Engineering Tumor-Targeted Gadolinium Hexanedione Nanoparticles

Uptake studies in tumor-cultured cells were investigated. ..... Within 30 min of incubation, up to 290 μg GdH per 105 cells was internalized as indic...
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Bioconjugate Chem. 2002, 13, 1328−1335

Engineering Tumor-Targeted Gadolinium Hexanedione Nanoparticles for Potential Application in Neutron Capture Therapy Moses O. Oyewumi and Russell J. Mumper* Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0082. Received June 20, 2002; Revised Manuscript Received September 17, 2002

Microemulsions (oil-in-water) have been employed as templates to engineer nanoparticles containing high concentrations of gadolinium for potential application in neutron capture therapy of tumors. Gadolinium hexanedione (GdH), synthesized by complexation of Gd3+ with 2,4-hexanedione, was used as the nanoparticle matrix alone or in combination with either emulsifying wax or PEG-400 monostearate. Solid nanoparticles (