The Design of Drugs to Macromolecular Targets (Beddell, C. R.

The Design of Drugs to Macromolecular Targets (Beddell, C. R.). J. Chem. ... Vaccines and cancer immunotherapies work by activating the immune system ...
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reviews Revitalizing Undergraduate Science: Why Some Things Work and Most Don't Sherla Tob~asResearch Corporat~on6840 E Broadway Blvd T~cson.AZ 85710-2815.1992 192 pp 15 1 x22 9cm PB $3 95 for postage for handlmg for flrslcopy, $1 tor eacn am tional wpy; $4 foreign

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Beginning with the mid-1970's, educational reformer Sheila Tobias has dedicated herself to answering "the question of why intelligent and motivated college students have task-specific disabilities in certain disciplines, particularly mathematics and sciences." In 1987 the Research Corporation initiated a program "to increase the flow of young people into the sciences with programs appropriate to the foundation's interest and expertise" and in 1990 published its first "occasional paper bn neglected problems in science education", Tobias' wellpublicized study They're Not Dumb. They're Different: Stalking the Second Tier (Research Corporation, 1990). This provocative monograph analyzed the characteristics of students who decided not to complete their studies in science but who were successful in other fields. Tobias'second book in this series, Revitalizing Undergraduate Science, disdains quick fixes to improve science education. In a n introductory chapter, "Science Education Reform," Tobias discusses What's Wrong with the Prwess" and argues that innovations per se requiring outside funding are less successful than steady improvement in existing programs. In keeping with her subtitle, Why Some Things Work and Most Don't, she presents case studies of "programs that work" as measured by productivity, student recruitment and retention, and high morale among faculty and undergraduates. These success stories were written in collaboration with 25 sources and on-site "rapporteurs"~ounselors,faculty, retired faculty, faculty spouses, department chairs-"always somwne with enough background to be able to report on the preselected program." Tobias describes and aualyzes introductory college physics and chemistry programs and courses in which unexpectedly large numbers of students, including minority students, are being recruited into and remaining in science, and she compares institutional responses to the challenge of teaching science to undergraduates. Tobias concludes that outside ideas, even those by experts. are less important than local initiative and control. In view of the dismal record of previous innovations in science education, I strongly urgethose instructors interested in educational reform to study carefully Tobias' case A

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Joseph S. Fruton. Haward University Press: Cambridge, MA, 1992. x +330pp. 15.3x23.3 cm. $27.95. Looking back on six decades of research and teaching, Joseph S. Fruton presents stimulating thoughts about scien-how it is practiced, how it is explained, and how its history is written. He brings his own skeptical vision to bear on how chemistry and biology interact to describe living systems by offering "thoughts about effortsto describe, advance, defend, or belittle the scientific endeavor to explain the properties of biological organisms through the study of the constitution and interactions of their chemical components." Among the significant questions that Fmton raises are: How does the "scientific method" work in practice? What is the nature of the tension between the cbemical and biological sciences? What are the rwts and future direction of molecular biology? .What is the proper place of expert scientists, as opposed to professional historians of science, in the historiography of science?

F N ~ ~intriguing ' S book should help to define and clarify the nature of some of the differences in the recent discourse about the role of the biochemical sciences in the growth of our knowledge of the natural world and should be of great interest to scientists, philosophers, historians, and sociologists. Georae B. Kauffman California~tatebniversit~, Fresno Fresno, CA 93740

The Design of Drugs to Macromolecular Targets C. R. Beddell, Editor. Wiley: New York, NY, 1992. xiv Figs. and tables. 15.9 x 23.7 cm.

Sheila Tobias, Revitalizing Undergraduate Science: Why Some Things Work and Most Don't

George B. Kauffman Laurie M. Kaufrnan

Joseph S. Fruton, A Skeptical Biochemist

George B. Kauffman

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Monographs

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Titles of Interest

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A Skeptical Biochemist

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George B. Kauffman and Laurie M. Kauffman CaliforniaState University, Fresno Fresno. CA 93740

Reviewed in This Issue

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studies and to ponder her conclusions before making changes in undergraduate programs in their own institutions.

Journal of Chemical Education

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