© Copyright 2003 by the American Chemical Society
Volume 42, Number 18
May 13, 2003
Accelerated Publications Picosecond Dynamics of G-Protein Coupled Receptor Activation in Rhodopsin from Time-Resolved UV Resonance Raman Spectroscopy† Judy E. Kim, Duohai Pan, and Richard A. Mathies* Department of Chemistry, UniVersity of California, Berkeley, California 94720 ReceiVed January 29, 2003; ReVised Manuscript ReceiVed March 21, 2003 ABSTRACT: The protein response to retinal chromophore isomerization in the visual pigment rhodopsin is studied using picosecond time-resolved UV resonance Raman spectroscopy. High signal-to-noise Raman spectra are obtained using a 1 kHz Ti:Sapphire laser apparatus that provides
