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Electrochemical immunosensor targets PCBs Field screening techniques are becoming increasingly important for on-site analysis of environmental pollutants. Chemosensors and biosensors have recently taken center stage, offering rapid cost-effective alternatives to traditional laboratory-based technologies. Of particular interest has been the development of sensors based on immunochemical methods that measure antibody-antigen (Ab-Ag) reactions. The first crucial step in developing an immunosensor is the immobilization of an antibody onto the surface of a transducer. Covalent bonding and irreversible adsorption can produce ineffective sensors because of problems with the stability of the Ab or Ag molecule and low Ab loading. Omowunmi A Sadik and Sharin Bender of the State University of New York at Binghamton prefer instead to incorporate Ab or
Separating structurally diverse combinatorial mixtures Combinatorial chemistry plays a critical role in modern drug discovery, but it also presents quite a challenge to the analyst responsible for screening the resulting mixtures. Craig E. Lunte of the University of Kansas and his co-workers at Dublin City University (Ireland) and Chiron Corporation have developed a CE separation method to characterize peptoid-based combinatorial mixtures. Five N-(substituted)glycine (NSG)-peptoid mixtures, representative of those that be encountered during drug discovery, were investigated to determine the best CE approach for mixtures with
