Article pubs.acs.org/journal/abseba
Fabrication and Properties of Ca‑P Bioceramic Spherical Granules with Interconnected Porous Structure Xiangfeng Li, Menglu Wang, Yanglong Deng, Xuening Chen,* Yumei Xiao,* and Xingdong Zhang National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China ABSTRACT: Spherical calcium phosphate (Ca-P) granules show advantages in filling bone cavity defects. In this study, gelatinizing technology combined with microspheresintering and gas-foaming methods was applied to fabricate porous spherical Ca-P bioceramic granules. The obtained three kinds of Ca-P granules (i.e., hydroxyapatite, HAG; biphasic calcium phosphate, BCP-G; and tricalcium phosphate, TCP-G) exhibited uniformly spherical shapes and interconnected pore structures with controlled macropores (about 600 μm), and abundant minor- (10−100 μm) to microsized (
