Synthesis and Evaluation of the Bis-Nor-Anachelin Chromophore as

University of Rochester. ‡ Purdue University. § University of Wisconsin. Scheme 1. 2258. J. Med. Chem. 2000, 43, 2258-2265. 10.1021/jm0001020 CCC: $19.00.

compounds show significant cytotoxicity under both aerobic and hypoxic conditions. Introduction. The presence of hypoxia and hypoxic cells in many.

We have discovered a number of nitrofuranylamides with submicromolar M. tuberculosis MIC values and acceptable therapeutic indexes. .... Yaling Gong , Selin Somersan Karakaya , Xiaoyong Guo , Purong Zheng , Ben Gold , Yao Ma , David Little , Julia Ro

Ronsisvalle, G.; Pappalardo, M. S.; Vittorio, F.; Pasquinucci, L.; Caruso, A.; Felice, A.; Amico-Roxas, M. Synthesis and pharmaceutical properties of N-thienyl ...

Aug 25, 1993 - 1994, 37, 268-274. Synthesis and Pharmacological Evaluation of Phenylacetamides as. Sodium-Channel Blockerst. Ioannis Roufos,* * Sheryl ...

The indenoisoquinolines represent a class of non-camptothecin topoisomerase I (Top1) inhibitors that exert cytotoxicity by trapping the covalent complex formed ...

Received April 6, 2004; Revised Manuscript Received July 17, 2004. ABSTRACT: Four isomeric terpolymers based on benzyl methacrylate (BzMA, nonionic ...

Figure 1 Representative topoisomerase I inhibitors. .... along with the mean graph midpoint (MGM) values, are summarized in Table 1. .... Carbamate-protected analogues 31 (Top1 0), 32 (Top1 0), and 33 (Top1 ++) .... The cleavage seen at base pair 70

Oct 9, 2009 - ... Nonomura,† Yoshimasa Misumi,† Yuko Otani,† Mayuko Ishida,§. Ryo Taguchi,§,^ Masafumi Tsujimoto,. ) Junken Aoki,*,‡,#,O Hiroyuki Arai,‡ ...

Mar 9, 2015 - For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder. Cover Image. A Chiron Approach to Diversity-Oriented Synthesis of Aminocyclitols, (−)-Conduramine F-4 and Polyhydroxyami