JANUARY 2009 Volume 20, Number 1 Copyright 2009 by the American Chemical Society
Editorial: The Twentieth Year of Bioconjugate Chemistry As we complete the second decade of the journal during this milestone year, we will occasionally look back to see how the subject has advanced. The science and technology of bioconjugate chemistry concern the joining of two or more molecular functions, using chemistry, biology, or combinations of the two, to make products with useful biological properties. While today the molecules involved may be almost anything, twenty years ago this was most highly developed with proteins. Appropriately, the first article in the first issue of Bioconjugate Chemistry was a review of protein chemistry by Means and Feeney (1), which begins, “With roots in ancient formulations, methods for the chemical derivatization of proteins continue to expand and develop. The creation of this new journal dealing exclusively with bioconjugate chemistry was barely conceivable just a few years ago. An explosion of interest in the subject during the last decade is, however, easily seen”. The authors go on to explain that those ancient formulations were based on empirical observations, without any real understanding of the underlying chemistry. One of the cardinal reasons for the American Chemical Society to found the journal was to help bring order to this sometimes-unruly subject. However, the empirical roots are still very much the basis for progress; without that “What will happen if I do this?” curiosity, bioconjugate chemistry would lose its essential spirit. Over the years, innovations such as intein-mediated labeling, native ligation, enzyme-catalyzed conjugation, and the ubiquitous click reaction have added surprising new dimensions to the preparation of proteins tagged with synthetic molecules. This suggests that even more unexpected developments lie ahead. As someone remarked at a recent meeting, the best of today’s bioconjugate chemistry is so remarkable, it is as if the dreams of a science fiction writer have become reality. Let us see what the new year brings.
Thanks to Our Reviewers It is a pleasure to acknowledge the contributions of the reviewers of manuscripts submitted in 2008 for publication in Bioconjugate Chemistry. Their unselfish service has been essential in the shaping of the nineteenth volume of the journal. The scientific community is fortunate that its members are willing to share their time and specialized knowledge in this way. The reviewers are listed on the following pages. Claude F. Meares Editor-in-Chief LITERATURE CITED (1) Means, G. E., and Feeney, R. E. (1990) Chemical modifications of proteins: history and applications. Bioconjugate Chem. 1, 2–12.
10.1021/bc800546x CCC: $40.75 2009 American Chemical Society Published on Web 01/21/2009
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Reviewers for 2008 Seetharama Acharya Samuel Achilefu Michael Adam Roger Adami Greg Adams Toshihiro Akaike Mitsuru Akashi Kazunari Akiyoshi Fernando Albericio Hugette Albrecht Cameron Alexander Christine Allen Stephen Alley Paulo Almeida Silvia del Valle Alonso Julio Alvarez Simon Ametamey Mansoor Amiji Carolyn Anderson Daniel Anderson David Andreu Kristi Anseth Yasushi Arano Bruce Armitage Luis Arnaut Shoichiro Asayama Ulysse Asseline You Han Bae Clive Bagshaw Sandor Bajusz Rumiana Bakalova James Baker Alexandru Balaban Rolf Barth Jacqueline Barton Amit Basu Annette Beck-Sickinger Christian Becker Craig Beeson Martin Behe Ettore Benedetti Dennis Benjamin David Benson Donald Bergstrom Michael Bienert Gary Bignami Jozsef Bodi Otto Boerman Alexei Bogdanov Elijah Bolotin Elizabeth Boon Geert-Jan Boons Darryl Bornhop A. Borsodi Ross Boyle Mark Bradley Martin Brechbiel Rui Brito
Steve Brocchini Roland Brock Lyudmila Bronstein Natalia Broude Tom Brown Donald Buchsbaum Jean-Claude Bunzli Jason Burdick Patrick Burke Cynthia Burrows Jean Cadet Paolo Caliceti Julio Camarero Jacek Capala Massimo Capobianco Peter Caravan Frank Carroll Hyung Cha Elliot Chaikof Ken Chang Kai Chen Xi Chen Xiaoyuan Chen Kun Cheng Dae Yoon Chi Sun Hang Cho Yearn Seong Choe Insung Choi Joon Sig Choi Bong Hyun Chung Seth Cohen Paul Cordopatis Patrick Couvreur James Cowan Gabriella Csik Wenjin Cui Alan Cuthbertson Ekaterina Dadachova Hongjie Dai Mark Davis Robert DeLong Gerald DeNardo Attila Demeter Mahendra Deonarain Michael Detty Gilles Divita Kalliopi Dodou Svetlana Doronina Steven Douglas Allen Ebens Eva Egelseer Joachim Engels Alan Epstein Ramon Eritja Dominique Erni Neil Fairweather Andreas Faust Jan Feijen
Min Feng Paolo Ferruti Gregg Fields David Filpula M. G. Finn Karen Forsberg-Nilson Keith Fox Ronald Frank Stefan Franzen Andreas Frey Peter Fugedi Nobutaka Fujii T. Fujii Kazuhisa Fujimoto Koichi Fukase Shiroh Futaki Marcel Garcia Franz Gabor Laurie Gahan Michael Gait Jinming Gao Xiaohu Gao Elisa Garcia-Garayoa Jean Gariepy Martin Garnett Corrada Geraci Carlos Geraldes Hanspeter Gerber Hamid Ghandehari Giovanna Ghirlanda Indraneel Ghosh Jeff Gildersleeve Todd Giorgio Christian Girard Maurice Goeldner Edie Goldsmith Jonathan Gordon Vicente Gotor Michael Gozin Ken Grabstein Duncan Graham Anna Grandas Scott Grayson Mark Green Ernest Groman Hermann Gruber Zhongwu Guo Rainer Haag Itaru Hamachi Philip Hamann Kevin Hamblett Justin Hanes Atsushi Harada Isabel Haro Eva Harth David Harvey Frederick Haselton Kenichi Hatanaka
Huixin He Kevin Healy Mary Hefford Karl-Erik Hellstrom Wim Hennink Piet Herdewijn Greg Hermanson Tomasz Heyduk Koji Higai Donald Hnatowich Robert Hoffman Miklos Hollosi Sarah Hook Daniel Horak Jari Hovinen John Howl Hideki Ichikawa Toshihiro Ihara Barbara Imperiali Marcos Intaglietta Joseph Irudayaraj Miya Ishihara Osamu Ito Yoshihiro Ito Bela Ivan Yasuhiko Iwasaki Hiroo Iwata Hieronim Jakubowski Scott Jeffrey Raz Jelinek J. Jimenez-Barbero Kai Johnsson Sangyong Jon Arwyn Jones Lee Josephson Jingyue Ju Rudolph Juliano Hans Junginger Ravi Kane Achillefs Kapanidis Kazunori Kataoka John Katzenellenbogen Hiroyoshi Kawakami Brian Kay David Kessel Michael Kilbourn Jong-Man Kim Sung Wan Kim William Alvin Kinney Yoshiaki Kiso Thomas Kissel Trevor Kitson Ronald Kluger Linda Knight Hisataka Kobayashi Laszlo Kohidai Robert Kok
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Makoto Komiyama Akihiko Kondo Kenji Kono Jindrich Kopecek Pavla Kopeckova Felix Kratz Murali Krishna James Kronauge Eugenia Kumacheva Hank Kung Jun Kunisawa Yutaka Kuroda Ester Kwon Young Kwon Vinod Labhasetwar Norbert Lange Robert Langer Kim Larsen Benedict Law Christopher Leamon Bernard Lebleu Doo Sung Lee Kang Choon Lee Robert Lee Raphael Levy Frederick Lewis Jason Lewis Michael Lewis Chun Li Jun Li Pei Li Shyh-Dar Li Xiangyang Liang Mi Hee Lim Michael Lindberg Karen E. Linder Jun-qiu Liu Shuang Liu Ye Liu Harri Lonnberg Zheng-Rong Lu Giovanni Lucignani Robert Mach Helmut Maecke Mizuo Maeda Bruno Maggio Edmond Magner Theodosia Maina Yoshie Maitani D. Majumdar Noah Malmstadt Marilena Manea Charles Manning Angel Maquieira Wojciech Markiewicz Jean Martinez Atsushi Maruyama Andreas Marx Stephen Mather Stefan Matile
Takehisa Matsuda Koji Matsuoka Mattias Hallbrink Heather Maynard Jason McCarthy Thomas Meade Igor Medintz Rajendra Mehta Oleg Melnyk Bernard Meunier Damon Meyer Gabor Mezo Yubin Miao Chad Mirkin Henning Mootz Amram Mor Catherine Murphy Niren Murthy Manfred Mutter Helmut Maecke K. Muller Yves Muhly Teruyuki Nagamune Takeshi Nagasaki Yukio Nagasaki Matthias Nahrendorf Hiroyuki Nakamura Masanori Nakamura Jun Nakanishi Ikuhiko Nakase Masamichi Nakayama Ravin Narain Ajit Narang Arutselvan Natarajan Hans Nauwynck Michal Neeman K. Neoh Dario Neri Edward Neuwelt Peter Nielsen Christof Niemeyer Takuro Niidome Makiya Nishikawa Yuji Nishiuchi Nobuhiro Nishiyama Berthold Nock Johannes Oehlke Yu-Kyoung Oh Yoshihiro Ohmiya Yuichi Ohya Nicole Okeley Naoto Oku Laszlo Otvos David Oupicky Takeaki Ozawa Daniel Pack Alan Packard Marty Pagel Emil Palecek Francesco Pampaloni
Ravindra Pandey Roberto Paolesse Anna Papini William Pardridge Jong-sang Park Ki-Dong Park Kinam Park Tae Gwan Park Gianfranco Pasut M. Patankar Laszlo Patthy John Patton James Paulson Thomas Perrier Cecile Perrio Thomas Peters Blake Peterson H. Pietzsch David Piwnica-Worms Michael Ploug Nicola Pohl Richard Pon Margus Pooga Vince Pozsgay Jozsef Prechl Glenn Prestwich Michael Przybylski Suzie Pun Roberto Purrello David Putnam Jozsef Rabai Michael Raghunath Tariq Rana Satya Reddy Prakash Reddy Manfred Reetz Vytas Reipa Rebecca Richards-Kortum Matthew Robinson Steve Roffler Buck Rogers Vincent Rotello Hirohide Saito Hideo Saji Maria Sakarellos-Daitsiotis Kazuo Sakurai Aliasger Salem Michele Samaja John Sanderson Kim Sapsford Toshinori Sato Nagichettiar Satyamurthy David Schaffer David Scheinberg Eyk Schellenberger Roger Schibli August Schubiger Benjamin Schuler David Schwartz Paolo Scrimin
Frank Seela Paul Selvin Takeshi Serizawa Norbert Sewald Robert Sharkey Min-da Shau Wei-Chiang Shen Dean Sherry Linda Shimizu John Shively Giovanni Sindona Dorothy Sipkins Masahiko Sisido Uwe Sleytr Stephen Sligar Krzysztof Slowinski Bradley Smith Charles Smith David Smith David Smithrud Claudia Sperling Caroline Springer Robert Stahelin Patrick Stayton Michael Strano Yasuo Suda H. Suli-Vargha Brent Sumerlin Guoming Sun Shouheng Sun Hsing-Wen Sung Avadhesha Surolia May Sutherland Sonke Svenson Mark Swihart Rita Szabo Francis Szoka Maryam Tabrizian Shigeori Takenaka Kazuhito Tanabe Akito Tanaka Fujie Tanaka Bertrand Tavitian Sankaran Thayumanavan Jim Thomas David Thompson Louis Tiefenauer Richard Tilley Jose Toca-Herrera Brian Toki Thomas Tolbert Don Tomalia Kenneth Tomer Vladimir Torchilin Eva Toth Gabor Toth Geza Toth Dirk Tourwe Alexander Trubetskoy Yiider Tseng
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Vassilios Tsikaris Andrew Tsourkas Eishun Tsuchida Ching-Hsuan Tung John Turchi Karel Ulbrich Hiroshi Uyama Eric Vives Ganesan Vaidyanathan Henry VanBrocklin Katalin Varnagy A. Varvarigou Graca Vicente Pierre Vierling Carlos Villa Frederick Villamena
Borbala Vincze Takehiko Wada John Wade Ernst Wagner Dong-An Wang J. Wang Lai-Xi Wang Qian Wang Xiang Wang Xueding Wang Cezary Watala Yoshihito Watanabe Ross Weatherman Ralf Weberskirch Alexander Wei Michael Welch
Paul Wentworth Lars Wesemann Andrew Whittaker Eric Wickstrom Chris Wiethoff Scott Wilbur Meir Wilchek Christopher Wilds Nicholas Williams Natalie Winblade Francoise Winnik Karen Wooley Dieter Worhrle Bing Xu Han-Mei Xu Kenji Yamamoto
Hidenori Yamada Tetsuji Yamaoka Motoo Yamasaki Kevin Yarema Herman Yee Venkata Yenugonda Yoon Yeo Makoto Yoshimoto Shigehiro Yoshimura Samuel Zalipsky Li-He Zhang Mingzhen Zhang Subiao Zhang Bingsuo Zou Andrew Zydney BC800546X
