Rapid, Selective Ru-Sulfonate-Catalyzed Allylation ... - ACS Publications

May 28, 2009 - avoiding the use of a (wasted) leaving group. The branched products are favored, and in a number of examples b/l ratios in excess of 20...
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Organometallics 2009, 28, 3437–3448

3437

Rapid, Selective Ru-Sulfonate-Catalyzed Allylation of Indoles Using Alcohols as Substrates Stefan Gruber, Alexey B. Zaitsev, Michael Wo¨rle, and Paul S. Pregosin* Laboratory of Inorganic Chemistry, ETHZ, Ho¨nggerberg, CH-8093 Zu¨rich, Switzerland

Luis F. Veiros Centro de Quı´mica Estrutural, Complexo I, Instituto Superior Te´cnico, AVenida RoVisco Pais 1, 1049-001 Lisbon, Portugal ReceiVed March 3, 2009

The Ru-catalyzed allylation of differing indole compounds using ArCH(OH)CHdCH2 (Ar ) Ph, 2-CH3C6H4, 2-CH3OC6H4 2-ClC6H4, and 1-naphthyl) is relatively fast (usually