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Feb 25, 2013 - FIRST LOOK AT FEBRUARY METEOR. Interstellar object that exploded over Russia on. Feb. 15 was a 10,000-ton chondrite, experts say. 8...
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VOLUME 91, NUMBER 8 FEBRUARY 25, 2013

22

JOHN C. LECHLEITER

C&EN talks with the Eli Lilly & Co. CEO about turning the company around.

GOVERNMENT & POLICY 23 24

CONCENTRATES EXPLOSIVE DILEMMA

Pakistani fertilizer plant project in Indiana has been suspended because of Afghan bomb link.

COVER STORY

26

SAVING ENDANGERED PHOTOS Triggered by cases of fraud, the science of photo conservation and authentication is blossoming. PAGE 9

AVIAN FLU STUDIES STALLED

U.S. funds to support research are on hold while guidelines are debated.

SCIENCE & TECHNOLOGY 28 30

CONCENTRATES CHEMISTS SHARE #REALTIMECHEM

Twitter hashtag connects a worldwide community.

QUOTE OF THE WEEK “Fifty-five percent of drugs used in America don’t work for the patients they are prescribed for.”

NEWS OF THE WEEK 4

Federal R&D agencies explain just what would be lost on March 1. 5

5

34

SUPREME COURT HEARS AG BIO CASE

ACS NATIONAL AWARDS 38

2013 WINNERS

Betley, Burke, Ediger, Evans, Haire, Jonas, Palmer, and Richmond.

CONGRESS REOPENS PUBLIC ACCESS

House, Senate bills go further than past efforts to broaden access to taxpayer-funded research. 6

WHY SN2 REACTIONS FAIL IN WATER

Cluster study shows progress of reaction is impeded by presence of just three water molecules.

PEPTIDE THAT SAYS “DON’T EAT ME”

Justices seem friendly to Monsanto’s patent rights and self-replicating technologies. 6

FLOURISHING FLUORINE

Field continues its rapid growth with a new round of simple, efficient reactions.

Nanoparticles tagged with the synthetic model of key human protein evade the immune system.

G. STEVEN BURRILL, CHIEF EXECUTIVE OFFICER, BURRILL & CO. PAGE 17

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SEQUESTER BUDGET CUTS DETAILED

CELL PAPER RETRACTED, REPLACED

24

Former MIT postdoc accused of falsifying data; lab publishes a better version of synapse imaging method. 7

FIGHTING FLU DRUG RESISTANCE

New family of inhibitors may help prevent drugresistant flu strains from arising.

30 7

GOOD NEWS AT INFORMEX ...

Fine and custom chemical executives report strong sector, return of business from Asia. 8

... BUT BAD NEWS FROM EUROPE

Region’s economic recession continues to bedevil chemical manufacturers. 8

FIRST LOOK AT FEBRUARY METEOR

Interstellar object that exploded over Russia on Feb. 15 was a 10,000-ton chondrite, experts say.

BUSINESS 15 17

CONCENTRATES AFTER CLINICAL TRIALS

Pharmaceutical firms gather real-world data on patient outcomes to evaluate therapies. 20

THE DEPARTMENTS 2 3 36 37 43 45 48

LETTERS EDITOR’S PAGE ACS COMMENT ACS NEWS OBITUARIES CLASSIFIEDS NEWSCRIPTS

FEWER HUGE DEALS IN 2012

Specialty chemical acquisitions drove mergers, but total value of large deals declined.

COVER: Shutterstock/C&EN

CENEAR 91 (8) 1–48 • ISSN 0009-2347