A detailed study of the kinetics and mechanism of each of these reactions is now underway in this laboratory and will be reported later. Acknow1edgmen.t.---Thanks are expressed to The James G. Boswell Foundation (Stanford Research Institute) and to The Public Health Service (Grant GM 08347-02, Division of General Medical Sciences) for financial support.
capable of forming aggregates. We have independent evidence that points to secondary structure in guanosine oligc,nucleotidcs. (1) .\ iiiixturc of guaniiiecoiitaiiiin;: oligonucleotides of arwage chaiti length equal to (iwas unusually resistant to Takadiastase ribonuclease TI" and pork liver nuclease.4 A preliminary heating of the substrate resulted iii somewhat more rapid hydrolysis, but the rates still were very slow. (2) Removal of terminal phosphate by E . coli alkaline its structure [G. Oster, J. S . Bellin a n d B. Holmstrom, E x p e r i e n l i a , 18, 249 phosphatase5 was extremely slow and incomplete for (1902) 1. Polarographic studies in this laboratory indicate both FMS and lumichrome (LC) are formed upon re
