202 0
JOURNAL O F CHEMICAL EDUCATION ORGANIC SYNTHESES: AN ANNUAL PUBLICATION OF SATISFACTORY METHODS FOR THE PREPARATION OF ORGANIC CHEMICALS. VOLUME 35 (1955)
pyrimidine fractions by absorption spectrophotometry," by H. S. Loring; "The separation of nucleic acid derivatives by chromatography on ion-exchange columns," by W. E. Cohn; "Separation of nucleic acid components by chromatography on filter T. L. Cairns, Editor-in-Chief. John Wiley & Sons, Inc., New paper?" hy G. R. Wyatt; "The electrophoretic separation of York, 1955. vi 122pp. 15.5 X 23.5cm. $3.75. nucle~cacid components," by J. D. Smith; "Color reactions of nucleic acid components," by Z. Dische; "Isolation and compoTars latest volume of the well known "Organic Syntheses" sition of the deoxypentose nucleic acids and of the corresponding series contains the contributions of 59 organic chemists and deals nucleoproteins" by Erwin Chartgraff; "Isolation and eomposiwith 36 important preparations. Volume 35, like the previous tion of the pentose nucleic acids and of the corresponding nuoleoones, contains the best available directions for preparing a wide proteins," by B. Msgasanik; "Evidence on the nature of the variety of useful organic compounds. All the reactions discussed chemical bond in nueleic acids," by D. M. Brown and A. R. have been earefullv checked and verified bv leadinx chemists Todd; "The physical properties of nucleic acids," by D. 0. Jordan; "Optical properties of nucleic acids and their components," by G. H. Beaven, E. R. Holiday, and E. A. Johnson; and "Nucleases and enzymes attacking.nucleic acid eom~onents." . hv. G. included. Schmidt. Preparations are listed under common names and Chemical Each of these chapters represents a painstakiigly prepared and Abstracts names for: I-acetylcyclohexanal, 2-amino-3-nitrotol- noteworthy contribution. In the opinion of the reviewer the uene, 3-benzyl3-methylpentanoic acid, pbromomandelic acid, chapters by Chargaff, by Jordan, and by Schmidt are particularly sec-bntyl-~IZ-carproylpropionate,n-butyl glyoxylate, Z-butyn- outstanding. The chapter by Schmidt provides the connecting -1-01, chloro-p-hensoquinone, N-chlorohetainyl chloride, a - ( 4 link between the two volumes. chlorophenyl)-rphenylacet~a~etonitrile, 1-(pchloropheny1)-3Volume I1 covers the main biological and metabolic aspects phenyl-%propanone, 2-chloropyrimidine, Accholesten-3,6dione, with the following chapter headingsandcontribntors: "The nuAkholesten-3-one, cholesterol, A%halesten-3-one, A4-cholesten- cleic acid content of tissues and cells," by I. Leslie; "Cytochemi3-one, diacetyld-tartaric anhydride, diethyl mercaptoacetal, cal techniques for nucleic acids," by H. Swift; "Thc isolation and diethylthiocarhamy1chloride,2(dimethylano)pynmidine, ethyl composition of cell nuclei and nucleoli," by A. L. Dounce; diethoxyacetate, ethyl isocyanide, ethyl N-phenylformimidate, "The deoxyrihonucleic acid content of the nucleus," by R. 2-furfury1 merceptan, gurtnylthiourea, hexamethylbenzene, o- Vendrely; "Nueleie acids in chromosomes and mitotic division," methoxyphenylrtcetone, 5-methyl-fu~furyl-dimethylamine, 4 by B. Thorell; "The cytoplasm," by G. H. Hogeboomand W. C. methyl-&hydroxypyrimidine, I-methyl-3-phenylindane,methyl-2 Sohneider; "Biosynthesis of pentoses," by G. E. Glook; "Biosynthienyl sulfide, 8-methyl-bvalerolactone, trans-o-nitrea-phenyl- thesis of purines and pyrimidines," by P. Reichard; "Biosynthesia einnamic acid, 2-phenylcycloheptanone, l-tetralone, thiobenzo- of nuoleosides and nucleotides," by F. Schlenk; "Biosynthesis of phenone, and ptoluenesylfenyl chloride. nncleic acids," by G. B. Brown and P. M. Roll; "The metabolism The cumulative subject index comprises all material contained of the nucleic acids," by R. M. S. Smellie; "The biological role of in volumes 30-35 inclusive, all previous preparations having been the deoxypentose nucleic acids," by R. D. Hotchkiss; and "The tabulated in collective volumes 1, 2, and 3. This latest volume is biological role of the pentose nucleio acids," by J. Brachet. identical in size, style, appearance, and quality with a11 previous As is the case for Volume I the chapters for Volume I1 me exreleases in the series. Practicing organic chemists have long cellently prepared. Those chapters concerning biosynthesis and since learned to await the arrival of each new suceeedine volume metabolism are of exceptional merit. Volume I1 should have a great appeal for many biologists not directly in the current of nucleic acid research but who wish to know of recent advances. The editors are to be congratulated. RALPH E. DUNBAR
+
N O ~ TDAHOT* H STATE C O L L E ~ E FAROO. NORTA DAKOTA
0
THE NUCLEIC ACIDS: CHEMISTRY AND BIOLOGY. VOLUMES I AND I1
Edited by Erwjn Chargaff, Deparbnent of Biochemistry, Calumbia University, and 3. N. Davidson, Department of Biochemistry, University of Glasgow. Academic Press, Inc., New York. 1955. Volume I: xi 692 pp. Many figs. and tables. 16 X 23 cm. 516.80. Volume 11: xi 576 pp. Figs. and tables. 16 X 23 cm. 514.50.
+
+
A CONSTANT ROWof literature continues to affirm the great investigational enthusiasm with which all aspects of nucleic acids researoh are heine annrosehed. The two volumes under review
chapters are linked together with abundant cross references. Tables, charts, and graphs are extensive and complete. These latter give the two volumes the distinction of being a ready reference book to which many will find it necessary to refer on many occasions. Volume I covers the main chemical aspects with the following chapter headings and contributors: "Chemistry of ribose and deoxyribose," by W. G. Overend and M. Stacey; "Chemistry of purines and pyrimidines," by A. Bendich; "Chemistry of nucleosides and nucleotides," by J . Baddiley; "Hydrolysis of nucleic acids and procedures for the direct estimation of purine and
0
THE QUANTITATIVE ANALYSIS OF DRUGS
D. C. Garratf, Chief Analyst, Boots Pure Drug Co., Ltd. Second edition. The Philosophical Library, New York, 19SS. xv 670 pp. S figs. 51 tables. 15 X 2 3 em. $11.50.
+
THE second edition of this valuable laboratory reference work is completely revisod and enlarged and conforms to the methods and procedures for the analysis of drugs described in the latest editions of the British Pharmeceuticd Codex. The United States Phmmacopeia, and The National ~ormular&. The drugs discussed are arranged alphabetically and complete det& are given concerning the analysis of the common pharmaceutied preparations suoh a8 801utions, capsules, tablets, etc., containing the drug. References to the most recent literature concerning the drug and its analysis are placed after the discussion of the drug. Numerous tables are also included and these aid in the interpretation of the analytical data presented. Special procedures for the determination of water in drugs, alkaloids, trace elements, organic chemicals from vicera and vomit, etc., make this work an invaluable aid to the pharmacist, chemist, and toxicologist. N. M. FERGUSON U~xvezsmrO F Hons~oirCOLLECE OP PHARMACT HODBTON. TEX*.
