Synthesis of branched-chain apiosylpyrimidines and their inhibition of

706 Journal of Medicinal Chemistr),, 1978. Voi. 21.

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References and Notes (1) A. Bloch in “Medicinal Chemistry. A Series of Monographs. Volume IV. Drug Design”,E. J. Ariens, Ed., Academic Press, 1973, p 345. New York, N.Y., ( 2 ) F. Cramer, Ace. Chem. Res., 2, 338 (1969). (3) For a review on nucleocidin see R. J . Suhadolnik. “Nucleoside Antibiotics”, Wiley-Interscience, New York. N.Y., 1970, pp 246-255. ( 4 ) (a) D. A. Shuman, R. K. Robins, and M. J. Robins, J . A m . Chern. SOC.,91,3391 (1969); (b) D. A. Shuman, M. .J. Robins, arid R. K. Robins, ibid., 92. 3431 (1970). (,5) .4. Bloch and C. Coutsogeorgopoulos, Riochernistrj, 10,4394 (19711.

Notes

(6) B. Jastorff and H. Hettler. Chern. Ber., 102, 4119 (1969). ( 7 ) J. P. Horwitz, A.