Article pubs.acs.org/ac
Open Access on 07/10/2015
Temperature-Ramped
129
Xe Spin-Exchange Optical Pumping
Panayiotis Nikolaou,* Aaron M. Coffey,†,# Michael J. Barlow,‡ Matthew S. Rosen,§,∥ Boyd M. Goodson,⊥ and Eduard Y. Chekmenev*,†,#,∇,○ ,†
†
Department of Radiology, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232, United States ‡ Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, NG7 2RD, United Kingdom § Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts 02129, United States ∥ Department of Physics, Harvard University, Cambridge, Massachusetts 02138, United States ⊥ Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, United States # Department of Biomedical Engineering, ∇Department of Biochemistry, and ○Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37205, United States ABSTRACT: We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”where the 129Xe hyperpolarization rate is maximal, (ii) “warm”where the 129Xe hyperpolarization approaches unity, and (iii) “cool”where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content (
