Facile intramolecular coupling of alkyl and acyl ligands induced by

Jul 1, 1988 - Facile intramolecular coupling of alkyl and acyl ligands induced by Lewis acids: Mechanistic studies on the formation of zirconium keton...
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Organometallics 1988, 7, 1631-1635 through a quartz photolysis well. After 43 h, lgF NMR spectroscopy indicated no further conversion to 19. The solvent was removed under reduced pressure, and the residue was chromatographed on silica gel (60 X 2 cm) at -40 OC. Elution with hexane/CHzClz (80:30) (total amount of solvent = 150 mL) produced a yellow band containing 7b (0.030 g, 46%). Elution with CH2Cl2(total amount of solvent = 50 mL) eluted a second yellow band containing 19 (0.030 g, 35%) which was characterized as described above. Reaction of [Rh(q5-CgH,)(1,2,5,6-q-C8F8)] (3) with tertButyl Isocyanide. To a solution of 5 (0.010 g, 0.02 mmol) in CDC1, (0.5 mL) in a 5-mm NMR tube was added tert-butyl isocyanide (0.18 pL, 0.02 mmol). The mixture was photolyzed, and the reaction was monitored by '?F NMR spectroscopy. After 5.5 h, resonances corresponding to 23 were observed [6 107.7,113.1, 174.5, 182.6 (an analysis of the coupling constants for an isostructural complex 19 appears above, and inspection reveals a similar coupling pattern for 23)]. After 60 h of photolysis, the '9F NMR spectrum of the solution indicated complete conversion

1631

to the ring-closed product 24. 19FNMR (THF): 6 140.4 (m, F,, F6),164.3 (m, FJ, 195.9 (m, Fl), 202.7 (m, Fz). Reaction of Rh(q5-CgH,)(1,2,5,6-q-C8H8) (25) with tertButyl Isocyanide. To a stirred solution of 25 (0.020 g, 0.06mmol) in hexane (10 mL) was added tert-butyl isocyanide (0.007 mL, 0.06 mmol). The solution was allowed to stir for 24 h, and the solvent was removed under reduced pressure. The residue was crystallized from hexane at -20 "C to afford Rh(q5-C9H7)(t-BuNC), as an orange solid (0.009 g) identified by comparison of its spectroscopic properties with the reported literature ~a1ues.l~ A c k n o w l e d g m e n t . We are grateful t o the Air Force Office of Scientific Research (Grant AFOSR-86-0075), the donors of the Petroleum Research Fund, administered by the American Chemical Society, and the National Science Foundation for generous support of this work. T h e loan of rhodiuni trichloride by Johnson Matthey Inc. is also gratefully acknowledged.

Facile Intramolecular Coupling of Alkyl and Acyl Ligands Induced by Lewis Acids: Mechanistic Studies on the Formation of Zirconium Ketone Complexes Robert M. Waymouth and Robert H. Grubbs' Arnold and Mabel Beckman Laboratory of Chemical Synthesis, California Institute of Technology, Pasadena, California 9 1125 Received February 2, 1988

Bis(cyclopentadieny1)zirconium acyl complexes Cp2Zr(X)COR (X = C1, Me) react rapidly with alkylaluminum reagents R'2A1Y (Y= R', C1) to give alkylaluminum adducts of zirconium ketone complexes CpzZr(p-q2-OCRR')(F-C~)A~R',.Zirconium aldehyde complexes Cp2Zr(p-q2-0C(H)R)(p-C1)ALRz are prepared analogously by treating the acyl complexes with diisobutylaluminum hydride. Mechanistic investigations, including isotopic labeling and crossover experiments, indicate that aluminum reagents induce the intramolecular coupling of zirconium alkyl and acyl ligands to give ketone complexes.

Introduction T h e effect of Lewis acid cocatalysts a n d Lewis acidic oxide supports on the activity of transition-metal catalysts is of considerable theoretical a n d practical interest.'V2 Main-group Lewis acids are important cocatalysts for industrial processes such as Ziegler-Natta polymerization3 and olefin m e t a t h e ~ i s . ~ Lewis acidic oxides, such as silica a n d alumina, are used as supports for heterogeneous polymerization, metathesis, a n d CO reduction catalyst^.^ However, the role of Lewis acidic sites in catalytic reactions remains poorly underst0od.l Interactions between transition-metal complexes a n d Lewis acidic reagents6 can reveal important information regarding the effects of Lewis acidic sites on the reactivity of transition-metal centers a n d coordinated ligands. Shriver6 a n d others' have demonstrated t h a t Lewis acids can have a dramatic effect on t h e rate of CO migratory insertion reactions. These studies provide a model for the interactions between transition-metal catalysts and Lewis acidic supports a n d the cooperativity that may be a n important feature of t h e catalyst-support interface.8 Transition-metal acyl complexes occupy a central role in catalytic reactions involving carbon monoxide. Few Contribution no. 7727.

0276-7333/88/2307-1631$01.50/0

Table I. Preparation of Zirconium Ketone Complexes acvl R reagent aroduct R' vield (70) la Me A1Me3 2a Me 71 lb Et A1Me3 2b Me 85 IC CH2CH2CMe3 AlMe3 2c Me 68 IC CH,CH2CMe3 AlEt, 2d Et 65 Id C-C~H~, AlMe, 2e Me 91 studies have investigated the effect of coordinated Lewis acids on t h e reactivity of these intermediates, although (1) (a) Baker, R. J.; Tauster, S. J. Strong Metal Support Interactions;

ACS Symposium Series 298; American Chemical Society: Washington,

DC, 1986. (b) Imelik, B., Naccache, D., Condurier, G., Praliand, H., Meriandeau, P., Martin, G. A., Vedrine, J. C., Eds. Metal Support and Metal Additive Effects in Catalysis; Elsevier: New York, 1982. (2) Shriver, D. F. Catalytic Actiuation of Carbon Monoxides; Ford, P . C., Ed.; ACS Symposium Series 152; American Chemical Society: Washington, DC, 1981. (3) (a) Pino, P.; Mulhaupt, R. Angew. Chem., Int. Ed. Engl. 1980,19, 857-875. (b) Sinn, H.; Kaminsky, W. Adu. Organomet. chem. 1980, 18, 99-149. (c) Boor, J. Ziegler-Natta Catalysis and Polymerizations; Academic: London, 1983. (4) (a) Grubbs, R. H. Comprehensiue Organometallic Chemistry; Wilkinson, G., Stone, F. G. A., Abel, E. W., Eds.; Pergamon: Oxford, 1982; Vol. 9. (b) Ivin, K. J. Olefin Metathesis; Academic: London, 1983. (5) (a) Iwasawa, Y. Tailored Metal Catalysts; D. Reidel: Boston, 1986. (b) Yermakov, Y. I.; Kuznetzov, B. N., Zakharov, V. A., Eds. Catalysis by Supported Metal Complexes; Elsevier: Amsterdam, 1981.

0 1988 American Chemical Society

1632 Organometallics, Vol. 7, No. 7, 1988 reactions of later transition-metal acyl complexes with electrophiles is a common route to Fischer-type ~ a r b e n e s . ~ In this paper, we report details'O of a series of novel reactions between zirconium acyl complexes and alkylaluminum reagents. These reactions provide an efficient route to alkylaluminum adducts of zirconium ketone complexes. Mechanistic studies have revealed that aluminum reagents induce the intramolecular coupling of a zirconium acyl ligand and a cis alkyl ligand to give ketone complexes.

Results and Discussion Preparation of Zirconium Ketone and Aldehyde Complexes, Treatment of bis(cyclopentadieny1)zirconium chloro acyl complexes la-d with trialkylaluminum reagents" in aromatic solvents affords the complexes Cp2Zr(p-$-OCRR') (p-C1)A1R2 (2a-e) in isolated yields of 65-90% (Table I, eq 1). The reaction of the acyl comR

.,1.

-

Cp2Zr(OCMe,).A1Me2C1+ py 2a Cp2Zr(OCMez).A1MezC1.py(2) 4 Ketone complexes can also be prepared by treating Cp2Zr(Me)COMe (3) with dialkylaluminum chloride reagents. Addition of an equimolar12amount of Me,AlCl to a toluene-ds solution of the acyl complex 3 a t -30 "C (eq 3) produced a mixture of products, of which the major product was identified as the ketone complex 2a (6070, 'H NMR vs internal standard).

3

The reaction of the acyl 3 with an equimolar amount of diisobutylaluminum chloride proceeded in higher yield to give the ketone complex 5 (eq 4).13 These reactions are

..,

+

2

plexes la-d with alkylaluminum reagents is exothermic; significant decomposition of the ketone complexes is observed unless the reaction is carried out a t reduced temperatures (30 "C, but can be isolated as pale yellow or colorless powders that are stable under an inert atmosphere below 25 "C. They are moderately air-stable but hydrolyze readily to secondary alcohols and unidentified zirconium products. Complexes 2a-e are formally 1:l adducts between a zirconium ketone complex and AlMe2C1. Attempts to obtain crystals suitable for an X-ray analysis were unsuccessful, nevertheless, spectroscopic and analytical data indicate that AlMe2Clremains coordinated to the ketone ligand, presumably via reciprocal Zr-0-A1 and A1-C1-Zr bridging interactions. For example, resonances due to the AIMez moiety of 2a appear a t -0.28 and -6.32 ppm in the lH and '3c NMR spectra, respectively. Moreover, AIMezCl remains coordinated to the ketone ligand even in the presence of strong Lewis bases such as pyridine. Treatment of 2a with pyridine leads to the formation of the pyridine adduct 4, which can be recrystallized from a mixture of pyridine and ether (eq 2). (6) (a) Collman, J. P.; Finke, R. G.; C a m , J. N.; Brauman, J. I. J. Am. Chem. SOC. 1978,100,4766. (b) Richmond, T. G.; Shriver, D. F. Inorg. Chem. 1982,21, 1272. (c) Butts, S. B.; Strauss, S. H.; Holt, E. M.; 1980,102, Stimson, R. E.; Alcock, N. W.; Shriver, D. F. J. Am. Chem. SOC. 5093. (d) Correa, F.; Nakamura, R.; Stimson, R. E.; Burwell, R. L., Jr.; Shriver, D. F. Zbid. 1980,102,5112. (e) Toscano, P. J.; Marks, T. J. Organometallics 1986,5,400-402. (7).(a) Labinger, J. A.; Bonfiglio, J. N.; Grimmet, D. L.; Masuo, T.; Shearin, E.; Muller, J. S. Organometallics 1983,2,733.(b) Lindner, E.; von Au, G. Angew. Chem., Int. Ed. Engl. 1980,19,824. (8) For an interesting model study in a zirconium-rhodiumsystem see: Ferguson, G. S.; Wolczanski, P. T. J . Am. Chem. SOC. 1986,108,8293. (9)(a) Fischer, H.; Kriessl, F. R.; Hofmann, P.; Dotz, K. H.; Weiss, K. Transrtion Metal Carbene Compleres; Verlag Chemie: Weinhem, 1983. (b) Brown, T. J. Prog. Znorg. Chem. 1980,27,1-122. (c) Casey, C. P. In Reactive Intermediates; Jones, M., Jr., Moss, R. A., Eds.; Wiley: New York, 1981;Vol. 2,pp 135-174. (10)A preliminary account of a portion of this work has appeared: Waymouth, R. M.; Klauser, K. R.; Grubbs, R. H. J. Am. Chem. SOC.1986, 108,6385. (11)Treatment of the acyl complexes 1 with AICIB results in the transmetalation of the acyl ligand from zirconium to aluminum. Carr, D. B.; Schwartz, J. J . Am. Chem. SOC.1979,101,3521.

Waymouth and Grubbs

(~EU),AICI

-u \

CH3

3

5

rapid; no intermediates could be observed for the formation of 5 when a frozen toluene-ds solution of 3 and diisobutylaluminum chloride was allowed to thaw in the NMR probe that had been cooled to -50 "C. Zirconium aldehyde complexes are prepared by treatment of Cp,Zr(Cl)COR with diisobutylaluminum hydride. The aldehyde complex 6a (R = CH,CH,) forms rapidly upon addition of (i-Bu),AlH to a C6D6solution of lb (80% yield, lH NMR, eq 5). The aldehyde complexes were C,H, Cp,Zr;;O~

c H z c : (I-Bu),AIH CI

-

, O°C

YHZCH3

* Cp,Zr-O \

CI-

\

(5)

Al(i-Bu),

lb

isolated as yellow oils and characterized by hydrolysis to the primary alcohols and by spectroscopic comparison with the ketone complexes 2 and related aldehyde complexes reported in the 1iterat~re.l~ In particular, the lH and 13C (12)Treatment of CpzZr(Me)COMewith 0.5 equiv of RzAlX leads to the formation of trinuclear zirconium ketone complexes (Cp2Zr(pq2OCR)),(p-X)(p-Al&). Waymouth, R. M.; Potter, K. S.; Schaefer, W. P.; Grubbs, R. H., manuscript in preparation. (13)The 'H NMR spectrum of the diisobutylaluminum adduct 5 displays doublets for the methyl (1.21ppm) and methylene (0.33ppm) protons of the isobutyl groups (see Experimental Section). However, these protons are diastereotopic in the static structure represented in eq 4 and 8, suggesting that there is a fluxional process which interconverts the isobutyl groups on the NMR time scale. This process most likely involves rotation around the aluminum-oxygen bond. Further studies are underway to address this point. (14)For representative early-transition-metal aldehyde complexes see: (a) Gambarrota, S.; Floriani, C.; Chiesi-Villa, A.; Guastini, C. J. J . Am. Chem. SOC. 1983,105,1690.(b) Fachinetti, G.; Floriani, C.; Roselli, A.; Pucci, S. J. Chem. SOC.,Chem. Commun. 1978,278. (c) Erker, G. Acc. Chem. Res. 1984,17,103.(d) Erker, G.; Kropp, K. Chem. Ber. 1982,115, 2437. ( e ) Kropp, K.; Skibbe, V.; Erker, G . J . Am. Chem. SOC.1983,105, 3353. (0 Kropp, K.; Skibbe, V.; Erker, G. Tetrahedron 1982,38,1285. (9) Skibbe, V.; Erker, G. J. Organomet. Chem. 1983,241,15. (h) Roddick, D. M. Ph.D. Thesis, California Institute of Technology, Pasadena, CA, 1984. (i) Gell, K. I.; Posin, B.; Schwartz, J.; Williams, G. M. J. Am. Chem. SOC.1982,104, 1846. 6) Marsella, J. A.; Folting, D.; Huffman, J. C.; 1981. 103. 5596. See also: (k) FerCaulton. K. G. J. am. Chem. SOC. nandez, J. M.; Emerson, K.; Larsen, R. H.;Gladysz, J. A. J.Am. Chem. SOC.1986,108,8268.

Intramolecular Coupling of Alkyl and Acyl Ligands

Organometallics, Vol. 7, No. 7, 1988 1633

-

k.,

k, T

:D"

CI-AI(CH3)z

7 u

NMR spectra of complex 6a exhibit chara~teristicl~ resoNorton has shown that zirconium ketone complexes can nances at 3.15 and 82.9 ppm for the aldehydic proton and be formed in bimolecular reactions between zirconium acyl the carbonyl carbon, respectively. The spectroscopic data complexes and dimethylzirc~nocene.~~ To rule out that and crystallographic data on related c o m p o u n d ~ ~ ~ J ~ more J ~ than one zirconium center is involved in the reaction suggest that the bonding in these complexes is best deof 3 with dialkylaluminum chloride reagents, a crossover scribed in terms of metalloxiranes rather than n-complexes. experiment was carried out. The reaction between a Mechanism. Two possible reaction pathways for the mixture of 3-d6J3Cand 3 and diisobutylaluminumchloride formation of 2a-e from the chloro acyl complexes 1 are gives the ketone complexes 5-d6J3C and 5 (eq 8). No given in eq 6 and 7. The simplest mechanism (path 1, eq CD. 6) involves the direct reductive alkylation15 of the acyl ligand by Me3Al. Similar mechanisms have been proposed for reductions of acyl ligands by boranes,16 metal hyCI-AI d r i d e ~ and , ~ ~zirconium alkyls.17 Another mechanistic possibility (path B, eq 7) involves a stepwise pathway proceeding by initial transmetalation to give the alkyl acyl (8) complex 3, followed by a 1,Zmigration of the alkyl group to the acyl ligand.

r

R

Cp,Zr-

i

CI-AI

.5. R

R

The observation that the alkyl acyl complexes 3 react with alkylaluminum chlorides to give ketone complexes establishes the feasibility of the latter mechanism but does not rule out direct alkylation (path A). Before further conclusions could be drawn regarding the mechanism of ketone formation from the chloro acyl complexes, it was necessary to establish in detail the mechanism of the reaction between Cp,Zr(Me)COMe (3) and dialkylaluminum chloride reagents. Isotopic labeling studies were employed to probe the mechanism of these reactions and the role of the aluminum reagent. (15) This mechanism is similar to that proposed for the reductive alkylation of organic carbonyl substrates by alkylaluminum reagents. Eisch, J. J. In Comprehensiue Organometallic Chemistry; Wilkinson, G., Stone, F. G. A., Abel, E. W., Eds.; Pergamon: Oxford, 1982; Vol. 9, p 499. (16) (a) Van Doorn, J. A.; Masters, C.; Vogler, H. C. J. Organomet. Chem. 1976, 105, 245. (b) Casey, C. P.; Neumann, S. M.; Andrews, M. A.; McAlister, D. R. Pure Appl. Chem. 1980,52,625. (c) Gladysz, J. A. Aldrichim. Acta 1979, 12, 13. (17) Martin, B. D.; Matchett, S. A.; Norton, J. R.; Anderson, 0. P. J. Am. Chem. SOC.1985, 107, 7952.

crossover products were detected by lH or 13CNMR of the ketone complexes or by GC/mass spectroscopy of the alcohols generated upon hydrolysis of the reaction mixture, a clear indication that the ketone complexes are formed at one zirconium center. Deuterium labeling studies provided further information on the mechanism of this reaction. Treatment of the 3-d6 with MezAICl in toluene-d8 at 0 OC produced the ketone complexes 7 and 8 in a ratio of 4.8:l and an overall yield of 60% (eq 9). The observed product ratio clearly es-

rr

Cp,Zr-.O + \ CD3

Me,AICI

-

CI-A!-CH,

-

CI

-A!

CH3

-

(9) C D,

CH3

8,

7

4:1

tablishes that the predominant pathway for the reaction

1634 Organometallics, Vol. 7, No. 7, 1988

Waymouth and Grubbs

between 3 and MezAICl (eq 2 and 8) involves the intramolecular migration of the methyl group to the acyl ligand and not transmetalation to the 1 followed by direct alkylation by A1(CH3),CD3. As seen in Scheme I, the acyl intermediates 1 and 3 are related by transmetalation between the chloro acyl Me3A1adduct 9 and the alkyl acyl Me2AlC1 adduct 10. Treatment of 3-d, with MezAICl should initially produce 10. Transmetalation to 9 followed by alkylation by A1(CH3)&D3would produce 7 and 8 in a statistical ratio18 of 1:2 due to scrambling of the labeled methyl groups a t the aluminum center. The experimentally observed ratio of 4.8:l (7:8)rules out A as the dominant pathway and implies that the major pathway from the acyl intermediate 10 involves the Lewis acid assisted coupling of the alkyl and acyl ligands (path B). The observation of a small amount of the d3 ketone complex 8 indicates that scrambling processes are competitive with coupling of the alkyl and acyl ligands of 10. The d3 ketone complex 8 could be formed by transmetalation to 9 followed by either (1) direct alkylation of the acyl ligand of 9 by A1(CH3)2CD3or (2) transmetalation back to 10 (with scrambling of the labeled methyl groups) followed by coupling of the alkyl and acyl ligands. At the present time, we cannot distinguish between these two possibilities since no direct information is available concerning the relative rates of direct alkylation of the acyl ligand vs transmetalation from 9 to 10 (k, vs k+ Scheme I). For similar reasons, we cannot rule out A as a pathway for formation of the ketone complexes 2 from the chloro acyl complexes 1 and trialkylaluminum reagents. Given that the relative rates of alkylation vs transmetalation are sensitive" to both the nature of the acyl ligand and the aluminum reagent, both pathways must be considered in a mechanism for the formation of ketone and aldehyde complexes from zirconium acyl complexes and alkylaluminum reagents.lg Further studies will be required to determine the factors that govern the relative rates of alkylation (or hydride addition, path A) vs transmetalation, reductive coupling (path B). A significant result of the labeling studies is the demonstration that ketone complexes can be formed by an intramolecular migration of an alkyl group to a cis acyl ligand and that aluminum reagents induce this coupling reaction. In a related study, Erker has shownz0that in the absence of dialkylaluminum chlorides, the acyl Cp,Zr(Ph)COPh isomerizes to the benzophenone complex [CpZZrOCPh2l2after one hour at 70 OC (eq 10). In the

i"

Cp,Zr-.O \ Ph

p7xph

Cp,Zr-O 70°C 1 hr w

\

\

O-i!rCp,

K

Ph

(10)

Ph

presence of AIRzC1,the acyl complex 3 rearranges rapidly a t -50 OC to give the ketone complexes (eq 3 and 4). Although these reactions yield different products, it is clear that the aluminum reagent facilitates the coupling of alkyl and acyl ligands a t zirconium centers. The role of the aluminum reagent in promoting this coupling reaction is not clear, but it is likely that the aluminum reagent helps to increase the electrophilicity of the acyl carbon by coordinating to the oxygen of the acyl ligand, thereby faci(18) This ratio

assumes a negligible kinetic isotope effect. (19) A transmetalation, reductive coupling mechanism (path B)might also be applicable to reductions observed when acyl ligands are treated

with hydrido" and alkyl" zirconium reagents. (20) (a) Erker, G.; Dorf, U.; Czisch, P.; Peterson, J. L. Organometallics 1986,5668. (b) Erker, G.; Rosenfeldt,F. J. Orgummet. Chem. 1982,224, 29. (c) Rosenfeldt, F.; Erker, G. Tetrahedron Lett. 1980, 21, 1637.

litating migration of the alkyl to the acyl ligand.21 Implications: CO Reduction. The role of alkylaluminum reagents in mediating the formation of zirconium ketone complexes and the formation of ketone complexes from acyl precursors have important implications for CO reduction. Molecular Lewis acids6,' and aluminum promote the migratory insertion of CO to give acyl complexes (eq 11). Our results imply that Lewis 0

0

acidic centers can also assist in the further reduction of acyl ligands to give ketone complexes. Ketone complexes have been proposed as intermediates to explain branching in hydrocarbons produced over metal oxide CO reduction catalysts;zzthe present results provide a mechanistic rational for the formation of such intermediates on the catalyst surface.

Conclusions We have demonstrated that aluminum reagents promote the intramolecular coupling of zirconium alkyl and acyl ligands. These results introduce an additional mechanistic pathway for the reduction of transition-metal acyl complexes. Transmetalation, followed by an intramolecular ligand coupling, has been shown to be an important pathway for the formation of zirconium ketone and aldehyde complexes; similar pathways might be important in reactions of other transition-metal acyl c0mp1exes.l~ The reactivity of these zirconium ketone and aldehyde c o m p l e x e ~as , ~well ~ ~ ~as~the synthesis and structure of related trinuclear Zr,Al bridging ketone complexes,12will be the subjects of forthcoming papers. Experimental Section General Procedures. The general experimental techniques and procedures were described previou~ly.~~ The acyl complexes la-e," 4,24 and were prepared by literature procedures. Me3Al was used neat (Alfa) or as 2 M solutions in toluene (Aldrich). Et& Me2AlC1,(i-Bu)2A1C1,and (i-Bu)2A1Hwere obtained neat from Texas Alkyls and were used without further purification. Mesitylene was dried over calcium hydride, vacuum transferred, and stored in the drybox. NMR solvents were purified as previously described.% All NMR chemical shifts are reported in parts per million relative to TMS and were recorded a t 25 OC unless otherwise indicated. Mass spectra were obtained a t the UC Riverside Mass Spectra facility. Cp2Zr(p-q2-OCMe2)(p-C1)AlMe2 (2a). In a typical procedure, 0.563 g of la (1.88 mmol) was suspended in 10 mL of 1/1 benzenelhexane and cooled to 0 "C in an ice bath. This suspension was treated with 1mL of a 2 M solution of Me3Alto give a yellow solution. Solvent was removed in vacuo a t 0 "C and the pale yellow residue washed with two 5-mL portions of pentane to give 2a as a pale yellow powder (0.465 g, 1.31 mmol, 79%): 'H NMR (CeD6)5.57 (8, 10 H),1.49 (s, 6 H), -0.28 ppm (s, 6 H); I3C NMR (C6D6) 109.9, 80.9, 33.5, -6.32 ppm. Anal. Calcd for (21) Calculations on the isomerization of Cp,Zr(Me)COMe to the ketone complex CpzZr(OCMez)in the absence of Lewis acids suggest that the electrophilicity of the acyl carbon is important in favoring the 1,2migration of the alkyl to the acyl ligand. Hofmann, P., manuscript in preparation. We thank Prof. Hofmann for communicating his results prior to publication. (22) Mazenec, T. J. J. Catal. 1986, 98,115. (23) Waymouth, R. M.; Wysong, E. B.; Grubbs, R. H., unpublished results. (24) Waymouth, R. M.; Santarsiero,B. D.; Coots, R. J.; Brownikowski, M. J.; Grubbs, R. H. J . Am. Chem. SOC.1986,108, 1427. (25) Negishi, E.; Van Horn, D. E.; Yoshida, T. J . Am. Chem. SOC.1985, 107,6639.

Intramolecular Coupling of Alkyl and Acyl Ligands

Organometallics, Vol. 7, No. 7, 1988 1635

ene/hexane and cooled to 0 "C. Neat (i-Bu),AlH (0.352 g, 2.47 ClSH2,0C1ZrAl: C, 48.4; H, 6.0; C1, 9.5. Found: C, 48.47; H, 5.96; mmol) was dissolved in hexane and cannulated into the acyl C1, 9.61. suspension to give a yellow solution. This solution was stirred CpzZr[pq2-OC(Me)CHzCH3](p-C1)AlMez (2b). The acyl l b (0.690 g, 2.204 mmol) was treated with Me3A1by using the profor 15 min and evacuated to give 6a as a yellow oil, which turned brown upon standing for 2 h at room temperature: 'H NMR cedure described for 2a to give 2b as a pale yellow powder (0.728 (C&) 5.59 (5, 5 H), 5.58 (5, 5 H), 3.15 (dd, J = 8.1 Hz, J = 8.3 g, 1.89 mmol, 86%): 'H NMR (C6D6)5.61 (9, 5 H), 5.59 (s, 5 H), 1.92 (m, J = 6.3 Hz, 1 H), 1.62 (m, 1 H), 1.43 (9, 3 H), 0.884 (t, Hz, 1H), 2.15 (m, 2 H), 1.80 (m, 1H), 1.59 (m, 1H), 1.20 (m (br), J = 7.37 Hz, 3 H), -0.25 ppm (s br, 6 H); 13CNMR (C6D6)110.0, 12 H), 1.04 (t,J = 7.32 Hz, 3 H), 0.36 ppm (d, J = 7.32 Hz, 4 H); 13CNMR (C&) 109.2, 109.1, 82.8, 32.4, 28.95, 28.90, 26.8, 15.9 109.9, 86.6, 38.9, 29.9, 12.4 ppm. Cp,Zr [p-q2-OC(Me)CH2CH,CMe3](p-Cl) (AlMe2) (212). The PPm. acyl IC (0.500 g, 1.36 mmol) was treated with Me3A1by using the Cp,Zr(p-~z-OC(H)CH,CH2)(p-C1)(Al(i-Bu)2) (6b) was preprocedure described for 2a to give 2c as a yellow powder (0.450 pared in a manner similar to that of 6a: 'H NMR (C6D6)5.65 (s, 5 H), 5.62 (9, 5 H), 3.17 (m, 1 H), 1.20 (m, 12 H), 0.97 (s, 9 H), g, 1.02 mmol, 7 5 % ) : 'H NMR (COD,)5.68 (9, 5 H), 5.61 (9, 5 H), 1.97 (m, 2 H), 1.47 (s, 3 H), 1.35 (m, 2 H), 0.94 (s, 9 H), -0.22 (s, 0.39 (s, 2 H), 0.32 ppm (s, 2 H). 3 H), -0.29 ppm (s, 3 H); 13CNMR (C6D6) 11O.O,109.08,85.5,41.4, Crossover Experiment. The acyl 3 (8 mg, 0.029 mpol) and the doubly labeled acyl 3-dg13C (9 mg, 0.031 mmol) were weighed 40.8, 30.9, 30.5, 29.7, 6.13 ppm. Anal. Calcd for C20H320C1ZrAr: into an NMR tube modified with a 14/20 joint. A side-arm C, 54.31; H, 7.30. Found: C, 54.25; H, 7.26. CpzZr[p-q2-OC(Et)CH2CH2CMe3](p-C1)AlEt2 (2d). Neat addition tube was charged with 5 pL of mesitylene, 0.14 mL (0.072 Et3Al (0.395 mL, 2.8 mmol) was dissolved in benzene and canmmol) of neat (i-Bu),AlCl, and 0.500 mL of toluene-d8 and atnulated dropwise into a precooled (0 "C) benzene solution of the tached to the NMR tube. The contents of the side arm were added acyl IC (1.043 g, 2.82 mmol). Solvent was removed in vacuo to to the sample at 77 K, and the NMR tube was sealed under CO. afford a waxy yellow solid, which was washed with three 5-mL The sample was thawed at -50 "C and placed in a precooled -30 "C NMR probe. 5, 5-d6-l3C 'H NMR (C7D8,-30 "C) 5.57 (s, 20 portions of pentane to give 2d as a light yellow powder (0.880 g, H), 1.51 (9, 6 H), 1.35 (m, 4 H), 1.21 (d, J = 6.5 Hz, 24 H), 0.38 64%): 'H NMR (C6D6) 6 5.68 (s, 5 H), 5.64 (s, 5 H), 1.94 (m, J = 7.32 Hz, 2 H), 1.68 (m, J = 7.32 Hz, 2 H), 1.39 (m, 3 H), 1.25 ppm (d, J = 6.5 Hz, 8 H); l3 C NMR (C7D8,-30 "C) 79.7 ppm. (m, 2 H), 0.96 (s, 9 H), 0.90 (m, 3 H), 0.35 ppm (m, 4 H). Anal. The NMR tube was then cracked open and the sample hydrolyzed Calcd for C2xHRROClZrAl: C, 57.05; H, 7.91; C1,7.32. Found: C, with water to afford the labeled and unlabeled 2-propanols: 'H 56.98; H, 7.89;C1, 7.41. NMR (C7DB)3.58 (m, J = 6.1 Hz, 1H), 0.94 ppm (d, J = 6.1 Hz, 6 H); 13C NMR (C7D8)63.3 ppm (d, J = 140.1 Hz). GC-mass Cp2Zr[p-q2-OC(Me)CH(CH2),](p-C1)A1Me, (2e). The acyl spectroscopy of the hydrolyzed samples yielded peaks at 49 l e was treated with Me3A1by using the procedure described for (CD23CHOH+)and at 45 (CH312CHOH+)amu, but none a t 48 2a to give 2e as a light yellow powder (0.734 g, 1.668 mmol, 91%): (CD312CHOH+)or at 46 (CH3l3CHOH+)amu. 'H NMR (C,jD,3) 5.63 (s, 5 H), 5.62 (s, 5 H), 1.69 (m, 5 H), 1.47 Labeling Studies. An NMR tube, modified with a 14/20 joint, (m, 1 H), 1.36 (s, 3 H), 1.20 (m, 5 H), -0.29 (s, 3 H), -0.38 ppm was charged with 13 mg (0.045 mmol) of the doubly labeled acyl (s, 3 HI. Cp2Zr(p-q2-OCMe,)(A1Me2Cl)(py) (4). The ketone complex 3-d6-13C,fitted with a side-arm addition tube and a gas bulb 2a (0.700 g, 1.88 mmol) was dissolved in benzene and treated with adaptor. To the side-arm addition tube were added 0.17 mL of excess pyridine via syringe. The resulting pale yellow solution a 2.6 M C6D6solution of A1Me2Cl, 0.500 mL of C7DB,and 5 pL was filtered through a pad of Celite on a fine frit and evacuated of mesitylene as an internal standard. The contents of the addition tube were added to the acyl at 77 K, the NMR tube was sealed to give 4 as a yellow powder (0.556 g, 1.24 mmol, 66%). A sample for analysis was obtained by dissolving 2a in a minimum of under CO, and the spectra were recorded at 0 "C. Integration of the cyclopentadienyl vs the mesitylene resonances indicated pyridine, layering with Et20, and cooling slowly to -50 "C: 'H a 60% yield of 7 and 8. Integration of the cyclopentadienyl vs NMR (C6D6)8.40 (m, 2 H), 6.80 (m, 1 H), 6.50 (m, 2 H), 5.76 (8, 10 H), 1.73 (s, 6 H), -0.12 ppm (s, 6 H); l3cNMR (C6D6)148.2, the methyl resonance at 1.48 ppm revealed a ratio of 4.81 for 7:s: 138.9, 124.3, 109.8, 78.1, 35.3. Anal. Calcd ~ O ~ ' C ~ ~ H ~ ~ O C'H~NMR Z ~ A(C&) ~ : 5.51 (s, 20 H), 1.48 (d, J = 5.37 Hz, 0.63 H), -0.21 C, 53.25; H, 6.03; N, 3.11; C1, 7.86. Found: C, 53.25; H, 6.06; N, ppm (s, 11H); 13CNMR (C7DB)79.7 ppm; ,D NMR (C7D8)1.43 3.21; C1, 7.93. PPm. Formation of 5 from 3. The acyl 3 (28 mg, 0.10 mmol) was weighed into an NMR tube modified with a 14/20 joint and Acknowledgment. We gratefully acknowledge finandissolved in 0.500 mL of toluenedBcontaining 5 pL of mesitylene cial support from the Department of Energy. R.M.W. was as an internal standard. Diisobutylaluminum chloride (0.02 mL) supported in part by a W.R. Grace Fellowship and SOH10 was condensed into the NMR tube at 77 K and the tube sealed fellowship in catalysis. We thank Dr. W. Tu" for helpful with a torch under CO. The solution was allowed to thaw at -50 comments and suggestions. "C, and the NMR spectra were recorded at -10 "C. Integration of the cyclopentadienyl and mesitylene resonances of the 'H NMR Registry No. la, 77001-15-1; lb, 83385-24-4;IC,82808-20-6; Id, 104114-54-7;2a, 114789-53-6;2b, 114762-78-6;2c, 114762-79-7; spectrum indicated an 87% yield of the ketone complex 5: 'H NMR (C7DB)5.57 (s, 10 H), 1.50 (s, 6 H), 1.35 (m, 2 H), 1.21 (d, 2d, 114762-80-0; 2e, 114762-81-1; 3, 60970-97-0; 3-d6-13C, 114762-88-8;4,114762-82-2;5,114762-83-3;6-d6-13C,114762-85-5; J = 6.6 Hz, 12 H), 0.33 ppm (d, J = 7.08 Hz, 4 H); 13C NMR 6a, 114762-84-4;7, 114762-86-6;8, 114762-87-7;A1Me3, 75-24-1; (C7DB):109.3, 80.3, 33.5, 28.5, 26.5, 21.2 ppm. AlEt,, 97-93-8; Me2AlC1, 1184-58-3; ( i - B ~ ) ~ A l 1779-25-2; cl, Cp2Zr[p-q2-OCH(CH2CH3)](p-C1)(Al(i-Bu)z) (6a). The acyl (iBu),AlH, 1191-15-7. l b (0.766 g, 2.44 mmol) was suspended in 10 mL of 1/1 benz-