Chem. Res. Toxicol., Vol. 7, No. 4, 1994 583
Additions and Corrections
Additions and Corrections N-Nitroso-N-methylvinylamine: Reaction of the Epoxide with Guanyl and Adenyl Moieties To Yield Adducts Derived from Both Parts of the Molecule [Volume 6, Number 2, MarchIApril 1993, pp 168-1731 O s m O w ,MAGNUS PERSMARK, AND F. PETER GUENGERICH*
Page 169. In paragraph 1, lines 8 and 9, “1H NMR (‘HCCl3) 6 3.17 (a, 1H, CH3), 4.75 (dd, 1H, CHyCH), 4.85 (apparent dd, 2 H, CH2=CH)” should be changed to the following: “1H NMR (2HCCl3) 6 3.17 (s,3 H, CH3), 4.83 (dd, 1 H, HCH,,=CH, ‘J 1Hz, 3Jcb= 9.3 Hz), 5.08 (dd, 1 H, HCHtra,=CH, ‘J 1 Hz, 3Jtrons = 16 Hz), 7.89 (9,1 H, CHFCH, 3Jc, = 9.4 Hz, 3Jtrans = 9.4 Hz)”. We thank ProfessorR. Loeppky (Universityof Missouri,Columbia,MO) for calling our attention to the original assignment and suggesting reevaluation.
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Endogenous DNA Adducts: Potential and Paradox [Volume 6, Number 6, NovembedDecember 1993, pp 771J. hhRNETT* AND PHILIP c. BURCHAM 7851 LAWRENCE Page 779. Table I is missing footnotes g through 1. They are as follows: g F.-L. Chung, personal communication. h J. Swenberg, personal communication. Polycyclic aromatic hydrocarbon-DNA adducts. j From ref 235. 8-(4-Aminobiphenylyl)-2’-deoxyguanosine. 1 Calculated from estimates (26).
Announcements Designing Safer Chemicals The United States Environmental Protection Agency (EPA) and the Division of Environmental Chemistry of the American Chemical Society (ACS) are hosting a one-day symposium entitled “Designing Safer Chemicals” on Thursday, August 25,1994, in Washington, DC. The symposium will be part of the ACS National Meeting to be held in Washington, DC, August 21-25, 1994. The purpose of this symposium is: (1)to stimulate chemical companies to think about the toxicity of chemicals before they are made, and to minimize toxicity whenever possible through rational chemical design; (2) to stimulate academicians to consider research in safe chemical design; and (3) to stimulate funding institutions to consider funding academic research in safe chemical design. Topics that will be covered include: toxic mechanisms; controlling bioactivation; retrometabolic concepts; isoteric replacement; controlling bioavailability; examples of functional groups or chemicals that the EPA is particularly concerned with; and specific examples of how safer chemicals have been designed by commercial manufacturers.
For further information, please contact either: Dr. Stephen C. DeVito (mail code 7406; phone: 202-260-1748; fax: 202-260-0981) or Dr. Roger L. Garrett (mail code 7403; phone: 202-260-4302), U.S.EPA, 401 M Street, S.W., Washington, DC 20460.
0893-228~/94/2707-0583$04.50/0 0 1994 American Chemical Society
