Published on Web 07/02/2009
Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin Kai Cheng, Sheng Peng, Chenjie Xu, and Shouheng Sun* Department of Chemistry, Brown UniVersity, ProVidence, Rhode Island 02912 Received April 30, 2009; E-mail:
[email protected] Abstract: We report a new approach to cisplatin storage and release using porous hollow nanoparticles (PHNPs) of Fe3O4. We prepared the PHNPs by controlled oxidation of Fe NPs at 250 °C followed by acid etching. The opening pores (∼2-4 nm) facilitated the cisplatin diffusion into the cavity of the hollow structure. The porous shell was stable in neutral or basic physiological conditions, and cisplatin escape from the cavity through the same pores was a diffusion-controlled slow process with t1/2 ) 16 h. However, in low pH (
