Vol. 68, 2003 James A. Marshall,* Arnaud Piettre, Mikell A. Paige, and Frederick Valeriote. Total Synthesis and Structure Confirmation of the Annonaceous Acetogenins 30(S)-Hydroxybullatacin, Uvarigrandin A, and 5(R)-Uvarigrandin A (Narumicin I?).
Page 1780. The concentration units for Table 1 were incorrectly listed as g/mL rather than µg/mL. The corrected table follows: TABLE 1. Cytotoxicity of Annonaceous Acetogenins toward H-116 Colon Cancer Cells compound (30S)-hydroxybullatacina uvarigrandin Aa (5R)-uvarigrandin Aa 5-fluorouracilb a
10-4
2× 2 × 10-4 2.5 × 10-4 1.5 × 10-1
1 µg/mL ≈ 1.5 µM. b 1 µg/mL ≈ 7 µM.
JO035268Y 10.1021/jo035268y Published on Web 09/18/2003
8290
IC50 (µg/mL)
J. Org. Chem. 2003, 68, 8290
IC90 (µg/mL) 2 × 10-1 1.5 × 10-2 3 × 10-1 1.5
