Journal of Medicinal Chemistry, 1979, Vol. 22, No. 8 931
Tripeptide Analogues of MIF
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Tripeptide Analogues of Melanocyte-stimulating Hormone Release-Inhibiting Hormone (Pro-Leu-Gly-NH2)as Inhibitors of Oxotremorine-Induced Tremor Sven Bjorkman,* Staffan Castensson, and Hans Sievertsson Department of Organic Pharmaceutical Chemistry, Biomedical Center, University of Uppsala, S-751 23 Uppsala, Sweden. Received February 20, 1979
Fourteen di- and tripeptide analogues of MIF, Pro-Leu-Gly-NH,,have been synthesized and assayed for inhibition of oxotremorine-inducedtremor. Replacement of Pro by HCO-Pro or cyclopentanecarboxylicacid gave inactive analogues, while some peptides of the general structure
