Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and

Dec 23, 2009 - Health, Harvard School of Public Health, Boston, MA, and. Vincent Memorial ... thyroid and reproductive hormone levels in 167 men recru...
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Environ. Sci. Technol. 2010, 44, 1458–1463

Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormone Levels in Men from an Infertility Clinic J O H N D . M E E K E R , * ,† ANTONIA M. CALAFAT,‡ AND R U S S H A U S E R §,| Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, Centers for Disease and Control and Prevention, Atlanta, GA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, and Vincent Memorial Obstetrics and Gynecology Service, Andrology Laboratory and In Vitro Fertilization Unit, Massachusetts General Hospital, Boston, MA

Received September 21, 2009. Revised manuscript received December 5, 2009. Accepted December 8, 2009.

Human exposure to bisphenol A (BPA) is widespread. Animal studies have demonstrated that BPA can alter endocrine function, but human studies are limited. For the present study, we measured urinary BPA concentrations and serum thyroid and reproductive hormone levels in 167 men recruited through an infertility clinic. BPA was detected in 89% of urine samples with a median (range) of 1.3 (