diuresis and saluresis in rats and dogs while potassium excretion is unaffected or repressed. Cyclization of a number ofthese compounds produced the...
from EtOH gave material with mp 249-251° dec. ... The synthesis of a series of N-amidino-3-substituted pyrazinecarboxamides, principally by the reaction of a.
Pyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines. James Holden Jones, and Edward J. Cragoe Jr.
Preparation and Diuretic Properties of Novel Amiloride Analogues. Thomas Russ , Walter Ried , Frank Ullrich , Ernst Mutschler. Archiv der Pharmazie 1992 325 ...
pattern. This first paper of a series reports the syn- thesis and diuretic activity of theX-amidino-3-amino-. (i-halopyrazinecarboxamides of general structure. I. NR3.
and dried to give 5.20 g (835~:, nip 233-248'). Recrystallization from EtOH gave material with mp 249-231" dec. The IIV spectral data are given in Table 111.
described by Ellingson and Henry.4 Chlorination conducted analogously gave ..... lyte effects of DOCA is a rise in Na/K ratio over that obtained with DOCA alone ...
1. Mechanism of inhibition by amiloride analogs. Robert S. Slaughter , Maria L. Garcia , Edward J. Cragoe , Jr. , John P. Reeves , and Gregory J. Kaczorowski.
III the evalLmtioii a h diuretivs of the N-amiclirin-:~-:iriiitrv~~raaitiec:t~t~o~aiiiid~~,. :t series ilf 5- :tiid ti-alkyl,. -rycloalkyl, and -aryl derivatives KVRS syrthesized ...
John B. Bicking, James W. Mason, Otto W. WoltersdorfJr., James H. Jones, Sara F. Kwong, Charles M. Robb, Edward J. CragoeJr. J. Med. Chem. , 1965, 8 (5), ...
administered at the stated dosage level in feed for a period of 10 days to two pigs in concrete-floored pens. An infection of 10,000 embryonated Ascaris suum.
\'Ill, I:!
The syiitliesis of it aeries of (pyrazinecarI~o~iti~ii~~~)giiaiiidiiies by :t iiiiiii1)cr of i i i v i ttods is rtcssczritwtl. 'Pltc-
