Article pubs.acs.org/Biomac
Stability Enhancing N‑Terminal PEGylation of Oxytocin Exploiting Different Polymer Architectures and Conjugation Approaches Jennifer Collins,† Kristian Kempe,†,‡ Paul Wilson,†,‡ Claudia A. Blindauer,† Michelle P. McIntosh,‡ Thomas P. Davis,‡ Michael R. Whittaker,*,‡ and David M. Haddleton*,†,‡ †
Department of Chemistry, University of Warwick, CV4 7AL, Coventry, United Kingdom ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia
‡
S Supporting Information *
ABSTRACT: Oxytocin, a cyclic nine amino acid neurohypophyseal hormone therapeutic, is effectively used in the control of postpartum hemorrhaging (PPH) and is on the WHO List of Essential Medicines. However, oxytocin has limited shelf life stability in aqueous solutions, particularly at temperatures in excess of 25 °C and injectable aqueous oxytocin formulations require refrigeration (
