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Cite This: ACS Appl. Bio Mater. XXXX, XXX, XXX−XXX
Enzyme-Responsive Theranostic FRET Probe Based on L‑Aspartic Amphiphilic Polyester Nanoassemblies for Intracellular Bioimaging in Cancer Cells Sonashree Saxena, Anu Pradeep, and Manickam Jayakannan* Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune, Maharashtra 411008, India Downloaded via NOTTINGHAM TRENT UNIV on July 27, 2019 at 01:54:40 (UTC). See https://pubs.acs.org/sharingguidelines for options on how to legitimately share published articles.
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ABSTRACT: The present study reports one of the first attempts on the design and development of an enzymaticbiodegradable theranostic fluorescence resonance energy transfer (FRET) probe constructed on L-amino acid polymer nanoassemblies and demonstrates the proof-of-concept in live cell bioimaging. L-Aspartic acid was converted into amide or carbamate pendants containing bis-carboxylic acid ester monomers, and they were subjected to melt polymerization along with commercial diols to produce amphiphilic aliphatic polyesters. Nanoparticles of size
