Effects of pH on anionic inhibition of carbonic anhydrase activities

Effects of pH on anionic inhibition of carbonic anhydrase activities. Y. Pocker ... Influence of Active Site Location on Catalytic Activity in de Novo...
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2424

J . Am. Chem. SOC.1982, 104, 2424-2434

Effects of pH on the Anionic Inhibition of Carbonic Anhydrase Activities Y. Pocker* and Thomas L. Deits Contribution from the Department of Chemistry, University of Washington, Seattle, Washington 981 95. Received August 14, I981

Abstract: We present the first investigation of the inhibition of bovine carbonic anhydrase (BCA) by simple monoanions as a function of both substrate employed and variation in pH. At low pH (pH