Biochemistry (ISSN 0006-2960) is published weekly except for the first week in January by the American Chemical Society at 1155 16th St., NW, Washington, DC 20036. Periodicals postage paid at Washington, DC and additional mailing offices. POSTMASTER: Send address changes to Biochemistry, Subscription Services, P.O. Box 3337, Columbus, OH 43210.
American Chemical Society 1155 16th St., NW, Washington, DC 20036 (202) 872-4600; TDD (202) 872-6076; Fax (202) 776-8264
Publications Division Brian D. Crawford, President
Customer Service & Information http://pubshelp.acs.org. Tel (202) 872-4376 E-mail
[email protected] Journals Publishing Group Susan King, Senior Vice President Anirban Mahapatra, Assistant Director, Editorial Development
Journal Production & Manufacturing Operations American Chemical Society 2540 Olentangy River Rd. P.O. Box 3330, Columbus, OH 43210 (614) 447-3665; Fax (614) 447-3745 E-mail
[email protected] Journal Production & Manufacturing Operations Robert S. O’Dell, Vice President, Manufacturing Operations Diane E. Needham, Manager, Journals Editing Sean M. Lammers, Senior Associate Editor
ACS Publications Advertising Office 1155 16th St., NW, Washington, DC 20036 (610) 964-8061; E-mail
[email protected] Subscription Services P.O. Box 3337, Columbus, OH 43210 Members contact: Member Services (614) 447-3776; (800) 333-9511; Fax (614) 447-3671 E-mail
[email protected] Agencies & Institutions contact: Sales Analysis & Support (614) 447-3674; (888) 338-0012; Fax (614) 447-5475 E-mail
[email protected] Sales & Marketing Brandon A. Nordin, Vice President, Sales, Marketing & Web Strategy Sean D. Abell, Director of Marketing Jonathan Morgan, Director, Digital Strategy & Platform Development Tara Pritchett, Assistant Director, Marketing Editorial Office Operations Sarah B. Tegen, Director, Editorial Office Operations Charley Trowbridge, Assistant Director, Peer Review Operations Samantha Luck, Peer Review Analyst
Copyright Permission: See the ACS Journal Publishing Agreement for certain rights (http://pubs.acs.org/page/copyright/journals/index.html). Reprographic copying beyond that permitted by Section 107 or 108 of the U.S. Copyright Act is allowed, provided that the current per article fee is paid to the Copyright Clearance Center. Tel: +1 978-750-8400. Republication or reproduction of material for which ACS owns copyright in this journal is permitted only through Rightslink at http://pubs.acs.org/page/4authors/copyright/index.html.
Instructions for Authors and the ACS Journal Publishing Agreement: Visit the ACS Web site (http://paragonplus.acs.org/login). Please conform to these instructions when submitting manuscripts. Manuscript Submission: Submit via the Journal Web site (http://pubs.acs.org/journal/bichaw). Accepted Papers and Proofs: Direct correspondence to Journal Production & Manufacturing Operations (see above).
Digital Object Identifier (DOI): The DOI identification system for digital media has been designed to provide persistent and reliable identification of digital objects. Information on the DOI and its governing body, the International DOI Foundation, can be found at http://www.doi.org. The DOI is prominently displayed on each published paper. Claims for Issues Not Received: Claims will be honored only if submitted within 90 days of the issue date for subscribers in North America or within 180 days of the issue date for all other subscribers. Contact Sales Analysis & Support. Tel (614) 447-3674 or (888) 338-0012; Fax (614) 447-5475; E-mail
[email protected].
Journal Policies: The American Chemical Society and its Editors assume no responsibility for the statements and opinions advanced by contributors. Registered names and trademarks, etc., Back Issue Orders: used in this publication, even without specific indication thereof, are not to be considered Single issues from January 2010 forward are available for a fee from the Office of unprotected by law. Society Services. Tel (800) 227-5558 (US); (202) 872-4600 (worldwide); Fax (202) 872Change of E-mail or Mailing Address: 6067; E-mail
[email protected]. For members only, notify Subscription Services (see above). Include both old and new Bulk Reprint Orders: addresses. For information on ordering reprints, see the specific article on http://pubs.acs.org or New and Renewal Subscriptions: instructions at http://pubs.acs.org/page/copyright/permissions.html or contact Cierant Members send payment to American Chemical Society, P.O. Box 182426, Columbus, Corporation at (866)-305-0111 9am to 5pm EST. OH 43218-2426. Institutions send payment to American Chemical Society, P.O. Box Supporting Information (SI): 182977, Columbus, OH 43218-2977. SI from 1995 to present is available free of charge from the journal’s home page 2013 Subscription and Ordering Information: (http://pubs.acs.org/journal/bichaw). For information on electronic access, send e-mail ACS members may purchase a Web subscription for $90. Contact Member Services (see to
[email protected]. SI prior to 1995 is available for a fee, from Office of above). Institutional subscribers may contact Sales Analysis & Support (see above) for Society Services. Tel (800) 227-5558 (US); (202) 872-4600 (worldwide); Fax (202) 872-6067; E-mail
[email protected]. Web and print subscription information.
Canadian GST Reg. No. 127571347 © Copyright 2013 American Chemical Society
EDITOR-IN-CHIEF: RICHARD N. ARMSTRONG
Vanderbilt University School of Medicine, Department of Biochemistry 832 RRB, Nashville, Tennessee 37232-0146 (615) 343-3915; Fax (202) 354-5420 E-mail
[email protected] ASSOCIATE EDITORS Karen Allen Boston University
John A. Gerlt University of Illinois, Urbana-Champaign
Mark S. P. Sansom University of Oxford
Jeffrey L. Benovic Thomas Jefferson University
Catherine A. Royer Université Montpellier
Ming-Daw Tsai Academia Sinica
Gary W. Brudvig Yale University
Charles R. Sanders Vanderbilt University School of Medicine
Leslie Wilson University of California, Santa Barbara
EDITORIAL ADVISORY BOARD Pia Ädelroth Stockholm University
David R. Davies National Institutes of Health
Masao Ikeda-Saito Tohoku University
Natalie G. Ahn University of Colorado, Boulder
Victoria DeRose University of Oregon
Barbara Imperiali Massachusetts Institute of Technology
Johan Aqvist Uppsala University
Jack E. Dixon Howard Hughes Medical Institute
Fraser A. Armstrong University of Oxford
Debra Dunaway-Mariano University of New Mexico
David S. Auld Harvard Medical School
Irwin Fridovich Duke University Medical Center
Barbara A. Baird Cornell University James R. Bamburg Colorado State University Dorothy Beckett University of Maryland Stephen J. Benkovic The Pennsylvania State University Robert E. Blankenship Washington University in St. Louis David F. Bocian University of California, Riverside J. Martin Bollinger The Pennsylvania State University James U. Bowie University of California, Los Angeles David L. Brautigan University of Virginia School of Medicine Laura Busenlehner The University of Alabama Richard A. Cerione Cornell University Benjamin F. Cravatt The Scripps Research Institute Valerie D. Daggett University of Washington
Martin Gellert National Institutes of Health Marc M. Greenberg Johns Hopkins University Angela M. Gronenborn University of Pittsburgh Paul J. Hagerman University of California, Davis Kathleen B. Hall Washington University School of Medicine Jeffrey J. Hayes University of Rochester Medical Center George P. Hess Cornell University Stefan Highsmith University of the Pacific Donald Hilvert ETH Zurich Richard H. Himes University of Kansas Dick Hoekstra University Medical Center Groningen Hazel M. Holden University of Wisconsin, Madison Tony E. Hugli Torrey Pines Institute for Molecular Studies
Matthew P. Jacobson California Institute for Quantitative Biosciences Robert L. Jernigan Iowa State University Lewis E. Kay University of Toronto Jeffery W. Kelly The Scripps Research Institute Clara Kielkopf University of Rochester
Narla Mohandas Lindsley F. Kimball Research Institute Adrian Mulholland University of Bristol Robert K. Nakamoto University of Virginia Gary L. Nelsestuen University of Minnesota Marcia E. Newcomer Louisiana State University Daniel D. Oprian Brandeis University Paul R. Ortiz de Montellano University of California, San Francisco
Claude B. Klee National Cancer Institute
Neil Osheroff Vanderbilt University School of Medicine
Judith P. Klinman University of California, Berkeley
Krzysztof Palczewski Case Western Reserve University
Elizabeth Komives University of California, San Diego
Arthur Pardi University of Colorado, Boulder
John W. Kozarich ActivX Biosciences, Inc.
Daniel Raleigh Stony Brook University
John D. Lipscomb University of Minnesota
Frank M. Raushel Texas A&M University
Hung-Wen (Ben) Liu University of Texas at Austin
Ivan Rayment University of Wisconsin, Madison
Erwin London Stony Brook University Michael A. Marletta The Scripps Research Institute Richard E. McCarty Johns Hopkins University Thomas J. McIntosh Duke University Medical Center Christopher Miller Brandeis University
Joachim Seelig University of Basel Shu-ou Shan California Institute of Technology Yunyu Shi University of Science & Technology of China Edward I. Solomon Stanford University Reinhard Sterner University of Regensburg Witold K. Surewicz Case Western Reserve University Dan Tawfik Weizmann Institute of Science Robert Tycko National Institutes of Health Jayant B. Udgaonkar National Centre for Biological Sciences John H. Viles University of London Gerhard Wagner Harvard Medical School Bonnie A. Wallace University of London Mårten Wikström University of Helsinki
John P. Richard University at Buffalo
W. David Wilson Georgia State University
J. Evan Sadler Washington University School of Medicine
Stephen Withers University of British Columbia
Nicole Sampson Stony Brook University
Peter E. Wright The Scripps Research Institute
Harold A. Scheraga Cornell University Franz X. Schmid Universität Bayreuth
Cheng-Wen Wu National YangMing University
