Synthesis of some antithyroid compounds. II - Journal of Medicinal

Pramod Kumar Srivastava, Meerasahid Saleem. J. Med. Chem. , 1969, 12 (6), pp 1092–1093. DOI: 10.1021/jm00306a028. Publication Date: November 1969...
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Blank 272,189 f 13,670 237,730 f 12,340 Thiouracil (0 500) 39,428 i 9233* 30,679 i 764.ib I (0 913) 13,714 i 6683b 38,247 i 3837b IT (1 2 2 ) 41,152 i- 17,73;ib 31,984 =t16,240'' I11 (1 15) 21,761 i 5672b 18,318 i- 4762b IV (1 13) 64,26.5 i 12,0,5Rh :2,448 i 10,TOKb 1- (1 30) 22,967 i Xllh 1,5,674 i 1131h \ I (1 54) 29,OO.i zt 4056b 22,.i38 i 3638b VI1 (1 46) 63,647 i 10,866h .i2,93.i i 8888b VI11 (1 01) 87,403 i 2 3 , 3 3 2 74,372 i- 21,921" IX (1 06) 71,005 i 12,561b 62,403 i. 22,.i13b x (1 19) 128,604 i 33,855c 113,338 i 31,297 Concentration of test compounds equimolar to thiouracil. * P < 0.001. c P < 0.01. 1100-125 g ) \\-ere maintained on a low-iodide diet for 3 days theti divided into groups consisting of four rats in each group. The animals in each groiip received an intraperitoneal injection of 1 ml of either a blank (0,