Downloaded by 80.82.77.83 on December 20, 2017 | http://pubs.acs.org Publication Date (Web): October 24, 2017 | doi: 10.1021/bk-2017-1264.pr001
Preface On the occasion of Prof. Yoshihisa Ozoe receiving the International Award for Research in Agrochemicals from the American Chemical Society Agrochemicals Division, a symposium was organized by Aaron Gross and Joel Coats in Dr. Ozoe’s honor. There were many excellent presentations from an array of international experts in the fields of ion channels, G-protein coupled receptors (GPCRs), and gap junctions. The overall theme was movement toward a broader understanding of how endogenous biogenic amines function at various neuroreceptors and the mechanisms by which some insecticides interfere with normal function at those receptors. There were new mechanisms of action, novel chemistries, new targets and methodologies, and creative ways of attacking old targets. The opening chapter of this volume is authored by Dr. Tom Sparks who has been living and breathing insecticide mechanisms of action for many years. He is certainly one of the world’s foremost authorities on the inexorable demand for novel ways to deal with pests that threaten the security of our food, fiber, households, and public health. It is followed by the chapter from Yoshi Ozoe, the Award Winner, who provides an in-depth discussion of chloride channels and phenolamine GPCRs as important targets for insecticides currently and in the future. Dr. Ozoe’s chapter is followed by contributions by a list of the most highly regarded insecticide scientists in the world. Each of their chapters provides molecular insight into well-known targets, prospective new targets, or creative novel techniques for examining interactions between insecticides and their target sites or for evaluating compounds in search of more potent, more selective, or more environmentally friendly active ingredients. An overview of research on voltage-gated sodium channels is especially relevant given the number of historically important and current insecticides that assert their toxic actions at those sites. Other chapters address new methods for investigating action of insecticides (microtransplant techniques and gap junctions), insecticide effects on highly important species (mosquitoes and honey bees), or chemical prospecting in cultured strains of fungi. We feel that this book will provide a timely and thoughtful treatment of the current state of the art. We hope it serves as a timely update on several critically important groups of insecticide chemistry and can serve as a valuable reference volume for the readers. Each of these chapters provides many references which can inform pesticide scientists everywhere and perhaps springboard a new generation of pest management scientists, educators, and trainers.
ix Gross et al.; Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest ... ACS Symposium Series; American Chemical Society: Washington, DC, 2017.
Downloaded by 80.82.77.83 on December 20, 2017 | http://pubs.acs.org Publication Date (Web): October 24, 2017 | doi: 10.1021/bk-2017-1264.pr001
Aaron D. Gross Virginia Polytechnic Institute and State University Department of Entomology 207 Latham Hall (MC 0390) 220 Ag Quad Ln Blacksburg, Virginia 24061, United States
[email protected] (e-mail)
Yoshihisa Ozoe Faculty of Life and Environmental Science Shimane University Matsue, Shimane 690-8504, Japan
[email protected] (e-mail)
Joel R. Coats Distinguished Professor of Entomology and Toxicology Department of Entomology 116 Insectary Iowa State University Ames, Iowa 50011-3140, United States
[email protected] (e-mail)
x Gross et al.; Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest ... ACS Symposium Series; American Chemical Society: Washington, DC, 2017.
