The Fluctuogram of Protein Dynamics

Coupling strengths between protein residues (output of fluctuogram) capture the func on-‐gaining muta on sites iden fied in directed evolu on. ...
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The  Fluctuogram  of  Protein  Dynamics  

Protein  Structure  Network    

Fluctuogram  

Sequence  Alignment  

•  Fluctuogram  reveals  the  mechanism  of  allosteric  coupling.   •  Coupling  strengths  between  protein  residues  (output  of  fluctuogram)  capture  the   func@on-­‐gaining  muta@on  sites  iden@fied  in  directed  evolu@on.   •  Fluctuogram  also  captures  residues  with  high  correla@on  in  sequence  alignment.