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Environmental Epidemiology
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
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ADVANCES
IN C H E M I S T R Y S E R I E S
241
Environmental Epidemiology Effects of Environmental Chemicals on Human Health
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William M . Draper, EDITOR California
Department of Health
Services
Developed from a symposium sponsored by the Division of Environmental Chemistry, Inc. at the 203rd National Meeting of the American Chemical Society, San Francisco, California, A p r i l 5-10, 1992
American Chemical Society, Washington, DC 1994
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
RA 565 .E59 1994 Copy 1
Environmental epidemiology
Library of Congress Cataloging-in-Publicatiori Data
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Environmental epidemiology: effects of environmental chemicals on human health / William M . Draper, editor. p. cm.—(Advances in chemistry series, ISSN 0065-2393; 241). "Developed from a symposium sponsored by the Division of Environmental Chemistry, Inc., at the 203rd National Meeting of the American Chemical Society, San Francisco, California, April 5-10, 1992." Includes bibliographical references and index. ISBN 0-8412-2517-6 (clothbound) ISBN 0-8412-2933-3 (paperback) 1. Environmental health—Congresses. 2. Pollution—Toxicology—Congresses. 3. Environmentally induced diseases—Epidemiology—Congresses. I. Draper, William M . , 1952II. American Chemical Society. Division of E n vironmental Chemistry, Inc. III. American Chemical Society. Meeting (203rd: 1992: San Francisco, Calif.). IV. Series QDi.A355 no. 241 [RA565] 540 s—dc20 [615.9(fm02]
94-28456 CIP
The paper used in this publication meets the minimum requirements of American National Standard for Information Sciences—Permanence of Paper for Printed Library Materials, ANSI Z39.48-1984.
Copyright © 1994 American Chemical Society All Rights Reserved. The appearance of the code at the bottom of the first page of each chapter in this volume indicates the copyright owners consent that reprographic copies of the chapter may be made for personal or internal use or for the personal or internal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, Inc., 27 Congress Street, Salem, M A 01970, for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. This consent does not extend to copying or transmission by any means— graphic or electronic—for any other purpose, such as for general distribution, for advertising or promotional purposes, for creating a new collective work, for resale, or for information storage and retrieval systems. The copying fee for each chapter is indicated in the code at the bottom of the first page of the chapter. The citation of trade names and/or names of manufacturers in this publication is not to be construed as an endorsement or as approval by ACS of the commercial products or services referenced herein; nor should the mere reference herein to any drawing, specification, chemical process, or other data be regarded as a license or as a conveyance of any right or permission to the holder, reader, or any other person or corporation, to manufacture, reproduce, use, or sell any patented invention or copyrighted work that may in any way be related thereto. Registered names, trademarks, etc., used in this publication, even without specific indication thereof, are not to be considered unprotected by law. PRINTED IN T H E U N I T E D STATES O F A M E R I C A
Itoierfcan Chemical Sockty Library 115516th s t , K.w. Draper; Environmental Washington, DX\ Epidemiology 20036 Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
1994 Advisory Board Advances in Chemistry Series
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M . Joan Comstock, Series Editor Robert J. Alaimo
Douglas R. Lloyd
Procter & Gamble
The University of Texas at Austin
Pharmaceuticals
Mark Arnold University of Iowa
David Baker University of Tennessee
Arindam Bose Pfizer Central Research
Robert F. Brady, Jr. Naval Research Laboratory
Margaret A. Cavanaugh National Science Foundation
Arthur B. Ellis University of Wisconsin at Madison
Dennis W. Hess
Cynthia A. Maryanoff R. W. Johnson Pharmaceutical Research Institute
Julius J. Menn Western Cotton Research Laboratory, U . S . Department of Agriculture
Roger A. Minear University of Illinois at Urbana-Champaign
Vincent Pecoraro University of Michigan
Marshall Phillips Delmont Laboratories
George W. Roberts North Carolina State University
Lehigh University
Hiroshi Ito
A. Truman Schwartz Macalaster College
I B M Almaden Research Center
Madeleine M . Joullie
John R. Shapley
University of Pennsylvania
University of Illinois at Urbana-Champaign
Lawrence P. Klemann
L . Somasundaram
Nabisco Foods Group
DuPont
Gretchen S. Kohl
Michael D . Taylor
Dow-Corning Corporation Parke-Davis Pharmaceutical Research
Bonnie Lawlor Institute for Scientific Information
Peter Willett University of Sheffield (England)
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
FOREWORD T h e A D V A N C E S I N C H E M I S T R Y SERIES was f o u n d e d i n 1949 b y the A m e r i c a n C h e m i c a l Society as an outlet for symposia a n d collections o f data i n special areas o f topical interest that c o u l d not be a c c o m m o d a t e d i n the Society's journals. It provides a m e d i u m for symposia that w o u l d otherwise be fragm e n t e d because t h e i r papers w o u l d be d i s t r i b u t e d a m o n g several j o u r n a l s or not p u b l i s h e d at a l l . Papers are r e v i e w e d c r i t i c a l l y a c c o r d i n g to A C S e d i t o r i a l standards a n d receive the careful attention a n d processing characteristic of A C S p u b l i c a -
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tions. V o l u m e s i n the A D V A N C E S I N C H E M I S T R Y SERIES m a i n t a i n the i n t e g rity of the symposia o n w h i c h t h e y are based; however, v e r b a t i m r e p r o d u c tions of p r e v i o u s l y p u b l i s h e d papers are not accepted. Papers may i n c l u d e reports of research as w e l l as r e v i e w s , because symposia may e m b r a c e b o t h types of presentation.
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.
ABOUT T H E EDITOR WILLIAM M. DRAPER is a research chemist with the State of California Department of Health Services (CDHS). (B.S.,
He
1974)
received
degrees
in
and agricultural and
biochemistry environmental
chemistry ( P h . D . , 1979) at the University of California at Davis. Later he spent two years as a postdoctoral researcher at the Pesticide Chemistry and Toxicology Laboratory at the Berkeley campus.
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During the past 15 years his research interests in environmental chemistry included chemical fate and transport in aquatic systems, emissions testing in i n ternal combustion
engines
used in underground
mining, and human biomonitoring. H e is particularly interested in trace organic chemical analysis by mass spectrometry
and other instrumental tech-
niques and in the measurement of reaction rate constants that determine chemical fate in the environment. Dr. Draper has served on the faculties of Utah State University and the University of Minnesota School of Public Health. While at Utah State University he was chief chemist at the Epidemiologic Studies Program laboratory, with support from the U . S . Environmental Protection Agency Office of Pesticide Programs. In his current position his co-workers include epidemiologists, toxicologists, and physicians from California's Department of Health Services and Environmental Protection Agency.
Draper; Environmental Epidemiology Advances in Chemistry; American Chemical Society: Washington, DC, 1994.