NOTES
September 1969 TABLE III'
98 1
Studies on the Cholinergic Receptor.
IV.1 of
INHIBITION O F HUM IX PLASMA PSECDOCHOLINESTER.~SE The Synthesis and Muscarinic Activity B Y x , x - I ) I E T H Y L [3-(1-ILKYLPIPERIDYL)] C.XRBOXbYIDE
3,7-Dimethyl-2,4-dioxo-7-azaspiro[3.4]octane Methiodide
HYDROH.4LIDES'
H. F.RIDLEY,s. s. CHITTERJEE,3a J. F.hIORhN,3b AKD D. J. TRIGGLE3c c/c inliil, a t K
I
x
10-3
JI
CHa 34 CsHj 4;j CaH; 47 CaH9 48 C:,Hii 76 CsHia 82 CiaHu 91 a The data report,ed here, previously nut published as such, were kindly provided by Dr. -4ndrew Lasslo. The values were obtained manometrically, at 37", and are averages from two or more flasks; human plasma "pseudo"-cholinesterase (Cholase, Ciitter Laboratories, Berkeley, Calif.) was used as the enzyme and acetylcholine iodide as the substrate. Details of the specific procediire appeared in earlier papers.la
