Anal. Chem. 2001, 73, 3947-3953
Dynamic Secondary Ion Mass Spectrometry Analysis of Boron from Boron Neutron Capture Therapy Drugs in Co-Cultures: Single-Cell Imaging of Two Different Cell Types within the Same Ion Microscopy Field of Imaging Daniel R. Lorey, II,* George H. Morrison, and Subhash Chandra
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301
In areas of biology and medicine, there is often a need for an analytical technique with the capability of quantitatively measuring chemical gradients at a subcellular level. One area of ongoing medical research where a methodology for subcellular chemical analysis is required is that of boron neutron capture therapy (BNCT) for the brain cancer glioblastoma multiforme and for certain types of melanomas.1,2 BNCT is based on the fission reaction that occurs when a boron-10 atom captures a thermal (
