Drug Metabolism Concepts A C S Symposium Series No. 4 4 Donald M. Jerina, Editor The National Institutes of
Health
A symposium co-sponsored by the Division of Medicinal Chemistry and the Division of Analytical Chemistry of the American Chemical Society. Eight chapters present in-depth research reports o n t h e role of e n z y m e systems, especially c y t o c h r o m e P - 4 5 0 , in drug activation a n d detoxification. This timely study on drug metabolic p a t h w a y s is vital b e c a u s e of t h e possibilities of toxic or carcinogenic intermediates c a u s e d by the action of e n z y m e s o n drugs a n d anesthetics. CONTENTS Cytochrome P-450 in Oxygen Activation for Drug Metabolism · Synthetic Models for the Reaction Stages of Cytochrome P-450 · Isolation of Mutliple Forms of Liver Microsomal Cytochrome P-450 · Resolution of Multiple Forms of Rabbit Liver Cytochrome P-450 · Enantiomeric Selectivity and Perturbation of Product Ratios as Methods for Studying the Multiplicity of Microsomal Enzymes · Purified Cytochrome P-448 and Epoxide Hydrase in the Activation and Detoxification of Benzo[a]pyrene · In vitro Reactions of the Diastereomeric 9,10-Epoxides of ( + ) and (-)-frans-7,8-Dihydroxy7,8-dihydrobenzo[a)pyrene with Polyguanylic Acid · Metabolic Activation in Chemical-Induced Tissue Injury
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