. Chem. 1996, 61, 5468-5473

Phototransformations of Bridgehead-Disubstituted Dibenzobarrelenes. Interesting Rearrangements of Dibenzosemibullvalene Intermediates Derived from 9-(Hydroxyalkyl)-10-methoxy-Substituted Dibenzobarrelenes1 D. Ramaiah,2a S. A. Kumar,2a C. V. Asokan,2a,d T. Mathew,2a S. Das,2a N. P. Rath,2b and M. V. George*,2a,c Photochemistry Research Unit, Regional Research Laboratory (CSIR), Trivandrum 695 019, India, Department of Chemistry, University of MissourisSt. Louis, Missouri 63121, and Radiation Laboratory, University of Notre Dame, Notre Dame, Indiana 46556 Received November 20, 1995X

The photochemistry of 11,12-dibenzoyl-9,10-dihydro-9-(hydroxymethyl)-10-methoxy-9,10-ethenoanthracene (7a) and 11,12-dibenzoyl-9,10-dihydro-9-(1-hydroxyethyl)-10-methoxy-9,10-ethenoanthracene (7b) has been studied through steady-state photolysis, product analysis, and laser flash photolysis. Irradiation of 7a in benzene, methanol, or acetone gave 69-72% yields of a dibenzopentalene ketone 11a, arising through a dibenzosemibullvalene precursor. Irradiation of 7b, which exists in equilibrium with its cyclic form 7b′, gave a mixture of the dibenzopentalene ketone 11b (41%) and the dibenzopentalenopyran derivative, 16b′ (26%). The photochemistry of 11,12-dibenzoyl-9,10-dihydro-9,10-dimethoxy-9,10-ethenoanthracene (17) has been reinvestigated. Irradiation of 17 in benzene and methanol gives a 90% yield of an isomeric pentacyclic product 24, formed through the rearrangement of a dibenzosemibullvalene precursor. Irradiation of 17 in aqueous methanol gives a mixture of the dibenzopentalene ketone 22 (40%) and a pentacyclic methanol adduct 21 (34%). The structures of 7b′, 11a,b, 16b′, 21, and 24 were confirmed through X-ray crystallographic analysis. The 308 nm laser flash photolysis of 7a,b in benzene results in the formation of their triplets (φT ) 0.55-0.76). These triplets possess short lifetimes (0.45-0.75 µs) and are quenched by oxygen, 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO), 4-hydroxy-2,2,6,6tetramethylpiperidinyl-1-oxy (HTEMPO), ferrocene, and β-carotene at rates in the range (0.264.7) × 109 M-1 s-1. Introduction Several aspects of the phototransformations of dibenzobarrelenes are reported in the literature.3 In general, they undergo photorearrangement, leading primarily to dibenzocyclooctatetraenes and dibenzosemibullvalenes. It has been suggested that the dibenzocyclooctatetraenes are formed through a singlet state pathway, involving a [2 + 2] cycloaddition (phenyl-vinyl bridging), followed by further rearrangements, whereas the dibenzosemibullvalenes arise through triplet state mediated pathways.4 In an earlier publication,5 we had reported that a bridgehead disubstituted dibenzobarrelene such as 11,12-dibenzoyl-9,10-dihydro-9,10-dimethyl-9,10-ethenoan-

Abstract published in Advance ACS Abstracts, July 15, 1996. (1) Contribution No. NDRL-3616 from the Notre Dame Radiation Laboratory and No. RRLT-PRU-32 from the Regional Research Laboratory (CSIR), Trivandrum. (2) (a) Regional Research Laboratory, Trivandrum. (b) University of Missouri-St. Louis. (c) University of Notre Dame. (d) Present address: School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India. (3) (a) For some recent reviews on the photochemistry of dibenzobarrelenes and the general di-π-methane rearrangement, see: (a) Zimmerman, H. E. In Rearrangement in Ground and Excited States; de Mayo, P., Ed.; Academic: New York, 1980; Vol. 3, Chapter 16, pp 131-166. (b) Zimmerman, H. E. In Organic Photochemistry; Padwa, A., Ed.; Marcell Dekker: New York, 1991; Vol. 11, pp 1-36. (c) Scheffer, J. R.; Pokkuluri, P. R. In Photochemistry in Organized and Constrained Media; Ramamurthy, V., Ed.; VCH: New York, 1991; pp 185-246. (d) de Lucchi, O.; Adam, W. In ComprehensiveOrganic Synthesis; Trost, B. M., Paquette, L. A., Eds.; Pergamon Press: Oxford, 1991; Vol. 5, pp 193-214. (e) Chen, J.; Scheffer, J. R.; Trotter, J. Tetrahedron 1992, 48, 3251-3274. (f) Zimmerman, H. E.; Sulzbach, H. M.; Tollefson, M. B. J. Am. Chem Soc. 1993, 115, 6548-6556. (g) Scheffer, J. R.; Yang, J. In CRC Handbook of Organic Photochemistry and Photobiology; Horspool, W. M., Song, P. S., Eds.; CRC Press: Boca Raton, FL, 1995; Chapter 16, pp 204-221. X

S0022-3263(95)02046-9 CCC: $12.00

thracene (1) on photolysis gives a mixture of products consisting of a dibenzocyclooctatetraene 2 and a dibenzopentalene derivative 3, in addition to an oxygenated hexacyclic peroxy carbinol 4, formed through the oxygen trapping of diradical intermediates (Scheme 1). The formation of the dibenzocyclooctatetraene 2 with C2 symmetry and the dibenzopentalene derivative 3 has been rationalized on the basis of a tri-π-methane pathway6 and involving 1,4-diradical intermediates. In contrast, the phototransformations of an analogous bridgehead disubstituted dibenzobarrelene, namely 11,12dibenzoyl-9,10-dihydro-9-(hydroxymethyl)-10-methyl-9,10ethenoanthracene (5), resulted in the formation of an oxadibenzopropallane carbinol 6 exclusively, arising through a dibenzosemibullvalene precursor7 (Scheme 2). The objective of the present investigation has been to study the photochemistry of two dibenzobarrelenes with unsymmetrical bridgehead substituents such as hydroxyalkyl and methoxy groups with a view to examining the nature of the products formed in these cases. Further, we wanted to examine whether the dibenzosemibullvalenes, formed in these reactions as primary prod(4) (a) Ciganek, E. J. Am. Chem. Soc. 1966, 88, 2882-2883. (b) Rabideau, P. W.; Hamilton, J. B.; Friedman, L. J. Am. Chem. Soc. 1968, 90, 4465-4466. (5) Asokan, C. V.; Kumar, S. A.; Das, S.; Rath, N. P.; George, M. V. J. Org. Chem. 1991, 56, 5890-5893. (6) For some earlier references on tri-π-methane rearrangement, see: (a) Zimmerman, H. E.; Grunewald, G. L. J. Am.Chem. Soc. 1966, 88, 183-184. (b) Zimmerman, H. E.; Binkley, R. W.; Givens, R. S.; Sherwin, M. A. J. Am. Chem. Soc. 1967, 89, 3932-3933. (c) Pokkuluri, P. R.; Scheffer, J. R.; Trotter, J. J. Am. Chem. Soc. 1990, 112, 36753676. (d) Chen. J.; Pokkuluri, P. R., Scheffer, J. R.; Trotter, J. J. Photochem. Photobiol. A: Chem. 1991, 7, 21-26. (7) Kumar, S. A.; Asokan, C. V.; Das, S.; Wilbur, J. A.; Rath, N. P.; George, M. V. J. Photochem. Photobiol. A: Chem. 1993, 71, 27-31.

© 1996 American Chemical Society

Bridgehead-Disubstituted Dibenzobarrelenes

J. Org. Chem., Vol. 61, No. 16, 1996 5469

1. Steady-State Photolysis and Product Identification. The starting dibenzobarrelenes 7a,b were obtained in 70-80% yields by the reaction of the appropriate anthracenes with DBA in refluxing xylene, whereas 17 was prepared as per a reported procedure.8 In the case of 7b, the 1H NMR spectrum showed the presence of an isomeric cyclic carbinol 7b′, formed through the interaction of the hydroxyethyl substituent at the C-9 position with the benzoyl group at the C-12 position. Both 7b and 7b′ exist in equilibrium in solution. The IR spectrum of 7b in KBr showed a single absorption for hydroxyl group at 3448 cm-1, whereas in chloroform solution it showed two peaks at 3560 and 3448 cm-1 due to 7b′ and 7b, respectively. Further, the equilibrium between 7b and 7b′ has been found to be solvent dependent, which has been confirmed by 1H NMR analysis. The methyl protons of 7b and 7b′ in CDCl3, for example, appear as two distinct doublets, centered at δ 1.65 (J ) 7 Hz) and 2.35 (J ) 7.5 Hz), respectively. The methoxy protons appeared as two distinct singlets at δ 3.60 and 3.68, and the hydroxyl protons appeared as singlets at 3.30 and 3.71, which are exchangeable with D2O. The methine protons appeared as quartets at δ 5.50 and 5.85. Similarly, the 13C NMR spectrum revealed that the methyl carbons of 7b and 7b′ in CDCl3 appear at

16.76 and 22.10 and the methoxy carbons at δ 56.47 and 57.10, respectively. On the basis of 1H NMR analysis in various deuterated solvents, it was found that the ratio of 7b and 7b′ is 2:1 in C6D6, 1:1 in CDCl3 and CD3CN, and 1:2 in C5D5N, CD3OD, and DMSO-d6, thereby indicating that in less polar solvents it exists predominantly in the open form (7b), whereas in more polar solvents the cyclic carbinol (7b′) is preferred. The structure of the cyclic carbinol 7b′ was unambiguously proved through X-ray crystallographic analysis.9 Irradiation of 7a in benzene, methanol, or acetone gave 69-72% yields of 11a (Scheme 3). Irradiation of 7b in benzene, on the other hand, gave a mixture of products consisting of 11b (41%) and 16b′ (26%). In order to examine the effect of the equilibrium ratio between 7b and 7b′ on product formation, we have carried out the photolysis at ambient temperature in both CDCl3 and C6D6 and monitored the progress of the reaction in each case by 1H NMR. Irradiation of 7b in CDCl3, where it exists in equilibrium with 7b′ in a 1:1 ratio, for 1 h resulted in a mixture of 11b (50%) and 16b′ (28%), along with 22% of the unreacted starting mixture as analyzed by 1H NMR, following the methyl and methoxy protons. Thus, for example, the methyl protons of 11b in CDCl3 appeared as a doublet at δ 1.25 (J ) 7 Hz), whereas in 16b′ they appeared as a singlet at δ 2.45. In addition, the methanol formed in the reaction could be detected through the presence of a singlet at δ 3.45, roughly equal to the yield of 11b. Similarly, when the irradiation of 7b was carried out in C6D6, where it exists in equilibrium with 7b′ in the ratio of 2:1, for 1 h and the reaction mixture analyzed by 1H NMR the presence of 11b and 16b′ in nearly a 2:1 ratio was revealed. The structures of the photoproducts 11a,b and 16b′ were confirmed through X-ray crystal structure determination.9 In view of the formation of the demethylated dibenzopentalene ketones 11a,b from the methoxy-substituted dibenzobarrelenes 7a,b, respectively, we have reexamined the phototransformation of the 9,10-dimethoxydibenzobarrelene 17. We had reported earlier8 that the irradiation of 17 in methanol, benzene, or acetone gave good yields of the dibenzosemibullvalene 20 (Scheme 4). A careful reexamination of the structure of the photoproduct (90%) formed in a mixture (4:1) of methanol and benzene from 17 through X-ray crystallographic analysis9 reveals that it is correctly represented as the dibenzopentalenofuran derivative 24. When the photolysis of 17, however, was carried out in a mixture of benzene and aqueous methanol, a mixture of products consisting of the pentacyclic methanol adduct 21 (34%) and the dibenzopentalene ketone 22 (40%) was formed. The structures of 21 and 22 were based on analytical results and spectral data. Further confirmation of the structure of 21 was derived through X-ray crystallographic analysis.9 To examine whether 21 is formed through the addition of methanol to 24, we have irradiated a solution of 24 in methanol and have observed that none of 21 is formed under analogous reaction conditions. When the irradiation of 24 was carried out in methanol containing a small amount of hydrochloric acid, none of 21 could be observed; instead, a complex mixture of products resulted, as revealed by 1H NMR.

(8) Murty, B. A. R. C.; Pratapan, S.; Kumar, C. V.; Das, P. K.; George, M. V. J. Org. Chem. 1985, 50, 2533-2538.

(9) Full details on the crystal and molecular structures will be published separately.

Scheme 1

Scheme 2

ucts, having trisubstituted cyclopropyl ketone functionalities, would undergo subsequent rearrnagements, leading to different secondary products. Also, it was of interest to examine the nature of the transients involved in these cases through nanosecond laser flash photolysis studies. The substrates that we have examined are 11,12dibenzoyl-9,10-dihydro-9-(hydroxymethyl)-10-methoxy9,10-ethenoanthracene (7a) and 11,12-dibenzoyl-9,10dihydro-9-(1-hydroxyethyl)-10-methoxy-9,10-ethenoanthracene (7b). In addition, the photochemistry of 11,12-dibenzoyl-9,10-dihydro-9,10-dimethoxy-9,10ethenoanthracene (17) has been reexamined. Results

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Ramaiah et al. Scheme 3

Scheme 4

2. Laser Flash Photolysis Studies. In order to obtain information on the nature of the transients involved in the phototransformations of 7a,b, they were subjected to laser flash photolysis studies, employing either 308 or 337.1 nm laser pulse excitation. The transients observed over 0.1-100 µs, following 308 nm laser excitation of 7a,b, were characterized by broad and diffuse absorption spectra extending beyond 700 nm. The transient spectra are presented in Figure 1. The transients which are produced within the laser pulse, as a result of laser excitation, decay predominantly by firstorder kinetics with lifetimes varying in the range of 0.450.75 µs (see the insets a and b in Figure 1). These transients are quenched efficiently by typical triplet quenchers, such as oxygen, TEMPO (2,2,6,6-tetramethylpiperidinyl-1-oxy), HTEMPO (4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy), ferrocene, and β-carotene. With β-carotene as the triplet quencher, the growth of intense

transient absoprtions due to β-carotene triplet was observed at 510-550 nm on the same time scale as the decay of the transients of 7a,b. The quenching characteristics of these transients strongly suggest a triplet assignment for them. The triplet yields (φT) and maxT of 7a,b were determined in benzene solutions by comparative techniques using benzophenone triplet (φT ) 1, maxT ) 7.6 × 103 M-1 cm-1 at 532 nm) formation in benzene for actinometry and β-carotene as a triplet quencher by methods described in earlier publications.10,11 The bimolecular rate constants (kq) for the quenching were obtained from the slopes of the linear plots of observed, pseudo-first-order rate constants (kobsd) for transient decay against quencher concentration. The triplet photo(10) Kumar, C. V.; Murty, B. A. R. C.; Lahiri, S.; Chachachery, E.; Scaiano, J. C.; George, M. V. J. Org. Chem. 1984, 49, 4923-4929. (11) Kumar, C. V.; Quin, L.; Das, P. K. J. Chem. Soc., Faraday Trans. 2 1984, 80, 783-793.

Bridgehead-Disubstituted Dibenzobarrelenes

Figure 1. Transient absorption spectra, following 308 nm laser excitation of 7a (A, A′) and 7b (B, B′) in deaerated benzene at the indicated times. Insets: kinetic traces for decay of transient absorption at the indicated wavelengths, as observed for 7a (a) and 7b (b) in benzene.

physical properties such as φT, maxT, τT and the quenching rate constants (kqT) are summarized in Table 1. The broad and diffuse nature of the triplet-triplet absorption spectra of 7a,b suggests that the triplet excitation is not localized on the dibenzoylalkene moiety, but involves the dibenzobarrelene chromophore as a whole. The fact that the triplets of 7a and 7b are efficiently quenched by ferrocene (ET ) 38-41 kcal mol-1)12 and other low-energy triplet quenchers (Table 1) suggests that the ET values for these compounds are near 40 kcal mol-1. The triplet yields (φT) of 7a (0.76) and 7b (0.55) are close to the φT of several substituted dibenzobarrelenes (0.6-0.7) reported earlier.8,13 The high φT values for 7a and 7b support the experimental observation that mainly the triplet-state-mediated di-πmethane rearrangement products are observed in each case. Discussion Phototransformations of bridgehead-unsymmetrically disubstituted barrelenes such as 7a and 7b would be expected to proceed through multichannel pathways, leading to isomeric dibenzosemibullvalenes. Thus, the irradiation of 7a, for example, could proceed through a phenyl-vinyl bridging (di-π-methane pathway), involving a [4a,11] bonding, to give the diradical intermediate 8a, which could then lead to the 4b-(hydroxymethyl)-8bmethoxydibenzosemibullvalene (10a) (Scheme 3). In contrast, a [9a,12] bonding would lead to the isomeric 4b-methoxy-8b-(hydroxymethyl)dibenzosemibullvalene. The formation of the dibenzopentalene ketone 11a could be rationalized in terms of an ionic opening of the cyclopropyl ketone functionality in 10a to give the zwitterionic intermediate 13a, which could then lead to (12) Herkstroetter, W. G. J. Am Chem. Soc. 1975, 97, 4161-4167. (13) (a) Pratapan, S.; Ashok, K.; Cyr, D. R.; Das, P. K.; George, M. V. J. Org. Chem. 1987, 52, 5512-5517. (b) Pratapan, S.; Ashok, K.; Gopidas, K. R.; Rath, N. P.; Das, P. K.; George, M. V. J. Org. Chem. 1990, 55, 1304-1308.

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the demethylated dibenzopentalene ketone 12a through hydrolysis with adventitious water present in the solvent. It may be pointed out that a similar demethylated dibenzopentalene ketone has been isolated as a minor product in the photolysis of dimethyl 9,10-dihydro-9methoxy-9,10-ethenoanthracene-11,12-dicarboxylate.14 The bridgehead hydroxymethyl and benzoyl groups in 12a are close to each other, and the formation of the rearranged product 11a could proceed through an aldol intermediate, involving the interaction of these two groups. Such an aldol intermediate has actually been isolated, in an analogous case, where the subsequent migration of the benzoyl group is not feasible.7 It is interesting to note that 7b with a hydroxyethyl group at 9-position, instead of hydroxymethyl group as in 7a, exists in equilibrium with the cyclic carbinol 7b′ in solution. This may be due to steric interactions exerted by the methyl group in 7b, favoring the interaction between the hydroxyethyl substituent at the 9-position with the benzoyl group at the 12-positon leading to the cyclic carbinol 7b′. Similar cases favoring carbinol formation in related systems have been reported in the literature.15 The formation of 11b from 7b could be rationalized through the dibenzosemibullvalene intermediate 10b, formed by involving a [4a,11] bonding as in the case of 7a, whereas 16b′ could be formed through the hexacyclic dibenzosemibullvalene intermediate 15b′, formed through a [9a,12] bonding in 7b′ (Scheme 3). The observed regioselectivity arising through a [4a,11] bonding in the case of 7a,b and [9a,12] bonding in 7b′ could be due to the relative stabilities of the diradical intermediates 8a,b and 14b′ involved in these transformations. Similar observations were made earlier by Zimmerman3b and Scheffer16 in the phototransformations of several substituted 9,10-ethenoanthracene derivatives, where the radical-stabilizing ability of the substituents is important in determining the regioselectivity. The fact that the formation of photoproducts 11b and 16b′ in the ratio of 2:1 in benzene as well as in chloroform, where the equilibrium ratio between 7b and 7b′ is 2:1 and 1:1, respectively, indicates that 7b may have a greater photoreactivity as compared to 7b′. The involvement of ionic intermediates such as 13a,b in the transformation of the dibenzosemibullvalenes 10a,b has been inferred through the isolation of the pentacyclic, ring-enlarged product 24 in the photolysis of the symmetrically substituted 9,10-dimethoxydibenzobarrelene 17 in benzene-methanol mixture. The formation of 24 is assumed to be through the zwitterionic intermediate 23, derived from the dibenzosemibullvalene 20, which in turn is formed through a [9a,12] bridging of 17, as shown in Scheme 4. Similar ring-enlarged, pentacylic products have been isolated in the photolysis of 9-aryldibenzobarrelenes.13b The isolation of the demethylated, dibenzopentalene ketone 22 and the methanol adduct 21, when the photolysis of 17 is carried out in a mixture of benzene and aqueous methanol, would clearly support the involvement of the ionic intermediate 23 (Scheme 4). The fact that none of 21 is formed, on (14) Paddick, R. G.; Richards, K. E.; Wright, G. J. Aust. J. Chem. 1976, 29, 1005-1015. (15) (a) Chen, J.; Pokkuluri, P. R.; Scheffer, J. R.; Trotter, J. Tetrahedron Lett. 1992, 33, 1535-1538. (b) Kumar, A. S.; Rajesh, C. S.; Das, S.; Rath, N. P.; George, M. V. J. Photochem. Photobiol. A: Chem. 1995, 86, 177-183. (16) Rattray, G.; Yang, J.; Gudmundsdottir, A. D.; Scheffer, J. R. Tetrahedron Lett. 1993, 34, 35-38.

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Table 1. Photophysical Properties of Dibenzobarrelene Triplets in Benzene at 298 K kqT,c 109 M-1 s-1 substrate 7a 7b d

T,a

λmon

500 500

nm

max

T ,b

103 M-1

cm-1

6.15 2.82

φ T ,b

τT,c

0.76 0.55

0.75 0.45

O2

TEMPOd

HTEMPOe

ferrocene

β-carotene

0.57 0.51

0.24 0.26

0.40 0.43

5.1 4.6

4.2 4.7

a These are the wavelengths where the triplets were monitored. b (30%; the monitoring wavelegnths are indicated in column 2. c (15%. TEMPO: 2,2,6,6-tetramethylpiperidinyl-1-oxy. e HTEMPO: 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy.

irradiation of 24 in methanol, both in the absence and in the presence of a small amount of acid, would indicate that 21 is formed most likely through the addition of methanol to the zwitterionic intermediate 23 under our reaction conditions.

Experimental Section The equipment and procedures for melting point determination and spectral recordings are described in earlier papers.7,8,11,13 All steady-state irradiation experiments were carried out in a Srinivasan-Griffin-Rayonet Photochemical Reactor (RPR 3000 Å) or by using Pyrex-filtered light from a Hanovia 450 W medium-pressure mercury lamp. Solvents for photolysis experiments were purified and distilled before use. Aldrich Gold-Label solvents were used for laser studies. TEMPO and HTEMPO, from Aldrich, were used as received, whereas ferrocene and β-carotene were recrystallized from suitable solvents before use. Starting Materials. Dibenzoylacetylene (DBA)17,18 mp 110-111 °C, 9-(hydroxymethyl)-10-methoxyanthracene,19 mp 149-151 °C, and 11,12-dibenzoyl-9,10-dihydro-9,10-dimethoxy9,10-ethenoanthracene (17),8 mp 221 °C, were prepared by reported procedures. Preparation of 9-(1-Hydroxyethyl)-10-methoxyanthracene. Treatment of methylmagnesium bromide (Grignard reagent prepared from 423 mg (3 mmol) of methyl iodide and 75 mg (3 mmol) of magnesium in 20 mL of diethyl ether) with 9-methoxyanthracene-10-carboxaldehyde (715 mg, 3 mmol) in dry benzene (20 mL) for 2 h and workup in the usual manner by treatment with a mixture of crushed ice and ammonium chloride and extraction with ether gave 212 mg (84%) of 9-(1hydroxyethyl)-10-methoxyanthracene, mp 129-130 °C, after recrystallization from diethyl ether: IR νmax (KBr) 3424, 3381, 2979, 2935, 1620, 1603 cm-1; UV λmax (CH3OH) 251 nm ( 65 800), 258 (115 300), 340 (2420), 356 (4690), 375 (6860), 396 (5950); 1H NMR (CDCl3) δ 1.81 (3H, d, J ) 6 Hz), 4.20 (3H, s), 5.25 (1H, s, D2O-exchangeable), 6.32 (1H, q, J ) 6 Hz), 7.18.8 (8H, m); 13C NMR (CDCl3) δ 23.41, 62.95, 66.80, 122.68, 124.11, 124.53, 124.98, 125.36, 129.36, 131.90; mass spectrum m/e (relative intensity) 252 (M+, 87), 237 (100), 220 (47), 193 (29), 178 (33), 165 (52), 152 (18); mol wt calcd for C17H16O2 252.1150, found 252.1156 (high-resolution mass spectrometry). Preparation of 11,12-Dibenzoyl-9,10-dihydro-9,10ethenoanthracenes 7a,b. The dihydrobarrelenes 7a and 7b were prepared by refluxing mixtures of the appropriate anthracenes and DBA in xylene. The solvent, from the reaction mixture, in each case, was removed under vacuum, and the residual solid was subjected to flash chromatography over silica gel using chloroform and later recrystallized from cyclohexane. 7a. Reaction of 476 mg (2 mmol) of 9-hydroxymethyl-10methoxy-anthracene with DBA (468 mg, 2 mmol) for 10 h gave 755 mg (80%) of 7a, mp 216-217 °C: IR νmax (KBr) 3430, 1652 cm-1; UV λmax (CH3OH) 224 nm ( 24 300), 258 (24 800); 1H NMR (CDCl3) δ 2.43 (1H, t, J ) 5 Hz, D2O-exchangeable), 3.72 (3H, s), 5.02 (2H, d, J ) 5 Hz), 6.80-7.85 (18H, m); 13C NMR (CDCl3) δ 56.80, 57.10, 59.15, 89.09, 121.27, 121.87, 125.12, 125.31, 127.95, 128.13, 129.37, 133.13, 133.46, 136.92, 137.22, 143.36, 146.27, 151.33, 153.09, 153.23, 193.46, 196.43; mass (17) Lutz, R. E. In Organic Synthesis; Horning, E. C., Ed.; Wiley: New York, 1955; Collect. Vol. 3, pp 248-250. (18) Lutz, R. E. Smithy, W. R., Jr. J. Org. Chem. 1951, 16, 648654. (19) Rigaudy, J.; Nedlic, L. Bull. Soc. Chim. Fr. 1959, 648-654.

spectrum m/e (relative intensity) 472 (M+, 25), 442 (52), 367 (40), 337 (46), 245 (96), 238 (96), 105 (100), 77 (33); mol wt calcd for C32H24O4 472.1674, found 472.1670 (high-resolution mass spectrometry). 7b + 7b′. Reaction of 2.52 g (10 mmol) of 9-(1-hydroxyethyl)-10-methoxyanthracene with DBA (468 mg, 2 mmol) for 3 h gave 680 mg (70%) of 7b, mp 163-164 °C (single crystal of 7b′, mp 147-148 °C): IR νmax (KBr) 3448, 1655 cm-1; IR νmax (CHCl3) 3560, 3448, 1655 cm-1; UV λmax (CH3OH) 207 nm ( 41 300), 253 (19 100); 1H NMR (CDCl3) δ 1.65 (3H, d, J ) 7 Hz), 2.35 (3H, d, J ) 7.5 Hz), 3.30 (1H, s, D2O-exchangeable) 3.60 (3H, s), 3.68 (3H, s) 3.71 (1H, s, D2O-exchangeable), 5.50 (1H, q, J ) 7 Hz), 5.85 (1H, q, J ) 7.5 Hz), 6.73-8.45 (36H, m); 1H NMR (C6D6) δ 1.61 (3H, d, J ) 7 Hz), 2.05 (3H, d, J ) 7.4 Hz), 3.25 (1H, s, D2O-exchangeable), 3.43 (3H, s), 3.55 (3H, s), 3.57 (1H, s, D2O-exchangeable), 5.35 (1H, q, J ) 7 Hz), 5.85 (1H, q, J ) 7.4 Hz), 6.55-8.15 (36H, m); 13C NMR (CDCl3) δ 16.76, 22.10, 56.47, 57.10, 60.94, 62.29, 88.78, 89.56, 101.52, 120.97, 121.42, 122.49, 122.91, 124.64, 125.15, 125.45, 126.25, 127.15, 127.54, 127.89, 128.10, 129.15, 129.21, 132.58, 133.23, 136.13, 136.81, 137.17, 139.53, 143.41, 144.27, 144.87, 145.50, 148.21, 162.89, 193.41, 194.46; mass spectrum m/e (relative intensity) 486 (M+, 10), 442 (16), 337 (33), 259 (43), 252 (13), 105 (100), 77 (30); mol wt calcd for C33H26O4 486.1831, found 486.1820 (high-resolution mass spectrometry). Irradiation of 7a. A benzene solution of 7a (472 mg, 1 mmol in 350 mL) was irradiated (Hanovia 450 W) for 30 min. Removal of the solvent under vacuum gave a residual solid, which was chromatographed over silica gel. Elution with a mixture (1:1) of petroleum ether (bp 60-80 °C) and chloroform gave 340 mg (72%) of 11a, mp 176-177 °C, after recrystallization from acetonitrile: IR νmax (KBr) 3063, 2952, 1713, 1682 cm-1; UV λmax (CH3OH) 250 nm ( 28900); 1H NMR (CDCl3) δ 4.10 (1H, d, J ) 3 Hz), 5.05 (2H, dd, J ) 11 Hz), 5.52 (1H, d, J ) 3 Hz), 6.85-8.35 (18H, m); 13C NMR (CDCl3) δ 52.60, 58.92, 60.07, 68.52, 123.69, 123.84, 124.04, 126.41, 128.17, 128.32, 128.53, 128.60, 129.02, 129.24, 129.41, 132.96, 135.64, 138.08, 140.86, 143.03, 154.76, 166.05, 198.66, 203.35; mass spectrum m/e (relative intensity) 458 (M+, 21), 336 (15), 231 (24), 189 (20), 105 (100), 76 (56); mol wt calcd for C31H22O4 458.1518, found 458.1509 (high-resolution mass spectrometry). In repeat runs, irradiations of methanol (30 min) and acetone (2 h) solutions of 7a gave 11a in 69% and 71% yields, respectively. Irradiation of 7b. A solution of 7b (486 mg, 1 mmol) in benzene (250 mL) was irradiated (Hanovia 450 W) for 15 min. Removal of the solvent under vacuum gave a residual solid, which was subsequently chromatographed over alumina. Elution with a mixture (1:1) of petroleum ether (bp 60-80 °C) and chloroform gave 122 mg (26%) of 16b′, mp 232-233 °C, after recrystallization from acetonitrile: IR νmax (KBr) 3064, 2938, 2840, 1679, 1598 cm-1; UV λmax (CH3OH) 270 nm ( 22 000), 326 (10 200); 1H NMR (CDCl3) δ 2.45 (3H, s), 3.10 (3H, s), 7.08-7.95 (18H, m); 13C NMR (CDCl3) δ 17.18, 53.69, 69.72, 97.00, 119.44, 119.93, 120.73, 122.36, 125.52, 127.34, 127.76, 128.37, 128.64, 129.49, 129.74, 129.94, 131.71, 133.12, 138.10, 138.22, 138.54, 142.35, 143.27, 149.00, 152.78, 157.03, 200.38; mass spectrum m/e (relative intensity) 468 (M+, 14), 363 (78), 332 (100), 303 (16), 105(5); mol wt calcd for C33H24O3 468.1725, found 468.1725 (high-resolution mass spectrometry). Further elution with chloroform gave 195 mg (41%) of 11b, mp 173-174 °C, after recrystallization from acetonitrile: IR νmax (KBr) 3060, 2930, 1702, 1680 cm-1, UV λmax (CH3OH) 205 nm ( 36 200), 251 (17 500); 1H NMR (CDCl3) δ 1.25 (3H, d, J ) 7 Hz), 4.15 (1H, d, J ) 11 Hz), 5.61 (1H, d, J ) 11 Hz), 6.05 (1H, q, J ) 7 Hz), 6.95-8.25 (18H, m); 13C NMR (CDCl3) δ

Bridgehead-Disubstituted Dibenzobarrelenes 16.45, 26.84, 53.52, 56.63, 64.43, 123.81, 124.22, 125.76, 128.30, 128.42, 128.48, 128.74, 129.15, 130.04, 133.00, 133.17, 135.55, 136.68, 138.13, 140.99, 143.83, 155.42, 165.62, 198.98, 204.18; mass spectrum m/e (relative intensity) 473 (MH+, 60), 351 (29), 307 (20), 245 (15), 229 (22), 154 (87), 136 (56), 105 (100), 77 (19); mol wt calcd for C32H24O4 472.1675, found 472.1666 (high-resolution mass spectrometry). 1H NMR Monitoring of the Photoreaction of 7b. A solution of 7b in CDCl3 (20 mg in 1 mL) in an NMR tube was irradiated with an RPR (3000 Å) light source for 1 h, and its 1 H NMR spectrum was recorded. The 1H NMR spectrum revealed that the product mixture consisted of 50% of 11b, 28% of 16b′, and methanol (equal to the yield of 11b), along with 22% of the unreacted starting material. When the irradiation was carried out for 2 h, the product mixture consisted of 11b (64%), 16b′ (36%), and methanol. In a separate experiment, when the irradiation of 7b in C6D6 (20 mg in 1 mL) in an NMR tube was carried out for 1 h, under analogous conditions, the product mixture consisted of 11b (62%), 16b′ (38%), and methanol (equal to that of 11b) as analyzed by 1H NMR. Irradiation of 17. A solution of 17 (188 mg, 0.25 mmol) in a mixture (4:1, 50 mL) of methanol and benzene was irradiated (RPR 3000 Å light source) for 8 h (after bubbling with nitrogen) and worked up by removal of the solvent under vacuum and chromatographing the residue on Chromatotron. Elution with a mixture (19:1) of petroleum ether (bp 60-80 °C) and ethyl acetate gave 106 mg (90%) of 24, mp 158-159 °C, after recrystallization from a mixture (1:1) of methylene chloride and methanol: IR νmax (KBr) 3060, 2970, 2920, 2850, 1690, 1610 cm-1; UV λmax (CH3OH) 223 nm ( 24 100), 240 (17 100), 320 (9150); 1H NMR (CDCl3) δ 3.26 (3H, s), 3.72 (3H, s), 7.00-7.90 (18H, m); 13C NMR (CDCl3) δ 54.08. 55.04, 57.04, 80.72, 97.22, 118.8, 121.00, 121.50, 121.82, 124.05, 124.85, 125.51, 127.30, 127.63, 127.86, 127.98, 128.34, 128.49, 128.88, 129.51, 129.95. 130.49, 133.59, 133.95, 136.84, 141.05, 141.50, 142.04, 143.95, 149.55, 200.48; mass spectrum m/e (relative intensity) 472 (M+, 40), 441 (16), 367 (94), 336 (100), 293 (69), 105 (23), 77 (14); mol wt calcd for C32H24O4 472.1675, found 472.1662 (high-resolution mass spectrometry). In repeat runs, when the irradiation of 17 was carried out in benzene (1.5 h) and acetone (5 h), 24 was formed in 30% and 82% yields, respectively. Irradiation of 17 in a Mixture of Benzene and Aqueous Methanol. A solution of 17 (472 mg, 1 mmol) in a mixture of methanol (150 mL), benzene (40 mL), and water (10 mL) was irradiated (RPR, 3000 Å light source) for 8 h under bubbling nitrogen. Removal of the solvent under vacuum gave a residual solid, which was chromatographed on a Chromatotron. Elution with a mixture (19:1) of petroleum ether (bp 60-80 °C) and ethyl acetate gave 160 mg (34%) of 21, mp 249-250 °C, after recrystallization from a mixture (4: 1) of methylene chloride and methanol: IR νmax (KBr) 3080, 2980, 2950, 2850, 1680, 1605, 1585 cm-1; UV λmax (CH3OH) 232 nm ( 13 400), 2500 (11 800), 275 (3360); 1H NMR (CDCl3) δ 2.60 (3H, s), 3.29 (3H, s), 3.65 (3H, s), 5.45 (1H, s), 5.80 (1H, d, J ) 8 Hz), 6.65-7.95 (17H, m); 13C NMR (CDCl3) δ 50.61, 52.55, 52.80, 63.60, 83.52, 97.85, 116.90, 118.15, 123.51, 124.00, 124.25, 127.89, 128.00, 128.22, 128.58, 128.96, 129.05, 129.23, 129.55, 130.52, 131.68, 131.92, 137.60, 138.57, 139.43, 141.68, 147.45, 195.65; mass spectrum m/e (relative intensity) 472 (M+ - CH3OH, 14), 368 (47), 263 (100), 232 (67), 217 (28), 105 (27); mol wt calcd for C32H24O4 (M - CH3OH) 472.1674, found 472.1678 (high-resolution mass spectrometry). Further elution with a mixture (9:1) of petroleum ether and ethyl acetate gave 190 mg (40%) of 22, mp 210 °C, after recrystallization from a mixture (1:1) of methylene chloride and methanol: IR νmax (KBr) 3080, 2950, 2870, 1710, 1690, 1600, 1585 cm-1; UV λmax (CH3OH) 225 nm ( 28 600), 252 (30 000), 308 (2040); 1H NMR (CDCl3) δ 3.30 (3H, s), 5.82 (1H, s), 6.85-8.45 (18H, m); 13C NMR (CDCl3) δ 53.05, 55.51, 83.50, 94.59, 122.51, 122.60, 124.50, 124.95, 126.65, 127.01, 127.42, 127.95, 128.05, 128.21, 129.52, 131.45, 132.67, 134.75, 136.78, 137.56, 138.95, 139.98, 156.53, 193.95, 196.53, 198.63; mass spectrum m/e (relative intensity) 458 (M+, 30), 353 (12), 322 (27), 294 (9), 217 (13), 105 (100), 77 (23); mol wt calcd for

J. Org. Chem., Vol. 61, No. 16, 1996 5473 C31H22O4 458.1518, found 458.1536 (high-resolution mass spectrometry). Irradiation of 24 in a Mixture of Benzene and Aqueous Methanol. A solution of 24 (47mg, 0.1 mmol) in a mixture of methanol (75 mL), benzene (20 mL), and water (5 mL) was irradiated (RPR, 3000 Å light source) for 4 h under bubbling nitrogen. Removal of the solvent under vacuum gave 47 mg (100%) of the unreacted starting material 24, mp 158159 °C (mixture mp). In a separate experiment, when the irradiation of 24 (47 mg, 0.1 mmol) in a mixture of methanol (75 mL), benzene (20 mL), and water (5 mL containing 0.25 N hydrochloric acid) was carried out under analogous conditions for 4 h, a complex mixture of products was formed. No 21 could be detected in the mixture on the basis of 1H NMR comparision. X-ray Structure Determination of 7b′, 11a,b, 16b′, 21, and 24. Colorless crystals of 7b′, 11a,b, 16b′, 21, and 24 were subjected to X-ray crystallographic analysis, employing a Siemens R3 automated four-circle diffractometer. The results of these studies will be published elsewhere.9 7b′: space group Pbca, a ) 16.722(5) Å, b ) 16.680(5) Å, c ) 17.561(7) Å, Z ) 8, R ) 0.0856 (wR ) 0.200) for 4464 reflections (F > 2.0σ(F)). 11a: space group P21/c, a ) 10.960(3) Å, b ) 9.246(2) Å, c ) 23.0976(5) Å; β ) 99.15 (2)°, Z ) 4, R ) 0.046 (wR ) 0.042) for 2512 reflections (F >4.0σ(F)). 11b: space group P1, a ) 10.634(3) Å, b ) 11.278(3) Å, c ) 12.470(3) Å, R ) 69.00(2)°, β ) 79.72 (2)°, γ ) 77.37 (2)°, Z ) 2, R ) 0.081 (wR ) 0.079) for 3262 reflections (F > 4.0σ(F)). 16b′: space group P1, a ) 9.503(7) Å, b ) 12.158(3) Å, c ) 12.549(6) Å, R ) 83.41(3)°, β ) 76.49(5)°, γ ) 71.52(4)°, Z ) 2, R ) 0.055 (wR ) 0.038) for 3220 reflections (F > 1.5σ(F)). 21: space group Pbca, a ) 17.513(5) Å, b ) 14.897(6) Å, c ) 19.587(8) Å, Z ) 8, R ) 0.042 (wR ) 0.055) for 2500 reflections (F > 3.0σ(F)). 24: space group P21/n, a ) 11.664(4) Å, b ) 17.476(6) Å, c ) 12.408(4) Å, β ) 94.81(3)°, Z ) 4, R ) 0.064 (wR ) 0.068) for 2145 reflections (F > 3.0σ(F)). Laser Flash Photolysis. Pulse excitation was carried out mainly at 308 nm using a Lambda Physic EMG 101 MCS excimer laser (50 mJ, 10 ns, XeCl) and 337.1 nm (8 ns, 2-3 mJ) from a Molectron UV-400 nitrogen laser source. The output from the excimer laser was suitably attenuated to 20 mJ pulse-1 or less and defocused to minimize multiphoton processes. The transient phenomena were observed in 3 × 7 mm quartz cells by using a kinetic spectrometer, described elsewhere.20,21 For transient absorption spectra, a flow cell was used. Unless oxygen effects were to be studied, the solutions were deoxygenated by purging with pure argon.

Acknowledgment. This work was supported by the Council of Scientific and Industrial Research, Government of India (D.R., S.A.K., C.V.A., T.M., S.D.), and the Office of Basic Energy Sciences of the U.S. Department of Energy (M.V.G. (in part)). Supporting Information Available: Copies of 1H NMR spectra of compounds 7a, 7b + 7b′, 11a,b, 16b′, 21, 22, and 24, 13C NMR spectra of compounds 7a, 7b + 7b′, 11b, 16b′, 21, 22, and 24, and X-ray ORTEP diagrams of 7b′, 11a,b, 16b′, 21, and 24 (22 pages). This material is contained in libraries on microfiche, immediately follows this article in the microfilm version of the journal, and can be ordered from the ACS; see any current masthead page for ordering information. JO952046U (20) Das, P. K.; Encinas, M. V.; Small, R. D., Jr.; Scaiano, J. C. J. Am. Chem. Soc. 1979, 101, 6965-6970. (21) Nagarajan, V.; Fessenden, R. W. J. Phys. Chem. 1985, 89, 2330-2335.