Downloaded by 80.82.77.83 on May 31, 2018 | https://pubs.acs.org Publication Date (Web): October 24, 2017 | doi: 10.1021/bk-2017-1265.pr001
Preface Pest management often depends on the use of chemical insecticides that affect important physiological and pharmacological processes in arthropods. The development of chemical insecticides has primarily attacked the arthropod nervous system by targeting and disrupting the function of ligand-gated or voltage-gated ion channels. The use of broad classes of synthetic chemistries with common modes of action, along with the widespread, and sometimes improper, use of chemical insecticides has resulted in the urgent need to find new chemistry and novel or underutilized targets, such as G-protein-coupled receptors (GPCRs) for screening, discovery, and development of novel agrochemicals. In addition, we are presenting several recent updates to our knowledge of vital ion channels. Through our authors’ highlighting of rapidly expanding research on GPCRs, as well as more traditional targets, we hope to spur new lines of research and design of new synthetic or biorational agrochemicals. We offer here chapters that describe investigations on GPCR’s that document the substantial progress that has been made recently in understanding the mechanisms of ligand interactions at the receptors, the downstream cascades, and the exciting promise that this large class of receptors has as targets for new agrochemical products. Multiple experts focus on the latest developments on characterization of their molecular pharmacology, on dopamine-specific GPCRs, and on the breadth of various GPCRs as future targets. Our authors have also contributed multiple chapters on insect GABA receptors, addressing their characterization, pharmacology and specificity, as well as specific insecticides and analogs that are active at those receptors. There is also a review of the aminothiazolines as agrochemicals, and a chapter focused on the ever-growing problems from insecticide-resistant pests, in this case, specifically in rice plant hoppers. As the challenges of controlling arthropod pests loom larger each year, we hope this book will serve to ignite new directions, new collaborations, and novel solutions for the security of our food and fiber, as well as the protection of public health. ADG dedicates this book to his family and his great academic mentors. YO dedicates this book to the late Professors M. Eto and F. Matsumura, and his family. JRC dedicates this book to his grandchildren.
ix Gross et al.; Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest ... ACS Symposium Series; American Chemical Society: Washington, DC, 2017.
Downloaded by 80.82.77.83 on May 31, 2018 | https://pubs.acs.org Publication Date (Web): October 24, 2017 | doi: 10.1021/bk-2017-1265.pr001
Aaron D. Gross Virginia Polytechnic Institute and State University Department of Entomology 207 Latham Hall (MC 0390) 220 Ag Quad Lane Blacksburg, Virginia 24061, United States
[email protected] (e-mail)
Yoshihisa Ozoe Faculty of Life and Environmental Science Shimane University Matsue, Shimane 690-8504, Japan
[email protected] (e-mail)
Joel R. Coats Distinguished Professor of Entomology and Toxicology Department of Entomology 116 Insectary Iowa State University Ames, Iowa 50011-3140, United States
[email protected] (e-mail)
x Gross et al.; Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest ... ACS Symposium Series; American Chemical Society: Washington, DC, 2017.
