Retraction pubs.acs.org/JACS
Cite This: J. Am. Chem. Soc. XXXX, XXX, XXX−XXX
Retraction of “Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity” Sophie B. Sun, Shiladitya Sen, Nam-Jung Kim, Thomas J. Magliery,* Peter G. Schultz,* and Feng Wang* J. Am. Chem. Soc. 2013, 135, 9980−9983; DOI: 10.1021/ja402927u.
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he authors retract this article on the basis of duplicated data within and between some of the melting curves presented. In the course of an examination of data unrelated to this publication, it came to our attention that some of the thermal melt data collected at The Ohio State University contains irregularities, namely, identical values within and between data sets that are highly improbable. We conducted an extensive review of the available primary thermal melt data, reprepared several key protein samples, and carried out DSF thermal melts in replicate. The replicates produced Tm values that were generally in agreement with the reported values. However, duplicate values in the Excel file used to generate Figure S5 make it impossible to have confidence in the validity of all the melt curves presented. Based on these concerns, we retract the entire report. These problems occurred despite blinding of the identities of all samples, which were prepared at the Scripps Research Institute and measured at The Ohio State University, as well as regular examination of the melting data by multiple authors throughout the course of this work. We apologize to the readers of this paper for not detecting these problems sooner and for any negative consequences that may have resulted. The original article was published on June 24, 2013, and retracted on January 29, 2018.
© XXXX American Chemical Society
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DOI: 10.1021/jacs.7b08106 J. Am. Chem. Soc. XXXX, XXX, XXX−XXX
